fhl1 (SPAC1142.08)

Gene Standard Namefhl1 Characterisation Statuspublished
Systematic IDSPAC1142.08 Feature Typeprotein coding
SynonymsSPAC8C9.01 Name Description
Productforkhead transcription factor Fhl1 Product Size743aa, 81.13 kDa
Genomic Location Chromosome I, 3639860-3642338 (2479nt); CDS:3639988-3642219 (2232nt)

Ensembl Gene Location
GO Molecular Function
GO Biological Process
Term NameCount
cell cycle959
Annotation ExtensionEvidenceWith/FromReference
positive regulation of transcription from RNA polymerase II promoter87
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000725resistance to methyl methanesulfonateCell growth assayfhl1ΔNullPMID:157777222
FYPO:0001701sensitive to bortezomib256
expressivity FYPO_EXT:0000003Cell growth assayfhl1ΔNullPECO:0000005, PECO:0000137PMID:21760946
FYPO:0001234slow vegetative cell population growthCell growth assayfhl1ΔNullPMID:1577772278
FYPO:0002060viable vegetative cell populationMicroscopyfhl1ΔNullPECO:0000005, PECO:0000137PMID:236978063759

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000303decreased conjugation frequencyCell growth assayfhl1ΔNullPMID:1805947536
FYPO:0000223elongated multiseptate cell48
penetrance FYPO_EXT:0000003Microscopyfhl1ΔNullPMID:15777722
FYPO:0000590normal sporulationMicroscopyfhl1ΔNullPMID:1577772245
FYPO:0001492viable elongated vegetative cell221
penetrance FYPO_EXT:0000003Microscopyfhl1ΔNullPMID:15777722
FYPO:0002177viable vegetative cell with normal cell morphology3089
penetrance FYPO_EXT:0000001Microscopyfhl1ΔNullPECO:0000005, PECO:0000137PMID:23697806
Ensembl transcript structure with UTRs, exons and introns


Exon Start End


Region Coordinates Reference
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00250 Pfam IPR001766 Transcription factor, fork head 291 384 4
PF00498 Pfam IPR000253 Forkhead-associated (FHA) domain 39 111 8
SM00339 SMART IPR001766 Transcription factor, fork head 289 379 4
SM00240 SMART IPR000253 Forkhead-associated (FHA) domain 38 94 6
PS50006 Prosite Profiles IPR000253 Forkhead-associated (FHA) domain 39 94 8
PS50039 Prosite Profiles IPR001766 Transcription factor, fork head 291 385 4
PTHR11829:SF108 HMMPANTHER 17 741 1
PTHR11829 HMMPANTHER 17 741 4 Gene3D IPR000253 Forkhead-associated (FHA) domain 32 127 8 Gene3D IPR011991 Winged helix-turn-helix DNA-binding domain 286 376 46
SSF46785 SuperFamily 290 384 49
SSF49879 SuperFamily IPR008984 SMAD/FHA domain 28 125 8
PR00053 PRINTS IPR001766 Transcription factor, fork head 335 352 4
PR00053 PRINTS IPR001766 Transcription factor, fork head 312 329 4
PR00053 PRINTS IPR001766 Transcription factor, fork head 291 304 4

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0013111forkhead domainTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0013111

Protein Properties

Ave. residue weight 109.19 Da
Charge 16.00
Isoelectric point 9.35
Molecular weight 81.13 kDa
Number of residues 743
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
NDduring cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
3.1during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
1.3during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633
Species Distribution
conserved in fungi4600
conserved in eukaryotes4514
conserved in eukaryotes only2497

Manually curated orthologous groups


Orthologs in Compara

Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
ams2cell cycle regulated GATA-type transcription factor Ams2 Positive GeneticPMID:22681890
pnk1DNA kinase/phosphatase Pnk1 Synthetic Growth DefectPMID:18931302
Negative GeneticPMID:22681890
SPAC323.03cSchizosaccharomyces specific protein Negative GeneticPMID:22681890
btf3nascent polypeptide-associated complex beta subunit Negative GeneticPMID:22681890
ase1antiparallel microtubule cross-linking factor Ase1 Synthetic Growth DefectPMID:18931302
Negative GeneticPMID:22681890
lsk1P-TEFb-associated cyclin-dependent protein kinase Lsk1 Positive GeneticPMID:22681890
rps2340S ribosomal protein S23 (predicted) Negative GeneticPMID:22681890
mph1dual specificity protein kinase Mph1 Synthetic Growth DefectPMID:18931302
ppk14serine/threonine protein kinase Ppk14 (predicted) Negative GeneticPMID:22681890
shf1small histone ubiquitination factor Shf1 Positive GeneticPMID:22681890
rfp1SUMO-targeted ubiquitin-protein ligase subunit Rfp1 Synthetic Growth DefectPMID:18931302
spn1septin Spn1 Negative GeneticPMID:22681890
ago1argonaute Negative GeneticPMID:22681890
atp15F0-ATPase epsilon subunit (predicted) Negative GeneticPMID:22681890
mga2IPT/TIG ankyrin repeat containing transcription regulator of fatty acid biosynthesis (predicted) Negative GeneticPMID:22681890
ftp105Ubp5 interacting protein Ftp105 Negative GeneticPMID:22681890
swd1Set1C complex subunit Swd1 Positive GeneticPMID:22681890
SPAC56F8.02AMP binding enzyme (predicted) Negative GeneticPMID:22681890
zfs1CCCH tandem zinc finger protein, human Tristetraprolin homolog Zfs1, involved in mRNA catabolism Negative GeneticPMID:22681890
snu66U4/U6 x U5 tri-snRNP complex subunit Snu66 Negative GeneticPMID:22681890
spf38U5 snRNP complex subunit Spf38 Negative GeneticPMID:22681890
hat1histone acetyltransferase Hat1 Negative GeneticPMID:22681890
ypa2protein phosphatase type 2A regulator, PTPA family Ypa2 Positive GeneticPMID:22681890
elp3elongator complex subunit Elp3 (predicted) Positive GeneticPMID:22681890
sre2membrane-tethered transcription factor Sre2 Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
arf6ADP-ribosylation factor, Arf family Arf6 Negative GeneticPMID:22681890
SPBC56F2.08cRNA-binding protein (predicted) Negative GeneticPMID:22681890
SPCC663.15cconserved fungal protein Negative GeneticPMID:22681890
yam8stretch-activated calcium channel Yam8 Synthetic Growth DefectPMID:18931302
SPBC725.01aspartate aminotransferase (predicted) Negative GeneticPMID:22681890
rmt3type I ribosomal protein arginine N-methyltransferase Rmt3 Negative GeneticPMID:22681890
rps80140S ribosomal protein S8 (predicted) Negative GeneticPMID:22681890
vps1dynamin family protein Vps1 Negative GeneticPMID:22681890
SPBPB7E8.01Schizosaccharomyces specific protein, predicted GPI anchor Negative GeneticPMID:22681890
SPBC839.02arrestin Aly1 related, implicated in endocytosis Negative GeneticPMID:22681890
pst2Clr6 histone deacetylase complex subunit Pst2 Negative GeneticPMID:22681890
res1MBF transcription factor complex subunit Res1 Negative GeneticPMID:22681890
slm9hira protein Slm9 Synthetic Growth DefectPMID:18931302
rik1silencing protein Rik1 Synthetic Growth DefectPMID:18931302
dsc3Golgi Dsc E3 ligase complex subunit Dsc3 Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
SPCC550.03cSki complex RNA helicase Ski2 (predicted) Negative GeneticPMID:22681890
sck2serine/threonine protein kinase Sck2 Negative GeneticPMID:24463365
uch1ubiquitin C-terminal hydrolase Uch1 Negative GeneticPMID:22681890
pmc2mediator complex subunit Pmc2/Med1 Negative GeneticPMID:22681890
stm1G-protein coupled receptor Stm1 Negative GeneticPMID:22681890
SPCC16C4.106-phosphogluconolactonase (predicted) Negative GeneticPMID:22681890
SPBC17A3.06phosphoprotein phosphatase (predicted) Positive GeneticPMID:22681890
SPAC6G9.14RNA-binding protein (predicted) Negative GeneticPMID:22681890
sft1SNARE Sft1 (predicted) Positive GeneticPMID:22681890
pac10prefoldin subunit 3 Pac10 (predicted) Positive GeneticPMID:22681890
SPAC9.07cGTPase Rbg1 (predicted) Negative GeneticPMID:22681890
rpl160160S ribosomal protein L13/L16 (predicted) Negative GeneticPMID:22681890
med13mediator complex subunit Srb9 Negative GeneticPMID:22681890
SPAC2H10.01transcription factor, zf-fungal binuclear cluster type (predicted) Negative GeneticPMID:22681890
dsc1Golgi Dsc E3 ligase complex subunit Dsc1 Negative GeneticPMID:21504829
rps170240S ribosomal protein S17 (predicted) Negative GeneticPMID:22681890
fkh2forkhead transcription factor Fkh2 Phenotypic EnhancementPMID:18059475
ssp2serine/threonine protein kinase Ssp2 Negative GeneticPMID:22681890
rps40240S ribosomal protein S4 (predicted) Negative GeneticPMID:22681890
shk2PAK-related kinase Shk2 Synthetic Growth DefectPMID:18931302
cdc37Hsp90 co-chaperone Cdc37 Negative GeneticPMID:22681890
SPBC365.16conserved protein Negative GeneticPMID:22681890
nro1negative regulator of Ofd1, Nro1 Negative GeneticPMID:22681890
meu10GPI anchored cell surface protein involved in ascospore wall assembly Meu10 Negative GeneticPMID:22681890
kin1microtubule affinity-regulating kinase Kin1 Negative GeneticPMID:22681890
sgf73SAGA complex subunit Sgf73 Positive GeneticPMID:25076038
SPBPB10D8.02carylsulfatase (predicted) Negative GeneticPMID:22681890
mkh1MEK kinase (MEKK) Mkh1 Synthetic Growth DefectPMID:18931302
SPCC162.11curidine kinase/uracil phosphoribosyltransferase (predicted) Positive GeneticPMID:22681890
otu2ubiquitin specific cysteine protease, OTU family, Otu2 Negative GeneticPMID:22681890
rpl170260S ribosomal protein L17 (predicted) Negative GeneticPMID:22681890
sat1Golgi membrane exchange factor subunit Sat1 (predicted) Negative GeneticPMID:22681890
prz1calcineurin responsive transcription factor Prz1 Negative GeneticPMID:22681890
pof7F-box protein Pof7 Negative GeneticPMID:22681890
abc4glutathione S-conjugate-exporting ATPase Abc4 Negative GeneticPMID:22681890
lsc1Lsk1 associated cyclin Positive GeneticPMID:22681890
rps40140S ribosomal protein S4 (predicted) Negative GeneticPMID:22681890
fft3SMARCAD1 family ATP-dependent DNA helicase Fft3 Positive GeneticPMID:22681890
alg6glucosyltransferase Alg6 Positive GeneticPMID:22681890
fus1formin Fus1 Negative GeneticPMID:22681890
mfs2MFS family membrane transporter Mfs2 (predicted) Negative GeneticPMID:22681890
raf2Rik1-associated factor Raf2 Negative GeneticPMID:22681890
SPCC736.07cunconventional prefoldin involved in translation initiation (predicted) Positive GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPAC1142.08 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC1142.08 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC1142.08 BioGRID Interaction Datasets
Expression Viewer SPAC1142.08 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC1142.08 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC1142.08 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC1142.08 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC1142.08 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC1142.08 Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC1142.08 Cell Cycle Data
GEO SPAC1142.08 GEO profiles
PInt SPAC1142.08 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC1142.08 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC1142.08 Fission yeast phenotypic data & analysis
SPD / RIKEN38/38A12Orfeome Localization Data
UniProtKB/SwissProtO14270Fork head transcription factor 1
ModBaseO14270Database of comparative protein structure models
STRINGO14270Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_594272fork head transcription factor Fhl1
RefSeq mRNANM_001019695972h- fork head transcription factor Fhl1 (fhl1), mRNA
European Nucleotide ArchiveCAB77015.1ENA Protein Mapping
UniParcUPI000013B77EUniProt Archive

Literature for fhl1

Search: Europe PMC or PubMed

Release Version: PomBase:23_47 - 27 Oct 2014