mre11 (SPAC13C5.07)


Gene Standard Namemre11 Characterisation Statuspublished
Systematic IDSPAC13C5.07 Feature Typeprotein coding
Synonymsrad32 Name Description
ProductMre11 nuclease Product Size649aa, 73.69 kDa
Genomic Location Chromosome I, 435170-439980 (4811nt); CDS:436214-438369 (2156nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0008311double-stranded DNA 3'-5' exodeoxyribonuclease activityTASPMID:154859222
GO:0030145manganese ion bindingIEAIPR007281GO_REF:00000029
GO:0005515protein bindingIPInbs1PMID:15964794887
IPInbs1PMID:23080121
GO:0008310single-stranded DNA 3'-5' exodeoxyribonuclease activityTASPMID:154859221
GO:0000014single-stranded DNA endodeoxyribonuclease activityTASPMID:154859223
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0000737DNA catabolic process, endonucleolyticTASPMID:1548592213
GO:0000729DNA double-strand break processingIGIpku70, exo1PMID:179367104
IMPPMID:23080121
GO:0034613cellular protein localization556
localizes ctp1IMPPMID:17936710
localizes pku70IMPPMID:17936710
localizes exo1IMPPMID:17936710
GO:0006302double-strand break repair44
requiredIMPPMID:7885834
GO:0000724double-strand break repair via homologous recombinationIGIrad2PMID:1294448131
GO:0006303double-strand break repair via nonhomologous end joiningIMPPMID:103735827
IMPPMID:19211838
GO:0031573intra-S DNA damage checkpoint16
requiredIMPPMID:12944482
GO:0042138meiotic DNA double-strand break formationTASPMID:1565409410
GO:0006311meiotic gene conversion8
requiredIDAPMID:12628934
GO:0044773mitotic DNA damage checkpointIMPPMID:1294448240
GO:0007131reciprocal meiotic recombination45
requiredIMPPMID:7885834
GO:0000723telomere maintenanceIMPPMID:1037358250
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0030870Mre11 complexTASPMID:129444823
GO:0035861site of double-strand breakIDAPMID:2308012143
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001407decreased cell population growth on glucose carbon sourceCell growth assaymre11ΔNullPECO:0000102PMID:2308012185
Cell growth assaynuclease-dead (H134S)EndogenousPECO:0000102PMID:23080121
Cell growth assayW248R (W248R)EndogenousPECO:0000102PMID:23080121
FYPO:0000969normal cell population growth during cellular response to UVCell growth assayN122S (N122S)EndogenousPECO:0000102PMID:2308012119
Cell growth assayW215C (W215C)EndogenousPECO:0000102PMID:23080121
FYPO:0002169normal cell population growth during cellular response to gamma radiationCell growth assayW215C (W215C)EndogenousPECO:0000102PMID:230801215
Cell growth assayN122S (N122S)EndogenousPECO:0000102PMID:23080121
FYPO:0001164normal cell population growth on glucose carbon sourceCell growth assayW215C (W215C)EndogenousPECO:0000102PMID:23080121101
FYPO:0000963normal cell population growth on hydroxyureaCell growth assayW215C (W215C)EndogenousPECO:0000102PMID:2308012116
Cell growth assayN122S (N122S)EndogenousPECO:0000102PMID:23080121
Cell growth assayW215C (W215C)EndogenousPECO:0000102PMID:23080121
FYPO:0001098sensitive to 4-nitroquinoline N-oxideCell growth assaymre11ΔNullPECO:0000137, PECO:0000005PMID:19264558159
expressivity FYPO_EXT:0000001
FYPO:0000266sensitive to DNA damaging agentsCell growth assayW248R (W248R)EndogenousPMID:230801217
FYPO:0000268sensitive to UV during vegetative growthCell growth assaynuclease-dead (H134S)EndogenousPECO:0000102PMID:2308012182
Cell growth assayW248R (W248R)EndogenousPECO:0000102PMID:23080121
Cell growth assaymre11ΔNullPECO:0000102PMID:23080121
FYPO:0000085sensitive to camptothecinCell growth assaynuclease-dead (H134S)EndogenousPECO:0000102PMID:23080121200
Cell growth assaymre11ΔNullPECO:0000102PMID:23080121
Cell growth assayW248R (W248R)EndogenousPECO:0000102PMID:23080121
expressivity FYPO_EXT:0000001Cell growth assaymre11ΔNullPECO:0000137, PECO:0000005PMID:19264558
FYPO:0000088sensitive to hydroxyureaCell growth assayW248R (W248R)EndogenousPECO:0000102PMID:23080121233
Cell growth assaymre11ΔNullPECO:0000102PMID:23080121
expressivity FYPO_EXT:0000001Cell growth assaymre11ΔNullPECO:0000137, PECO:0000005PMID:19264558
Cell growth assaynuclease-dead (H134S)EndogenousPECO:0000102PMID:23080121
FYPO:0000267sensitive to ionizing radiationCell growth assayW248R (W248R)EndogenousPECO:0000102PMID:2308012141
Cell growth assaynuclease-dead (H134S)EndogenousPECO:0000102PMID:23080121
expressivity FYPO_EXT:0000001Cell growth assaymre11ΔNullPECO:0000137, PECO:0000005PMID:19264558
Cell growth assaymre11ΔNullPECO:0000102PMID:23080121
FYPO:0000089sensitive to methyl methanesulfonateCell growth assaynuclease-dead (H134S)EndogenousPECO:0000102PMID:2308012163
Cell growth assayW248R (W248R)EndogenousPECO:0000102PMID:23080121
Cell growth assaymre11ΔNullPECO:0000102PMID:23080121
expressivity FYPO_EXT:0000001Cell growth assaymre11ΔNullPECO:0000137, PECO:0000005PMID:19264558
yFS473 (W215C,N122S)PMID:19211838
FYPO:0002060viable vegetative cell populationMicroscopymre11ΔNullPMID:204732893755
Microscopymre11ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000007abnormal S-phase DNA damage checkpointno_namePMID:192118389
FYPO:0000051abnormal meiosismre11ΔNullPMID:1921183835
FYPO:0000059abnormal mitotic cell cycleMicroscopymre11ΔNullPECO:0000005, PECO:0000137PMID:23697806564
FYPO:0000121abnormal sporulationMicroscopyW248R (W248R)Not specifiedPMID:23080121110
FYPO:0000913abnormal sporulation resulting in formation of ascus containing non-uniform sporesMicroscopynuclease-dead (H134S)Not specifiedPMID:230801214
Microscopymre11ΔNullPMID:23080121
FYPO:0000122abnormal telomere maintenancemre11ΔNullPMID:192118382
FYPO:0000705abolished protein bindingCo-immunoprecipitation experimentRRRR (C453R,L454R,C478R,V479R)Not specifiedPMID:2308012130
affecting rad50
affecting mre11
FYPO:0000218decreased Mre11 complex assemblyCo-immunoprecipitation experimentW248R (W248R)EndogenousPMID:230801212
yFS473 (W215C,N122S)PMID:19211838
FYPO:0000708decreased mating efficiencyhigh throughput nucleotide sequencing assay evidencemre11ΔNullPECO:0000015PMID:23950735222
FYPO:0001645decreased protein bindingCo-immunoprecipitation experimentW215C (W215C)Not specifiedPMID:2308012121
affecting nbs1
affecting mre11
affecting nbs1Co-immunoprecipitation experimentN122S (N122S)Not specifiedPMID:23080121
affecting mre11
affecting nbs1Co-immunoprecipitation experimentW248R (W248R)Not specifiedPMID:23080121
affecting mre11
affecting rad50Co-immunoprecipitation experimentW248R (W248R)Not specifiedPMID:23080121
affecting mre11
FYPO:0001324decreased protein level during vegetative growthWestern blot assayW248R (W248R)Not specifiedPMID:2308012133
affecting mre11
affecting nbs1Western blot assayW215C (W215C)Not specifiedPMID:23080121
affecting nbs1Western blot assayW248R (W248R)Not specifiedPMID:23080121
affecting nbs1Western blot assaymre11ΔNullPMID:23080121
FYPO:0002474decreased protein localization to double-strand break siteChromatin immunoprecipitation experimentW248R (W248R)Not specifiedPMID:230801213
affecting ctp1
FYPO:0002470decreased protein phosphorylation during cellular response to ionizing radiationWestern blot assaynuclease-dead (H134S)EndogenousPMID:230801211
affecting chk1
affecting chk1Western blot assayW248R (W248R)EndogenousPMID:23080121
affecting chk1Western blot assaymre11ΔNullPMID:23080121
FYPO:0000581decreased spore germinationCell growth assaymre11ΔNullPMID:2308012112
Cell growth assaynuclease-dead (H134S)Not specifiedPMID:23080121
FYPO:0001122elongated vegetative cellmre11ΔNullPMID:19211838624
mre11ΔNullPMID:12944481
FYPO:0000241genome stability defectsmre11ΔNullPMID:192118384
FYPO:0000972increased number of Rad22 fociMicroscopynuclease-dead (H134S)EndogenousPMID:230801218
Microscopymre11ΔNullPMID:23080121
MicroscopyW248R (W248R)EndogenousPMID:23080121
FYPO:0002475increased protein localization to double-strand break siteChromatin immunoprecipitation experimentW248R (W248R)Not specifiedPMID:230801211
affecting mre11
FYPO:0000703normal protein bindingCo-immunoprecipitation experimentW215C (W215C)Not specifiedPMID:2308012118
affecting rad50
affecting mre11
affecting rad50Co-immunoprecipitation experimentN122S (N122S)Not specifiedPMID:23080121
affecting mre11
FYPO:0001492viable elongated vegetative cellMicroscopyW248R (W248R)EndogenousPMID:23080121170
Microscopynuclease-dead (H134S)EndogenousPMID:23080121
penetrance FYPO_EXT:0000001Microscopymre11ΔNullPECO:0000005, PECO:0000137PMID:23697806
Microscopymre11ΔNullPMID:23080121
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
1435170436381
2436430436935
3437006437580
4437624437807
5437853439980

UTRs

Region Start End Reference
five_prime_UTR435170436213PMID:21511999
three_prime_UTR438370439980PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00149 Pfam IPR004843 Phosphoesterase domain 18 254 20
PF04152 Pfam IPR007281 Mre11, DNA-binding 299 467 1
PTHR10139 HMMPANTHER IPR003701 DNA repair protein Mre11 3 645 1
G3DSA:3.60.21.10 Gene3D 18 87 22
G3DSA:3.60.21.10 Gene3D 121 304 22
SSF56300 SuperFamily 122 381 22
SSF56300 SuperFamily 18 88 22
Low complexity (SEG) seg 95 109
PIRSF000882 PIRSF IPR003701 DNA repair protein Mre11 1 647 1
TIGR00583 tigrfam IPR003701 DNA repair protein Mre11 15 414 1

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0000362phosphoesterase motifPMID:9826747Temporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000362

Protein Properties

Ave. residue weight 113.54 Da
Charge -11.00
Isoelectric point 5.45
Molecular weight 73.69 kDa
Number of residues 649
Modifications

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
MOD:00696phosphorylated residuePMID:98267471192
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
NDduring cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
NDduring GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
0.4during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
1.2during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
Disease Association
DescriptionQualifierReferenceCount
cancer PMID:15126332141
neurological disorders38
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3080
conserved in fungi4564
conserved in eukaryotes4482
conserved in metazoa3419
conserved in vertebrates3394
conserved in eukaryotes only2485
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
med20mediator complex subunit Med20 Negative GeneticPMID:18818364
pnk1DNA kinase/phosphatase Pnk1 Negative GeneticPMID:18818364
taz1human TRF ortholog Taz1 Phenotypic SuppressionPMID:23335786
Synthetic RescuePMID:7885834
Phenotypic SuppressionPMID:12196391
Synthetic RescuePMID:23188080
Synthetic RescuePMID:12861005
rik1silencing protein Rik1 Negative GeneticPMID:18818364
klp6kinesin-like protein Klp6 Negative GeneticPMID:18818364
hip4histone promoter control protein Hip4 Negative GeneticPMID:18818364
pcf2CAF assembly factor (CAF-1) complex subunit B, Pcf2 Negative GeneticPMID:18818364
mga2IPT/TIG ankyrin repeat containing transcription regulator of fatty acid biosynthesis (predicted) Negative GeneticPMID:18818364
atb2tubulin alpha 2 Negative GeneticPMID:18818364
rad9checkpoint clamp complex protein Rad9 Negative GeneticPMID:18818364
Phenotypic SuppressionPMID:12196391
Synthetic Growth Defect
swd1Set1C complex subunit Swd1 Negative GeneticPMID:18818364
ddb1damaged DNA binding protein Ddb1 Negative GeneticPMID:18818364
ssb1DNA replication factor A subunit Ssb1 Negative GeneticPMID:18818364
pmc3mediator complex subunit Pmc3/Med27 Positive GeneticPMID:18818364
swi6HP1 family chromodomain protein Swi6 Negative GeneticPMID:18818364
rad1checkpoint clamp complex protein Rad1 Negative GeneticPMID:18818364
Synthetic Growth DefectPMID:12196391
ash2Ash2-trithorax family protein Negative GeneticPMID:18818364
spo6Spo4-Spo6 kinase complex regulatory subunit Spo6 Negative GeneticPMID:18818364
dad2DASH complex subunit Dad2 Negative GeneticPMID:18818364
mcl1DNA polymerase alpha accessory factor Mcl1 Negative GeneticPMID:18818364
rad17RFC related checkpoint protein Rad17 Negative GeneticPMID:18818364
Phenotypic SuppressionPMID:12196391
amo1nuclear rim protein Amo1 Negative GeneticPMID:18818364
ccr4CCR4-Not complex subunit Ccr4 (predicted) Negative GeneticPMID:18818364
rtt109RTT109 family histone lysine acetyltransferase Negative GeneticPMID:18818364
cay1cactin, spliceosome complex subunit (predicted) Negative GeneticPMID:18818364
csn1COP9/signalosome complex subunit Csn1 Negative GeneticPMID:18818364
SPAC25B8.07chypoxia induced family protein Positive GeneticPMID:18818364
spc34DASH complex subunit Spc34 Negative GeneticPMID:18818364
SPBP8B7.10cU3 snoRNP-associated protein Utp16 (predicted) Negative GeneticPMID:18818364
ubc6ubiquitin conjugating enzyme Ubc6 (predicted) Negative GeneticPMID:18818364
fkbp39FKBP-type peptidyl-prolyl cis-trans isomerase (predicted) Negative GeneticPMID:18818364
rad51RecA family recombinase Rad51/Rhp51 Phenotypic SuppressionPMID:20065069
Positive GeneticPMID:18818364
SPBC4B4.04translation initiation factor eIF2A (predicted) Positive GeneticPMID:18818364
hus1checkpoint clamp complex protein Hus1 Negative GeneticPMID:18818364
Phenotypic SuppressionPMID:12196391
fft3SMARCAD1 family ATP-dependent DNA helicase Fft3 Negative GeneticPMID:18818364
mrc1mediator of replication checkpoint 1 Negative GeneticPMID:18818364
nth1DNA endonuclease III Negative GeneticPMID:18818364
lub1WD repeat protein Lub1 Negative GeneticPMID:18818364
caf1CCR4-Not complex CAF1 family ribonuclease subunit Caf1 Negative GeneticPMID:18818364
exo1exonuclease I Exo1 Negative GeneticPMID:18818364
Synthetic Growth DefectPMID:23211746
pku70Ku domain protein Pku70 Phenotypic SuppressionPMID:12196391
tdp1tyrosyl-DNA phosphodiesterase Tdp1 Synthetic Growth DefectPMID:21408210
rnh201ribonuclease H2 complex subunit Rnh201 (predicted) Negative GeneticPMID:18818364
fml1ATP-dependent 3' to 5' DNA helicase, FANCM ortholog Fml1 Negative GeneticPMID:18818364
SPBC1347.08cribonuclease H2 complex subunit (predicted) Negative GeneticPMID:18818364
rec10meiotic recombination protein Rec10 Synthetic RescuePMID:16043696
zds1zds family protein phosphatase type A regulator Zds1 (predicted) Negative GeneticPMID:18818364
mal3EB1 family Mal3 Negative GeneticPMID:18818364
raf2Rik1-associated factor Raf2 Negative GeneticPMID:18818364
hta2histone H2A beta Synthetic Growth DefectPMID:15226425
rad26ATRIP, ATR checkpoint kinase regulatory subunit Rad26 Negative GeneticPMID:18818364
pbr1human CTD-binding SR-like protein rA9 homolog (predicted) Negative GeneticPMID:18818364
pds5cohesin-associated protein Pds5 Negative GeneticPMID:18818364
SPBC29A3.09cAAA family ATPase Gcn20 (predicted) Negative GeneticPMID:18818364
byr2MAP kinase kinase kinase Byr2 Negative GeneticPMID:18818364
clr3histone deacetylase (class II) Clr3 Negative GeneticPMID:18818364
pub3HECT-type ubiquitin-protein ligase Pub3 (predicted) Positive GeneticPMID:18818364
par1protein phosphatase regulatory subunit Par1 Negative GeneticPMID:18818364
trt1telomerase reverse transcriptase 1 protein Trt1 Phenotypic SuppressionPMID:23335786
ast1asteroid homolog, XP-G family protein Synthetic Growth DefectPMID:23211746
arp6actin-like protein Arp6 Positive GeneticPMID:18818364
csn71COP9/signalosome complex subunit 7a (predicted) Negative GeneticPMID:18818364
alp14TOG ortholog Alp14 Negative GeneticPMID:18818364
elp2elongator complex subunit Elp2 (predicted) Positive GeneticPMID:18818364
rdp1RNA-directed RNA polymerase Rdp1 Negative GeneticPMID:18818364
ryh1GTPase Ryh1 Negative GeneticPMID:18818364
hta1histone H2A alpha Synthetic Growth DefectPMID:15226425
set1histone lysine methyltransferase Set1 Negative GeneticPMID:18818364
arp8actin-like protein, Ino80 complex subunit Arp8 Negative GeneticPMID:18818364
iwr1RNA polymerase II nuclear import protein Iwr1 (predicted) Positive GeneticPMID:18818364
clr4histone H3 lysine methyltransferase Clr4 Negative GeneticPMID:18818364
rec12endonuclease Rec12 Negative GeneticPMID:18818364
Phenotypic EnhancementPMID:15238514
Phenotypic SuppressionPMID:15654094
rpa12DNA-directed RNA polymerase complex I subunit Rpa12 Negative GeneticPMID:18818364
SPAC644.08methionine salvage haloacid dehalogenase-like hydrolase (predicted) Negative GeneticPMID:18818364
cho1phosphatidyl-N-methylethanolamine N-methyltransferase (predicted) Negative GeneticPMID:18818364
rec6meiotic recombination protein Rec6 Phenotypic EnhancementPMID:15238514
trm13tRNA 2'-O-methyltransferase Trm13 (predicted) Negative GeneticPMID:18818364
nup60nucleoporin Nup60 Negative GeneticPMID:18818364
pdp1PWWP domain protein Pdp1 Negative GeneticPMID:18818364
ppk30Ark1/Prk1 family protein kinase Ppk30 Positive GeneticPMID:18818364
epe1Jmjc domain chromatin associated protein Epe1 Negative GeneticPMID:18818364
crb2DNA repair protein Rad9 homolog, Rhp9 Negative GeneticPMID:18818364
wpl1Wings apart-like homolog Wpl1 Negative GeneticPMID:18818364
rsc4RSC complex subunit Rsc4 Negative GeneticPMID:18818364
arp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:18818364
hrr1Helicase Required for RNAi-mediated heterochromatin assembly Hrr1 Negative GeneticPMID:18818364
srs2ATP-dependent DNA helicase, UvrD subfamily Negative GeneticPMID:18818364
chp1chromodomain protein Chp1 Negative GeneticPMID:18818364
eme1Holliday junction resolvase subunit Eme1 Negative GeneticPMID:18818364
gcn5SAGA complex histone acetyltransferase catalytic subunit Gcn5 Negative GeneticPMID:18818364
spf1Set1C PHD Finger protein Spf1 Negative GeneticPMID:18818364
pdx1pyruvate dehydrogenase protein x component, Pdx1 (predicted) Negative GeneticPMID:18818364
SPAC23A1.02cphosphoprotein phosphatase (predicted) Negative GeneticPMID:18818364
rad13DNA repair nuclease Rad13 Synthetic Growth DefectPMID:7885834
SPAC1952.06cspliceosomal complex subunit (predicted) Positive GeneticPMID:18818364
swd2Set1C complex subunit Swd2.1 Negative GeneticPMID:18818364
sub1transcription coactivator PC4 Positive GeneticPMID:18818364
ubp6ubiquitin C-terminal hydrolase Ubp6 Negative GeneticPMID:18818364
swd3WD repeat protein Swd3 Negative GeneticPMID:18818364
pku80Ku domain protein Pku80 Positive GeneticPMID:18818364
Phenotypic SuppressionPMID:21931565
Phenotypic Enhancement
Synthetic Rescue
Synthetic RescuePMID:23080121
mad1mitotic spindle checkpoint protein Mad1 Negative GeneticPMID:18818364
apn2AP-endonuclease Apn2 Negative GeneticPMID:18818364
tea2kinesin-like protein Tea2 Negative GeneticPMID:18818364
ask1DASH complex subunit Ask1 Negative GeneticPMID:18818364
hrq1RecQ type DNA helicase Hrq1 (predicted) Negative GeneticPMID:18818364
rad3ATR checkpoint kinase Rad3 Synthetic LethalityPMID:7885834
Phenotypic EnhancementPMID:23080121
Synthetic Growth Defect
rec24meiotic recombination protein Rec24 Synthetic RescuePMID:21429938
crn1actin binding protein, coronin Crn1 Negative GeneticPMID:18818364
mug154conserved fungal protein Negative GeneticPMID:18818364
dlc2dynein light chain Dlc2 (predicted) Negative GeneticPMID:18818364
pob3FACT complex subunit Pob3 Negative GeneticPMID:18818364
cds1replication checkpoint kinase Cds1 Negative GeneticPMID:18818364
rhp14XP-A family homolog Rhp14 Negative GeneticPMID:18818364
rad2FEN-1 endonuclease Rad2 Phenotypic SuppressionPMID:12861005
Synthetic LethalityPMID:7885834
Phenotypic Suppression
Synthetic LethalityPMID:23080121
Negative GeneticPMID:18818364
top1DNA topoisomerase I Positive GeneticPMID:18818364
mit1SHREC complex subunit Mit1 Negative GeneticPMID:18818364
SPBC36B7.08cnucleosome assembly protein (predicted) Positive GeneticPMID:18818364
swi3replication fork protection complex subunit Swi3 Negative GeneticPMID:18818364
tfs1transcription elongation factor TFIIS Negative GeneticPMID:18818364
sir2Sir2 family histone deacetylase Sir2 Negative GeneticPMID:18818364
cuf2middle-meiotic transcription factor Cuf2 Positive GeneticPMID:18818364
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
rad50DNA repair protein Rad50 Affinity Capture-WesternPMID:12861005
Affinity Capture-WesternPMID:23080121
nbs1Mre11 complex subunit Nbs1 Affinity Capture-WesternPMID:12944482
Two-hybridPMID:12944481
Co-crystal StructurePMID:22705791
Co-fractionation
Two-hybridPMID:15964794
Affinity Capture-WesternPMID:23080121
Two-hybrid
External References
Database Identifier Description
NBRP SPAC13C5.07 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC13C5.07 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC13C5.07 BioGRID Interaction Datasets
Expression Viewer SPAC13C5.07 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC13C5.07 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC13C5.07 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC13C5.07 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC13C5.07 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC13C5.07 Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC13C5.07 Cell Cycle Data
GEO SPAC13C5.07 GEO profiles
PInt SPAC13C5.07 Protein-Protein Interaction Predictor (Bähler Lab)
WikiGene2542757Rad32 nuclease
EntrezGene2542757Rad32 nuclease
SPD / RIKEN40/40H02Orfeome Localization Data
UniProtKB/SwissProtQ09683DNA repair protein rad32
ModBaseQ09683Database of comparative protein structure models
StringQ09683Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_592935Rad32 nuclease
RefSeq mRNANM_001018336972h- Rad32 nuclease (rad32), mRNA
European Nucleotide ArchiveCAA57765ENA Protein Mapping
European Nucleotide ArchiveCAA90458ENA Protein Mapping
UniParcUPI0000133025UniProt Archive

Literature for mre11

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014