naa10 (SPAC15E1.08)


Gene Standard Namenaa10 Characterisation Statusbiological role inferred
Systematic IDSPAC15E1.08 Feature Typeprotein coding
Synonymsard1 Name DescriptionN-Alpha-Acetyltransferase
ProductNatA N-acetyltransferase complex catalytic subunit Naa10 (predicted) Product Size177aa, 20.31 kDa
Genomic Location Chromosome I, 3729739-3731015 (1277nt); CDS:3729807-3730991 (1185nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
peptide alpha-N-acetyltransferase activity5
Annotation ExtensionEvidenceWith/FromReference
peptide-glutamate-N-acetyltransferase activity1
Annotation ExtensionEvidenceWith/FromReference
peptide-serine-N-acetyltransferase activity1
Annotation ExtensionEvidenceWith/FromReference
protein binding863
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
N-terminal peptidyl-glutamic acid acetylation1
Annotation ExtensionEvidenceWith/FromReference
N-terminal peptidyl-methionine acetylation10
Annotation ExtensionEvidenceWith/FromReference
N-terminal peptidyl-serine acetylation2
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
cytoplasm4211
Annotation ExtensionEvidenceWith/FromReference
cytosol2307
Annotation ExtensionEvidenceWith/FromReference
NatA complex4
Annotation ExtensionEvidenceWith/FromReference
nucleus2691
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Inviable

Single-allele Phenotypes

Population Phenotype

Term NameGenotypesCount
inviable vegetative cell populationnaa10Δ1444

Cell Phenotype

Term NameGenotypesCount
abolished peptide-serine-N-acetyltransferase activity1
affecting GO:0031415E24A (E24A)
affecting GO:0031415Y139A (Y139A)
decreased peptide-serine-N-acetyltransferase activity2
affecting GO:0031415R80A (R80A)
affecting GO:0031415E61A (E61A)
affecting GO:0031415H111A (H111A)
affecting GO:0031415H20A (H20A)
affecting GO:0031415E62A (E62A)
affecting GO:0031415H72A (H72A)
affecting GO:0031415K59A,E61A (K59A, E61A)
affecting GO:0031415K29A,Y33A (K29A, Y33A)
affecting GO:0031415K59A (K59A)
affecting GO:0031415E24Q (E24Q)
affecting GO:0031415K29A (K29A)
affecting GO:0031415K59A,E62A (K59A, E62A)
affecting GO:0031415Y26A (Y26A)
affecting GO:0031415L22A (L22A)
affecting GO:0031415R113A (R113A)
affecting GO:0031415Y33A (Y33A)
affecting GO:0031415P23A (P23A)
affecting GO:0031415E24D (E24D)
increased peptide-glutamate-N-acetyltransferase activity1
affecting GO:0031415E24A (E24A)
inviable vegetative cell, abnormal cell shape, normal cell sizenaa10Δ199
Target Of
OntologyRelationshipGeneProduct
FYPO affected by mutation in dbr1 RNA lariat debranching enzyme Dbr1
FYPO affected by mutation in naa15 NatA N-acetyltransferase complex regulatory subunit Naa15 (predicted)
FYPO affected by mutation in prp2 U2AF large subunit (U2AF-59)
FYPO affected by mutation in slu7 splicing factor Slu7
GO regulated by naa15 NatA N-acetyltransferase complex regulatory subunit Naa15 (predicted)
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons3729739..3729897, 3729984..3730178, 3730494..3730596, 3730644..3730700, 3730904..3731015
Intron3729898..3729983, 3730179..3730493, 3730597..3730643, 3730701..3730903
mRNA3729739..3731015
5' UTR3729739..3729806PMID:21511999
CDS3729807..3729897, 3729984..3730178, 3730494..3730596, 3730644..3730700, 3730904..3730991
3' UTR3730992..3731015PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00583 Pfam IPR000182 GNAT domain 49 124 12
PS51186 Prosite Profiles IPR000182 GNAT domain 1 153 17
PTHR23091:SF4 HMMPANTHER 1 165 1
PTHR23091 HMMPANTHER 1 165 6
3.40.630.30 Gene3D IPR016181 Acyl-CoA N-acyltransferase 1 151 24
SSF55729 SuperFamily IPR016181 Acyl-CoA N-acyltransferase 1 154 26

View domain organization at Pfam

Protein Properties

Ave. residue weight 114.72 Da
Charge 5.00
Isoelectric point 8.39
Molecular weight 20.31 kDa
Number of residues 177
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
14525during GO:0000080PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
16718during GO:0000084PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
14718during GO:0000085PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
15309during GO:0000087PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
15130during GO:0072690PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
13580.5during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
615.65during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
2.7during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
0.41during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3090
conserved in fungi4604
conserved in eukaryotes4514
conserved in metazoa3421
conserved in vertebrates3396
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Load gene that interact physically with SPAC15E1.08 into the Query Builder
View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
co-purifies withnaa15NatA N-acetyltransferase complex regulatory subunit Naa15 (predicted) Co-purificationPMID:23912279
affinity captured bypir2zf-C2H2 type zinc finger protein, implicated in RNAi (predicted) Affinity Capture-MSPMID:24713849
co-locates (via crystalisation or NMR) withnaa15NatA N-acetyltransferase complex regulatory subunit Naa15 (predicted) Co-crystal or NMR structurePMID:23912279
External References
Database Identifier Description
NBRP SPAC15E1.08 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC15E1.08 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC15E1.08 BioGRID Interaction Datasets
Expression Viewer SPAC15E1.08 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC15E1.08 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC15E1.08 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC15E1.08 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC15E1.08 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC15E1.08 Transcriptome Viewer (Bähler Lab)
GEO SPAC15E1.08 GEO profiles
PInt SPAC15E1.08 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC15E1.08 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC15E1.08 Fission yeast phenotypic data & analysis
Cyclebase SPAC15E1.08.1 Cell Cycle Data
SPD / RIKEN18/18G11Orfeome Localization Data
UniProtKB/SwissProtQ9UTI3N-terminal acetyltransferase A complex catalytic subunit ard1
ModBaseQ9UTI3Database of comparative protein structure models
STRINGQ9UTI3Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_594309NatA N-acetyltransferase complex catalytic subunit Naa10 (predicted)
RefSeq mRNANM_001019732972h- NatA N-acetyltransferase complex catalytic subunit Naa10 (predicted) (naa10), mRNA
European Nucleotide ArchiveCU329670ENA EMBL mapping
ePDB4KVMThe European PDB
PDB4KVMPDB
PDBsum4KVMPDBsum
ePDB4KVOThe European PDB
PDB4KVOPDB
PDBsum4KVOPDBsum
ePDB4KVXThe European PDB
PDB4KVXPDB
PDBsum4KVXPDBsum
European Nucleotide ArchiveCAB52427ENA Protein Mapping
European Nucleotide ArchiveCAB52427.1ENA Protein Mapping
UniParcUPI000006C102UniProt Archive

Literature for naa10

Search: Europe PMC or PubMed

Release Version: PomBase:29_56 - 12 Nov 2015