alp11 (SPAC13D6.05)


Gene Standard Namealp11 Characterisation Statuspublished
Systematic IDSPAC13D6.05 Feature Typeprotein coding
SynonymsSPAC4G9.01 Name Description
Producttubulin specific chaperone cofactor B Product Size234aa, 26.67 kDa
Genomic Location Chromosome I, 2253359-2254440 (1082nt); CDS:2253468-2254172 (705nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0043014alpha-tubulin bindingIPInda2PMID:109053432
GO:0005515protein bindingIPIalp21PMID:10473641887
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0000226microtubule cytoskeleton organizationICGO:0006457GO_REF:0000001110
GO:0006457protein foldingTASPMID:10905343112
GO:0007021tubulin complex assemblyISOSGD:S000006162GO_REF:000002420
GO:0072668tubulin complex biogenesisISOSGD:S000006162GO_REF:000002421
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005737cytoplasmIDAPMID:104736414198
GO:0005856cytoskeletonIEAUniProtKB-KW:KW-0206GO_REF:0000037390
GO:0005829cytosolIDAPMID:168233722317
GO:0005634nucleusIDAPMID:168233722730
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002061inviable vegetative cell populationMicroscopyalp11ΔNullPECO:0000005, PECO:0000137PMID:236978061309
Microscopyalp11ΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002481inviable branched, curved vegetative cellMicroscopyalp11ΔNullPECO:0000005, PECO:0000137PMID:236978067
FYPO:0002113inviable curved vegetative cellMicroscopyalp11ΔNullPECO:0000005, PECO:0000137PMID:2369780630
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
122533592254440

UTRs

Region Start End Reference
three_prime_UTR22541732254440PMID:21511999
five_prime_UTR22533592253467PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF01302 Pfam IPR000938 CAP Gly-rich domain 155 221 3
PF14560 Pfam IPR027933 Ubiquitin-like domain 4 86 1
SM01052 SMART IPR000938 CAP Gly-rich domain 154 221 3
SM00213 SMART IPR000626 Ubiquitin domain 4 84 16
PS50245 Prosite Profiles IPR000938 CAP Gly-rich domain 174 216 3
PS50053 Prosite Profiles IPR000626 Ubiquitin domain 4 81 18
PS00845 Prosite Patterns IPR000938 CAP Gly-rich domain 172 205 3
PTHR18916 HMMPANTHER 3 231 3
G3DSA:2.30.30.190 Gene3D IPR000938 152 231 3
G3DSA:3.10.20.90 Gene3D 4 87 26
SSF54236 SuperFamily 1 88 29
SSF74924 SuperFamily IPR000938 92 224 3

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0001447ubiquitin family proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0001447

Protein Properties

Ave. residue weight 113.98 Da
Charge -4.50
Isoelectric point 5.06
Molecular weight 26.67 kDa
Number of residues 234
Modifications

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
MOD:00696phosphorylated residuePMID:182575171192
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
8439.04during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
8341.03during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
3.7during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
0.81during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3080
conserved in fungi4564
conserved in eukaryotes4482
conserved in metazoa3419
conserved in vertebrates3394
conserved in eukaryotes only2485
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
atb2tubulin alpha 2 Dosage RescuePMID:10473641
alp1tubulin specific chaperone cofactor D, Alp1 Dosage RescuePMID:10683446
Dosage RescuePMID:10473641
alp21tubulin specific chaperone cofactor E Dosage RescuePMID:10683446
Dosage RescuePMID:10473641
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
atb2tubulin alpha 2 Affinity Capture-WesternPMID:10473641
nda2tubulin alpha 1 Co-fractionationPMID:10905343
nda3tubulin beta Nda3 Co-fractionationPMID:10905343
alp21tubulin specific chaperone cofactor E Affinity Capture-WesternPMID:10473641
External References
Database Identifier Description
NBRP SPAC13D6.05 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC13D6.05 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC13D6.05 BioGRID Interaction Datasets
Expression Viewer SPAC13D6.05 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC13D6.05 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC13D6.05 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC13D6.05 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC13D6.05 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC13D6.05 Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC13D6.05 Cell Cycle Data
GEO SPAC13D6.05 GEO profiles
PInt SPAC13D6.05 Protein-Protein Interaction Predictor (Bähler Lab)
WikiGene2542814tubulin specific chaperone cofactor B
EntrezGene2542814tubulin specific chaperone cofactor B
SPD / RIKEN08/08C09Orfeome Localization Data
UniProtKB/SwissProtQ10235Cell polarity protein alp11
ModBaseQ10235Database of comparative protein structure models
StringQ10235Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_593683tubulin specific chaperone cofactor B
RefSeq mRNANM_001019115972h- tubulin specific chaperone cofactor B (alp11), mRNA
European Nucleotide ArchiveBAA23375ENA Protein Mapping
European Nucleotide ArchiveCAB59431ENA Protein Mapping
UniParcUPI000012578FUniProt Archive

Literature for alp11

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014