mug134 (SPAC10F6.16)


Gene Standard Namemug134 Characterisation Statusbiological role inferred
Systematic IDSPAC10F6.16 Feature Typeprotein coding
Synonymsigo1 Name DescriptionMeiotically Upregulated Gene
ProductmRNA stability protein Igo1 (predicted) Product Size139aa, 15.44 kDa
Genomic Location Chromosome I, 1238896-1240185 (1290nt); CDS:1238896-1239424 (529nt)

Ensembl Gene Location
GO Biological Process
Term NameCount
mRNA stabilization4
Annotation ExtensionEvidenceWith/FromReference
regulation of phosphoprotein phosphatase activity5
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
cytoplasm4211
Annotation ExtensionEvidenceWith/FromReference
cytoplasmic mRNA processing body14
Annotation ExtensionEvidenceWith/FromReference
cytosol2302
Annotation ExtensionEvidenceWith/FromReference
nucleus2692
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

Term NameGenotypesCount
increased cell population growth ratemug134Δ256
sensitive to 5-fluorouracilmug134Δ273
viable vegetative cell populationmug134Δ3840

Cell Phenotype

Term NameGenotypesCount
viable vegetative cell with normal cell morphologymug134Δ3100
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons1238896..1238979, 1239025..1239108, 1239173..1240185
Intron1238980..1239024, 1239109..1239172
mRNA1238896..1240185
CDS1238896..1238979, 1239025..1239108, 1239173..1239424
3' UTR1239425..1240185SPAB1289
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF04667 Pfam IPR006760 Endosulphine 26 97 1
PTHR10358:SF6 HMMPANTHER 16 139 1
PTHR10358 HMMPANTHER 16 139 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 111.09 Da
Charge 8.50
Codon Adaptation Index 0.36
Isoelectric point 10.33
Molecular weight 15.44 kDa
Number of residues 139
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serine 1676
present during mitotic M phaseS64
present during mitotic M phaseS31
present during mitotic M phaseS102
present during mitotic M phaseS99
present during mitotic M phaseS89
level fluctuates during mitotic cell cycleS64
S31
Annotation ExtensionEvidenceResidueReference
present during mitotic M phase experimental evidence S64 PMID:21712547
present during mitotic M phase experimental evidence S31 PMID:21712547
present during mitotic M phase experimental evidence S102 PMID:21712547
present during mitotic M phase experimental evidence S99 PMID:21712547
present during mitotic M phase experimental evidence S89 PMID:21712547
level fluctuates during mitotic cell cycle experimental evidence S64 PMID:24763107
experimental evidence S31 PMID:24763107
O-phospho-L-threonine 701
present during mitotic M phaseT92
Annotation ExtensionEvidenceResidueReference
present during mitotic M phase experimental evidence T92 PMID:21712547
mannosylated residue 89
Annotation ExtensionEvidenceResidueReference
mass spectrometry evidence PMID:26644575
Sequence
Gene Expression

Qualitative Gene Expression

DescriptionLevelEvidenceReference
RNA levelincreased during GO:0051321experimental evidencePMID:16303567

Quantitative Gene Expression

View graphical display of gene expression data for mug134 (SPAC10F6.16)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
9229.33during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
7280.95during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
2.7during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
0.82during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4606
conserved in eukaryotes4516
conserved in metazoa3424
conserved in vertebrates3399
conserved in eukaryotes only2506
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


External References
Database Identifier Description
NBRP SPAC10F6.16 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC10F6.16 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC10F6.16 BioGRID Interaction Datasets
Expression Viewer SPAC10F6.16 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC10F6.16 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC10F6.16 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC10F6.16 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC10F6.16 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC10F6.16 Transcriptome Viewer (Bähler Lab)
GEO SPAC10F6.16 GEO profiles
PInt SPAC10F6.16 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC10F6.16 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC10F6.16 Fission yeast phenotypic data & analysis
Cyclebase SPAC10F6.16.1 Cell Cycle Data
SPD / RIKEN05/05D01Orfeome Localization Data
UniProtKB/SwissProtP79058mRNA stability protein mug134
ModBaseP79058Database of comparative protein structure models
STRINGP79058Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_593267mRNA stability protein Igo1 (predicted)
RefSeq mRNANM_001018664972h- mRNA stability protein Igo1 (predicted) (mug134), mRNA

Literature for mug134

Search: Europe PMC or PubMed

Release Version: PomBase:30_59 - 12 Apr 2016