pyp3 (SPAC11E3.09)

Gene Standard Namepyp3 ChromosomeI
Systematic IDSPAC11E3.09 Gene Start5298656
Synonyms Gene End5300189
Productprotein-tyrosine phosphatase Pyp3 Gene Length1534
Feature Typeprotein coding CDS Start5298838
Name Description CDS End5299854
Characterisation Statuspublished CDS Length1017

Ensembl Gene Location
  1. sea3
  2. SPNCRNA.1067
  3. map1
  4. vma4
  5. nse6
  6. pyp3
  7. SPAC11E3.10
  8. syt22
  9. SPAC11E3.12
  10. gas5
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0000648small viable vegetative cellMicroscopypyp3+ (wild type)wild_typeOverexpressionPECO:0000005, PECO:0000126PMID:1464318
FYPO:0001420normal vegetative cell population growth rateCell growth assaypyp3delta (deletion)deletionNot specifiedPMID:1464318
FYPO:0002060viable vegetative cell populationMicroscopypyp3delta (deletion)deletionPMID:20473289
GO Molecular Function

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Term IDTerm NameEvidenceWith/FromReference
GO:0004725protein tyrosine phosphatase activity
has_direct_input cdc2IDAPMID:1464318
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0006470protein dephosphorylationIDAPMID:1464318
GO:0007165signal transductionICGO:0007346, GO:0004725GO_REF:0000001
GO:0010971positive regulation of G2/M transition of mitotic cell cycleIMPPMID:1464318
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0005634nucleusIDAPMID:16823372
GO:0005737cytoplasmISSUniProtKB:P25044GO_REF:0000001
GO:0005829cytosolIDAPMID:16823372
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
152986565299125
252992315300189

References

Region Start End Reference
three_prime_UTR52998555300189PMID:21511999
three_prime_UTR52998555300189PMID:21511999
five_prime_UTR52986565298837PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF00102 IPR000242 Pfam Protein-tyrosine phosphatase, receptor/non-receptor type 51 289 3
SM00194 IPR000242 SMART Protein-tyrosine phosphatase, receptor/non-receptor type 22 294 3
PS50056 IPR000387 Prosite Profiles Protein-tyrosine/Dual specificity phosphatase 203 283 6
PS50055 IPR000242 Prosite Profiles Protein-tyrosine phosphatase, receptor/non-receptor type 52 292 3
PS00383 IPR016130 Prosite Patterns Protein-tyrosine phosphatase, active site 225 235 7
G3DSA:3.90.190.10 Gene3D 46 295 8
SSF52799 SuperFamily 43 296 9
PR00700 IPR000242 PRINTS Protein-tyrosine phosphatase, receptor/non-receptor type 222 240 3
PR00700 IPR000242 PRINTS Protein-tyrosine phosphatase, receptor/non-receptor type 181 198 3
PR00700 IPR000242 PRINTS Protein-tyrosine phosphatase, receptor/non-receptor type 92 112 3
PR00700 IPR000242 PRINTS Protein-tyrosine phosphatase, receptor/non-receptor type 259 274 3
PR00700 IPR000242 PRINTS Protein-tyrosine phosphatase, receptor/non-receptor type 275 285 3
PR00700 IPR000242 PRINTS Protein-tyrosine phosphatase, receptor/non-receptor type 77 84 3
PTHR19134:SF68 hmmpanther 24 293 1
PTHR19134 hmmpanther 24 293 3

View domain organization at Pfam

Protein Properties

Ave. residue weight 114.14 Da
Charge 3.00
Isoelectric point 7.94
Molecular weight 34.58 kDa
Number of residues 303
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencesingle-celled organism vegetative growth phasePECO:0000005,
PECO:0000014		population_widePMID:23101633
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127		population_widePMID:23101633
RNA levelexpression microarray evidencecellular response to oxidative stressincreasedPMID:12529438
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide0.39PMID:23101633
experimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide1.3PMID:23101633
Species Distribution
DescriptionQualifierReference
conserved in fungi
conserved in eukaryotes
conserved in metazoa
conserved in vertebrates
conserved in eukaryotes only
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
cdc2cyclin-dependent protein kinase Cdk1/Cdc2 Dosage LethalityPMID:1464318
SPCC794.01cglucose-6-phosphate 1-dehydrogenase (predicted) Positive GeneticPMID:22681890
SPBC21C3.14csequence orphan Positive GeneticPMID:22681890
SPCC584.11cSvf1 family protein Svf1 Positive GeneticPMID:22681890
cdc25M phase inducer phosphatase Cdc25 Phenotypic EnhancementPMID:7961734
Dosage Rescue
Dosage RescuePMID:1464318
Dosage RescuePMID:11238887
ash2Ash2-trithorax family protein Positive GeneticPMID:22681890
SPCP1E11.10ankyrin repeat protein, unknown biological role Negative GeneticPMID:22681890
swi10DNA repair endonuclease Swi10 Synthetic Growth DefectPMID:18931302
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
cdc2cyclin-dependent protein kinase Cdk1/Cdc2 Biochemical ActivityPMID:1464318
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External References
Database Identifier Description
NBRP SPAC11E3.09 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC11E3.09 Retrieval of eukaryotic orthologs
BioGrid SPAC11E3.09 BioGRID Interaction Datasets
Bähler Lab SPAC11E3.09 Cell Cycle Expression Profile
Bähler Lab SPAC11E3.09 Meiosis/Sporulation Expression Profies
Bähler Lab SPAC11E3.09 Pheromone response/mating expression profiles
Bähler Lab SPAC11E3.09 Environmental stress expression profiles
Bähler Lab SPAC11E3.09 Bähler Lab Transcriptome Viewer
Cyclebase SPAC11E3.09 Cell Cycle Data
PInt SPAC11E3.09 Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPAC11E3.09 Entrez Gene
IntEnz3.1.3.48
EntrezGene2541443protein-tyrosine phosphatase Pyp3
Uniprot_genenamePYP3
WikiGene2541443protein-tyrosine phosphatase Pyp3
SPD / RIKEN52/52A10Orfeome Localization Data
UniProtKB/SwissProtP32587Tyrosine-protein phosphatase 3
ModBaseP32587Database of comparative protein structure models
Pfam Protein DomainsP32587Pfam Domain Arrangement
RefSeq PeptideNP_594934protein-tyrosine phosphatase Pyp3
RefSeq mRNANM_001020365972h- protein-tyrosine phosphatase Pyp3 (pyp3), mRNA
European Nucleotide ArchiveCAA49609ENA Protein Mapping
European Nucleotide ArchiveCAB11188ENA Protein Mapping
UniParcUPI000004DC17UniProt Archive

Literature for pyp3
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Search: UK PMC or PubMed

Release Version: PomBase:18_35 - 11 May 2013