erg11 (SPAC13A11.02c)


Gene Standard Nameerg11 Characterisation Statusbiological_role_inferred
Systematic IDSPAC13A11.02c Feature Typeprotein coding
Synonymscyp51 Name Description
Productsterol 14-demethylase Erg11 (predicted) Product Size495aa, 56.33 kDa
Genomic Location Chromosome I, 577171-574652 (2520nt); CDS:576622-575135 (1488nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0046872metal ion bindingIEAUniProtKB-KW:KW-0479GO_REF:0000037747
GO:0005515protein bindingIPIdap1PMID:17276356887
GO:0008398sterol 14-demethylase activityISSUniProtKB:P10614GO_REF:00000011
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0070988demethylationISSUniProtKB:P10614GO_REF:000000113
GO:0006696ergosterol biosynthetic processIEPPMID:1579738339
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005783endoplasmic reticulumIDAPMID:16823372594
GO:0005789endoplasmic reticulum membraneISSUniProtKB:P10614GO_REF:0000001207
GO:0016021integral component of membraneIEAUniProtKB-KW:KW-0812GO_REF:00000371016
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002061inviable vegetative cell populationMicroscopyerg11ΔNullPECO:0000005, PECO:0000137PMID:236978061309
Microscopyerg11ΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001991inviable after spore germination, without cell divisionMicroscopyerg11ΔNullPECO:0000005, PECO:0000137PMID:23697806463
penetrance FYPO_EXT:0000001
FYPO:0001511inviable vegetative cell, abnormal cell shape, normal cell sizeMicroscopyerg11ΔNullPECO:0000005, PECO:0000137PMID:23697806198
penetrance FYPO_EXT:0000003
Target Of
RelationshipGeneProductReference
regulated by sre1 sterol regulatory element binding protein, transcription factor Sre1 PMID:16537923
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
1577171574652

UTRs

Region Start End Reference
three_prime_UTR575134574652PMID:21511999
five_prime_UTR577171576623PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00067 Pfam IPR001128 Cytochrome P450 37 489 2
TMhelix TMHMM 5 22 959
TMhelix TMHMM 35 57 959
PS00086 Prosite Patterns IPR017972 Cytochrome P450 435 444 2
PTHR24286:SF4 HMMPANTHER 1 495 1
PTHR24286 HMMPANTHER 1 495 2
G3DSA:1.10.630.10 Gene3D IPR001128 32 495 2
SSF48264 SuperFamily IPR001128 29 494 2
Low complexity (SEG) seg 4 15
PR00385 PRINTS IPR001128 Cytochrome P450 442 453 2
PR00385 PRINTS IPR001128 Cytochrome P450 288 305 2
PR00385 PRINTS IPR001128 Cytochrome P450 341 352 2
PR00385 PRINTS IPR001128 Cytochrome P450 433 442 2
PR00465 PRINTS IPR002403 Cytochrome P450, E-class, group IV 371 385 1
PR00465 PRINTS IPR002403 Cytochrome P450, E-class, group IV 387 405 1
PR00465 PRINTS IPR002403 Cytochrome P450, E-class, group IV 55 78 1
PR00465 PRINTS IPR002403 Cytochrome P450, E-class, group IV 442 460 1
PR00465 PRINTS IPR002403 Cytochrome P450, E-class, group IV 426 442 1
PR00465 PRINTS IPR002403 Cytochrome P450, E-class, group IV 336 352 1
PR00465 PRINTS IPR002403 Cytochrome P450, E-class, group IV 33 50 1
PR00465 PRINTS IPR002403 Cytochrome P450, E-class, group IV 279 305 1

View domain organization at Pfam

Sequence Ontology

Term IDTerm NameReferenceCount
SO:0001812transmembrane_helix465

Protein Properties

Ave. residue weight 113.80 Da
Charge 13.50
Isoelectric point 9.03
Molecular weight 56.33 kDa
Number of residues 495
Modifications

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
MOD:00696phosphorylated residuePMID:182575171192
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
10512.65during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
31313.1during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
3.1during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
23during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
Disease Association
DescriptionQualifierReferenceCount
cholesterinosis1
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3080
conserved in fungi4564
conserved in eukaryotes4482
conserved in metazoa3419
conserved in vertebrates3394
conserved in eukaryotes only2485
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
prp19ubiquitin-protein ligase E4 Affinity Capture-MSPMID:21386897
cwf2RNA-binding protein Cwf2 Affinity Capture-MSPMID:21386897
hhp1serine/threonine protein kinase Hhp1 Affinity Capture-MSPMID:24055157
tea1cell end marker Tea1 Affinity Capture-MSPMID:21652630
epe1Jmjc domain chromatin associated protein Epe1 Affinity Capture-MSPMID:24013502
hhp2serine/threonine protein kinase Hhp2 Affinity Capture-MSPMID:24055157
External References
Database Identifier Description
NBRP SPAC13A11.02c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC13A11.02c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC13A11.02c BioGRID Interaction Datasets
Expression Viewer SPAC13A11.02c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC13A11.02c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC13A11.02c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC13A11.02c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC13A11.02c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC13A11.02c Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC13A11.02c Cell Cycle Data
GEO SPAC13A11.02c GEO profiles
PInt SPAC13A11.02c Protein-Protein Interaction Predictor (Bähler Lab)
IntEnz1.14.13.70Integrated relational Enzyme database
Rhea1.14.13.70Annotated reactions database
WikiGene2542599sterol 14-demethylase
EntrezGene2542599sterol 14-demethylase
SPD / RIKEN24/24A02Orfeome Localization Data
UniProtKB/SwissProtQ09736Lanosterol 14-alpha demethylase erg11
ModBaseQ09736Database of comparative protein structure models
StringQ09736Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_592990sterol 14-demethylase
RefSeq mRNANM_001018389972h- sterol 14-demethylase (erg11), mRNA
European Nucleotide ArchiveCAA90803ENA Protein Mapping
UniParcUPI00001281EFUniProt Archive

Literature for erg11

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014