acp1 (SPAC12B10.07)

Gene Standard Nameacp1 ChromosomeI
Systematic IDSPAC12B10.07 Gene Start4584465
Synonyms Gene End4586536
ProductF-actin capping protein alpha subunit Gene Length2072
Feature Typeprotein coding CDS Start4585255
Name Description CDS End4586135
Characterisation Statuspublished CDS Length881

Ensembl Gene Location
  1. bun62
  2. SPNCRNA.1001
  3. pby1
  4. icp55
  5. acp1
  6. emi5
  7. SPAC12B10.08c
  8. SPAC12B10.09
  9. SPAC12B10.10
  10. SPNCRNA.1002
  11. exg2
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0002060viable vegetative cell populationno_name (unrecorded)unrecordedPMID:15743909
Microscopyacp1delta (deletion)deletionPMID:20473289
GO Molecular Function

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Term IDTerm NameEvidenceWith/FromReference
GO:0051015actin filament bindingIDAPMID:15743909
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0000910cytokinesis
antagonistic_interactionIGIcdc12PMID:15743909
GO:0008360regulation of cell shapeIGIfim1PMID:11694585
GO:0030036actin cytoskeleton organizationIGIfim1PMID:11694585
GO:0030835negative regulation of actin filament depolymerizationIDAPMID:15743909
GO:0034613cellular protein localization
has_input twf1IMPPMID:15743909
has_input acp2IMPPMID:15743909
GO:0051016barbed-end actin filament cappingIDAPMID:15743909
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0005884actin filamentIDAPMID:15743909
GO:0008290F-actin capping protein complexIDAPMID:15743909
GO:0030479actin cortical patchIDAPMID:15743909
GO:0032153cell division siteIDAPMID:16823372
GO:0051286cell tipIDAPMID:16823372
exists_during interphase of mitotic cell cycleIDAPMID:15743909
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
145844654585324
245853714585564
345856294586536

References

Region Start End Reference
three_prime_UTR45861364586536PMID:21511999
three_prime_UTR45861364586536PMID:21511999
five_prime_UTR45844654585254PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF01267 IPR002189 Pfam WASH complex, F-actin capping protein, alpha subunit 2 255 1
PS00749 IPR017865 Prosite Patterns F-actin capping protein, alpha subunit, conserved site 230 240 1
PS00748 IPR017865 Prosite Patterns F-actin capping protein, alpha subunit, conserved site 176 184 1
SSF90096 SuperFamily 3 253 2
PR00191 IPR002189 PRINTS WASH complex, F-actin capping protein, alpha subunit 226 245 1
PR00191 IPR002189 PRINTS WASH complex, F-actin capping protein, alpha subunit 175 188 1
PR00191 IPR002189 PRINTS WASH complex, F-actin capping protein, alpha subunit 145 159 1
PTHR10653:SF0 hmmpanther 3 253 1
PTHR10653 IPR002189 hmmpanther WASH complex, F-actin capping protein, alpha subunit 3 253 1

View domain organization at Pfam

Protein Modifications (PSI-MOD)

Term IDTerm NameEvidenceResidueReference
MOD:00696phosphorylated residuePMID:18257517

Protein Properties

Ave. residue weight 116.44 Da
Charge -8.00
Isoelectric point 4.92
Molecular weight 29.81 kDa
Number of residues 256
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide15231.48PMID:23101633
experimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide14248.78PMID:23101633
RNA levelexperimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide3.5PMID:23101633
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide0.44PMID:23101633
Species Distribution
DescriptionQualifierReference
conserved in fungi
conserved in eukaryotes
conserved in metazoa
conserved in vertebrates
conserved in eukaryotes only
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
php3CCAAT-binding factor complex subunit Php3 Positive GeneticPMID:22681890
cph2Clr6 histone deacetylase associated PHD protein-2 Cph2 Negative GeneticPMID:22681890
SPBC1347.08cribonuclease H2 complex subunit (predicted) Synthetic Growth DefectPMID:18931302
sap114U2 snRNP subunit Sap114 Negative GeneticPMID:22681890
cdc3profilin Synthetic LethalityPMID:16866873
rng2IQGAP Synthetic Growth DefectPMID:16866873
mid1medial ring protein Mid1 Negative GeneticPMID:22681890
rpl160160S ribosomal protein L13/L16 (predicted) Negative GeneticPMID:22681890
elp2elongator complex subunit Elp2 (predicted) Negative GeneticPMID:22681890
adf1actin depolymerizing factor, cofilin Synthetic LethalityPMID:16866873
Synthetic LethalityPMID:16467379
pyp2tyrosine phosphatase Pyp2 Negative GeneticPMID:22681890
fft3fun thirty related protein Fft3 Negative GeneticPMID:22681890
ain1alpha-actinin Synthetic Growth DefectPMID:16866873
cdc4myosin II light chain Synthetic LethalityPMID:16866873
par1protein phosphatase regulatory subunit Par1 Negative GeneticPMID:22681890
spc34DASH complex subunit Spc34 Negative GeneticPMID:22681890
crn1actin binding protein, coronin Crn1 Negative GeneticPMID:22681890
Synthetic Growth DefectPMID:18931302
ase1antiparallel microtubule cross-linking factor Ase1 Negative GeneticPMID:22681890
pom1DYRK family protein kinase Pom1 Negative GeneticPMID:22681890
fim1fimbrin Synthetic Growth DefectPMID:11694585
Synthetic Growth DefectPMID:16866873
for3formin For3 Synthetic Growth DefectPMID:18931302
ssp2serine/threonine protein kinase Ssp2 Negative GeneticPMID:22681890
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
ags1alpha-1,4-glucan synthase Ags1 Co-localizationPMID:10087262
acp2F-actin capping protein beta subunit (predicted) Affinity Capture-WesternPMID:16866873
Co-localization
fim1fimbrin Co-localizationPMID:11694585
stg1SM22/transgelin-like actin modulating protein Stg1 Reconstituted ComplexPMID:16256112
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External References
Database Identifier Description
NBRP SPAC12B10.07 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC12B10.07 Retrieval of eukaryotic orthologs
BioGrid SPAC12B10.07 BioGRID Interaction Datasets
Bähler Lab SPAC12B10.07 Cell Cycle Expression Profile
Bähler Lab SPAC12B10.07 Meiosis/Sporulation Expression Profies
Bähler Lab SPAC12B10.07 Pheromone response/mating expression profiles
Bähler Lab SPAC12B10.07 Environmental stress expression profiles
Bähler Lab SPAC12B10.07 Bähler Lab Transcriptome Viewer
Cyclebase SPAC12B10.07 Cell Cycle Data
PInt SPAC12B10.07 Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPAC12B10.07 Entrez Gene
WikiGene2542679F-actin capping protein alpha subunit
Uniprot_genenameACP1
EntrezGene2542679F-actin capping protein alpha subunit
SPD / RIKEN41/41G03Orfeome Localization Data
UniProtKB/SwissProtQ10434F-actin-capping protein subunit alpha
ModBaseQ10434Database of comparative protein structure models
Pfam Protein DomainsQ10434Pfam Domain Arrangement
RefSeq PeptideNP_594639F-actin capping protein alpha subunit
RefSeq mRNANM_001020067972h- F-actin capping protein alpha subunit (acp1), mRNA
European Nucleotide ArchiveCAA94697ENA Protein Mapping
UniParcUPI0000126ED4UniProt Archive

Literature for acp1
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Search: UK PMC or PubMed

Release Version: PomBase:18_35 - 11 May 2013