cid14 (SPAC12G12.13c)


Gene Standard Namecid14 Characterisation Statuspublished
Systematic IDSPAC12G12.13c Feature Typeprotein coding
Synonyms Name Description
Productpoly(A) polymerase Cid14 Product Size684aa, 78.30 kDa
Genomic Location Chromosome I, 321764-324129 (2366nt); CDS:321924-323978 (2055nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005524ATP bindingIEAUniProtKB-KW:KW-0067GO_REF:0000037558
GO:0003723RNA bindingIEAUniProtKB-KW:KW-0694GO_REF:0000037648
GO:0046872metal ion bindingIEAUniProtKB-KW:KW-0479GO_REF:0000037748
GO:0004652polynucleotide adenylyltransferase activityIMPPMID:164789926
GO:0043023ribosomal large subunit bindingIDAPMID:204039713
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0065007biological regulationNASGO_REF:00000511401
GO:0007049cell cycleIEAUniProtKB-KW:KW-0131GO_REF:0000037789
GO:0006397mRNA processingIEAUniProtKB-KW:KW-0507GO_REF:0000037211
GO:0043630ncRNA polyadenylation involved in polyadenylation-dependent ncRNA catabolic processISOSGD:S000005475GO_REF:00000244
GO:0007000nucleolus organizationIMPPMID:164789927
GO:0031125rRNA 3'-end processingIGIdis3PMID:1647899216
GO:0016075rRNA catabolic processIGIdis3PMID:1647899216
GO:0016077snoRNA catabolic processISOSGD:S000005475GO_REF:00000242
GO:0016078tRNA catabolic processISOSGD:S000005475GO_REF:000002416
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0031499TRAMP complexIDAPMID:204039714
IDAPMID:17512405
GO:0005730nucleolus357
predominantlyIDAPMID:16478992
GO:0005634nucleusIDAPMID:168233722737
IDAPMID:16478992
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001355decreased vegetative cell population growthCell growth assaycid14ΔNullPECO:0000005PMID:20129053342
FYPO:0002061inviable vegetative cell populationCell growth assaycid14ΔNullPECO:0000006PMID:201290531337
FYPO:0002060viable vegetative cell populationMicroscopynot recorded (unrecorded)PMID:164789923751
Microscopycid14ΔNullPMID:20473289
Microscopycid14ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000156abnormal chromatin silencing at silent mating-type cassetteTranscript expression level evidencecid14ΔNullPMID:2268326911
FYPO:0000029abnormal chromosome segregationnot recorded (unrecorded)PMID:16478992178
FYPO:0000051abnormal meiosisnot recorded (unrecorded)PMID:1647899295
FYPO:0000059abnormal mitotic cell cycleMicroscopycid14ΔNullPECO:0000005, PECO:0000137PMID:23697806640
FYPO:0002353decreased chromatin silencingTranscript expression level evidencecid14ΔNullPECO:0000005, PECO:0000137PMID:2040397114
FYPO:0000825increased RNA level during vegetative growth122
affecting SO:0001925Northern assay evidencecid14ΔNullPMID:22139915
affecting SO:0001923Northern assay evidencecid14ΔNullPMID:22139915
FYPO:0002933increased snoRNA level3
expressivity FYPO_EXT:0000003
affecting sno12
Transcript expression level evidencecid14ΔNullPMID:20129053
FYPO:0001317normal RNA level during vegetative growth68
affecting SO:0001924Northern assay evidencecid14ΔNullPMID:22139915
affecting SO:0001926Northern assay evidencecid14ΔNullPMID:22139915
FYPO:0002360normal chromatin silencing at centromereTranscript expression level evidencecid14ΔNullPMID:226832695
FYPO:0002358normal histone H3-K9 dimethylation at silent mating-type cassetteChromatin immunoprecipitation experimentcid14ΔNullPMID:226832692
FYPO:0002359normal histone H3-K9 dimethylation at telomereChromatin immunoprecipitation experimentcid14ΔNullPMID:226832692
FYPO:0001492viable elongated vegetative cell197
expressivity FYPO_EXT:0000003
penetrance FYPO_EXT:0000001
Microscopycid14ΔNullPECO:0000137, PECO:0000005PMID:23697806
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
1321764324129
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF01909 Pfam IPR002934 Nucleotidyl transferase domain 266 364 6
PF03828 Pfam IPR002058 PAP/25A-associated 434 492 6
PTHR23092 HMMPANTHER 9 674 2
PTHR23092:SF13 HMMPANTHER 9 674 1
3.30.460.10 Gene3D 254 403 11
SSF81301 SuperFamily 224 391 11
SSF81631 SuperFamily 379 520 7

View domain organization at Pfam

Protein Properties

Ave. residue weight 114.47 Da
Charge 8.50
Isoelectric point 7.76
Molecular weight 78.30 kDa
Number of residues 684
Modifications

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
MOD:00046O-phospho-L-serineS169PMID:247631071670
present during mitotic M phaseS163PMID:21712547
S163PMID:24763107
present during mitotic M phaseS600PMID:21712547
present during mitotic M phaseS602PMID:21712547
present during cellular response to thiabendazoleIDAS163PMID:18257517
present during mitotic M phaseS658PMID:21712547
MOD:00696phosphorylated residueNASPMID:182575171922
NASPMID:19547744
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
2954during GO:0000080PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
3018during GO:0000084PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
3174during GO:0000085PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
2530during GO:0000087PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
2732during GO:0072690PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
703.79during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
398.03during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
2.6during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
0.6during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Misc
DescriptionQualifierReferenceCount
deletion mutant expression profiling PMID:1802510578
heterochromatic mRNAs transcribed in cid14delta are not translated PMID:226832691
Warning
DescriptionQualifierReferenceCount
gene structure updated432
Pathway
DescriptionQualifierReferenceCount
Mad2-dependent checkpoint response PMID:164789927
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4599
conserved in eukaryotes4514
conserved in metazoa3428
conserved in vertebrates3402
conserved in eukaryotes only2498
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
swi6HP1 family chromodomain protein Swi6 Phenotypic EnhancementPMID:22683269
ago1argonaute Phenotypic SuppressionPMID:21892171
dcr1dicer Phenotypic EnhancementPMID:20178743
ran1serine/threonine protein kinase Ran1 Phenotypic SuppressionPMID:16478992
pab2poly(A) binding protein Pab2 Phenotypic SuppressionPMID:22965128
Phenotypic EnhancementPMID:21981922
Synthetic Growth DefectPMID:20129053
Phenotypic EnhancementPMID:20622014
bub1serine/threonine protein kinase Bub1 Synthetic LethalityPMID:16478992
mft1THO complex subunit 7 Mft1 (predicted) Synthetic Growth DefectPMID:22965128
SPBC577.04human THOC5 ortholog (predicted) Synthetic Growth DefectPMID:22965128
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
tif32translation initiation factor eIF3a Affinity Capture-MSPMID:21436456
rps110240S ribosomal protein S11 (predicted) Affinity Capture-MSPMID:20403971
rps240S ribosomal protein S2 (predicted) Affinity Capture-MSPMID:20403971
rps740S ribosomal protein S7 (predicted) Affinity Capture-MSPMID:20403971
rpl160260S ribosomal protein L13/L16 (predicted) Affinity Capture-MSPMID:20403971
gar2nucleolar protein required for rRNA processing Affinity Capture-WesternPMID:20403971
SPAC4H3.07cprotein phosphatase Fmp31 (predicted) Affinity Capture-MSPMID:21436456
rpl100160S ribosomal protein L10 Affinity Capture-MSPMID:20403971
rpl180260S ribosomal protein L18 (predicted) Affinity Capture-MSPMID:20403971
rpl110160S ribosomal protein L11 (predicted) Affinity Capture-MSPMID:20403971
rpl40260S ribosomal protein L4 (predicted) Affinity Capture-MSPMID:20403971
tif51translation elongation factor eIF5A (predicted) Affinity Capture-MSPMID:21436456
far10SIP/FAR complex FHA domain subunit Far10/Csc1 Affinity Capture-MSPMID:21436456
rpl4460S ribosomal protein L28/L44 (predicted) Affinity Capture-MSPMID:20403971
rpl2260S ribosomal protein L22 (predicted) Affinity Capture-MSPMID:20403971
SPAC890.04cribosome biogenesis protein Ytm1 (predicted) Affinity Capture-MSPMID:21436456
rps180140S ribosomal protein S18 (predicted) Affinity Capture-MSPMID:20403971
rpl1560S ribosomal protein L15 (predicted) Affinity Capture-MSPMID:20403971
rps300240S ribosomal protein S30 (predicted) Affinity Capture-MSPMID:20403971
rps220240S ribosomal protein S15a (predicted) Affinity Capture-MSPMID:20403971
rps220140S ribosomal protein S15a (predicted) Affinity Capture-MSPMID:20403971
oga1Stm1 homolog Oga1 Affinity Capture-MSPMID:21436456
tif212translation initiation factor eIF2 beta subunit (predicted) Affinity Capture-MSPMID:21436456
tif6translation initiation factor eIF6 Affinity Capture-MSPMID:21436456
rpl40160S ribosomal protein L4 (predicted) Affinity Capture-MSPMID:20403971
SPAC926.08cBrix domain protein Rpf2 (predicted) Affinity Capture-MSPMID:21436456
brx1ribosome biogenesis protein Brx1 (predicted) Affinity Capture-MSPMID:21436456
SPAC1486.09ribosome biogenesis protein Nob1 (predicted) Affinity Capture-MSPMID:21436456
tif471translation initiation factor eIF4G Affinity Capture-MSPMID:21436456
spb1rRNA methyltransferase Spb1 (predicted) Affinity Capture-MSPMID:21436456
rps140140S ribosomal protein S14 (predicted) Affinity Capture-MSPMID:20403971
sum3translation initiation RNA helicase Sum3 Affinity Capture-MSPMID:21436456
srp2mRNA export factor Srp2 Affinity Capture-MSPMID:21436456
rps110140S ribosomal protein S11 (predicted) Affinity Capture-MSPMID:20403971
rps150240S ribosomal protein S15 (predicted) Affinity Capture-MSPMID:20403971
rpl230260S ribosomal protein L23 Affinity Capture-MSPMID:20403971
rps170140S ribosomal protein S17 (predicted) Affinity Capture-MSPMID:20403971
rps260240S ribosomal protein S26 (predicted) Affinity Capture-MSPMID:20403971
rpl280260S ribosomal protein L27/L28 Affinity Capture-MSPMID:20403971
SPAC8F11.04U3 snoRNP-associated protein Cic1/Utp30 family (predicted) Affinity Capture-MSPMID:21436456
rpl210160S ribosomal protein L21 (predicted) Affinity Capture-MSPMID:20403971
rpl80360S ribosomal protein L8 (predicted) Affinity Capture-MSPMID:20403971
sec65signal recognition particle subunit Sec65 (predicted) Affinity Capture-MSPMID:21436456
rrp16rRNA processing protein Rrp16 (predicted) Affinity Capture-MSPMID:21436456
rps160140S ribosomal protein S16 (predicted) Affinity Capture-MSPMID:20403971
rps540S ribosomal protein S5 (predicted) Affinity Capture-MSPMID:20403971
mlo3RNA binding protein Mlo3 Affinity Capture-WesternPMID:21436456
Affinity Capture-MS
rps1340S ribosomal protein S13 Affinity Capture-MSPMID:20403971
rpl2660S ribosomal protein L26 (predicted) Affinity Capture-MSPMID:20403971
rpl200160S ribosomal protein L20a (predicted) Affinity Capture-MSPMID:20403971
rpl1460S ribosomal protein L14 (predicted) Affinity Capture-MSPMID:20403971
SPAC10F6.08cHMG box protein Affinity Capture-MSPMID:21436456
utp15U3 snoRNP protein Utp15 (predicted) Affinity Capture-MSPMID:21436456
rps250240S ribosomal protein S25 (predicted) Affinity Capture-MSPMID:20403971
rpl1360S ribosomal protein L13 (predicted) Affinity Capture-MSPMID:20403971
rps80140S ribosomal protein S8 (predicted) Affinity Capture-MSPMID:20403971
mmi1YTH family RNA binding protein Mmi1 Affinity Capture-MSPMID:21436456
air1zinc knuckle TRAMP complex subunit Air1 Affinity Capture-MSPMID:21436456
Affinity Capture-MSPMID:20403971
Affinity Capture-Western
SPCC1827.05cnucleolar RNA-binding protein NIFK (predicted) Affinity Capture-MSPMID:21436456
rpl240160S ribosomal protein L24 (predicted) Affinity Capture-MSPMID:20403971
rpl320160S ribosomal protein L32 Affinity Capture-MSPMID:20403971
rps140240S ribosomal protein S14 (predicted) Affinity Capture-MSPMID:20403971
tif33translation initiation factor eIF3c Affinity Capture-MSPMID:21436456
rpl200260S ribosomal protein L20 (predicted) Affinity Capture-MSPMID:20403971
rpl10160S ribosomal protein L10a Affinity Capture-MSPMID:20403971
rps60240S ribosomal protein S6 (predicted) Affinity Capture-MSPMID:20403971
tef5translation elongation factor EF-1 beta subunit (eEF1B) Affinity Capture-MSPMID:21436456
rpl340160S ribosomal protein L34 Affinity Capture-MSPMID:20403971
SPBC4F6.14RNA-binding protein (predicted) Affinity Capture-MSPMID:21436456
rpl270160S ribosomal protein L27 Affinity Capture-MSPMID:20403971
sce3translation initiation factor (predicted) Affinity Capture-MSPMID:21436456
ppk9serine/threonine protein kinase Ppk9 (predicted) Affinity Capture-MSPMID:21436456
rpl190160S ribosomal protein L19 Affinity Capture-MSPMID:20403971
mtr4ATP-dependent RNA helicase, TRAMP complex subunit Mtr4 Affinity Capture-MSPMID:21436456
Affinity Capture-WesternPMID:20403971
Affinity Capture-MS
rpl150260S ribosomal protein L15b (predicted) Affinity Capture-MSPMID:20403971
rpl180160S ribosomal protein L18 Affinity Capture-MSPMID:20403971
rpl300160S ribosomal protein L30 (predicted) Affinity Capture-MSPMID:20403971
rpl70160S ribosomal protein L7 Affinity Capture-MSPMID:20403971
rps90140S ribosomal protein S9 Affinity Capture-MSPMID:20403971
rpl360160S ribosomal protein L36 Affinity Capture-MSPMID:20403971
cid14poly(A) polymerase Cid14 Affinity Capture-MSPMID:20403971
grn1GTPase Grn1 Affinity Capture-MSPMID:21436456
rnp24RNA-binding protein Rnp24 Affinity Capture-MSPMID:21436456
rpl70260S ribosomal protein L7 Affinity Capture-MSPMID:20403971
rps90240S ribosomal protein S9 (predicted) Affinity Capture-MSPMID:20403971
rpl3560S ribosomal protein L35 Affinity Capture-MSPMID:20403971
rrs1ribosome biogenesis protein Rrs1 (predicted) Affinity Capture-MSPMID:21436456
rps10140S ribosomal protein S3a Affinity Capture-MSPMID:20403971
rps260140S ribosomal protein S26 (predicted) Affinity Capture-MSPMID:20403971
SPBC4F6.13cWD repeat/BOP1NT protein (predicted) Affinity Capture-MSPMID:21436456
rpl660S ribosomal protein L6 (predicted) Affinity Capture-MSPMID:20403971
rps160240S ribosomal protein S16 (predicted) Affinity Capture-MSPMID:20403971
rpl280160S ribosomal protein L27/L28 Affinity Capture-MSPMID:20403971
rpl30160S ribosomal protein L3 Affinity Capture-MSPMID:20403971
nop12RNA-binding protein Nop12 (predicted) Affinity Capture-MSPMID:21436456
rpl270260S ribosomal protein L27 (predicted) Affinity Capture-MSPMID:20403971
ebp2rRNA processing protein Ebp2 (predicted) Affinity Capture-MSPMID:21436456
rpl80260S ribosomal protein L8 (predicted) Affinity Capture-MSPMID:20403971
SPAC227.02crRNA processing protein Rrp15 (predicted) Affinity Capture-MSPMID:21436456
rps180240S ribosomal protein S18 (predicted) Affinity Capture-MSPMID:20403971
rpl860S ribosomal protein L7a/L8 (predicted) Affinity Capture-MSPMID:20403971
nog1GTP binding protein Nog1 (predicted) Affinity Capture-MSPMID:21436456
Affinity Capture-WesternPMID:20403971
SPCC1183.07U3 snoRNP-associated protein Rrp5 (predicted) Affinity Capture-MSPMID:21436456
fib1fibrillarin, rRNA methyltransferase Affinity Capture-WesternPMID:20403971
rpl430160S ribosomal protein L37a (predicted) Affinity Capture-MSPMID:20403971
rpl3160S ribosomal protein L31 (predicted) Affinity Capture-MSPMID:20403971
SPBC16H5.08cribosome biogenesis ATPase, Arb family ABCF2-like (predicted) Affinity Capture-MSPMID:21436456
SPBC365.04cRNA-binding protein, involved in ribosome biogenesis (predicted) Affinity Capture-MSPMID:21436456
rps340S ribosomal protein S3 (predicted) Affinity Capture-MSPMID:20403971
fnx1vacuolar membrane amino acid uptake transporter Fnx1 Affinity Capture-MSPMID:21436456
SPBC16H5.12cconserved fungal protein Affinity Capture-MSPMID:21436456
rps240240S ribosomal protein S24 (predicted) Affinity Capture-MSPMID:20403971
rps10240S ribosomal protein S3a (predicted) Affinity Capture-MSPMID:20403971
tif213translation initiation factor eIF2 gamma subunit (predicted) Affinity Capture-MSPMID:21436456
rpl80160S ribosomal protein L8 (predicted) Affinity Capture-MSPMID:20403971
SPBC106.12cTHO complex subunit (predicted) Affinity Capture-MSPMID:21436456
sum1translation initiation factor eIF3i Affinity Capture-MSPMID:21436456
SPCC126.11cRNA-binding protein, rrm type Affinity Capture-MSPMID:21436456
rec24meiotic recombination protein Rec24 Affinity Capture-MSPMID:21436456
SPCP1E11.08ribosome biogenesis protein Nsa2 (predicted) Affinity Capture-MSPMID:21436456
SPCC18.05cnotchless-like protein (predicted) Affinity Capture-MSPMID:21436456
rpl250160S ribosomal protein L25 (predicted) Affinity Capture-MSPMID:20403971
dbp2ATP-dependent RNA helicase Dbp2 Affinity Capture-MSPMID:21436456
Affinity Capture-WesternPMID:20403971
SPAC6F6.03cribosome export GTPase (predicted) Affinity Capture-MSPMID:21436456
Affinity Capture-WesternPMID:20403971
rpl110260S ribosomal protein L11 (predicted) Affinity Capture-MSPMID:20403971
smd2Sm snRNP core protein Smd2 Affinity Capture-MSPMID:21436456
rpl210260S ribosomal protein L21 (predicted) Affinity Capture-MSPMID:20403971
nop2RNA methyltransferase Nop2 (predicted) Affinity Capture-MSPMID:21436456
Affinity Capture-WesternPMID:20403971
tif211translation initiation factor eIF2 alpha subunit Affinity Capture-MSPMID:21436456
rpl370360S ribosomal protein L37 (predicted) Affinity Capture-MSPMID:20403971
puf6Puf family RNA-binding protein Puf6 (predicted) Affinity Capture-MSPMID:21436456
sla1La protein homolog Affinity Capture-MSPMID:21436456
SPAC23G3.06U3 snoRNP protein Nop58 (predicted) Affinity Capture-MSPMID:21436456
gar1snoRNP pseudouridylase box H/ACA snoRNP complex protein Gar1 Affinity Capture-MSPMID:21436456
rpl230160S ribosomal protein L23 Affinity Capture-MSPMID:20403971
rps300140S ribosomal protein S30 (predicted) Affinity Capture-MSPMID:20403971
rps240140S ribosomal protein S24 (predicted) Affinity Capture-MSPMID:20403971
SPAC1093.04ctRNA nucleotidyltransferase (predicted) Affinity Capture-MSPMID:21436456
External References
Database Identifier Description
NBRP SPAC12G12.13c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC12G12.13c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC12G12.13c BioGRID Interaction Datasets
Expression Viewer SPAC12G12.13c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC12G12.13c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC12G12.13c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC12G12.13c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC12G12.13c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC12G12.13c Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC12G12.13c Cell Cycle Data
GEO SPAC12G12.13c GEO profiles
PInt SPAC12G12.13c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC12G12.13c Peptides identified in tandem mass spectrometry proteomics experiments
IntEnz2.7.7.1Integrated relational Enzyme database
Rhea2.7.7.1Annotated reactions database
SPD / RIKEN26/26B12Orfeome Localization Data
UniProtKB/SwissProtQ9UTN3Poly(A) RNA polymerase cid14
ModBaseQ9UTN3Database of comparative protein structure models
STRINGQ9UTN3Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_001018181poly(A) polymerase Cid14
RefSeq mRNANM_001018285972h- poly(A) polymerase Cid14 (cid14), mRNA
European Nucleotide ArchiveCAI79317.1ENA Protein Mapping
UniParcUPI00005053CCUniProt Archive

Literature for cid14

Search: Europe PMC or PubMed

Release Version: PomBase:23_46 - 30 Aug 2014