mre11 (SPAC13C5.07)

Gene Standard Namemre11 Characterisation Statuspublished
Systematic IDSPAC13C5.07 Feature Typeprotein coding
Synonymsrad32 Name Description
ProductMre11 nuclease Product Size649aa, 73.69 kDa
Genomic Location Chromosome I, 435170-439980 (4811nt); CDS:436214-438369 (2156nt)

Ensembl Gene Location
GO Molecular Function
GO Biological Process
Term NameCount
cellular protein localization555
Annotation ExtensionEvidenceWith/FromReference
DNA catabolic process, endonucleolytic14
Annotation ExtensionEvidenceWith/FromReference
DNA double-strand break processing4
Annotation ExtensionEvidenceWith/FromReference
double-strand break repair49
Annotation ExtensionEvidenceWith/FromReference
double-strand break repair via nonhomologous end joining7
Annotation ExtensionEvidenceWith/FromReference
intra-S DNA damage checkpoint16
Annotation ExtensionEvidenceWith/FromReference
meiotic DNA double-strand break formation8
Annotation ExtensionEvidenceWith/FromReference
meiotic gene conversion7
Annotation ExtensionEvidenceWith/FromReference
mitotic DNA damage checkpoint31
Annotation ExtensionEvidenceWith/FromReference
reciprocal meiotic recombination42
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
Mre11 complex3
Annotation ExtensionEvidenceWith/FromReference
site of double-strand break46
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
decreased cell population growth on glucose carbon sourcemre11ΔNull154
nuclease-dead (H134S)Endogenous
W248R (W248R)Endogenous
decreased mating efficiencymre11ΔNull247
normal growth during cellular response to gamma radiationN122S (N122S)Endogenous16
W215C (W215C)Endogenous
normal growth during cellular response to UVN122S (N122S)Endogenous36
W215C (W215C)Endogenous
normal growth on glucose carbon sourceW215C (W215C)Endogenous189
normal growth on hydroxyureaN122S (N122S)Endogenous31
W215C (W215C)Endogenous
sensitive to 4-nitroquinoline N-oxide159
expressivity FYPO_EXT:0000001mre11ΔNull
sensitive to camptothecinmre11ΔNull214
expressivity FYPO_EXT:0000001mre11ΔNull
nuclease-dead (H134S)Endogenous
W248R (W248R)Endogenous
sensitive to DNA damaging agentsW248R (W248R)Endogenous7
sensitive to doxorubicin91
expressivity FYPO_EXT:0000002mre11ΔNull
sensitive to hydroxyureamre11ΔNull518
expressivity FYPO_EXT:0000001mre11ΔNull
nuclease-dead (H134S)Endogenous
W248R (W248R)Endogenous
sensitive to ionizing radiationmre11ΔNull58
expressivity FYPO_EXT:0000001mre11ΔNull
nuclease-dead (H134S)Endogenous
rad31-1Not specified
expressivity FYPO_EXT:0000001rad32-1Not specified
W248R (W248R)Endogenous
sensitive to methyl methanesulfonatemre11ΔNull227
expressivity FYPO_EXT:0000001mre11ΔNull
nuclease-dead (H134S)Endogenous
W248R (W248R)Endogenous
yFS473 (W215C, N122S)
sensitive to UV during vegetative growthmre11ΔNull133
nuclease-dead (H134S)Endogenous
expressivity FYPO_EXT:0000002rad32-1Not specified
W248R (W248R)Endogenous
viable vegetative cell populationmre11ΔNull3781

Cell Phenotype

Term NameAlleleExpressionCount
abnormal chromatin organization during vegetative growthmre11ΔNull71
abnormal DNA damage checkpointD65N (D65N)Endogenous21
H134S (H134S)Endogenous
abnormal double-strand break repairrad32-1Not specified18
abnormal double-strand break repair via nonhomologous end joiningmre11ΔNull7
abnormal meiosismre11ΔNull113
abnormal microtubule cytoskeleton morphology during mitotic interphase186
penetrance FYPO_EXT:0000002mre11ΔNull
abnormal mitotic cell cyclemre11ΔNull794
abnormal S-phase DNA damage checkpointnot recorded (unrecorded)11
abnormal sporulationW248R (W248R)Not specified195
abnormal sporulation resulting in formation of ascus containing non-uniform sporesmre11ΔNull8
nuclease-dead (H134S)Not specified
abnormal telomere maintenancemre11ΔNull3
abolished nuclease activityH134S (H134S)Not specified10
abolished protein binding68
affecting mre11 and rad50RRRR (C453R, L454R, C478R, V479R)Not specified
abolished protein phosphorylation during mitotic G2 phase during cellular response to ionizing radiation2
affecting chk1D65N (D65N)Endogenous
affecting chk1H134S (H134S)Endogenous
decreased double-strand break repairmre11ΔNull6
decreased meiotic recombinationrad32-1Not specified38
decreased Mre11 complex assemblyW248R (W248R)Endogenous2
yFS473 (W215C, N122S)
decreased protein binding51
affecting mre11 and nbs1N122S (N122S)Not specified
affecting mre11 and nbs1W215C (W215C)Not specified
affecting mre11 and rad50W248R (W248R)Not specified
affecting mre11 and nbs1W248R (W248R)Not specified
decreased protein level during vegetative growth80
affecting nbs1mre11ΔNull
affecting nbs1W215C (W215C)Not specified
affecting mre11W248R (W248R)Not specified
affecting nbs1W248R (W248R)Not specified
decreased protein localization to double-strand break site4
affecting ctp1W248R (W248R)Not specified
decreased protein phosphorylation during cellular response to ionizing radiation3
affecting chk1mre11ΔNull
affecting chk1nuclease-dead (H134S)Endogenous
affecting chk1W248R (W248R)Endogenous
decreased spore germinationmre11ΔNull24
nuclease-dead (H134S)Not specified
decreased sporulationmre11ΔNull65
elongated vegetative cellmre11ΔNull703
increased error-free double-strand break repairmre11ΔNull1
increased minichromosome loss upon segregation during vegetative growthrad32-1Not specified12
increased number of Rad52 focimre11ΔNull11
nuclease-dead (H134S)Endogenous
W248R (W248R)Endogenous
increased protein localization to double-strand break site1
affecting mre11W248R (W248R)Not specified
normal double-strand break repairD135N (D135N)Not specified1
D25N (D25N)Not specified
normal protein binding49
affecting mre11 and rad50N122S (N122S)Not specified
affecting mre11 and rad50W215C (W215C)Not specified
normal regulation of DNA replication during replication fork arrestrad32-D65N (D65N)Endogenous3
normal telomere lengthD135N (D135N)Not specified15
D25N (D25N)Not specified
shortened telomeresmre11ΔNull33
viable elongated vegetative cellmre11ΔNull231
penetrance FYPO_EXT:0000001mre11ΔNull
nuclease-dead (H134S)Endogenous
penetrance FYPO_EXT:0000003, expressivity FYPO_EXT:0000001rad32ΔNull
W248R (W248R)Endogenous
viable vegetative cellmre11ΔNull3613
viable vegetative cell with abnormal cell shape472
penetrance FYPO_EXT:0000001mre11ΔNull
Target Of
FYPO affected by mutation in ctp1 CtIP-related endonuclease PMID:21098122
FYPO affected by mutation in mre11 Mre11 nuclease PMID:23080121
FYPO affected by mutation in mre11 Mre11 nuclease PMID:22705791
FYPO affected by mutation in nbs1 Mre11 complex subunit Nbs1 PMID:22705791
Ensembl transcript structure with UTRs, exons and introns


Exon Start End


Region Coordinates Reference
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00149 Pfam IPR004843 Calcineurin-like phosphoesterase domain, apaH type 18 254 20
PF04152 Pfam IPR007281 Mre11, DNA-binding 299 467 1
PTHR10139 HMMPANTHER IPR003701 DNA repair protein Mre11 3 532 1 Gene3D IPR029052 Metallo-dependent phosphatase-like 18 87 23 Gene3D IPR029052 Metallo-dependent phosphatase-like 121 304 23
SSF56300 SuperFamily IPR029052 Metallo-dependent phosphatase-like 122 381 22
SSF56300 SuperFamily IPR029052 Metallo-dependent phosphatase-like 18 88 22
PIRSF000882 PIRSF IPR003701 DNA repair protein Mre11 1 647 1
TIGR00583 tigrfam IPR003701 DNA repair protein Mre11 15 414 1

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0000362phosphoesterase motifPMID:9826747Temporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000362

Protein Properties

Ave. residue weight 113.54 Da
Charge -11.00
Isoelectric point 5.45
Molecular weight 73.69 kDa
Number of residues 649

Protein Modifications

Term NameResidueCount
phosphorylated residue 1922
Annotation ExtensionEvidenceResidueReference
NAS PMID:9826747
Gene Expression

Quantitative Gene Expression

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1.2during GO:0072690PECO:0000005,
population wideexperimental evidencePMID:23101633
0.4during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population wideexperimental evidencePMID:23101633
Disease Association
cancer PMID:15126332142
neurological disorders98
Species Distribution
predominantly single copy (one to one)3092
conserved in fungi4604
conserved in eukaryotes4516
conserved in metazoa3432
conserved in vertebrates3407
conserved in eukaryotes only2503

Manually curated orthologous groups


Orthologs in Compara

Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
rad50DNA repair protein Rad50 Affinity Capture-WesternPMID:12861005
Affinity Capture-WesternPMID:23080121
nbs1Mre11 complex subunit Nbs1 Affinity Capture-WesternPMID:12944482
Co-crystal or NMR structurePMID:22705791
Affinity Capture-WesternPMID:23080121
mre11Mre11 nuclease Affinity Capture-WesternPMID:22705791
Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
med20mediator complex subunit Med20 Negative GeneticPMID:18818364
pnk1DNA kinase/phosphatase Pnk1 Negative GeneticPMID:18818364
taz1human TRF ortholog Taz1 Phenotypic SuppressionPMID:23335786
Synthetic RescuePMID:23188080
Phenotypic SuppressionPMID:12196391
Phenotypic SuppressionPMID:12861005
rik1silencing protein Rik1 Negative GeneticPMID:18818364
klp6kinesin-like protein Klp6 Negative GeneticPMID:18818364
hip4histone promoter control protein Hip4 Negative GeneticPMID:18818364
pcf2CAF assembly factor (CAF-1) complex subunit B, Pcf2 Negative GeneticPMID:18818364
mga2IPT/TIG ankyrin repeat containing transcription regulator of fatty acid biosynthesis (predicted) Negative GeneticPMID:18818364
atb2tubulin alpha 2 Negative GeneticPMID:18818364
rad9checkpoint clamp complex protein Rad9 Negative GeneticPMID:18818364
Phenotypic SuppressionPMID:12196391
swd1Set1C complex subunit Swd1 Negative GeneticPMID:18818364
ddb1damaged DNA binding protein Ddb1 Negative GeneticPMID:18818364
ssb1DNA replication factor A subunit Ssb1 Negative GeneticPMID:18818364
pmc3mediator complex subunit Pmc3/Med27 Positive GeneticPMID:18818364
swi6HP1 family chromodomain protein Swi6 Negative GeneticPMID:18818364
rad1checkpoint clamp complex protein Rad1 Negative GeneticPMID:18818364
Phenotypic SuppressionPMID:12196391
ash2Ash2-trithorax family protein Negative GeneticPMID:18818364
spo6Spo4-Spo6 kinase complex regulatory subunit Spo6 Negative GeneticPMID:18818364
dad2DASH complex subunit Dad2 Negative GeneticPMID:18818364
med6mediator complex subunit Med6 Negative GeneticPMID:18818364
mcl1DNA polymerase alpha accessory factor Mcl1 Negative GeneticPMID:18818364
rad17RFC related checkpoint protein Rad17 Negative GeneticPMID:18818364
Phenotypic SuppressionPMID:12196391
amo1nuclear rim protein Amo1 Negative GeneticPMID:18818364
ccr4CCR4-Not complex subunit Ccr4 (predicted) Negative GeneticPMID:18818364
rtt109RTT109 family histone lysine acetyltransferase Negative GeneticPMID:18818364
cay1cactin, spliceosome complex subunit (predicted) Negative GeneticPMID:18818364
csn1COP9/signalosome complex subunit Csn1 Negative GeneticPMID:18818364
rcf1cytochrome c oxidase assembly protein Rcf1 Positive GeneticPMID:18818364
spc34DASH complex subunit Spc34 Negative GeneticPMID:18818364
utp16U3 snoRNP-associated protein Utp16 (predicted) Negative GeneticPMID:18818364
pcf3CAF assembly factor (CAF-1) complex subunit C, Pcf3 Negative GeneticPMID:18818364
ubc6ubiquitin conjugating enzyme E2 Ubc6 (predicted) Negative GeneticPMID:18818364
fkbp39FKBP-type peptidyl-prolyl cis-trans isomerase (predicted) Negative GeneticPMID:18818364
rad51RecA family recombinase Rad51/Rhp51 Phenotypic SuppressionPMID:20065069
Positive GeneticPMID:18818364
SPBC4B4.04translation initiation factor eIF2A (predicted) Positive GeneticPMID:18818364
pbr1ubiquitin-protein ligase E3 (predicted) Negative GeneticPMID:18818364
clr3histone deacetylase (class II) Clr3 Negative GeneticPMID:18818364
mrc1mediator of replication checkpoint 1 Negative GeneticPMID:18818364
nth1DNA endonuclease III Negative GeneticPMID:18818364
lub1WD repeat protein Lub1 Negative GeneticPMID:18818364
caf1CCR4-Not complex CAF1 family ribonuclease subunit Caf1 Negative GeneticPMID:18818364
exo1exonuclease I Exo1 Synthetic Growth DefectPMID:23211746
Negative GeneticPMID:18818364
Synthetic Growth DefectPMID:23080121
pku70Ku domain protein Pku70 Synthetic RescuePMID:12861005
Phenotypic SuppressionPMID:12196391
tdp1tyrosyl-DNA phosphodiesterase Tdp1 Synthetic Growth DefectPMID:21408210
rnh201ribonuclease H2 complex subunit Rnh201 (predicted) Negative GeneticPMID:18818364
fml1ATP-dependent 3' to 5' DNA helicase, FANCM ortholog Fml1 Negative GeneticPMID:18818364
SPBC1347.08cribonuclease H2 complex subunit (predicted) Negative GeneticPMID:18818364
rec10meiotic recombination protein Rec10 Synthetic RescuePMID:16043696
zds1zds family protein phosphatase type A regulator Zds1 (predicted) Negative GeneticPMID:18818364
mal3EB1 family Mal3 Negative GeneticPMID:18818364
raf2Rik1-associated factor Raf2 Negative GeneticPMID:18818364
hta2histone H2A beta Synthetic Growth DefectPMID:15226425
rad26ATRIP, ATR checkpoint kinase regulatory subunit Rad26 Negative GeneticPMID:18818364
Synthetic Growth DefectPMID:12196391
hus1checkpoint clamp complex protein Hus1 Negative GeneticPMID:18818364
Phenotypic SuppressionPMID:12196391
pds5mitotic cohesin-associated protein Pds5 Negative GeneticPMID:18818364
gcn20AAA family ATPase Gcn20 (predicted) Negative GeneticPMID:18818364
byr2MAP kinase kinase kinase Byr2 Negative GeneticPMID:18818364
fft3SMARCAD1 family ATP-dependent DNA helicase Fft3 Negative GeneticPMID:18818364
pub3HECT-type ubiquitin-protein ligase E3 Pub3 (predicted) Positive GeneticPMID:18818364
par1protein phosphatase regulatory subunit Par1 Negative GeneticPMID:18818364
trt1telomerase reverse transcriptase 1 protein Trt1 Phenotypic SuppressionPMID:23335786
ast1asteroid homolog, XP-G family protein Synthetic Growth DefectPMID:23211746
arp6actin-like protein Arp6 Positive GeneticPMID:18818364
csn71COP9/signalosome complex subunit 7a (predicted) Negative GeneticPMID:18818364
alp14TOG ortholog Alp14 Negative GeneticPMID:18818364
elp2elongator complex subunit Elp2 (predicted) Positive GeneticPMID:18818364
rdp1RNA-directed RNA polymerase Rdp1 Negative GeneticPMID:18818364
ryh1GTPase Ryh1 Negative GeneticPMID:18818364
hta1histone H2A alpha Synthetic Growth DefectPMID:15226425
set1histone lysine methyltransferase Set1 Negative GeneticPMID:18818364
arp8actin-like protein, Ino80 complex subunit Arp8 Negative GeneticPMID:18818364
iwr1RNA polymerase II nuclear import protein Iwr1 (predicted) Positive GeneticPMID:18818364
clr4histone H3 lysine methyltransferase Clr4 Negative GeneticPMID:18818364
rec12meiotic recombination endonuclease Rec12 Negative GeneticPMID:18818364
Phenotypic EnhancementPMID:15238514
Phenotypic SuppressionPMID:15654094
ftp105Ubp5 interacting protein Ftp105 Negative GeneticPMID:18818364
rpa12DNA-directed RNA polymerase complex I subunit Rpa12 Negative GeneticPMID:18818364
SPAC644.08methionine salvage haloacid dehalogenase-like hydrolase (predicted) Negative GeneticPMID:18818364
cho1phosphatidyl-N-methylethanolamine N-methyltransferase (predicted) Negative GeneticPMID:18818364
rec6meiotic recombination protein Rec6 Phenotypic EnhancementPMID:15238514
trm13tRNA 2'-O-methyltransferase Trm13 (predicted) Negative GeneticPMID:18818364
nup60nucleoporin Nup60 Negative GeneticPMID:18818364
pdp1PWWP domain protein Pdp1 Negative GeneticPMID:18818364
ppk30Ark1/Prk1 family protein kinase Ppk30 Positive GeneticPMID:18818364
SPAC12B10.01cHECT-type ubiquitin-protein ligase E3 (predicted) Positive GeneticPMID:18818364
epe1Jmjc domain chromatin associated protein Epe1 Negative GeneticPMID:18818364
crb2DNA repair protein Rad9 homolog, Rhp9 Negative GeneticPMID:18818364
wpl1Wings apart-like homolog Wpl1 Negative GeneticPMID:18818364
rsc4RSC complex subunit Rsc4 Negative GeneticPMID:18818364
arp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:18818364
hrr1Helicase Required for RNAi-mediated heterochromatin assembly Hrr1 Negative GeneticPMID:18818364
srs2ATP-dependent DNA helicase, UvrD subfamily Negative GeneticPMID:18818364
chp1chromodomain protein Chp1 Negative GeneticPMID:18818364
eme1Holliday junction resolvase subunit Eme1 Negative GeneticPMID:18818364
gcn5SAGA complex histone acetyltransferase catalytic subunit Gcn5 Negative GeneticPMID:18818364
spf1Set1C PHD Finger protein Spf1 Negative GeneticPMID:18818364
pdx1pyruvate dehydrogenase protein x component, Pdx1 (predicted) Negative GeneticPMID:18818364
SPAC23A1.02cphosphoprotein phosphatase (predicted) Negative GeneticPMID:18818364
rad13DNA repair nuclease Rad13 Synthetic Growth DefectPMID:7885834
SPAC1952.06cspliceosomal complex subunit (predicted) Positive GeneticPMID:18818364
rad8ubiquitin-protein ligase E3 Rad8 Synthetic Growth DefectPMID:24875629
swd2Set1C complex subunit Swd2.1 Negative GeneticPMID:18818364
sub1transcription coactivator PC4 Positive GeneticPMID:18818364
ubp6ubiquitin C-terminal hydrolase Ubp6 Negative GeneticPMID:18818364
swd3WD repeat protein Swd3 Negative GeneticPMID:18818364
pku80Ku domain protein Pku80 Positive GeneticPMID:18818364
Synthetic RescuePMID:21931565
Phenotypic Enhancement
Phenotypic Suppression
Synthetic RescuePMID:23080121
mad1mitotic spindle checkpoint protein Mad1 Negative GeneticPMID:18818364
apn2AP-endonuclease Apn2 Negative GeneticPMID:18818364
tea2kinesin-like protein Tea2 Negative GeneticPMID:18818364
ask1DASH complex subunit Ask1 Negative GeneticPMID:18818364
hrq1RecQ type DNA helicase Hrq1 (predicted) Negative GeneticPMID:18818364
rad3ATR checkpoint kinase Rad3 Synthetic LethalityPMID:7885834
Phenotypic EnhancementPMID:23080121
Synthetic Growth DefectPMID:12196391
rec24meiotic recombination protein Rec24 Synthetic RescuePMID:21429938
crn1actin binding protein, coronin Crn1 Negative GeneticPMID:18818364
mug154conserved fungal protein Negative GeneticPMID:18818364
dlc2dynein light chain Dlc2 (predicted) Negative GeneticPMID:18818364
pob3FACT complex subunit Pob3 Negative GeneticPMID:18818364
cds1replication checkpoint kinase Cds1 Negative GeneticPMID:18818364
rhp14XP-A family homolog Rhp14 Negative GeneticPMID:18818364
rad2FEN-1 endonuclease Rad2 Negative GeneticPMID:18818364
Synthetic LethalityPMID:7885834
Synthetic LethalityPMID:23080121
Synthetic LethalityPMID:12944481
top1DNA topoisomerase I Positive GeneticPMID:18818364
mit1SHREC complex ATP-dependent DNA helicase subunit Mit1 Negative GeneticPMID:18818364
SPBC36B7.08cnucleosome assembly protein (predicted) Positive GeneticPMID:18818364
swi3replication fork protection complex subunit Swi3 Negative GeneticPMID:18818364
tfs1transcription elongation factor TFIIS Negative GeneticPMID:18818364
sir2Sir2 family histone deacetylase Sir2 Negative GeneticPMID:18818364
cuf2middle-meiotic transcription factor Cuf2 Positive GeneticPMID:18818364
External References
Database Identifier Description
NBRP SPAC13C5.07 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC13C5.07 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC13C5.07 BioGRID Interaction Datasets
Expression Viewer SPAC13C5.07 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC13C5.07 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC13C5.07 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC13C5.07 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC13C5.07 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC13C5.07 Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC13C5.07 Cell Cycle Data
GEO SPAC13C5.07 GEO profiles
PInt SPAC13C5.07 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC13C5.07 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC13C5.07 Fission yeast phenotypic data & analysis
SPD / RIKEN40/40H02Orfeome Localization Data
UniProtKB/SwissProtQ09683DNA repair protein rad32
ModBaseQ09683Database of comparative protein structure models
STRINGQ09683Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_592935Rad32 nuclease
RefSeq mRNANM_001018336972h- Rad32 nuclease (rad32), mRNA
ePDB4FBKThe European PDB
ePDB4FBQThe European PDB
ePDB4FBWThe European PDB
ePDB4FCXThe European PDB
European Nucleotide ArchiveCAA57765.1ENA Protein Mapping
European Nucleotide ArchiveCAA90458.1ENA Protein Mapping
UniParcUPI0000133025UniProt Archive

Literature for mre11

Search: Europe PMC or PubMed

Release Version: PomBase:25_48 - 10 Jan 2015