mre11 (SPAC13C5.07)


Gene Standard Namemre11 Characterisation Statuspublished
Systematic IDSPAC13C5.07 Feature Typeprotein coding
Synonymsrad32 Name Description
ProductMre11 nuclease Product Size649aa, 73.69 kDa
Genomic Location Chromosome I, 435170-439980 (4811nt); CDS:436214-438369 (2156nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
double-stranded DNA 3'-5' exodeoxyribonuclease activity2
Annotation ExtensionEvidenceWith/FromReference
manganese ion binding9
Annotation ExtensionEvidenceWith/FromReference
nuclease activity116
Annotation ExtensionEvidenceWith/FromReference
protein binding887
Annotation ExtensionEvidenceWith/FromReference
single-stranded DNA 3'-5' exodeoxyribonuclease activity1
Annotation ExtensionEvidenceWith/FromReference
single-stranded DNA endodeoxyribonuclease activity7
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
DNA double-strand break processing5
Annotation ExtensionEvidenceWith/FromReference
double-strand break repair54
Annotation ExtensionEvidenceWith/FromReference
double-strand break repair involved in meiotic recombination4
Annotation ExtensionEvidenceWith/FromReference
double-strand break repair via homologous recombination38
Annotation ExtensionEvidenceWith/FromReference
double-strand break repair via nonhomologous end joining9
Annotation ExtensionEvidenceWith/FromReference
intra-S DNA damage checkpoint18
Annotation ExtensionEvidenceWith/FromReference
meiotic DNA double-strand break formation9
Annotation ExtensionEvidenceWith/FromReference
reciprocal meiotic recombination45
Annotation ExtensionEvidenceWith/FromReference
telomere maintenance45
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
Mre11 complex3
Annotation ExtensionEvidenceWith/FromReference
nuclear chromosome, telomeric region53
Annotation ExtensionEvidenceWith/FromReference
site of double-strand break54
Annotation ExtensionEvidenceWith/FromReference
subtelomeric heterochromatin29
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

Term NameGenotypesCount
decreased cell population growth on glucose carbon sourcemre11Δ380
mre11-H134S (H134S)
mre11-W248R (W248R)
decreased mating efficiencymre11Δ275
decreased spore germination frequencymre11-D65N (D65N)69
mre11-H134S (H134S)
mre11Δ
decreased sporulation frequencymre11Δ103
decreased vegetative cell population growthmre11Δ729
rad32-1 (G403A)
mre11-D25N (D25N)
mre11-D65N (D65N)
inviable spore populationrad32-1 (G403A)21
mre11-D25N (D25N)
mre11Δ
normal growth during cellular response to gamma radiationmre11-W215C (W215C)18
mre11-N122S (N122S)
normal growth during cellular response to ionizing radiationmre11-P39S (P39S)25
normal growth during cellular response to UVmre11-N122S (N122S)79
mre11-W215C (W215C)
normal growth on glucose carbon sourcemre11-W215C (W215C)294
normal growth on hydroxyureamre11-N122S (N122S)75
mre11-W215C (W215C)
mre11-P39S (P39S)
normal growth on methyl methanesulfonatemre11-T517I (C1550T)58
normal sporulation frequencymre11-P39S (P39S)14
normal vegetative cell population growthmre11-P39S (P39S)813
sensitive to 4-nitroquinoline N-oxidemre11Δ159
sensitive to bleomycinmre11Δ92
sensitive to camptothecinmre11-W248R (W248R)257
mre11-H134S (H134S)
mre11Δ
sensitive to cisplatinmre11Δ106
sensitive to cobaltmre11Δ113
sensitive to DNA damaging agentsmre11-W248R (W248R)7
sensitive to doxorubicinmre11Δ95
sensitive to hydroxyureamre11-T517I (C1550T)594
rad32-1 (G403A)
mre11-D65N (D65N)
mre11-D25N (D25N)
mre11Δ
mre11-H134S (H134S)
mre11-W248R (W248R)
sensitive to ionizing radiation during vegetative growthmre11-D65N (D65N)74
rad31-1
mre11-T517I (C1550T)
mre11-D25N (D25N)
rad32-1 (G403A)
mre11-W248R (W248R)
mre11-H134S (H134S)
mre11Δ
sensitive to methyl methanesulfonatemre11-W248R (W248R)331
yFS473 (W215C, N122S)
mre11-P39S (P39S)
rad32-1 (G403A)
mre11-D25N (D25N)
mre11-H134S (H134S)
mre11-D65N (D65N)
mre11Δ
sensitive to thiabendazolemre11Δ329
sensitive to UV during mitotic S phasemre11Δ5
sensitive to UV during vegetative growthmre11-P39S (P39S)161
mre11-T517I (C1550T)
mre11-W248R (W248R)
mre11-D65N (D65N)
mre11-H134S (H134S)
mre11Δ
rad32-1 (G403A)
mre11-D25N (D25N)
slow vegetative cell population growthmre11Δ367
viable vegetative cell populationmre11Δ3850

Cell Phenotype

Term NameGenotypesCount
abnormal chromatin organization during vegetative growthmre11Δ156
abnormal double-strand break repair during vegetative growthrad32-1 (G403A)27
abnormal double-strand break repair via nonhomologous end joiningmre11Δ5
abnormal meiosismre11Δ134
abnormal microtubule cytoskeleton morphology during mitotic interphasemre11Δ186
abnormal mitotic cell cyclemre11Δ894
abnormal mitotic cell cycle regulation during cellular response to methyl methanesulfonatemre11Δ5
abnormal mitotic DNA damage checkpointmre11Δ36
mre11-H134S (H134S)
mre11-D65N (D65N)
abnormal S-phase DNA damage checkpoint11
abnormal sporulationmre11-W248R (W248R)178
abnormal sporulation resulting in formation of ascus containing non-uniform sporesmre11Δ11
mre11-H134S (H134S)
abnormal telomere maintenancemre11Δ3
abolished break-induced loss of heterozygosity via chromosomal translocationmre11Δ8
abolished meiotic recombination double-strand break repairmre11Δ2
abolished nuclease activitymre11-H134S (H134S)13
abolished protein binding147
affecting mre11 and rad50mre11-RRRR (C453R, L454R, C478R, V479R)
abolished protein localization to double-strand break site8
affects localization of ctp1mre11Δ
abolished protein phosphorylation during cellular response to bleomycin1
affecting ctp1mre11Δ
abolished protein phosphorylation during mitotic G2 phase during cellular response to ionizing radiation2
affecting chk1mre11-D65N (D65N)
affecting chk1mre11-H134S (H134S)
decreased break-induced loss of heterozygositymre11Δ6
decreased double-strand break repair during vegetative growthmre11Δ16
decreased double-strand break repair via homologous recombinationmre11Δ13
decreased duration of mitotic S phase during cellular response to methyl methanesulfonatemre11Δ1
decreased gene conversion during vegetative growthmre11Δ23
decreased meiotic recombinationrad32-1 (G403A)56
decreased mitotic recombination at hotspotmre11-D25A (D25A)2
decreased Mre11 complex assemblymre11-W248R (W248R)2
yFS473 (W215C, N122S)
decreased protein binding99
affecting mre11 and rad50mre11-D25A (D25A)
affecting mre11 and rad50mre11-W248R (W248R)
affecting mre11 and nbs1mre11-N122S (N122S)
affecting mre11 and nbs1mre11-W215C (W215C)
affecting mre11 and nbs1mre11-W248R (W248R)
decreased protein level during vegetative growth153
affecting mre11mre11-W248R (W248R)
affecting nbs1mre11-W215C (W215C)
affecting nbs1mre11Δ
affecting nbs1mre11-W248R (W248R)
decreased protein localization to double-strand break site5
affects localization of ssb1mre11Δ
affects localization of ctp1mre11-W248R (W248R)
decreased protein phosphorylation during cellular response to ionizing radiation9
affecting chk1mre11-W248R (W248R)
affecting chk1mre11Δ
affecting chk1mre11-H134S (H134S)
elongated vegetative cellmre11-D25N (D25N)802
rad32-1 (G403A)
mre11Δ
increased cellular reactive oxygen species level during vegetative growthmre11Δ28
increased duration of meiotic recombination double-strand break repairmre11Δ2
increased error-free double-strand break repairmre11Δ1
increased minichromosome loss during vegetative growthmre11Δ76
increased minichromosome loss upon segregation during vegetative growthrad32-1 (G403A)21
increased number of Rad52 foci during vegetative growthmre11Δ45
mre11-H134S (H134S)
mre11-W248R (W248R)
increased protein localization to double-strand break site1
affects localization of mre11mre11-W248R (W248R)
inviable vegetative cellmre11Δ1358
mre11-D25N (D25N)
mre11-D65N (D65N)
rad32-1 (G403A)
normal cell cycle regulation during cellular response to ionizing radiationmre11Δ17
normal chromatin silencing at telomeremre11Δ16
normal double-strand break repairrad32-D25N (D25N)13
rad32-D135N (D135N)
normal double-strand break repair via nonhomologous end joiningmre11Δ11
normal meiotic DNA double-strand break formationmre11Δ6
normal mitotic G2 DNA damage checkpoint during cellular response to UVmre11Δ4
normal protein binding91
affecting mre11 and rad50mre11-N122S (N122S)
affecting mre11 and rad50mre11-W215C (W215C)
normal protein localization to double-strand break site12
affecting rad9mre11Δ
normal protein localization to telomere during vegetative growth14
affecting mre11mre11-D25A (D25A)
normal regulation of DNA replication during replication fork arrestrad32-D65N (D65N)3
normal telomere lengthrad32-D135N (D135N)35
rad32-D25N (D25N)
mre11Δ
normal vegetative cell lengthrad32-1 (G403A)10
mre11-D65N (D65N)
mre11-D25N (D25N)
shortened telomeresmre11Δ44
telomere assembly at double-strand break sitemre11Δ9
viable elongated vegetative cellmre11-W248R (W248R)325
rad32Δ
mre11Δ
mre11-H134S (H134S)
viable vegetative cellmre11Δ3659
viable vegetative cell with abnormal cell shapemre11Δ705

FYPO Multi-allele Phenotypes

Population Phenotype

Term NameGenotypes
decreased spore germination frequencymre11+, mre11-D65N (D65N)
mre11-D25N (D25N), mre11Δ
rad32-1 (G403A), mre11Δ
mre11Δ, mre11-P39S (P39S)
mre11+, rad32-1 (G403A)
mre11-D25N (D25N), mre11+
mre11Δ, rec6Δ
rec12-117 (G202E), mre11-D65N (D65N)
mre11+, mre11-P39S (P39S)
mre11-D65N (D65N), mre11Δ
mre11Δ, rec12Δ
inviable cell populationmre11Δ, rfc3-1 (R216W)
normal growth during cellular response to ionizing radiationmre11-T517I (C1550T), mre11+
mre11+, mre11-D25N (D25N)
mre11-D65N (D65N), mre11+
rad32-1 (G403A), mre11+
normal growth during cellular response to UVmre11+, mre11-D25N (D25N)
mre11-D65N (D65N), mre11+
mre11-T517I (C1550T), mre11+
rad32-1 (G403A), mre11+
normal growth on methyl methanesulfonatepku70Δ, mre11Δ, ast1Δ
sensitive to ionizing radiation during vegetative growthrad50Δ, mre11Δ
hta1-S129A (S129A), mre11Δ, hta2-S128A (S128A)
nbs1Δ, mre11Δ, rad50Δ
nbs1Δ, mre11Δ
sensitive to methyl methanesulfonatenbs1Δ, mre11Δ
mre11Δ, pku70Δ
nbs1Δ, mre11Δ, rad50Δ
mre11Δ, exo1Δ, pku70Δ
mre11Δ, exo1Δ
rad50Δ, mre11Δ
mre11Δ, ast1Δ
slow vegetative cell population growthnrm1Δ, mre11Δ
nbs1Δ, mre11Δ, rad50Δ
mre11Δ, nbs1Δ
hta1-S129A (S129A), mre11Δ, hta2-S128A (S128A)

Cell Phenotype

Term NameGenotypes
circularized chromosomerad3Δ, mre11Δ, taz1Δ
trt1Δ, mre11Δ, taz1Δ
rad26Δ, mre11Δ, taz1Δ
mre11Δ, rad26Δ
mre11Δ, rad3Δ
decreased meiotic recombination at hotspotmre11-D65N (D65N), rec12Δ
elongated telomeresmre11Δ, taz1Δ
globally decreased meiotic recombinationmre11-D65N (D65N), rec12Δ
increased duration of meiotic recombination double-strand break repairctp1Δ, mre11Δ
increased telomeric 3' overhang lengthmre11-D25A (D25A), taz1Δ
taz1Δ, mre11Δ, pku70Δ
exo1Δ, pku70Δ, mre11Δ, taz1Δ
normal telomere lengthmre11Δ, chk1Δ
nbs1Δ, mre11Δ, rad50Δ
mre11Δ, nbs1Δ
tel1Δ, mre11Δ
crb2Δ, mre11Δ
mre11Δ, cds1Δ
cds1Δ, mre11Δ, chk1Δ
mre11Δ, taz1Δ
shortened telomeresmre11Δ, pku70Δ
rad1Δ, mre11Δ
mre11Δ, hus1Δ
rad9Δ, mre11Δ
mre11Δ, rad17Δ
telomeric 3' overhang absentmre11Δ, taz1Δ
Target Of
OntologyRelationshipGeneProduct
FYPO affected by mutation in mre11 Mre11 nuclease
FYPO affected by mutation in nbs1 Mre11 complex subunit Nbs1
FYPO localization affected by mutation in ctp1 CtIP-related endonuclease
FYPO localization affected by mutation in mre11 Mre11 nuclease
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons435170..436381, 436430..436935, 437006..437580, 437624..437807, 437853..439980
Intron436382..436429, 436936..437005, 437581..437623, 437808..437852
mRNA435170..439980
5' UTR435170..436213PMID:21511999
CDS436214..436381, 436430..436935, 437006..437580, 437624..437807, 437853..438369
3' UTR438370..439980PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00149 Pfam IPR004843 Calcineurin-like phosphoesterase domain, ApaH type 18 254 19
PF04152 Pfam IPR007281 Mre11, DNA-binding 299 467 1
SM01347 SMART IPR007281 Mre11, DNA-binding 299 467 1
PTHR10139:SF1 HMMPANTHER IPR003701 DNA double-strand break repair protein Mre11 4 542 1
PTHR10139 HMMPANTHER 4 542 1
3.60.21.10 Gene3D IPR029052 Metallo-dependent phosphatase-like 121 304 23
3.60.21.10 Gene3D IPR029052 Metallo-dependent phosphatase-like 18 87 23
SSF56300 SuperFamily IPR029052 Metallo-dependent phosphatase-like 18 88 22
SSF56300 SuperFamily IPR029052 Metallo-dependent phosphatase-like 122 381 22
PIRSF000882 PIRSF IPR003701 DNA double-strand break repair protein Mre11 5 644 1
TIGR00583 TIGRFAM IPR003701 DNA double-strand break repair protein Mre11 15 414 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 113.54 Da
Charge -11.00
Codon Adaptation Index 0.37
Isoelectric point 5.45
Molecular weight 73.69 kDa
Number of residues 649
Modifications

Protein Modifications

Term NameResidueCount
phosphorylated residue 2511
present during meiotic cell cycle, mitotic S phase, mitotic G1 phase
removed during mitotic G2 phase
absent during G2/M transition of mitotic cell cycle, mitotic M phase
Annotation ExtensionEvidenceResidueReference
present during meiotic cell cycle IDA PMID:9826747
present during mitotic S phase IDA PMID:12196391
present during mitotic S phase IDA PMID:9826747
present during mitotic G1 phase IDA PMID:9826747
removed during mitotic G2 phase IDA PMID:9826747
absent during mitotic M phase IDA PMID:9826747
absent during G2/M transition of mitotic cell cycle IDA PMID:9826747
Sequence
Gene Expression

Quantitative Gene Expression

View graphical display of gene expression data for mre11 (SPAC13C5.07)

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1.2during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
0.4during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
Disease Association
DescriptionQualifierReferenceCount
cancer PMID:15126332148
neurological disorders100
Taxonomic Conservation
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3093
conserved in fungi4607
conserved in eukaryotes4517
conserved in metazoa3427
conserved in vertebrates3402
conserved in eukaryotes only2502
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Load genes that interact physically with SPAC13C5.07 into the Query Builder
View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
binds activation domain construct withmre11Mre11 nuclease Two-hybridPMID:26771498
binds activation domain construct withrpf2Brix domain ribosome biogenesis protein Rpf2 Two-hybridPMID:26771498
binds activation domain construct withSPBC17G9.12chydrolase (predicted) Two-hybridPMID:26771498
binds activation domain construct withnbs1Mre11 complex subunit Nbs1 Two-hybridPMID:12944481
binds activation domain construct withrng3UCS-domain protein Rng3 Two-hybridPMID:26771498
binds DNA-binding domain construct withnbs1Mre11 complex subunit Nbs1 Two-hybridPMID:15964794
binds DNA-binding domain construct withrad50DNA repair protein Rad50 Two-hybridPMID:21441914
co-locates (via crystalisation or NMR) withmre11Mre11 nuclease Co-crystal or NMR structurePMID:23080121
co-locates (via crystalisation or NMR) withnbs1Mre11 complex subunit Nbs1 Co-crystal or NMR structurePMID:22705791
co-locates (via crystalisation or NMR) withrad50DNA repair protein Rad50 Co-crystal or NMR structurePMID:21441914
affinity capturesmre11Mre11 nuclease Affinity Capture-WesternPMID:22705791
affinity capturesnbs1Mre11 complex subunit Nbs1 Affinity Capture-WesternPMID:23080121
affinity captured bynbs1Mre11 complex subunit Nbs1 Affinity Capture-WesternPMID:12944482
affinity captured byrad50DNA repair protein Rad50 Affinity Capture-WesternPMID:12861005
co-fractionates withnbs1Mre11 complex subunit Nbs1 Co-fractionationPMID:22705791
Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPAC13C5.07 into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
negative genetic interaction withrsc4RSC complex subunit Rsc4 Negative GeneticPMID:18818364
negative genetic interaction withmed6mediator complex subunit Med6 Negative GeneticPMID:18818364
negative genetic interaction withfft3SMARCAD1 family ATP-dependent DNA helicase Fft3 Negative GeneticPMID:18818364
negative genetic interaction withhus1checkpoint clamp complex protein Hus1 Negative GeneticPMID:18818364
negative genetic interaction withccr4CCR4-Not complex subunit Ccr4 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withpdx1pyruvate dehydrogenase protein x component, Pdx1 (predicted) Negative GeneticPMID:18818364
negative genetic interaction witharp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:18818364
negative genetic interaction witheme1Holliday junction resolvase subunit Eme1 Negative GeneticPMID:18818364
negative genetic interaction witharp8actin-like protein, Ino80 complex subunit Arp8 Negative GeneticPMID:18818364
negative genetic interaction withfml1ATP-dependent 3' to 5' DNA helicase, FANCM ortholog Fml1 Negative GeneticPMID:18818364
negative genetic interaction withspo6Spo4-Spo6 kinase complex regulatory subunit Spo6 Negative GeneticPMID:18818364
negative genetic interaction withcsn71COP9/signalosome complex subunit 7a (predicted) Negative GeneticPMID:18818364
negative genetic interaction withrnh201ribonuclease H2 complex subunit Rnh201 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withpcf2CAF assembly factor (CAF-1) complex subunit B, Pcf2 Negative GeneticPMID:18818364
negative genetic interaction withnth1DNA endonuclease III Negative GeneticPMID:18818364
negative genetic interaction withchp1chromodomain protein Chp1 Negative GeneticPMID:18818364
negative genetic interaction withapn2AP-endonuclease Apn2 Negative GeneticPMID:18818364
negative genetic interaction withrad2FEN-1 endonuclease Rad2 Negative GeneticPMID:18818364
negative genetic interaction withubc6ubiquitin conjugating enzyme E2 Ubc6 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withrad9checkpoint clamp complex protein Rad9 Negative GeneticPMID:18818364
negative genetic interaction withswi6HP1 family chromodomain protein Swi6 Negative GeneticPMID:18818364
negative genetic interaction withmad1mitotic spindle checkpoint protein Mad1 Negative GeneticPMID:18818364
negative genetic interaction withatb2tubulin alpha 2 Negative GeneticPMID:18818364
negative genetic interaction withgcn5SAGA complex histone acetyltransferase catalytic subunit Gcn5 Negative GeneticPMID:18818364
negative genetic interaction withfkbp39FKBP-type peptidyl-prolyl cis-trans isomerase (predicted) Negative GeneticPMID:18818364
negative genetic interaction withzds1zds family protein phosphatase type A regulator Zds1 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withbyr2MAP kinase kinase kinase Byr2 Negative GeneticPMID:18818364
negative genetic interaction withcaf1CCR4-Not complex CAF1 family ribonuclease subunit Caf1 Negative GeneticPMID:18818364
negative genetic interaction withmga2IPT/TIG ankyrin repeat containing transcription regulator of fatty acid biosynthesis (predicted) Negative GeneticPMID:18818364
negative genetic interaction withswd3WD repeat protein Swd3 Negative GeneticPMID:18818364
negative genetic interaction withhip4histone promoter control protein Hip4 Negative GeneticPMID:18818364
negative genetic interaction withnup60nucleoporin Nup60 Negative GeneticPMID:18818364
negative genetic interaction withdad2DASH complex subunit Dad2 Negative GeneticPMID:18818364
negative genetic interaction withcho1phosphatidyl-N-dimethylethanolamine N-methyltransferase Negative GeneticPMID:18818364
negative genetic interaction withhrq1RecQ type DNA helicase Hrq1 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withtrm13tRNA 2'-O-methyltransferase Trm13 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withrad1checkpoint clamp complex protein Rad1 Negative GeneticPMID:18818364
negative genetic interaction withcrn1actin binding protein, coronin Crn1 Negative GeneticPMID:18818364
negative genetic interaction withcrb2DNA repair protein Rad9 homolog Crb2 Negative GeneticPMID:18818364
negative genetic interaction withrtt109RTT109 family histone lysine acetyltransferase Negative GeneticPMID:18818364
negative genetic interaction withpob3FACT complex subunit Pob3 Negative GeneticPMID:18818364
negative genetic interaction withexo1exonuclease I Exo1 Negative GeneticPMID:18818364
negative genetic interaction withtea2kinesin family plus-end microtubule motor Tea2 Negative GeneticPMID:18818364
negative genetic interaction withrik1silencing protein Rik1 Negative GeneticPMID:18818364
negative genetic interaction withtfs1transcription elongation factor TFIIS Negative GeneticPMID:18818364
negative genetic interaction withsrs2ATP-dependent DNA helicase, UvrD subfamily Negative GeneticPMID:18818364
negative genetic interaction withklp6kinesin-8 family plus-end microtubule motor Klp6 Negative GeneticPMID:18818364
negative genetic interaction withspf1Set1C PHD Finger protein Spf1 Negative GeneticPMID:18818364
negative genetic interaction withmcl1DNA polymerase alpha accessory factor Mcl1 Negative GeneticPMID:18818364
negative genetic interaction withmug154conserved fungal protein Negative GeneticPMID:18818364
negative genetic interaction withepe1Jmjc domain chromatin associated protein Epe1 Negative GeneticPMID:18818364
negative genetic interaction withclr3histone deacetylase (class II) Clr3 Negative GeneticPMID:18818364
negative genetic interaction withamo1nuclear rim protein Amo1 Negative GeneticPMID:18818364
negative genetic interaction withalp14TOG/XMAP14 family protein Alp14 Negative GeneticPMID:18818364
negative genetic interaction withwpl1cohesin loading/unloading factor (WAPL) Wpl1 Negative GeneticPMID:18818364
negative genetic interaction withgcn20AAA family ATPase Gcn20 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withswd1Set1C complex subunit Swd1 Negative GeneticPMID:18818364
negative genetic interaction withset1histone lysine methyltransferase Set1 Negative GeneticPMID:18818364
negative genetic interaction withpcf3CAF assembly factor (CAF-1) complex subunit C, Pcf3 Negative GeneticPMID:18818364
negative genetic interaction withask1DASH complex subunit Ask1 Negative GeneticPMID:18818364
negative genetic interaction withclr4histone H3 lysine methyltransferase Clr4 Negative GeneticPMID:18818364
negative genetic interaction withdlc2dynein light chain Dlc2 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withrad26ATRIP, ATR checkpoint kinase regulatory subunit Rad26 Negative GeneticPMID:18818364
negative genetic interaction withrec12meiotic recombination endonuclease Rec12 Negative GeneticPMID:18818364
negative genetic interaction withubp6ubiquitin C-terminal hydrolase Ubp6 Negative GeneticPMID:18818364
negative genetic interaction withrad17RFC related checkpoint protein Rad17 Negative GeneticPMID:18818364
negative genetic interaction withswd2Set1C complex subunit Swd2.1 Negative GeneticPMID:18818364
negative genetic interaction withftp105Ubp5 interacting protein Ftp105 Negative GeneticPMID:18818364
negative genetic interaction withhrr1Helicase Required for RNAi-mediated heterochromatin assembly Hrr1 Negative GeneticPMID:18818364
negative genetic interaction withsir2Sirtuin family histone deacetylase Sir2 Negative GeneticPMID:18818364
negative genetic interaction withcds1replication checkpoint kinase Cds1 Negative GeneticPMID:18818364
negative genetic interaction withmal3EB1 family Mal3 Negative GeneticPMID:18818364
negative genetic interaction withutr4methionine salvage haloacid dehalogenase-like hydrolase Utr4 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withrdp1RNA-directed RNA polymerase Rdp1 Negative GeneticPMID:18818364
negative genetic interaction withpdp1PWWP domain protein Pdp1 Negative GeneticPMID:18818364
negative genetic interaction withmit1SHREC complex ATP-dependent DNA helicase subunit Mit1 Negative GeneticPMID:18818364
negative genetic interaction withswi3replication fork protection complex subunit Swi3 Negative GeneticPMID:18818364
negative genetic interaction withddb1damaged DNA binding protein Ddb1 Negative GeneticPMID:18818364
negative genetic interaction withmrc1mediator of replication checkpoint 1 Negative GeneticPMID:18818364
negative genetic interaction withpbr1ubiquitin-protein ligase E3 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withSPAC23A1.02cphosphoprotein phosphatase (predicted) Negative GeneticPMID:18818364
negative genetic interaction withraf2Rik1-associated factor Raf2 Negative GeneticPMID:18818364
negative genetic interaction withlub1WD repeat protein Lub1 Negative GeneticPMID:18818364
negative genetic interaction withrpa12DNA-directed RNA polymerase complex I subunit Rpa12 Negative GeneticPMID:18818364
negative genetic interaction withmed20mediator complex subunit Med20 Negative GeneticPMID:18818364
negative genetic interaction withrhp14XP-A family homolog Rhp14 Negative GeneticPMID:18818364
negative genetic interaction withcay1cactin, spliceosome complex subunit Negative GeneticPMID:18818364
negative genetic interaction withutp16U3 snoRNP-associated protein Utp16 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withpds5mitotic and meiotic cohesin complex subunit Pds5 Negative GeneticPMID:18818364
negative genetic interaction withpar1protein phosphatase PP2A regulatory subunit B-56 Par1 Negative GeneticPMID:18818364
negative genetic interaction withcsn1COP9/signalosome complex subunit Csn1 Negative GeneticPMID:18818364
negative genetic interaction withpnk1DNA kinase/phosphatase Pnk1 Negative GeneticPMID:18818364
negative genetic interaction withspc34DASH complex subunit Spc34 Negative GeneticPMID:18818364
negative genetic interaction withryh1GTPase Ryh1 Negative GeneticPMID:18818364
negative genetic interaction withSPBC1347.08cribonuclease H2 complex subunit (predicted) Negative GeneticPMID:18818364
negative genetic interaction withssb1DNA replication factor A subunit Ssb1 Negative GeneticPMID:18818364
negative genetic interaction withash2Ash2-trithorax family protein Negative GeneticPMID:18818364
synthetic growth defect withexo1exonuclease I Exo1 Synthetic Growth DefectPMID:23080121
synthetic growth defect withhta2histone H2A beta Synthetic Growth DefectPMID:15226425
synthetic growth defect withrad3ATR checkpoint kinase Rad3 Synthetic Growth DefectPMID:12196391
synthetic growth defect withast1asteroid homolog, XP-G family protein Synthetic Growth DefectPMID:23211746
synthetic growth defect withtdp1tyrosyl-DNA phosphodiesterase Tdp1 Synthetic Growth DefectPMID:21408210
synthetic growth defect withhta1histone H2A alpha Synthetic Growth DefectPMID:15226425
synthetic growth defect withrad13DNA repair nuclease Rad13 Synthetic Growth DefectPMID:7885834
synthetic growth defect withnrm1MBF complex corepressor Nrm1 Synthetic Growth DefectPMID:25533348
synthetic growth defect withrad26ATRIP, ATR checkpoint kinase regulatory subunit Rad26 Synthetic Growth DefectPMID:12196391
synthetic growth defect withrad8ubiquitin-protein ligase E3 Rad8 Synthetic Growth DefectPMID:24875629
positive genetic interaction withcuf2middle-meiotic transcription factor Cuf2 Positive GeneticPMID:18818364
positive genetic interaction withelp2elongator complex subunit Elp2 (predicted) Positive GeneticPMID:18818364
positive genetic interaction witheif21translation initiation factor eIF2A (predicted) Positive GeneticPMID:18818364
positive genetic interaction withSPBC36B7.08cnucleosome assembly protein (predicted) Positive GeneticPMID:18818364
positive genetic interaction withrcf1cytochrome c oxidase assembly protein Rcf1 Positive GeneticPMID:18818364
positive genetic interaction withpub3HECT-type ubiquitin-protein ligase E3 Pub3 (predicted) Positive GeneticPMID:18818364
positive genetic interaction withpmc3mediator complex subunit Med27 Positive GeneticPMID:18818364
positive genetic interaction withSPAC1952.06cspliceosomal complex subunit (predicted) Positive GeneticPMID:18818364
positive genetic interaction withtop1DNA topoisomerase I Positive GeneticPMID:18818364
positive genetic interaction witharp6actin-like protein Arp6 Positive GeneticPMID:18818364
positive genetic interaction withrad51RecA family recombinase Rad51/Rhp51 Positive GeneticPMID:18818364
positive genetic interaction withiwr1RNA polymerase II nuclear import protein Iwr1 (predicted) Positive GeneticPMID:18818364
positive genetic interaction withpku80Ku domain protein Pku80 Positive GeneticPMID:18818364
positive genetic interaction withppk30Ark1/Prk1 family protein kinase Ppk30 Positive GeneticPMID:18818364
positive genetic interaction withsub1transcription coactivator PC4 Positive GeneticPMID:18818364
positive genetic interaction withSPAC12B10.01cHECT-type ubiquitin-protein ligase E3 (predicted) Positive GeneticPMID:18818364
synthetically rescued bypku80Ku domain protein Pku80 Synthetic RescuePMID:21931565
synthetically rescued byrec10meiotic recombination protein Rec10 Synthetic RescuePMID:16043696
synthetically rescued bypku70Ku domain protein Pku70 Synthetic RescuePMID:12861005
synthetically rescued byrec24meiotic recombination protein Rec24 Synthetic RescuePMID:21429938
rescued byrad51RecA family recombinase Rad51/Rhp51 Phenotypic SuppressionPMID:20065069
rescued byrec12meiotic recombination endonuclease Rec12 Phenotypic SuppressionPMID:15238514
rescued bypku80Ku domain protein Pku80 Phenotypic SuppressionPMID:21931565
rescued byrec6meiotic recombination protein Rec6 Phenotypic SuppressionPMID:15238514
rescued bytaz1human TRF ortholog Taz1 Phenotypic SuppressionPMID:12196391
rescued bypku70Ku domain protein Pku70 Phenotypic SuppressionPMID:12196391
rescued byrad17RFC related checkpoint protein Rad17 Phenotypic SuppressionPMID:12196391
rescued byhus1checkpoint clamp complex protein Hus1 Phenotypic SuppressionPMID:12196391
rescued byrad1checkpoint clamp complex protein Rad1 Phenotypic SuppressionPMID:12196391
rescued byrad9checkpoint clamp complex protein Rad9 Phenotypic SuppressionPMID:12196391
synthetically rescuestaz1human TRF ortholog Taz1 Synthetic RescuePMID:23188080
synthetic lethal withrad3ATR checkpoint kinase Rad3 Synthetic LethalityPMID:7885834
synthetic lethal withrad2FEN-1 endonuclease Rad2 Synthetic LethalityPMID:23080121
rescuesrec12meiotic recombination endonuclease Rec12 Phenotypic SuppressionPMID:15654094
rescuestaz1human TRF ortholog Taz1 Phenotypic SuppressionPMID:12861005
rescuestrt1telomerase reverse transcriptase 1 protein Trt1 Phenotypic SuppressionPMID:23335786
enhances phenotype ofrad3ATR checkpoint kinase Rad3 Phenotypic EnhancementPMID:23080121
phenotype enhanced bypku80Ku domain protein Pku80 Phenotypic EnhancementPMID:21931565
rescued by overexpression ofrec12meiotic recombination endonuclease Rec12 Dosage RescuePMID:17936710
External References
Database Identifier Description
NBRP SPAC13C5.07 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC13C5.07 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC13C5.07 BioGRID Interaction Datasets
Expression Viewer SPAC13C5.07 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC13C5.07 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC13C5.07 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC13C5.07 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC13C5.07 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC13C5.07 Transcriptome Viewer (Bähler Lab)
GEO SPAC13C5.07 GEO profiles
PInt SPAC13C5.07 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC13C5.07 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC13C5.07 Fission yeast phenotypic data & analysis
Cyclebase SPAC13C5.07.1 Cell Cycle Data
SPD / RIKEN40/40H02Orfeome Localization Data
UniProtKB/SwissProtQ09683DNA repair protein rad32
ModBaseQ09683Database of comparative protein structure models
STRINGQ09683Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_592935Rad32 nuclease
RefSeq mRNANM_001018336972h- Rad32 nuclease (rad32), mRNA
ePDB4FBKThe European PDB
PDB4FBKPDB
PDBsum4FBKPDBsum
ePDB4FBQThe European PDB
PDB4FBQPDB
PDBsum4FBQPDBsum
ePDB4FBWThe European PDB
PDB4FBWPDB
PDBsum4FBWPDBsum
ePDB4FCXThe European PDB
PDB4FCXPDB
PDBsum4FCXPDBsum
European Nucleotide ArchiveCAA57765.1ENA Protein Mapping
European Nucleotide ArchiveCAA90458.1ENA Protein Mapping
UniParcUPI0000133025UniProt Archive

Literature for mre11

Search: Europe PMC or PubMed

Release Version: PomBase:30_61 - 12 Sep 2016