rps601 (SPAC13G6.07c)


Gene Standard Namerps601 Characterisation Statuspublished
Systematic IDSPAC13G6.07c Feature Typeprotein coding
Synonymsp27, rps6-1 Name Description
Product40S ribosomal protein S6 Product Size239aa, 27.50 kDa
Genomic Location Chromosome I, 187683-186314 (1370nt); CDS:187563-186844 (720nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
structural constituent of ribosome257
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
cytoplasmic translation469
Annotation ExtensionEvidenceWith/FromReference
ribosome biogenesis338
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
cytosol2306
Annotation ExtensionEvidenceWith/FromReference
cytosolic small ribosomal subunit64
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

Term NameGenotypesCount
viable vegetative cell populationrps601Δ3837

Cell Phenotype

Term NameGenotypesCount
abolished protein phosphorylation during vegetative growth50
affecting rps601S235A,S236A (S235A, S236A)
elongated vegetative cellrps601+791
viable vegetative cell with normal cell morphologyrps601Δ3100

FYPO Multi-allele Phenotypes

Population Phenotype

Term NameGenotypes
viable vegetative cell populationrps601Δ, S235A,S236A (S235A, S236A)

Cell Phenotype

Term NameGenotypes
abolished protein phosphorylation during vegetative growth
affecting rps602rps601Δ, S235A,S236A (S235A, S236A)
Target Of
OntologyRelationshipGeneProduct
FYPO affected by mutation in fkh1 FKBP12 peptidyl-prolyl cis-trans isomerase Fkh1
FYPO affected by mutation in ksg1 serine/threonine protein kinase Ksg1
FYPO affected by mutation in leu1 3-isopropylmalate dehydrogenase Leu1
FYPO affected by mutation in psk1 serine/threonine protein kinase Psk1
FYPO affected by mutation in rhb1 Rheb GTPase Rhb1
FYPO affected by mutation in rps601 40S ribosomal protein S6
FYPO affected by mutation in sck2 serine/threonine protein kinase Sck2
FYPO affected by mutation in tor2 serine/threonine protein kinase Tor2
FYPO affected by mutation in tsc2 tuberin
GO substrate of psk1 serine/threonine protein kinase Psk1
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons187683..186314
5' UTR187683..187564PMID:21511999
3' UTR186843..186314PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF01092 Pfam IPR001377 Ribosomal protein S6e 1 126 2
PS00578 Prosite Patterns IPR018282 Ribosomal protein S6e, conserved site 52 63 2
PTHR11502 HMMPANTHER IPR001377 Ribosomal protein S6e 2 237 2
PIRSF002129 PIRSF IPR014401 Ribosomal protein S6, eukaryotic 1 239 2

View domain organization at Pfam

Protein Properties

Ave. residue weight 115.06 Da
Charge 34.00
Codon Adaptation Index 0.67
Isoelectric point 11.49
Molecular weight 27.50 kDa
Number of residues 239
Modifications

Protein Modifications

Sequence
Gene Expression

Quantitative Gene Expression

View graphical display of gene expression data for rps601 (SPAC13G6.07c)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
482619during GO:0000080PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
497991during GO:0000084PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
470213during GO:0000085PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
518690during GO:0000087PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
1159.5during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
466852during GO:0072690PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
5613.45during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
68during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
6.5during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
DescriptionQualifierReferenceCount
conserved in fungi4605
conserved in eukaryotes4515
conserved in metazoa3424
conserved in vertebrates3399
conserved in archaea238
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Load genes that interact physically with SPAC13G6.07c into the Query Builder
View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
affinity captured bycbf11CBF1/Su(H)/LAG-1 family transcription factor Cbf11 Affinity Capture-MSPMID:22540037
affinity captured bynak1PAK-related kinase Nak1 Affinity Capture-MSPMID:23462181
affinity captured bysog2leucine-rich repeat protein Lrp1 Affinity Capture-MSPMID:23462181
affinity captured bytea1cell end marker Tea1 Affinity Capture-MSPMID:21652630
Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPAC13G6.07c into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
phenotype enhanced byrps60240S ribosomal protein S6 Phenotypic EnhancementPMID:20144990
External References
Database Identifier Description
NBRP SPAC13G6.07c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC13G6.07c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC13G6.07c BioGRID Interaction Datasets
Expression Viewer SPAC13G6.07c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC13G6.07c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC13G6.07c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC13G6.07c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC13G6.07c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC13G6.07c Transcriptome Viewer (Bähler Lab)
GEO SPAC13G6.07c GEO profiles
PInt SPAC13G6.07c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC13G6.07c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC13G6.07c Fission yeast phenotypic data & analysis
Cyclebase SPAC13G6.07c.1 Cell Cycle Data
SPD / RIKEN08/08E07Orfeome Localization Data
UniProtKB/SwissProtP0575240S ribosomal protein S6-A
ModBaseP05752Database of comparative protein structure models
STRINGP05752Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_59283340S ribosomal protein S6
RefSeq mRNANM_001018234972h- 40S ribosomal protein S6 (rps601), mRNA

Literature for rps601

Search: Europe PMC or PubMed

Release Version: PomBase:30_58 - 11 Mar 2016