tim8 (SPAC13G6.04)


Gene Standard Nametim8 Characterisation Statusbiological_role_inferred
Systematic IDSPAC13G6.04 Feature Typeprotein coding
Synonyms Name Description
ProductTIM22 inner membrane protein import complex subunit Tim8 (predicted) Product Size87aa, 9.99 kDa
Genomic Location Chromosome I, 180272-181069 (798nt); CDS:180423-180911 (489nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0046872metal ion bindingIEAUniProtKB-KW:KW-0479GO_REF:0000037747
GO:0008565protein transporter activity48
contributes_toISSUniProtKB:P57744GO_REF:0000001
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0045039protein import into mitochondrial inner membraneISSUniProtKB:P57744GO_REF:000000112
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005829cytosolIDAPMID:168233722317
GO:0016020membraneIEAUniProtKB-KW:KW-0472GO_REF:00000371439
GO:0005758mitochondrial intermembrane spaceISSUniProtKB:P57744GO_REF:000000129
GO:0042719mitochondrial intermembrane space protein transporter complexISSUniProtKB:P57744GO_REF:00000014
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopytim8ΔNullPMID:204732893755
Microscopytim8ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphologyMicroscopytim8ΔNullPECO:0000005, PECO:0000137PMID:236978063078
penetrance FYPO_EXT:0000001
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
1180272180528
2180586180721
3180890181069

UTRs

Region Start End Reference
five_prime_UTR180272180422PMID:21511999
three_prime_UTR180912181069PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF02953 Pfam IPR004217 Tim10/DDP family zinc finger 22 84 4
PTHR21535 HMMPANTHER 1 87 3
G3DSA:1.10.287.810 Gene3D IPR004217 25 83 4
SSF144122 SuperFamily IPR004217 31 84 4

View domain organization at Pfam

Protein Properties

Ave. residue weight 114.80 Da
Charge -1.00
Isoelectric point 5.71
Molecular weight 9.99 kDa
Number of residues 87
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
22458.05during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
31735.3during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
0.25during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
1.7during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
Disease Association
DescriptionQualifierReferenceCount
dystonia-deafness syndrome1
deafness3
Warning
DescriptionQualifierReferenceCount
gene structure updated PMID:18488015426
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3080
conserved in fungi4564
conserved in eukaryotes4482
conserved in metazoa3419
conserved in vertebrates3394
conserved in eukaryotes only2485
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


External References
Database Identifier Description
NBRP SPAC13G6.04 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC13G6.04 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC13G6.04 BioGRID Interaction Datasets
Expression Viewer SPAC13G6.04 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC13G6.04 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC13G6.04 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC13G6.04 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC13G6.04 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC13G6.04 Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC13G6.04 Cell Cycle Data
GEO SPAC13G6.04 GEO profiles
PInt SPAC13G6.04 Protein-Protein Interaction Predictor (Bähler Lab)
WikiGene2542819TIM22 inner membrane protein import complex subunit Tim8 (predicted)
EntrezGene2542819TIM22 inner membrane protein import complex subunit Tim8 (predicted)
SPD / RIKEN42/42A06Orfeome Localization Data
UniProtKB/SwissProtQ09783Mitochondrial import inner membrane translocase subunit tim8
ModBaseQ09783Database of comparative protein structure models
StringQ09783Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_592830TIM22 inner membrane protein import complex subunit Tim8 (predicted)
RefSeq mRNANM_001018231972h- TIM22 inner membrane protein import complex subunit Tim8 (predicted) (tim8), mRNA
European Nucleotide ArchiveAAD40476ENA Protein Mapping
European Nucleotide ArchiveCAA91097ENA Protein Mapping
UniParcUPI0001B0623BUniProt Archive

Literature for tim8

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014