erg11 (SPAC13A11.02c)


Gene Standard Nameerg11 Characterisation Statusbiological role inferred
Systematic IDSPAC13A11.02c Feature Typeprotein coding
Synonymscyp51 Name Description
Productsterol 14-demethylase Erg11 (predicted) Product Size495aa, 56.33 kDa
Genomic Location Chromosome I, 577171-574652 (2520nt); CDS:576622-575135 (1488nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
metal ion binding749
Annotation ExtensionEvidenceWith/FromReference
protein binding872
Annotation ExtensionEvidenceWith/FromReference
sterol 14-demethylase activity1
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
ergosterol biosynthetic process45
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
endoplasmic reticulum596
Annotation ExtensionEvidenceWith/FromReference
endoplasmic reticulum membrane201
Annotation ExtensionEvidenceWith/FromReference
integral component of membrane962
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Inviable

Population Phenotype

Term NameGenotypesCount
inviable vegetative cell populationerg11Δ1452
normal growth on clotrimazoleerg11+ (wild type)13
normal growth on terbinafineerg11+ (wild type)41
resistance to clotrimazoleerg11+ (wild type)14
resistance to miconazoleerg11+ (wild type)4
sensitive to tamoxifenerg11+ (wild type)58

Cell Phenotype

Term NameGenotypesCount
inviable after spore germination, without cell divisionerg11Δ495
inviable vegetative cell, abnormal cell shape, normal cell sizeerg11Δ199
Target Of
OntologyRelationshipGeneProduct
GO regulated by sre1 sterol regulatory element binding protein, transcription factor Sre1
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons577171..574652
mRNA577171..574652
5' UTR577171..576623PMID:21511999
CDS576622..575135
3' UTR575134..574652PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00067 Pfam IPR001128 Cytochrome P450 37 489 2
TMhelix TMHMM 35 57 953
TMhelix TMHMM 5 22 953
PS00086 Prosite Patterns IPR017972 Cytochrome P450, conserved site 435 444 2
PTHR24286:SF24 HMMPANTHER 1 495 1
PTHR24286 HMMPANTHER 1 495 2
1.10.630.10 Gene3D IPR001128 Cytochrome P450 32 495 2
SSF48264 SuperFamily IPR001128 Cytochrome P450 29 494 2
PR00465 PRINTS IPR002403 Cytochrome P450, E-class, group IV 33 50 1
PR00465 PRINTS IPR002403 Cytochrome P450, E-class, group IV 336 352 1
PR00465 PRINTS IPR002403 Cytochrome P450, E-class, group IV 279 305 1
PR00465 PRINTS IPR002403 Cytochrome P450, E-class, group IV 387 405 1
PR00465 PRINTS IPR002403 Cytochrome P450, E-class, group IV 426 442 1
PR00465 PRINTS IPR002403 Cytochrome P450, E-class, group IV 371 385 1
PR00465 PRINTS IPR002403 Cytochrome P450, E-class, group IV 55 78 1
PR00465 PRINTS IPR002403 Cytochrome P450, E-class, group IV 442 460 1
PR00385 PRINTS IPR001128 Cytochrome P450 341 352 2
PR00385 PRINTS IPR001128 Cytochrome P450 442 453 2
PR00385 PRINTS IPR001128 Cytochrome P450 433 442 2
PR00385 PRINTS IPR001128 Cytochrome P450 288 305 2

View domain organization at Pfam

Term IDTerm NameReferenceCount
SO:0001812transmembrane_helix465

Protein Properties

Ave. residue weight 113.80 Da
Charge 13.50
Codon Adaptation Index 0.68
Isoelectric point 9.03
Molecular weight 56.33 kDa
Number of residues 495
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serine 1677
present during cellular response to thiabendazoleS138
present during cellular response to thiabendazoleS430
Annotation ExtensionEvidenceResidueReference
present during cellular response to thiabendazole IDA S138 PMID:18257517
present during cellular response to thiabendazole IDA S430 PMID:18257517
Sequence
Gene Expression

Qualitative Gene Expression

DescriptionLevelEvidenceReference
RNA levelincreased during GO:0071456expression microarray evidencePMID:22235339

Quantitative Gene Expression

View graphical display of gene expression data for erg11 (SPAC13A11.02c)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
95168during GO:0000080PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
91324during GO:0000084PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
101432during GO:0000085PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
85830during GO:0000087PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
31313.1during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
92035during GO:0072690PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
10512.65during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
23during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
3.1during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
Disease Association
DescriptionQualifierReferenceCount
cholesterinosis1
Taxonomic Conservation
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4606
conserved in eukaryotes4516
conserved in metazoa3424
conserved in vertebrates3399
conserved in eukaryotes only2505
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Load genes that interact physically with SPAC13A11.02c into the Query Builder
View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
affinity captured bytea1cell end marker Tea1 Affinity Capture-MSPMID:21652630
affinity captured byprp19ubiquitin-protein ligase E4 Prp19 Affinity Capture-MSPMID:21386897
affinity captured bycwf2RNA-binding protein Cwf2 Affinity Capture-MSPMID:21386897
External References
Database Identifier Description
NBRP SPAC13A11.02c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC13A11.02c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC13A11.02c BioGRID Interaction Datasets
Expression Viewer SPAC13A11.02c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC13A11.02c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC13A11.02c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC13A11.02c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC13A11.02c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC13A11.02c Transcriptome Viewer (Bähler Lab)
GEO SPAC13A11.02c GEO profiles
PInt SPAC13A11.02c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC13A11.02c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC13A11.02c Fission yeast phenotypic data & analysis
Cyclebase SPAC13A11.02c.1 Cell Cycle Data
SPD / RIKEN24/24A02Orfeome Localization Data
IntEnz1.14.13.70Integrated relational Enzyme database
Rhea1.14.13.70Annotated reactions database
UniProtKB/SwissProtQ09736Lanosterol 14-alpha demethylase erg11
ModBaseQ09736Database of comparative protein structure models
STRINGQ09736Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_592990sterol 14-demethylase (predicted)
RefSeq mRNANM_001018389972h- sterol 14-demethylase (predicted) (erg11), mRNA
European Nucleotide ArchiveCAA90803.1ENA Protein Mapping
UniParcUPI00001281EFUniProt Archive

Literature for erg11

Search: Europe PMC or PubMed

Release Version: PomBase:30_60 - 12 May 2016