SPAC11D3.14c


Gene Standard NameUnassigned Characterisation Statusbiological_role_inferred
Systematic IDSPAC11D3.14c Feature Typeprotein coding
Synonyms Name Description
Product5-oxoprolinase (ATP-hydrolizing) (predicted) Product Size1260aa, 138.78 kDa
Genomic Location Chromosome I, 135736-131190 (4547nt); CDS:135101-131319 (3783nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:00171685-oxoprolinase (ATP-hydrolyzing) activityISOSGD:S000001698GO_REF:00000242
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0006749glutathione metabolic processISOSGD:S000001698GO_REF:000002413
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005829cytosolIDAPMID:168233722317
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopySPAC11D3.14cΔNullPECO:0000005, PECO:0000137PMID:236978063755
MicroscopySPAC11D3.14cΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphologyMicroscopySPAC11D3.14cΔNullPECO:0000005, PECO:0000137PMID:236978063078
penetrance FYPO_EXT:0000001
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
1135736131190

UTRs

Region Start End Reference
three_prime_UTR131318131190PMID:21511999
five_prime_UTR135736135102PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF01968 Pfam IPR002821 Hydantoinase/oxoprolinase 230 523 2
PF05378 Pfam IPR008040 Hydantoinaseoxoprolinase, N-terminal 6 211 2
PF02538 Pfam IPR003692 Hydantoinase B/oxoprolinase 730 1257 2
PTHR11365 HMMPANTHER 1 1257 2
Low complexity (SEG) seg 431 446

View domain organization at Pfam

Protein Properties

Ave. residue weight 110.15 Da
Charge -9.00
Isoelectric point 5.95
Molecular weight 138.78 kDa
Number of residues 1260
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
4037.5during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
NDduring cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
2.9during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
1during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Genome Organisation
DescriptionQualifierReferenceCount
divergent duplication2
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3080
conserved in fungi4564
conserved in eukaryotes4482
conserved in bacteria1001
conserved in metazoa3419
conserved in vertebrates3394
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
elp3elongator complex, histone acetyltransferase subunit Elp3 (predicted) Positive GeneticPMID:22681890
ams2cell cycle regulated GATA-type transcription factor Ams2 Negative GeneticPMID:22681890
ssp2serine/threonine protein kinase Ssp2 Negative GeneticPMID:22681890
ppe1serine/threonine protein phosphatase Ppe1 Negative GeneticPMID:22681890
amk2AMP-activated protein kinase beta subunit Amk2 Negative GeneticPMID:22681890
ufd2ubiquitin-protein ligase E4 (predicted) Positive GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPAC11D3.14c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC11D3.14c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC11D3.14c BioGRID Interaction Datasets
Expression Viewer SPAC11D3.14c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC11D3.14c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC11D3.14c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC11D3.14c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC11D3.14c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC11D3.14c Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC11D3.14c Cell Cycle Data
GEO SPAC11D3.14c GEO profiles
PInt SPAC11D3.14c Protein-Protein Interaction Predictor (Bähler Lab)
WikiGene2542986oxoprolinase (predicted)
EntrezGene2542986oxoprolinase (predicted)
SPD / RIKEN39/39C08Orfeome Localization Data
UniProtKB/SwissProtQ10093Uncharacterized protein C11D3.14c
ModBaseQ10093Database of comparative protein structure models
StringQ10093Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_592809oxoprolinase (predicted)
RefSeq mRNANM_001018209972h- oxoprolinase (predicted) (SPAC11D3.14c), mRNA
European Nucleotide ArchiveCAA92315ENA Protein Mapping
UniParcUPI000013A13BUniProt Archive

Literature for SPAC11D3.14c

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014