mre11 (SPAC13C5.07)


Gene Standard Namemre11 Characterisation Statuspublished
Systematic IDSPAC13C5.07 Feature Typeprotein coding
Synonymsrad32 Name Description
ProductMre11 nuclease Product Size649aa, 73.69 kDa
Genomic Location Chromosome I, 435170-439980 (4811nt); CDS:436214-438369 (2156nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
double-stranded DNA 3'-5' exodeoxyribonuclease activity2
Annotation ExtensionEvidenceWith/FromReference
manganese ion binding9
Annotation ExtensionEvidenceWith/FromReference
nuclease activity117
Annotation ExtensionEvidenceWith/FromReference
protein binding859
single-stranded DNA 3'-5' exodeoxyribonuclease activity1
Annotation ExtensionEvidenceWith/FromReference
single-stranded DNA endodeoxyribonuclease activity7
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
cellular protein localization552
Annotation ExtensionEvidenceWith/FromReference
DNA double-strand break processing4
Annotation ExtensionEvidenceWith/FromReference
double-strand break repair52
Annotation ExtensionEvidenceWith/FromReference
double-strand break repair via nonhomologous end joining7
Annotation ExtensionEvidenceWith/FromReference
intra-S DNA damage checkpoint16
Annotation ExtensionEvidenceWith/FromReference
meiotic DNA double-strand break formation8
Annotation ExtensionEvidenceWith/FromReference
mitotic DNA damage checkpoint31
Annotation ExtensionEvidenceWith/FromReference
reciprocal meiotic recombination39
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
Mre11 complex3
Annotation ExtensionEvidenceWith/FromReference
site of double-strand break46
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
decreased cell population growth on glucose carbon sourcemre11ΔNull258
nuclease-dead (H134S)Endogenous
W248R (W248R)Endogenous
decreased mating efficiencymre11ΔNull252
normal growth during cellular response to gamma radiationN122S (N122S)Endogenous17
W215C (W215C)Endogenous
normal growth during cellular response to UVN122S (N122S)Endogenous56
W215C (W215C)Endogenous
normal growth on glucose carbon sourceW215C (W215C)Endogenous207
normal growth on hydroxyureaN122S (N122S)Endogenous42
W215C (W215C)Endogenous
sensitive to 4-nitroquinoline N-oxidemre11ΔNull159
sensitive to camptothecinmre11ΔNull225
nuclease-dead (H134S)Endogenous
W248R (W248R)Endogenous
sensitive to DNA damaging agentsW248R (W248R)Endogenous7
sensitive to doxorubicinmre11ΔNull91
sensitive to hydroxyureamre11ΔNull534
nuclease-dead (H134S)Endogenous
W248R (W248R)Endogenous
sensitive to ionizing radiationmre11ΔNull60
nuclease-dead (H134S)Endogenous
rad31-1Not specified
rad32-1Not specified
W248R (W248R)Endogenous
sensitive to methyl methanesulfonatemre11ΔNull239
nuclease-dead (H134S)Endogenous
W248R (W248R)Endogenous
yFS473 (W215C, N122S)
sensitive to UV during vegetative growthmre11ΔNull142
nuclease-dead (H134S)Endogenous
rad32-1Not specified
W248R (W248R)Endogenous
viable vegetative cell populationmre11ΔNull3809

Cell Phenotype

Term NameAlleleExpressionCount
abnormal chromatin organization during vegetative growthmre11ΔNull86
abnormal DNA damage checkpointD65N (D65N)Endogenous24
H134S (H134S)Endogenous
mre11ΔNull
abnormal double-strand break repairrad32-1Not specified20
abnormal double-strand break repair via nonhomologous end joiningmre11ΔNull4
abnormal meiosismre11ΔNull120
abnormal microtubule cytoskeleton morphology during mitotic interphasemre11ΔNull186
abnormal mitotic cell cyclemre11ΔNull834
abnormal S-phase DNA damage checkpointunnamed (unrecorded)11
abnormal sporulationW248R (W248R)Not specified208
abnormal sporulation resulting in formation of ascus containing non-uniform sporesmre11ΔNull10
nuclease-dead (H134S)Not specified
abnormal telomere maintenancemre11ΔNull3
abolished nuclease activityH134S (H134S)Not specified13
abolished protein binding95
affecting mre11 and rad50RRRR (C453R, L454R, C478R, V479R)Not specified
abolished protein phosphorylation during mitotic G2 phase during cellular response to ionizing radiation2
affecting chk1D65N (D65N)Endogenous
affecting chk1H134S (H134S)Endogenous
decreased double-strand break repairmre11ΔNull8
decreased meiotic recombinationrad32-1Not specified39
decreased Mre11 complex assemblyW248R (W248R)Endogenous2
yFS473 (W215C, N122S)
decreased protein binding66
affecting mre11 and nbs1N122S (N122S)Not specified
affecting mre11 and nbs1W215C (W215C)Not specified
affecting mre11 and rad50W248R (W248R)Not specified
affecting mre11 and nbs1W248R (W248R)Not specified
decreased protein level during vegetative growth95
affecting nbs1mre11ΔNull
affecting nbs1W215C (W215C)Not specified
affecting mre11W248R (W248R)Not specified
affecting nbs1W248R (W248R)Not specified
decreased protein localization to double-strand break site4
affecting ctp1W248R (W248R)Not specified
decreased protein phosphorylation during cellular response to ionizing radiation5
affecting chk1mre11ΔNull
affecting chk1nuclease-dead (H134S)Endogenous
affecting chk1W248R (W248R)Endogenous
decreased spore germinationmre11ΔNull31
nuclease-dead (H134S)Not specified
decreased sporulationmre11ΔNull73
elongated vegetative cellmre11ΔNull174
increased error-free double-strand break repairmre11ΔNull1
increased minichromosome loss upon segregation during vegetative growthrad32-1Not specified15
increased number of Rad52 focimre11ΔNull16
nuclease-dead (H134S)Endogenous
W248R (W248R)Endogenous
increased protein localization to double-strand break site1
affecting mre11W248R (W248R)Not specified
normal double-strand break repairD135N (D135N)Not specified2
D25N (D25N)Not specified
normal protein binding56
affecting mre11 and rad50N122S (N122S)Not specified
affecting mre11 and rad50W215C (W215C)Not specified
normal regulation of DNA replication during replication fork arrestrad32-D65N (D65N)Endogenous3
normal telomere lengthD135N (D135N)Not specified17
D25N (D25N)Not specified
shortened telomeresmre11ΔNull37
viable elongated vegetative cellmre11ΔNull301
nuclease-dead (H134S)Endogenous
rad32ΔNull
W248R (W248R)Endogenous
viable vegetative cellmre11ΔNull3524
viable vegetative cell with abnormal cell shapemre11ΔNull482
Target Of
OntologyRelationshipGeneProduct
FYPO affected by mutation in ctp1 CtIP-related endonuclease
FYPO affected by mutation in mre11 Mre11 nuclease
FYPO affected by mutation in nbs1 Mre11 complex subunit Nbs1
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons435170..436381, 436430..436935, 437006..437580, 437624..437807, 437853..439980
mRNA435170..439980
5' UTR435170..436213PMID:21511999
CDS436214..436381, 436430..436935, 437006..437580, 437624..437807, 437853..438369
3' UTR438370..439980PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF04152 Pfam IPR007281 Mre11, DNA-binding 299 467 1
PF00149 Pfam IPR004843 Calcineurin-like phosphoesterase domain, apaH type 18 254 20
PTHR10139 HMMPANTHER IPR003701 DNA repair protein Mre11 3 532 1
3.60.21.10 Gene3D IPR029052 Metallo-dependent phosphatase-like 18 87 23
3.60.21.10 Gene3D IPR029052 Metallo-dependent phosphatase-like 121 304 23
SSF56300 SuperFamily IPR029052 Metallo-dependent phosphatase-like 122 381 22
SSF56300 SuperFamily IPR029052 Metallo-dependent phosphatase-like 18 88 22
PIRSF000882 PIRSF IPR003701 DNA repair protein Mre11 5 644 1
TIGR00583 tigrfam IPR003701 DNA repair protein Mre11 15 414 1

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0000362phosphoesterase motifPMID:9826747Temporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000362

Protein Properties

Ave. residue weight 113.54 Da
Charge -11.00
Isoelectric point 5.45
Molecular weight 73.69 kDa
Number of residues 649
Modifications

Protein Modifications

Term NameResidueCount
phosphorylated residue 1927
Annotation ExtensionEvidenceResidueReference
NAS PMID:9826747
Sequence
Gene Expression

Quantitative Gene Expression

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1.2during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
0.4during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633
Disease Association
DescriptionQualifierReferenceCount
cancer PMID:15126332142
neurological disorders99
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4603
conserved in eukaryotes4514
conserved in metazoa3424
conserved in vertebrates3399
conserved in eukaryotes only2501
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
affinity capturesmre11Mre11 nuclease Affinity Capture-WesternPMID:22705791
mre11Mre11 nuclease Co-crystal or NMR structurePMID:23080121
affinity captured bynbs1Mre11 complex subunit Nbs1 Affinity Capture-WesternPMID:12944482
binds DNA-binding domain construct withnbs1Mre11 complex subunit Nbs1 Two-hybridPMID:12944481
binds activation domain construct withnbs1Mre11 complex subunit Nbs1 Two-hybridPMID:12944481
nbs1Mre11 complex subunit Nbs1 Co-crystal or NMR structurePMID:22705791
co-fractionates withnbs1Mre11 complex subunit Nbs1 Co-fractionationPMID:22705791
binds DNA-binding domain construct withnbs1Mre11 complex subunit Nbs1 Two-hybridPMID:15964794
binds DNA-binding domain construct withnbs1Mre11 complex subunit Nbs1 Two-hybridPMID:23080121
affinity capturesnbs1Mre11 complex subunit Nbs1 Affinity Capture-WesternPMID:23080121
affinity captured bynbs1Mre11 complex subunit Nbs1 Affinity Capture-WesternPMID:23080121
affinity captured byrad50DNA repair protein Rad50 Affinity Capture-WesternPMID:12861005
affinity captured byrad50DNA repair protein Rad50 Affinity Capture-WesternPMID:23080121
Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
negative genetic interaction withalp14TOG/XMAP14 family protein Alp14 Negative GeneticPMID:18818364
negative genetic interaction withamo1nuclear rim protein Amo1 Negative GeneticPMID:18818364
negative genetic interaction withapn2AP-endonuclease Apn2 Negative GeneticPMID:18818364
negative genetic interaction witharp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:18818364
positive genetic interaction witharp6actin-like protein Arp6 Positive GeneticPMID:18818364
negative genetic interaction witharp8actin-like protein, Ino80 complex subunit Arp8 Negative GeneticPMID:18818364
negative genetic interaction withash2Ash2-trithorax family protein Negative GeneticPMID:18818364
negative genetic interaction withask1DASH complex subunit Ask1 Negative GeneticPMID:18818364
synthetic growth defect withast1asteroid homolog, XP-G family protein Synthetic Growth DefectPMID:23211746
negative genetic interaction withatb2tubulin alpha 2 Negative GeneticPMID:18818364
negative genetic interaction withbyr2MAP kinase kinase kinase Byr2 Negative GeneticPMID:18818364
negative genetic interaction withcaf1CCR4-Not complex CAF1 family ribonuclease subunit Caf1 Negative GeneticPMID:18818364
negative genetic interaction withcay1cactin, spliceosome complex subunit Negative GeneticPMID:18818364
negative genetic interaction withccr4CCR4-Not complex subunit Ccr4 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withcds1replication checkpoint kinase Cds1 Negative GeneticPMID:18818364
negative genetic interaction withcho1phosphatidyl-N-dimethylethanolamine N-methyltransferase Negative GeneticPMID:18818364
negative genetic interaction withchp1chromodomain protein Chp1 Negative GeneticPMID:18818364
negative genetic interaction withclr3histone deacetylase (class II) Clr3 Negative GeneticPMID:18818364
negative genetic interaction withclr4histone H3 lysine methyltransferase Clr4 Negative GeneticPMID:18818364
negative genetic interaction withcrb2DNA repair protein Rad9 homolog Crb2 Negative GeneticPMID:18818364
negative genetic interaction withcrn1actin binding protein, coronin Crn1 Negative GeneticPMID:18818364
negative genetic interaction withcsn1COP9/signalosome complex subunit Csn1 Negative GeneticPMID:18818364
negative genetic interaction withcsn71COP9/signalosome complex subunit 7a (predicted) Negative GeneticPMID:18818364
positive genetic interaction withcuf2middle-meiotic transcription factor Cuf2 Positive GeneticPMID:18818364
negative genetic interaction withdad2DASH complex subunit Dad2 Negative GeneticPMID:18818364
negative genetic interaction withddb1damaged DNA binding protein Ddb1 Negative GeneticPMID:18818364
negative genetic interaction withdlc2dynein light chain Dlc2 (predicted) Negative GeneticPMID:18818364
positive genetic interaction witheif21translation initiation factor eIF2A (predicted) Positive GeneticPMID:18818364
positive genetic interaction withelp2elongator complex subunit Elp2 (predicted) Positive GeneticPMID:18818364
negative genetic interaction witheme1Holliday junction resolvase subunit Eme1 Negative GeneticPMID:18818364
negative genetic interaction withepe1Jmjc domain chromatin associated protein Epe1 Negative GeneticPMID:18818364
synthetic growth defect withexo1exonuclease I Exo1 Synthetic Growth DefectPMID:23211746
negative genetic interaction withexo1exonuclease I Exo1 Negative GeneticPMID:18818364
synthetic growth defect withexo1exonuclease I Exo1 Synthetic Growth DefectPMID:23080121
negative genetic interaction withfft3SMARCAD1 family ATP-dependent DNA helicase Fft3 Negative GeneticPMID:18818364
negative genetic interaction withfkbp39FKBP-type peptidyl-prolyl cis-trans isomerase (predicted) Negative GeneticPMID:18818364
negative genetic interaction withfml1ATP-dependent 3' to 5' DNA helicase, FANCM ortholog Fml1 Negative GeneticPMID:18818364
negative genetic interaction withftp105Ubp5 interacting protein Ftp105 Negative GeneticPMID:18818364
negative genetic interaction withgcn20AAA family ATPase Gcn20 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withgcn5SAGA complex histone acetyltransferase catalytic subunit Gcn5 Negative GeneticPMID:18818364
negative genetic interaction withhip4histone promoter control protein Hip4 Negative GeneticPMID:18818364
negative genetic interaction withhrq1RecQ type DNA helicase Hrq1 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withhrr1Helicase Required for RNAi-mediated heterochromatin assembly Hrr1 Negative GeneticPMID:18818364
synthetic growth defect withhta1histone H2A alpha Synthetic Growth DefectPMID:15226425
synthetic growth defect withhta2histone H2A beta Synthetic Growth DefectPMID:15226425
negative genetic interaction withhus1checkpoint clamp complex protein Hus1 Negative GeneticPMID:18818364
rescued byhus1checkpoint clamp complex protein Hus1 Phenotypic SuppressionPMID:12196391
positive genetic interaction withiwr1RNA polymerase II nuclear import protein Iwr1 (predicted) Positive GeneticPMID:18818364
negative genetic interaction withklp6kinesin-like protein Klp6 Negative GeneticPMID:18818364
negative genetic interaction withlub1WD repeat protein Lub1 Negative GeneticPMID:18818364
negative genetic interaction withmad1mitotic spindle checkpoint protein Mad1 Negative GeneticPMID:18818364
negative genetic interaction withmal3EB1 family Mal3 Negative GeneticPMID:18818364
negative genetic interaction withmcl1DNA polymerase alpha accessory factor Mcl1 Negative GeneticPMID:18818364
negative genetic interaction withmed20mediator complex subunit Med20 Negative GeneticPMID:18818364
negative genetic interaction withmed6mediator complex subunit Med6 Negative GeneticPMID:18818364
negative genetic interaction withmga2IPT/TIG ankyrin repeat containing transcription regulator of fatty acid biosynthesis (predicted) Negative GeneticPMID:18818364
negative genetic interaction withmit1SHREC complex ATP-dependent DNA helicase subunit Mit1 Negative GeneticPMID:18818364
negative genetic interaction withmrc1mediator of replication checkpoint 1 Negative GeneticPMID:18818364
negative genetic interaction withmug154conserved fungal protein Negative GeneticPMID:18818364
negative genetic interaction withnth1DNA endonuclease III Negative GeneticPMID:18818364
negative genetic interaction withnup60nucleoporin Nup60 Negative GeneticPMID:18818364
negative genetic interaction withpar1protein phosphatase regulatory subunit Par1 Negative GeneticPMID:18818364
negative genetic interaction withpbr1ubiquitin-protein ligase E3 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withpcf2CAF assembly factor (CAF-1) complex subunit B, Pcf2 Negative GeneticPMID:18818364
negative genetic interaction withpcf3CAF assembly factor (CAF-1) complex subunit C, Pcf3 Negative GeneticPMID:18818364
negative genetic interaction withpdp1PWWP domain protein Pdp1 Negative GeneticPMID:18818364
negative genetic interaction withpds5mitotic cohesin-associated protein Pds5 Negative GeneticPMID:18818364
negative genetic interaction withpdx1pyruvate dehydrogenase protein x component, Pdx1 (predicted) Negative GeneticPMID:18818364
synthetically rescued bypku70Ku domain protein Pku70 Synthetic RescuePMID:12861005
rescued bypku70Ku domain protein Pku70 Phenotypic SuppressionPMID:12196391
positive genetic interaction withpku80Ku domain protein Pku80 Positive GeneticPMID:18818364
rescued bypku80Ku domain protein Pku80 Phenotypic SuppressionPMID:21931565
phenotype enhanced bypku80Ku domain protein Pku80 Phenotypic EnhancementPMID:21931565
synthetically rescued bypku80Ku domain protein Pku80 Synthetic RescuePMID:21931565
synthetically rescued bypku80Ku domain protein Pku80 Synthetic RescuePMID:23080121
positive genetic interaction withpmc3mediator complex subunit Pmc3/Med27 Positive GeneticPMID:18818364
negative genetic interaction withpnk1DNA kinase/phosphatase Pnk1 Negative GeneticPMID:18818364
negative genetic interaction withpob3FACT complex subunit Pob3 Negative GeneticPMID:18818364
positive genetic interaction withppk30Ark1/Prk1 family protein kinase Ppk30 Positive GeneticPMID:18818364
positive genetic interaction withpub3HECT-type ubiquitin-protein ligase E3 Pub3 (predicted) Positive GeneticPMID:18818364
negative genetic interaction withrad1checkpoint clamp complex protein Rad1 Negative GeneticPMID:18818364
rescued byrad1checkpoint clamp complex protein Rad1 Phenotypic SuppressionPMID:12196391
synthetic growth defect withrad13DNA repair nuclease Rad13 Synthetic Growth DefectPMID:7885834
negative genetic interaction withrad17RFC related checkpoint protein Rad17 Negative GeneticPMID:18818364
rescued byrad17RFC related checkpoint protein Rad17 Phenotypic SuppressionPMID:12196391
synthetic lethal withrad2FEN-1 endonuclease Rad2 Synthetic LethalityPMID:7885834
negative genetic interaction withrad2FEN-1 endonuclease Rad2 Negative GeneticPMID:18818364
synthetic lethal withrad2FEN-1 endonuclease Rad2 Synthetic LethalityPMID:23080121
negative genetic interaction withrad26ATRIP, ATR checkpoint kinase regulatory subunit Rad26 Negative GeneticPMID:18818364
synthetic growth defect withrad26ATRIP, ATR checkpoint kinase regulatory subunit Rad26 Synthetic Growth DefectPMID:12196391
synthetic lethal withrad3ATR checkpoint kinase Rad3 Synthetic LethalityPMID:7885834
enhances phenotype ofrad3ATR checkpoint kinase Rad3 Phenotypic EnhancementPMID:23080121
synthetic growth defect withrad3ATR checkpoint kinase Rad3 Synthetic Growth DefectPMID:12196391
rescued byrad51RecA family recombinase Rad51/Rhp51 Phenotypic SuppressionPMID:20065069
positive genetic interaction withrad51RecA family recombinase Rad51/Rhp51 Positive GeneticPMID:18818364
synthetic growth defect withrad8ubiquitin-protein ligase E3 Rad8 Synthetic Growth DefectPMID:24875629
negative genetic interaction withrad9checkpoint clamp complex protein Rad9 Negative GeneticPMID:18818364
rescued byrad9checkpoint clamp complex protein Rad9 Phenotypic SuppressionPMID:12196391
negative genetic interaction withraf2Rik1-associated factor Raf2 Negative GeneticPMID:18818364
positive genetic interaction withrcf1cytochrome c oxidase assembly protein Rcf1 Positive GeneticPMID:18818364
negative genetic interaction withrdp1RNA-directed RNA polymerase Rdp1 Negative GeneticPMID:18818364
synthetically rescued byrec10meiotic recombination protein Rec10 Synthetic RescuePMID:16043696
negative genetic interaction withrec12meiotic recombination endonuclease Rec12 Negative GeneticPMID:18818364
phenotype enhanced byrec12meiotic recombination endonuclease Rec12 Phenotypic EnhancementPMID:15238514
rescued byrec12meiotic recombination endonuclease Rec12 Phenotypic SuppressionPMID:15654094
rescuesrec12meiotic recombination endonuclease Rec12 Phenotypic SuppressionPMID:15654094
synthetically rescued byrec24meiotic recombination protein Rec24 Synthetic RescuePMID:21429938
phenotype enhanced byrec6meiotic recombination protein Rec6 Phenotypic EnhancementPMID:15238514
negative genetic interaction withrhp14XP-A family homolog Rhp14 Negative GeneticPMID:18818364
negative genetic interaction withrik1silencing protein Rik1 Negative GeneticPMID:18818364
negative genetic interaction withrnh201ribonuclease H2 complex subunit Rnh201 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withrpa12DNA-directed RNA polymerase complex I subunit Rpa12 Negative GeneticPMID:18818364
negative genetic interaction withrsc4RSC complex subunit Rsc4 Negative GeneticPMID:18818364
negative genetic interaction withrtt109RTT109 family histone lysine acetyltransferase Negative GeneticPMID:18818364
negative genetic interaction withryh1GTPase Ryh1 Negative GeneticPMID:18818364
negative genetic interaction withset1histone lysine methyltransferase Set1 Negative GeneticPMID:18818364
negative genetic interaction withsir2Sirtuin family histone deacetylase Sir2 Negative GeneticPMID:18818364
positive genetic interaction withSPAC12B10.01cHECT-type ubiquitin-protein ligase E3 (predicted) Positive GeneticPMID:18818364
positive genetic interaction withSPAC1952.06cspliceosomal complex subunit (predicted) Positive GeneticPMID:18818364
negative genetic interaction withSPAC23A1.02cphosphoprotein phosphatase (predicted) Negative GeneticPMID:18818364
negative genetic interaction withSPBC1347.08cribonuclease H2 complex subunit (predicted) Negative GeneticPMID:18818364
positive genetic interaction withSPBC36B7.08cnucleosome assembly protein (predicted) Positive GeneticPMID:18818364
negative genetic interaction withspc34DASH complex subunit Spc34 Negative GeneticPMID:18818364
negative genetic interaction withspf1Set1C PHD Finger protein Spf1 Negative GeneticPMID:18818364
negative genetic interaction withspo6Spo4-Spo6 kinase complex regulatory subunit Spo6 Negative GeneticPMID:18818364
negative genetic interaction withsrs2ATP-dependent DNA helicase, UvrD subfamily Negative GeneticPMID:18818364
negative genetic interaction withssb1DNA replication factor A subunit Ssb1 Negative GeneticPMID:18818364
positive genetic interaction withsub1transcription coactivator PC4 Positive GeneticPMID:18818364
negative genetic interaction withswd1Set1C complex subunit Swd1 Negative GeneticPMID:18818364
negative genetic interaction withswd2Set1C complex subunit Swd2.1 Negative GeneticPMID:18818364
negative genetic interaction withswd3WD repeat protein Swd3 Negative GeneticPMID:18818364
negative genetic interaction withswi3replication fork protection complex subunit Swi3 Negative GeneticPMID:18818364
negative genetic interaction withswi6HP1 family chromodomain protein Swi6 Negative GeneticPMID:18818364
rescuestaz1human TRF ortholog Taz1 Phenotypic SuppressionPMID:23335786
synthetically rescuestaz1human TRF ortholog Taz1 Synthetic RescuePMID:23188080
rescued bytaz1human TRF ortholog Taz1 Phenotypic SuppressionPMID:12196391
rescuestaz1human TRF ortholog Taz1 Phenotypic SuppressionPMID:12861005
synthetic growth defect withtdp1tyrosyl-DNA phosphodiesterase Tdp1 Synthetic Growth DefectPMID:21408210
negative genetic interaction withtea2kinesin-like protein Tea2 Negative GeneticPMID:18818364
negative genetic interaction withtfs1transcription elongation factor TFIIS Negative GeneticPMID:18818364
positive genetic interaction withtop1DNA topoisomerase I Positive GeneticPMID:18818364
negative genetic interaction withtrm13tRNA 2'-O-methyltransferase Trm13 (predicted) Negative GeneticPMID:18818364
rescuestrt1telomerase reverse transcriptase 1 protein Trt1 Phenotypic SuppressionPMID:23335786
negative genetic interaction withubc6ubiquitin conjugating enzyme E2 Ubc6 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withubp6ubiquitin C-terminal hydrolase Ubp6 Negative GeneticPMID:18818364
negative genetic interaction withutp16U3 snoRNP-associated protein Utp16 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withutr4methionine salvage haloacid dehalogenase-like hydrolase Utr4 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withwpl1Wings apart-like homolog Wpl1 Negative GeneticPMID:18818364
negative genetic interaction withzds1zds family protein phosphatase type A regulator Zds1 (predicted) Negative GeneticPMID:18818364
External References
Database Identifier Description
NBRP SPAC13C5.07 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC13C5.07 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC13C5.07 BioGRID Interaction Datasets
Expression Viewer SPAC13C5.07 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC13C5.07 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC13C5.07 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC13C5.07 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC13C5.07 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC13C5.07 Transcriptome Viewer (Bähler Lab)
GEO SPAC13C5.07 GEO profiles
PInt SPAC13C5.07 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC13C5.07 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC13C5.07 Fission yeast phenotypic data & analysis
Cyclebase SPAC13C5.07.1 Cell Cycle Data
SPD / RIKEN40/40H02Orfeome Localization Data
UniProtKB/SwissProtQ09683DNA repair protein rad32
ModBaseQ09683Database of comparative protein structure models
STRINGQ09683Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_592935Rad32 nuclease
RefSeq mRNANM_001018336972h- Rad32 nuclease (rad32), mRNA
ePDB4FBKThe European PDB
PDB4FBKPDB
PDBsum4FBKPDBsum
ePDB4FBQThe European PDB
PDB4FBQPDB
PDBsum4FBQPDBsum
ePDB4FBWThe European PDB
PDB4FBWPDB
PDBsum4FBWPDBsum
ePDB4FCXThe European PDB
PDB4FCXPDB
PDBsum4FCXPDBsum
European Nucleotide ArchiveCAA57765.1ENA Protein Mapping
European Nucleotide ArchiveCAA90458.1ENA Protein Mapping
UniParcUPI0000133025UniProt Archive

Literature for mre11

Search: Europe PMC or PubMed

Release Version: PomBase:26_52 - 11 May 2015