New "Target Of" gene page section

Mon, 2013-10-28

With the October 2013 update, gene pages now include "Target Of" annotations, which describe genes that affect the gene of interest. These annotations are essentially the reciprocal of ontology annotation extensions. Each "Target Of" annotation includes a relationship that indicates how the genes are connected, the name and product of the second gene, and a reference. Genes listed under "Target Of" may include upstream regulators or enzymes that modify the product of the gene of interest. For example, the "Target Of" annotations for cdc2 indicate that it is a substrate of, and regulated by, the kinase Wee1 and the phosphatase Cdc25 (among others). At present, "Target Of" data includes annotations derived from GO annotation extensions. We will soon extend it to include data from phenotype annotation extensions.