arp2 (SPAC11H11.06)

Gene Standard Namearp2 ChromosomeI
Systematic IDSPAC11H11.06 Gene Start4783007
SynonymsSPAC22F8.01 Gene End4784765
ProductARP2/3 actin-organizing complex subunit Arp2 Gene Length1759
Feature Typeprotein coding CDS Start4783055
Name Description CDS End4784277
Characterisation Statuspublished CDS Length1223

Ensembl Gene Location
  1. mug162
  2. sst6
  3. SPAC11H11.03c
  4. mam2
  5. fta6
  6. arp2
  7. pvg5
  8. SPNCRNA.253
  9. SPAC22F8.03c
  10. SPAC22F8.04
  11. SPNCRNA.1024
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0002061inviable vegetative cell populationMicroscopyarp2delta (deletion)deletionPMID:20473289
GO Molecular Function

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Term IDTerm NameEvidenceWith/FromReference
GO:0003779actin bindingIEAUniProtKB:KW-0009GO_REF:0000037
GO:0005524ATP bindingIEAUniProtKB:KW-0067GO_REF:0000037
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0000147actin cortical patch assemblyICGO:0030479, GO:0034314GO_REF:0000001
GO:0030100regulation of endocytosisIMPPMID:16141239
GO:0034314Arp2/3 complex-mediated actin nucleationIDAPMID:18640983
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0005885Arp2/3 protein complexIDAPMID:18640983
GO:0030479actin cortical patchIDAPMID:18640983
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
147830074783102
247831534784765

References

Region Start End Reference
three_prime_UTR47842784784765PMID:21511999
five_prime_UTR47830074783054PMID:21511999
three_prime_UTR47842784784765PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF00022 IPR004000 Pfam Actin-related protein 2 384 11
SM00268 IPR004000 SMART Actin-related protein 3 386 10
PS01132 IPR020902 Prosite Patterns Actin-related protein 104 116 3
G3DSA:3.30.420.40 Gene3D 257 384 24
G3DSA:3.30.420.40 Gene3D 2 186 24
G3DSA:3.90.640.10 Gene3D 187 256 16
SSF53067 SuperFamily 1 153 25
SSF53067 SuperFamily 146 382 25
PR00190 IPR004000 PRINTS Actin-related protein 115 128 3
PR00190 IPR004000 PRINTS Actin-related protein 49 60 3
PR00190 IPR004000 PRINTS Actin-related protein 61 83 3
PR00190 IPR004000 PRINTS Actin-related protein 236 252 3
PR00190 IPR004000 PRINTS Actin-related protein 24 33 3
PR00190 IPR004000 PRINTS Actin-related protein 140 159 3
PTHR11937:SF37 hmmpanther 2 387 1
PTHR11937 IPR004000 hmmpanther Actin-related protein 2 387 11

View domain organization at Pfam

Protein Properties

Ave. residue weight 113.41 Da
Charge -2.50
Isoelectric point 5.97
Molecular weight 44.23 kDa
Number of residues 390
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide13055.83PMID:23101633
experimental evidencesingle-celled organism vegetative growth phasePECO:0000201,
PECO:0000005		single_cell46600PMID:16224022
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide18061.51PMID:23101633
RNA levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide1.7PMID:23101633
experimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide6.7PMID:23101633
Species Distribution
DescriptionQualifierReference
predominantly single copy (one to one)
conserved in fungi
conserved in eukaryotes
conserved in metazoa
conserved in vertebrates
conserved in eukaryotes only
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
cdc3profilin Synthetic RescuePMID:10588653
rpn719S proteasome regulatory subunit Rpn7 Synthetic Growth DefectPMID:20668161
gmf1cofilin/tropomyosin family Glia Maturation Factor homolog Gmf1 Phenotypic SuppressionPMID:20517925
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
arp8actin-like protein, Ino80 complex subunit Arp8 Affinity Capture-RNAPMID:22144913
arc1ARP2/3 actin-organizing complex subunit Sop2 Co-purificationPMID:10588653
myo1myosin type I Affinity Capture-MSPMID:16087707
arp9SWI/SNF and RSC complex subunit Arp9 Affinity Capture-RNAPMID:22144913
wsp1WASp homolog Reconstituted ComplexPMID:23148219
act1actin Act1 Reconstituted ComplexPMID:23148219
arp3actin-like protein Arp3 Reconstituted ComplexPMID:23148219
Co-purificationPMID:18640983
gmf1cofilin/tropomyosin family Glia Maturation Factor homolog Gmf1 Affinity Capture-WesternPMID:20517925
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External References
Database Identifier Description
NBRP SPAC11H11.06 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC11H11.06 Retrieval of eukaryotic orthologs
BioGrid SPAC11H11.06 BioGRID Interaction Datasets
Bähler Lab SPAC11H11.06 Cell Cycle Expression Profile
Bähler Lab SPAC11H11.06 Meiosis/Sporulation Expression Profies
Bähler Lab SPAC11H11.06 Pheromone response/mating expression profiles
Bähler Lab SPAC11H11.06 Environmental stress expression profiles
Bähler Lab SPAC11H11.06 Bähler Lab Transcriptome Viewer
Cyclebase SPAC11H11.06 Cell Cycle Data
PInt SPAC11H11.06 Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPAC11H11.06 Entrez Gene
WikiGene5802965ARP2/3 actin-organizing complex subunit Arp2
Uniprot_genenameARP2
EntrezGene5802965ARP2/3 actin-organizing complex subunit Arp2
SPD / RIKEN19/19D11Orfeome Localization Data
UniProtKB/SwissProtQ9UUJ1Actin-related protein 2
ModBaseQ9UUJ1Database of comparative protein structure models
Pfam Protein DomainsQ9UUJ1Pfam Domain Arrangement
RefSeq_mRNA_predictedXM_001713059972h- ARP2/3 actin-organizing complex subunit Arp2 (arp2), mRNA
RefSeq_peptide_predictedXP_001713111ARP2/3 actin-organizing complex subunit Arp2
European Nucleotide ArchiveAAF21808ENA Protein Mapping
European Nucleotide ArchiveCAB59802ENA Protein Mapping
UniParcUPI0000126057UniProt Archive

Literature for arp2
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Search: UK PMC or PubMed

Release Version: PomBase:18_35 - 11 May 2013