fur4 (SPAC1399.03)

Gene Standard Namefur4 Characterisation Statuspublished
Systematic IDSPAC1399.03 Feature Typeprotein coding
Synonyms Name Description
Producturacil permease Product Size581aa, 64.18 kDa
Genomic Location Chromosome I, 1843995-1841908 (2088nt); CDS:1843681-1841936 (1746nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
uracil:cation symporter activity2
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
uracil import across plasma membrane1
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
Golgi apparatus357
Annotation ExtensionEvidenceWith/FromReference
integral component of membrane967
Annotation ExtensionEvidenceWith/FromReference
plasma membrane raft3
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Single-allele Phenotypes

Population Phenotype

Term NameGenotypesCount
resistance to 5-fluorouracilfur4Δ1
viable vegetative cell populationfur4Δ3815

Cell Phenotype

Term NameGenotypesCount
viable vegetative cell with normal cell morphologyfur4Δ3095
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
5' UTR1843995..1843682PMID:18641648
5' UTR1843995..1843682PMID:20118936
3' UTR1841935..1841908PMID:18641648
3' UTR1841935..1841908PMID:20118936
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF02133 Pfam IPR001248 Purine-cytosine permease 48 499 3
TMhelix TMHMM 187 206 959
TMhelix TMHMM 410 432 959
TMhelix TMHMM 253 272 959
TMhelix TMHMM 494 516 959
TMhelix TMHMM 88 110 959
TMhelix TMHMM 384 403 959
TMhelix TMHMM 342 364 959
TMhelix TMHMM 459 481 959
TMhelix TMHMM 287 309 959
TMhelix TMHMM 210 232 959
PTHR30618:SF2 HMMPANTHER 2 576 2
PTHR30618 HMMPANTHER 2 576 3
TIGR00800 tigrfam IPR012681 Nucleobase cation symporter-1, NCS1 43 484 2

View domain organization at Pfam

Term IDTerm NameReferenceCount

Protein Properties

Ave. residue weight 110.46 Da
Charge 7.00
Codon Adpatation Index 0.56
Isoelectric point 7.65
Molecular weight 64.18 kDa
Number of residues 581

Protein Modifications

Term NameResidueCount
O-phospho-L-serineS570 1672
present during cellular response to thiabendazoleS570
present during mitotic M phaseS573
Annotation ExtensionEvidenceResidueReference
experimental evidence S570 PMID:24763107
present during cellular response to thiabendazole IDA S570 PMID:18257517
present during mitotic M phase experimental evidence S573 PMID:21712547
phosphorylated residue 1930
Annotation ExtensionEvidenceResidueReference
IDA PMID:19547744
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
2435.84during GO:0072690PECO:0000014,
population wideexperimental evidencePMID:23101633
21611.39during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
4.3during GO:0072690PECO:0000014,
population wideexperimental evidencePMID:23101633
3.9during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
population wideexperimental evidencePMID:23101633
functionally complemented by S. cerevisiae FUR4full PMID:6765174
Taxonomic Conservation
conserved in fungi4604
conserved in eukaryotes4514
conserved in bacteria1000

Manually curated orthologous groups


Orthologs in Compara

External References
Database Identifier Description
NBRP SPAC1399.03 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC1399.03 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC1399.03 BioGRID Interaction Datasets
Expression Viewer SPAC1399.03 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC1399.03 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC1399.03 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC1399.03 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC1399.03 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC1399.03 Transcriptome Viewer (Bähler Lab)
GEO SPAC1399.03 GEO profiles
PInt SPAC1399.03 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC1399.03 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC1399.03 Fission yeast phenotypic data & analysis
Cyclebase SPAC1399.03.1 Cell Cycle Data
SPD / RIKEN49/49B11Orfeome Localization Data
UniProtKB/SwissProtQ10279Uracil permease
ModBaseQ10279Database of comparative protein structure models
STRINGQ10279Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_593511uracil permease
RefSeq mRNANM_001018945972h- uracil permease (fur4), mRNA
European Nucleotide ArchiveCU329670ENA EMBL mapping
European Nucleotide ArchiveX98696ENA EMBL mapping
European Nucleotide ArchiveCAA67256ENA Protein Mapping
European Nucleotide ArchiveCAA67256.1ENA Protein Mapping
European Nucleotide ArchiveCAC19744ENA Protein Mapping
European Nucleotide ArchiveCAC19744.1ENA Protein Mapping
UniParcUPI000012AD72UniProt Archive

Literature for fur4

Search: Europe PMC or PubMed

Release Version: PomBase:28_55 - 09 Sep 2015