SPAC12G12.06c


Gene Standard NameUnassigned Characterisation Statusbiological_role_inferred
Systematic IDSPAC12G12.06c Feature Typeprotein coding
Synonyms Name Description
ProductrRNA processing protein (predicted) Product Size363aa, 39.53 kDa
Genomic Location Chromosome I, 336308-338157 (1850nt); CDS:336428-337519 (1092nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
endoribonuclease activity36
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process

GO Slim Terms

ribosome biogenesis


Term NameCount
RNA phosphodiester bond hydrolysis, endonucleolytic24
Annotation ExtensionEvidenceWith/FromReference
rRNA processing193
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
endoplasmic reticulum594
Annotation ExtensionEvidenceWith/FromReference
nucleolus343
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Inviable

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002061inviable vegetative cell populationMicroscopySPAC12G12.06cΔNullPECO:0000005, PECO:0000137PMID:236978061338
MicroscopySPAC12G12.06cΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000059abnormal mitotic cell cycleMicroscopySPAC12G12.06cΔNullPECO:0000005, PECO:0000137PMID:23697806686
FYPO:0000314inviable after spore germination with elongated germ tubeMicroscopySPAC12G12.06cΔNullPECO:0000005, PECO:0000137PMID:23697806163
FYPO:0001042inviable after spore germination, single or double cell divisionMicroscopySPAC12G12.06cΔNullPECO:0000005, PECO:0000137PMID:2369780697
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
1336308338157

UTRs

Region Coordinates Reference
five_prime_UTR336308..336427PMID:21511999
three_prime_UTR337520..338157PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF05189 Pfam IPR013791 RNA 3'-terminal phosphate cyclase, insert domain 184 285 1
PF01137 Pfam IPR023797 RNA 3'-terminal phosphate cyclase domain 6 340 1
PS01287 Prosite Patterns IPR020719 RNA 3'-terminal phosphate cyclase-like, conserved site 156 166 1
PTHR11096 HMMPANTHER IPR000228 RNA 3'-terminal phosphate cyclase 8 363 1
3kgdA01 Gene3D IPR023797 RNA 3'-terminal phosphate cyclase domain 8 176 1
3kgdA01 Gene3D IPR023797 RNA 3'-terminal phosphate cyclase domain 280 346 1
SSF55205 SuperFamily IPR013792 RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta 11 234 2
PIRSF005378 PIRSF IPR000228 RNA 3'-terminal phosphate cyclase 1 363 1
TIGR03400 tigrfam IPR016443 RNA 3'-terminal phosphate cyclase type 2 8 363 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 108.89 Da
Charge -0.50
Isoelectric point 6.29
Molecular weight 39.53 kDa
Number of residues 363
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
18659during GO:0000080PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
16363during GO:0000084PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
11317during GO:0000085PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
15787during GO:0000087PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
14632during GO:0072690PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
11881.02during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
5221.23during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
3.2during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
0.66during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4600
conserved in eukaryotes4514
conserved in bacteria1000
conserved in metazoa3425
conserved in vertebrates3400
conserved in archaea237
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
epe1Jmjc domain chromatin associated protein Epe1 Affinity Capture-MSPMID:24013502
mtl1TRAMP complex ATP-dependent RNA helicase (predicted) Affinity Capture-MSPMID:24713849
pir2zf-C2H2 type zinc finger protein, implicated in RNAi (predicted) Affinity Capture-MSPMID:24713849
hhp1serine/threonine protein kinase Hhp1 Affinity Capture-MSPMID:24055157
External References
Database Identifier Description
NBRP SPAC12G12.06c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC12G12.06c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC12G12.06c BioGRID Interaction Datasets
Expression Viewer SPAC12G12.06c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC12G12.06c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC12G12.06c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC12G12.06c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC12G12.06c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC12G12.06c Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC12G12.06c Cell Cycle Data
GEO SPAC12G12.06c GEO profiles
PInt SPAC12G12.06c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC12G12.06c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC12G12.06c Fission yeast phenotypic data & analysis
SPD / RIKEN17/17A10Orfeome Localization Data
UniProtKB/SwissProtQ09870Probable RNA 3'-terminal phosphate cyclase-like protein
ModBaseQ09870Database of comparative protein structure models
STRINGQ09870Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_592892rRNA processing protein (predicted)
RefSeq mRNANM_001018292972h- rRNA processing protein (predicted) (SPAC12G12.06c), mRNA
European Nucleotide ArchiveCAA91501.1ENA Protein Mapping
UniParcUPI000013346EUniProt Archive

Literature for SPAC12G12.06c

Search: Europe PMC or PubMed

Release Version: PomBase:23_47 - 27 Oct 2014