rad50 (SPAC1556.01c)

SynonymsSPAP4C9.01c ChromosomeI
ProductDNA repair protein Rad50 Gene Start3796023
Feature Typeprotein coding Gene End3791753
Name Description CDS Start3795856
Characterisation Statuspublished CDS End3791831

Ensembl Gene Location
SPNCRNA.234 SPNCRNA.95 emc5 > rad50 < SPNCRNA.936 sdh1 azr1 cdd1 cgr1
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
137960233795734
237956843795601
337955573792267
437922293791891
537918513791753

Protein Feature Information
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Protein Features

Ensembl protein image with mapped locations of structural domains
Feature ID Database Description Start End Score All Genes
PF04423 Pfam Rad50 zinc hook 654 704 47.7 1
52540 Superfamily 4 1256 108.5 295
PS51131 PROSITE Zinc hook, Rad50 630 726 9.132 1
TIGR00606 Tigrfam Recombination/repair protein Rad50 2 1283 264.1 1

Protein Properties

Ave. residue weight 115.98 Da
Charge -9.50
Isoelectric point 5.89
Molecular weight 149.03 kDa
Number of residues 1285
Sequence
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Fission Yeast Phenotype

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Term IDDescriptionSourceAll Genes
FYPO:0000124viableTemporary processing gif - replaced by AJAX with count of genes annotated with the term FYPO:0000124
FYPO:0000017elongated cellsTemporary processing gif - replaced by AJAX with count of genes annotated with the term FYPO:0000017

Gene Ontology Annotations

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Biological Process
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GO IDTermEvidenceWith/FromSourceAll Genes
GO:0000077DNA damage checkpointIMPTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - replaced by AJAX with count of genes annotated with the term GO:0000077
GO:0000723telomere maintenanceIMPTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - replaced by AJAX with count of genes annotated with the term GO:0000723
GO:0000723telomere maintenanceIMPTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - replaced by AJAX with count of genes annotated with the term GO:0000723
GO:0000734gene conversion at mating-type locus, DNA repair synthesisIMPTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - replaced by AJAX with count of genes annotated with the term GO:0000734
NOT GO:0006303double-strand break repair via nonhomologous end joiningIMPTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year reference
NOT GO:0006303double-strand break repair via nonhomologous end joiningIMPTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year reference
NOT GO:0006303double-strand break repair via nonhomologous end joiningIMPTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year reference
GO:0042138meiotic DNA double-strand break formationIMPTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - replaced by AJAX with count of genes annotated with the term GO:0042138

Cellular Component
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GO IDTermEvidenceWith/FromSourceAll Genes
GO:0000790nuclear chromatinIC GO:0030870GO_REF:0000001Temporary processing gif - replaced by AJAX with count of genes annotated with the term GO:0000790
GO:0030870Mre11 complexTASTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - replaced by AJAX with count of genes annotated with the term GO:0030870
IEAGO_REF:0000002

Molecular Function
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GO IDTermEvidenceWith/FromSourceAll Genes
GO:0003677DNA bindingTASTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - replaced by AJAX with count of genes annotated with the term GO:0003677
GO:0004003ATP-dependent DNA helicase activityTASTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - replaced by AJAX with count of genes annotated with the term GO:0004003
GO:0005524ATP bindingISS Interpro:IPR003439GO_REF:0000001Temporary processing gif - replaced by AJAX with count of genes annotated with the term GO:0005524
IEAGO_REF:0000002
IEAGO_REF:0000004
GO:0008270zinc ion bindingIEAGO_REF:0000002Temporary processing gif - replaced by AJAX with count of genes annotated with the term GO:0008270

Disease Association

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DescriptionSourceAll Genes
cancerTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000239

Warning

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DescriptionSourceAll Genes
gene structure updated Temporary processing gif - replaced by AJAX with the citation reference [author (year)]Temporary processing gif - replaced by AJAX with the citation reference [author (year)]Temporary processing gif - replaced by AJAX with the citation reference [author (year)]Temporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000070

Protein Family

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DescriptionSourceAll Genes
SMC familyTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000849
AAA family ATPaseTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000539

Species Distribution

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DescriptionSourceAll Genes
conserved in BacteriaTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000086
conserved in FungiTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000057
conserved in VertebratesTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000095
conserved in EukaryotesTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000058
conserved in ArchaeaTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000130
predominantly uniformly single copy (one to one)Temporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000104
conserved in MetazoaTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000094

Manually Curated Orthologs

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SpeciesGeneDescription

Interactions

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Genetic Interactions from BioGRID

Gene Feature Evidence Source
rad22DNA recombination protein Rad22 Phenotypic Enhancement
rad2FEN-1 endonuclease Rad2 Synthetic Lethality
SPCC830.03polynucleotide kinase Grc3 (predicted) Dosage Rescue
pku80Ku domain protein Pku80 Synthetic Rescue
pli1SUMO E3 ligase Pli1 Phenotypic Suppression
rec6meiotic recombination protein Rec6 Phenotypic Enhancement
dsc3conserved fungal protein Negative Genetic
sfr1Swi five-dependent recombination repair protein Sfr1 Phenotypic Enhancement
mst1KAT5 family histone acetyltransferase Mst1 Synthetic Growth Defect
rhp51RecA family recombinase Rhp51 Phenotypic Suppression
hst4Sir2 family histone deacetylase Hst4 Synthetic Growth Defect
ssb1DNA replication factor A subunit Ssb1 Synthetic Growth Defect
taz1human TRF ortholog Taz1 Phenotypic Suppression
rec12endonuclease Rec12 Phenotypic Suppression
Phenotypic Enhancement
pku70Ku domain protein Pku70 Synthetic Rescue
mek1Cds1/Rad53/Chk2 family protein kinase Mek1 Phenotypic Suppression
rhp55RecA family ATPase Rhp55 Phenotypic Enhancement
rad21mitotic cohesin complex, non-SMC subunit Rad21 (kleisin) Phenotypic Enhancement
exo1exonuclease I Exo1 Synthetic Lethality
Synthetic Growth Defect

Physical Interactions from BioGRID

Gene Feature Evidence Source
rad32Rad32 nuclease Affinity Capture-Western

External References

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Database Identifier Description
NBRP SPAC1556.01c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC1556.01c Retrieval of eukaryotic orthologs
BioGrid SPAC1556.01c BioGRID Interaction Datasets
Bähler Lab SPAC1556.01c Cell Cycle Expression Profile
Bähler Lab SPAC1556.01c Meiosis/Sporulation Expression Profies
Bähler Lab SPAC1556.01c Pheromone response/mating expression profiles
Bähler Lab SPAC1556.01c Environmental stress expression profiles
Bähler Lab SPAC1556.01c Bähler Lab Transcriptome Viewer
Cyclebase SPAC1556.01c Cell Cycle Data
Entrez Gene SPAC1556.01c Link to Entrez Gene
SPD / RIKEN39/39D10Orfeome Localization Data
UniProtKB/SwissProtQ9UTJ8DNA repair protein rad50
ArrayExpressQ9UTJ8Link to ArrayExpress
RefSeq_mRNA_predictedXM_001713038972h- DNA repair protein Rad50 (rad50), mRNA
RefSeq_peptide_predictedXP_001713090DNA repair protein Rad50
European Nucleotide ArchiveCU329670ENA EMBL mapping
European Nucleotide ArchiveCAB96041ENA Protein Mapping
UniParcUPI0001B0628BUniProt Archive

Literature for rad50

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Search: UK PMC or PubMed