mre11 (SPAC13C5.07)

Gene Standard Namemre11 ChromosomeI
Systematic IDSPAC13C5.07 Gene Start435170
Synonymsrad32 Gene End439980
ProductMre11 nuclease Gene Length4811
Feature Typeprotein coding CDS Start436214
Name Description CDS End438369
Characterisation Statuspublished CDS Length2156

Ensembl Gene Location
  1. tht1
  2. SPAC13C5.04
  3. SPNCRNA.645
  4. snR40
  5. SPAC13C5.05c
  6. mug121
  7. prl5
  8. SPNCRNA.646
  9. mre11
  10. SPNCRNA.647
  11. SPNCRNA.648
  12. fep1
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0000007abnormal S-phase DNA damage checkpointno_name (unrecorded)unrecordedPMID:19211838
FYPO:0000051abnormal meiosismre11delta (deletion)deletionPMID:19211838
FYPO:0000089sensitive to methyl methanesulfonateyFS473 (W215C|N122S)unknownPMID:19211838
FYPO:0000122abnormal telomere maintenancemre11delta (deletion)deletionPMID:19211838
FYPO:0000218decreased Mre11 complex assemblyyFS473 (W215C|N122S)unknownPMID:19211838
FYPO:0000241genome stability defectsmre11delta (deletion)deletionPMID:19211838
FYPO:0000266sensitive to DNA damaging agentsmre11delta (deletion)deletionPMID:19211838
FYPO:0001122elongated vegetative cellmre11delta (deletion)deletionPMID:19211838
mre11delta (deletion)deletionPMID:12944481
FYPO:0001491viable vegetative cellMicroscopymre11delta (deletion)deletionPMID:20473289
GO Molecular Function

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Term IDTerm NameEvidenceWith/FromReference
GO:0000014single-stranded DNA specific endodeoxyribonuclease activityTASPMID:15485922
GO:0005515protein bindingIPInbs1PMID:15964794
GO:0008310single-stranded DNA specific 3'-5' exodeoxyribonuclease activityTASPMID:15485922
GO:0008311double-stranded DNA specific 3'-5' exodeoxyribonuclease activityTASPMID:15485922
GO:0030145manganese ion bindingIEAIPR007281GO_REF:0000002
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0000077DNA damage checkpointIMPPMID:12944482
GO:0000723telomere maintenanceIMPPMID:10373582
GO:0000724double-strand break repair via homologous recombinationIGIrad2PMID:12944481
GO:0000729DNA double-strand break processingIGIpku70, exo1PMID:17936710
GO:0006302double-strand break repair
requiredIMPPMID:7885834
GO:0006303double-strand break repair via nonhomologous end joiningIMPPMID:10373582
IMPPMID:19211838
GO:0006311meiotic gene conversion
requiredIDAPMID:12628934
GO:0007131reciprocal meiotic recombination
requiredIMPPMID:7885834
GO:0031573intra-S DNA damage checkpoint
requiredIMPPMID:12944482
GO:0034613cellular protein localization
has_input ctp1IMPPMID:17936710
has_input exo1IMPPMID:17936710
has_input pku70IMPPMID:17936710
GO:0042138meiotic DNA double-strand break formationTASPMID:15654094
GO Cellular Component

Ontology Graph

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Term IDTerm NameEvidenceWith/FromReference
GO:0030870Mre11 complexTASPMID:12944482
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
1435170436381
2436430436935
3437006437580
4437624437807
5437853439980

References

Region Start End Reference
three_prime_UTR438370439980PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF04152 IPR007281 Pfam Mre11, DNA-binding 299 467 1
PF00149 IPR004843 Pfam Metallophosphoesterase domain 18 254 20
G3DSA:3.60.21.10 Gene3D 18 87 22
G3DSA:3.60.21.10 Gene3D 121 304 22
SSF56300 SuperFamily 122 381 22
SSF56300 SuperFamily 18 88 22
PIRSF000882 IPR003701 PIRSF DNA repair protein Mre11 1 647 1
PTHR10139 IPR003701 hmmpanther DNA repair protein Mre11 1 649 1
TIGR00583 IPR003701 tigrfam DNA repair protein Mre11 15 414 1

View domain organization at Pfam

Protein Modifications (PSI-MOD)

Term IDTerm NameEvidenceResidueReference
MOD:00696phosphorylated residuePMID:9826747

Manually Curated Family or Sub-families

Term IDTerm NameReferenceAll Genes
PBO:0000362phosphoesterase motifPMID:9826747Temporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000362

Protein Properties

Ave. residue weight 113.54 Da
Charge -11.00
Isoelectric point 5.45
Molecular weight 73.69 kDa
Number of residues 649
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127		population_widePMID:23101633
experimental evidencevegetative growth of a single-celled organismPECO:0000005,
PECO:0000014		population_widePMID:23101633
RNA levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide0.4PMID:23101633
experimental evidencevegetative growth of a single-celled organismPECO:0000014,
PECO:0000005		population_wide1.2PMID:23101633
Disease Association
DescriptionQualifierReference
cancer PMID:15126332
neurological disorders
Species Distribution
DescriptionQualifierReference
predominantly single copy (one to one)
conserved in fungi
conserved in eukaryotes
conserved in metazoa
conserved in vertebrates
conserved in eukaryotes only
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
csn1COP9/signalosome complex subunit Csn1 Negative GeneticPMID:18818364
srs2ATP-dependent DNA helicase, UvrD subfamily Negative GeneticPMID:18818364
rec24meiotic recombination protein Rec24 Synthetic RescuePMID:21429938
rad13DNA repair nuclease Rad13 Synthetic Growth DefectPMID:7885834
tea2kinesin-like protein Tea2 Negative GeneticPMID:18818364
alp14TOG ortholog Alp14 Negative GeneticPMID:18818364
pdx1pyruvate dehydrogenase protein x component, Pdx1 (predicted) Negative GeneticPMID:18818364
trt1telomerase reverse transcriptase 1 protein Trt1 Phenotypic SuppressionPMID:23335786
wpl1Wings apart-like homolog Wpl1 Negative GeneticPMID:18818364
rad2FEN-1 endonuclease Rad2 Synthetic LethalityPMID:7885834
Synthetic LethalityPMID:23080121
Negative GeneticPMID:18818364
clr4histone H3 lysine methyltransferase Clr4 Negative GeneticPMID:18818364
rad17RFC related checkpoint protein Rad17 Phenotypic SuppressionPMID:12196391
Negative GeneticPMID:18818364
iwr1RNA polymerase II nuclear import protein Iwr1 (predicted) Positive GeneticPMID:18818364
rec6meiotic recombination protein Rec6 Phenotypic EnhancementPMID:15238514
pmc5mediator complex subunit Pmc5 Negative GeneticPMID:18818364
atb2tubulin alpha 2 Negative GeneticPMID:18818364
trm13tRNA 2'-O-methyltransferase Trm13 (predicted) Negative GeneticPMID:18818364
ash2Ash2-trithorax family protein Negative GeneticPMID:18818364
set1histone lysine methyltransferase Set1 Negative GeneticPMID:18818364
mga2IPT/TIG ankyrin repeat containing transcription regulator of fatty acid biosynthesis (predicted) Negative GeneticPMID:18818364
mcl1DNA polymerase alpha accessory factor Mcl1 Negative GeneticPMID:18818364
mug154conserved fungal protein Negative GeneticPMID:18818364
clr3histone deacetylase (class II) Clr3 Negative GeneticPMID:18818364
ssb1DNA replication factor A subunit Ssb1 Negative GeneticPMID:18818364
spc34DASH complex subunit Spc34 Negative GeneticPMID:18818364
hta1histone H2A alpha Synthetic Growth DefectPMID:15226425
ask1DASH complex subunit Ask1 Negative GeneticPMID:18818364
rhp14XP-A family homolog Rhp14 Negative GeneticPMID:18818364
dad2DASH complex subunit Dad2 Negative GeneticPMID:18818364
spf1Set1C PHD Finger protein Spf1 Negative GeneticPMID:18818364
arp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:18818364
pnk1DNA kinase/phosphatase Pnk1 Negative GeneticPMID:18818364
caf1CCR4-Not complex CAF1 family ribonuclease subunit Caf1 Negative GeneticPMID:18818364
ubc6ubiquitin conjugating enzyme Ubc6 (predicted) Negative GeneticPMID:18818364
mrc1mediator of replication checkpoint 1 Negative GeneticPMID:18818364
lub1WD repeat protein Lub1 Negative GeneticPMID:18818364
sir2Sir2 family histone deacetylase Sir2 Negative GeneticPMID:18818364
SPBC29A3.09cAAA family ATPase Gcn20 (predicted) Negative GeneticPMID:18818364
SPAC644.08methionine salvage haloacid dehalogenase-like hydrolase (predicted) Negative GeneticPMID:18818364
nth1DNA endonuclease III Negative GeneticPMID:18818364
rtt109RTT109 family histone lysine acetyltransferase Negative GeneticPMID:18818364
pmc3mediator complex subunit Pmc3/Med27 Positive GeneticPMID:18818364
SPCC126.07chuman CTD-binding SR-like protein rA9 homolog (predicted) Negative GeneticPMID:18818364
swd2Set1C complex subunit Swd2.1 Negative GeneticPMID:18818364
chp1chromodomain protein Chp1 Negative GeneticPMID:18818364
spo6Spo4-Spo6 kinase complex regulatory subunit Spo6 Negative GeneticPMID:18818364
ubp6ubiquitin C-terminal hydrolase Ubp6 Negative GeneticPMID:18818364
zds1zds family protein phosphatase type A regulator Zds1 (predicted) Negative GeneticPMID:18818364
SPBC36B7.08cnucleosome assembly protein (predicted) Positive GeneticPMID:18818364
pub3HECT-type ubiquitin-protein ligase Pub3 (predicted) Positive GeneticPMID:18818364
rad26ATRIP, ATR checkpoint kinase regulatory subunit Rad26 Synthetic Growth DefectPMID:12196391
Negative GeneticPMID:18818364
pob3FACT complex subunit Pob3 Negative GeneticPMID:18818364
par1protein phosphatase regulatory subunit Par1 Negative GeneticPMID:18818364
crn1actin binding protein, coronin Crn1 Negative GeneticPMID:18818364
SPAC12B10.01cubiquitin-protein ligase E3 (predicted) Positive GeneticPMID:18818364
sub1transcription coactivator PC4 Positive GeneticPMID:18818364
ppk30Ark1/Prk1 family protein kinase Ppk30 Positive GeneticPMID:18818364
swd3WD repeat protein Swd3 Negative GeneticPMID:18818364
hrq1RecQ type DNA helicase Hrq1 (predicted) Negative GeneticPMID:18818364
ast1asteroid homolog, XP-G family protein Synthetic Growth DefectPMID:23211746
rpa12DNA-directed RNA polymerase complex I subunit Rpa12 Negative GeneticPMID:18818364
rec10meiotic recombination protein Rec10 Synthetic RescuePMID:16043696
swi3replication fork protection complex subunit Swi3 Negative GeneticPMID:18818364
raf2Rik1-associated factor Raf2 Negative GeneticPMID:18818364
epe1Jmjc domain chromatin associated protein Epe1 Negative GeneticPMID:18818364
nup60nucleoporin Nup60 Negative GeneticPMID:18818364
SPAC23A1.02cphosphoprotein phosphatase (predicted) Negative GeneticPMID:18818364
pku80Ku domain protein Pku80 Phenotypic EnhancementPMID:21931565
Synthetic Rescue
Phenotypic Suppression
Synthetic RescuePMID:23080121
Positive GeneticPMID:18818364
elp2elongator complex subunit Elp2 (predicted) Positive GeneticPMID:18818364
hus1checkpoint clamp complex protein Hus1 Phenotypic SuppressionPMID:12196391
Negative GeneticPMID:18818364
pdp1PWWP domain protein Pdp1 Negative GeneticPMID:18818364
SPAC25B8.07chypoxia induced family protein Positive GeneticPMID:18818364
med20mediator complex subunit Med20 Negative GeneticPMID:18818364
fkbp39FKBP-type peptidyl-prolyl cis-trans isomerase (predicted) Negative GeneticPMID:18818364
fml1ATP-dependent 3' to 5' DNA helicase, FANCM ortholog Fml1 Negative GeneticPMID:18818364
fft3fun thirty related protein Fft3 Negative GeneticPMID:18818364
hrr1Helicase Required for RNAi-mediated heterochromatin assembly Hrr1 Negative GeneticPMID:18818364
tfs1transcription elongation factor TFIIS Negative GeneticPMID:18818364
swd1Set1C complex subunit Swd1 Negative GeneticPMID:18818364
amo1nuclear rim protein Amo1 Negative GeneticPMID:18818364
cuf2middle-meiotic transcription factor Cuf2 Positive GeneticPMID:18818364
rec12endonuclease Rec12 Phenotypic SuppressionPMID:15654094
Phenotypic EnhancementPMID:15238514
Negative GeneticPMID:18818364
rdp1RNA-directed RNA polymerase Rdp1 Negative GeneticPMID:18818364
ccr4CCR4-Not complex subunit Ccr4 (predicted) Negative GeneticPMID:18818364
top1DNA topoisomerase I Positive GeneticPMID:18818364
klp6kinesin-like protein Klp6 Negative GeneticPMID:18818364
dlc2dynein light chain Dlc2 (predicted) Negative GeneticPMID:18818364
hta2histone H2A beta Synthetic Growth DefectPMID:15226425
gcn5SAGA complex histone acetyltransferase catalytic subunit Gcn5 Negative GeneticPMID:18818364
SPBC4B4.04translation initiation factor eIF2A (predicted) Positive GeneticPMID:18818364
rad1checkpoint clamp complex protein Rad1 Phenotypic SuppressionPMID:12196391
Negative GeneticPMID:18818364
SPBP8B7.10cU3 snoRNP-associated protein Utp16 (predicted) Negative GeneticPMID:18818364
SPBC1347.08cribonuclease H2 complex subunit (predicted) Negative GeneticPMID:18818364
ryh1GTPase Ryh1 Negative GeneticPMID:18818364
rad9checkpoint clamp complex protein Rad9 Phenotypic SuppressionPMID:12196391
Negative GeneticPMID:18818364
tdp1tyrosyl-DNA phosphodiesterase Tdp1 Synthetic Growth DefectPMID:21408210
mit1SHREC complex subunit Mit1 Negative GeneticPMID:18818364
crb2DNA repair protein Rad9 homolog, Rhp9 Negative GeneticPMID:18818364
arp6actin-like protein Arp6 Positive GeneticPMID:18818364
cds1replication checkpoint kinase Cds1 Negative GeneticPMID:18818364
rad3ATR checkpoint kinase Rad3 Synthetic Growth DefectPMID:12196391
Synthetic LethalityPMID:7885834
Phenotypic EnhancementPMID:23080121
rsc4RSC complex subunit Rsc4 Negative GeneticPMID:18818364
csn71COP9/signalosome complex subunit 7a (predicted) Negative GeneticPMID:18818364
pcf3CAF assembly factor (CAF-1) complex subunit C, Pcf3 Negative GeneticPMID:18818364
arp8actin-like protein, Ino80 complex subunit Arp8 Negative GeneticPMID:18818364
cho1phosphatidyl-N-methylethanolamine N-methyltransferase (predicted) Negative GeneticPMID:18818364
rad51RecA family recombinase Rad51/Rhp51 Phenotypic SuppressionPMID:20065069
Positive GeneticPMID:18818364
eme1Holliday junction resolvase subunit Eme1 Negative GeneticPMID:18818364
ddb1damaged DNA binding protein Ddb1 Negative GeneticPMID:18818364
ftp105Ubp5 interacting protein Ftp105 Negative GeneticPMID:18818364
rik1silencing protein Rik1 Negative GeneticPMID:18818364
mad1mitotic spindle checkpoint protein Mad1 Negative GeneticPMID:18818364
pcf2CAF assembly factor (CAF-1) complex subunit B, Pcf2 Negative GeneticPMID:18818364
taz1human TRF ortholog Taz1 Phenotypic SuppressionPMID:12196391
Phenotypic SuppressionPMID:23335786
Phenotypic SuppressionPMID:12861005
Synthetic RescuePMID:23188080
pku70Ku domain protein Pku70 Phenotypic SuppressionPMID:12196391
Synthetic RescuePMID:12861005
rqh1RecQ type DNA helicase Rqh1 Synthetic LethalityPMID:21931565
SPAC1952.06cspliceosomal complex subunit (predicted) Positive GeneticPMID:18818364
byr2MAP kinase kinase kinase Byr2 Negative GeneticPMID:18818364
pds5cohesin-associated protein Pds5 Negative GeneticPMID:18818364
swi6HP1 family chromodomain protein Swi6 Negative GeneticPMID:18818364
cay1cactin, spliceosome complex subunit (predicted) Negative GeneticPMID:18818364
rnh201ribonuclease H2 complex subunit Rnh201 (predicted) Negative GeneticPMID:18818364
apn2AP-endonuclease Apn2 Negative GeneticPMID:18818364
exo1exonuclease I Exo1 Synthetic LethalityPMID:21931565
Synthetic Growth DefectPMID:23080121
Negative GeneticPMID:18818364
Synthetic Growth DefectPMID:23211746
hip4histone promoter control protein Hip4 Negative GeneticPMID:18818364
mal3EB1 family Mal3 Negative GeneticPMID:18818364
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
nbs1Mre11 complex subunit Nbs1 Affinity Capture-WesternPMID:12944482
Two-hybridPMID:15964794
Affinity Capture-WesternPMID:23080121
Co-crystal StructurePMID:22705791
Co-fractionation
Two-hybridPMID:12944481
rad50DNA repair protein Rad50 Affinity Capture-WesternPMID:23080121
Affinity Capture-WesternPMID:12861005
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External References
Database Identifier Description
NBRP SPAC13C5.07 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC13C5.07 Retrieval of eukaryotic orthologs
BioGrid SPAC13C5.07 BioGRID Interaction Datasets
Bähler Lab SPAC13C5.07 Cell Cycle Expression Profile
Bähler Lab SPAC13C5.07 Meiosis/Sporulation Expression Profies
Bähler Lab SPAC13C5.07 Pheromone response/mating expression profiles
Bähler Lab SPAC13C5.07 Environmental stress expression profiles
Bähler Lab SPAC13C5.07 Bähler Lab Transcriptome Viewer
Cyclebase SPAC13C5.07 Cell Cycle Data
PInt SPAC13C5.07 Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPAC13C5.07 Entrez Gene
SPD / RIKEN40/40H02Orfeome Localization Data
WikiGene2542757Rad32 nuclease
Uniprot_genenameRAD32
EntrezGene2542757Rad32 nuclease
UniProtKB/SwissProtQ09683DNA repair protein rad32
ModBaseQ09683Database of comparative protein structure models
Pfam Protein DomainsQ09683Pfam Domain Arrangement
RefSeq PeptideNP_592935Rad32 nuclease
RefSeq mRNANM_001018336972h- Rad32 nuclease (rad32), mRNA
European Nucleotide ArchiveCAA57765ENA Protein Mapping
European Nucleotide ArchiveCAA90458ENA Protein Mapping
SPD / RIKEN40/40H02Orfeome Localization Data

Literature for mre11
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Search: UK PMC or PubMed

Release Version: PomBase:18.34 - 04 Apr 2013