Gene Standard NameUnassigned Characterisation Statusbiological role inferred
Systematic IDSPAC11D3.14c Feature Typeprotein coding
Synonyms Name Description
Product5-oxoprolinase (ATP-hydrolizing) (predicted) Product Size1260aa, 138.78 kDa
Genomic Location Chromosome I, 135736-131190 (4547nt); CDS:135101-131319 (3783nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
5-oxoprolinase (ATP-hydrolyzing) activity2
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process

GO Slim Terms


Term NameCount
Annotation ExtensionEvidenceWith/FromReference
glutathione metabolic process12
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Single-allele Phenotypes

Population Phenotype

Term NameGenotypesCount
viable vegetative cell populationSPAC11D3.14cΔ3815

Cell Phenotype

Term NameGenotypesCount
viable vegetative cell with normal cell morphologySPAC11D3.14cΔ3095
Target Of
FYPO affected by mutation in tsc1 hamartin
FYPO affected by mutation in tsc2 tuberin
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
5' UTR135736..135102PMID:21511999
3' UTR131318..131190PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF01968 Pfam IPR002821 Hydantoinase/oxoprolinase 230 523 2
PF02538 Pfam IPR003692 Hydantoinase B/oxoprolinase 730 1257 2
PF05378 Pfam IPR008040 Hydantoinaseoxoprolinase, N-terminal 6 211 2
PTHR11365 HMMPANTHER 1 1256 2
PTHR11365:SF2 HMMPANTHER 1 1256 2

View domain organization at Pfam

Protein Properties

Ave. residue weight 110.15 Da
Charge -9.00
Codon Adpatation Index 0.39
Isoelectric point 5.95
Molecular weight 138.78 kDa
Number of residues 1260
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
4037.5during GO:0072690PECO:0000014,
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
2.9during GO:0072690PECO:0000014,
population wideexperimental evidencePMID:23101633
1during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
population wideexperimental evidencePMID:23101633
Genome Organisation
divergent duplication2
Taxonomic Conservation
predominantly single copy (one to one)3090
conserved in fungi4604
conserved in eukaryotes4514
conserved in bacteria1000
conserved in metazoa3421
conserved in vertebrates3396

Manually curated orthologous groups


Orthologs in Compara

Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
negative genetic interaction withamk2AMP-activated protein kinase beta subunit Amk2 Negative GeneticPMID:22681890
negative genetic interaction withams2cell cycle regulated GATA-type transcription factor Ams2 Negative GeneticPMID:22681890
positive genetic interaction withelp3elongator complex subunit Elp3 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withppe1serine/threonine protein phosphatase Ppe1 Negative GeneticPMID:22681890
negative genetic interaction withssp2AMP-activated protein serine/threonine kinase alpha subunit Ssp2 Negative GeneticPMID:22681890
positive genetic interaction withufd2ubiquitin-protein ligase E4 Ufd2 (predicted) Positive GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPAC11D3.14c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC11D3.14c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC11D3.14c BioGRID Interaction Datasets
Expression Viewer SPAC11D3.14c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC11D3.14c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC11D3.14c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC11D3.14c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC11D3.14c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC11D3.14c Transcriptome Viewer (Bähler Lab)
GEO SPAC11D3.14c GEO profiles
PInt SPAC11D3.14c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC11D3.14c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC11D3.14c Fission yeast phenotypic data & analysis
Cyclebase SPAC11D3.14c.1 Cell Cycle Data
SPD / RIKEN39/39C08Orfeome Localization Data
UniProtKB/SwissProtQ10093Uncharacterized protein C11D3.14c
ModBaseQ10093Database of comparative protein structure models
STRINGQ10093Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_592809oxoprolinase (predicted)
RefSeq mRNANM_001018209972h- oxoprolinase (predicted) (SPAC11D3.14c), mRNA
European Nucleotide ArchiveCU329670ENA EMBL mapping
European Nucleotide ArchiveCAA92315ENA Protein Mapping
European Nucleotide ArchiveCAA92315.1ENA Protein Mapping
UniParcUPI000013A13BUniProt Archive

Literature for SPAC11D3.14c

Search: Europe PMC or PubMed

Release Version: PomBase:28_55 - 09 Sep 2015