naa10 (SPAC15E1.08)


Gene Standard Namenaa10 Characterisation Statusbiological_role_inferred
Systematic IDSPAC15E1.08 Feature Typeprotein coding
Synonymsard1 Name DescriptionN-Alpha-Acetyltransferase
ProductNatA N-acetyltransferase complex catalytic subunit Naa10 (predicted) Product Size177aa, 20.31 kDa
Genomic Location Chromosome I, 3729739-3731015 (1277nt); CDS:3729807-3730991 (1185nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0004596peptide alpha-N-acetyltransferase activityISOSGD:S000001055GO_REF:00000245
GO:1990190peptide-glutamate-N-acetyltransferase activity1
independent of naa15IDAPMID:23912279
GO:1990189peptide-serine-N-acetyltransferase activityIDAPMID:239122791
GO:0005515protein bindingIPInaa15PMID:23912279861
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0018002N-terminal peptidyl-glutamic acid acetylationIDAPMID:239122791
GO:0017196N-terminal peptidyl-methionine acetylationICGO:0031415GO_REF:000000110
GO:0017198N-terminal peptidyl-serine acetylationIDAPMID:239122791
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0031415NatA complexIDAPMID:239122794
ISOSGD:S000001055GO_REF:0000024
GO:0005737cytoplasmISOSGD:S000001055GO_REF:00000244201
GO:0005829cytosolIDAPMID:168233722316
GO:0005634nucleusIDAPMID:168233722740
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002061inviable vegetative cell populationMicroscopynaa10ΔNullPMID:204732891315
FYPO:0002060viable vegetative cell populationMicroscopynaa10ΔNullPECO:0000005, PECO:0000137PMID:236978063760

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002666abolished peptide-serine-N-acetyltransferase activity1
affecting GO:0031415Enzyme assay dataE24A (E24A)Not specifiedPECO:0000061PMID:23912279
affecting GO:0031415Enzyme assay dataY139A (Y139A)Not specifiedPECO:0000061PMID:23912279
FYPO:0002667decreased peptide-serine-N-acetyltransferase activity2
affecting GO:0031415Enzyme assay dataR80A (R80A)Not specifiedPECO:0000061PMID:23912279
affecting GO:0031415Enzyme assay dataK29A,Y33A (K29A, Y33A)Not specifiedPECO:0000061PMID:23912279
affecting GO:0031415Enzyme assay dataR113A (R113A)Not specifiedPECO:0000061PMID:23912279
affecting GO:0031415Enzyme assay dataK59A (K59A)Not specifiedPECO:0000061PMID:23912279
affecting GO:0031415Enzyme assay dataY33A (Y33A)Not specifiedPECO:0000061PMID:23912279
affecting GO:0031415Enzyme assay dataE61A (E61A)Not specifiedPECO:0000061PMID:23912279
affecting GO:0031415Enzyme assay dataP23A (P23A)Not specifiedPECO:0000061PMID:23912279
affecting GO:0031415Enzyme assay dataK59A,E62A (K59A, E62A)Not specifiedPECO:0000061PMID:23912279
affecting GO:0031415Enzyme assay dataE24Q (E24Q)Not specifiedPECO:0000061PMID:23912279
affecting GO:0031415Enzyme assay dataL22A (L22A)Not specifiedPECO:0000061PMID:23912279
affecting GO:0031415Enzyme assay dataE24D (E24D)Not specifiedPECO:0000061PMID:23912279
affecting GO:0031415Enzyme assay dataH72A (H72A)Not specifiedPECO:0000061PMID:23912279
affecting GO:0031415Enzyme assay dataH111A (H111A)Not specifiedPECO:0000061PMID:23912279
affecting GO:0031415Enzyme assay dataE62A (E62A)Not specifiedPECO:0000061PMID:23912279
affecting GO:0031415Enzyme assay dataK59A,E61A (K59A, E61A)Not specifiedPECO:0000061PMID:23912279
affecting GO:0031415Enzyme assay dataH20A (H20A)Not specifiedPECO:0000061PMID:23912279
affecting GO:0031415Enzyme assay dataK29A (K29A)Not specifiedPECO:0000061PMID:23912279
affecting GO:0031415Enzyme assay dataY26A (Y26A)Not specifiedPECO:0000061PMID:23912279
FYPO:0002670increased peptide-glutamate-N-acetyltransferase activity1
affecting GO:0031415Enzyme assay dataE24A (E24A)Not specifiedPECO:0000061PMID:23912279
FYPO:0001511inviable vegetative cell, abnormal cell shape, normal cell size199
expressivity FYPO_EXT:0000003
penetrance FYPO_EXT:0000001
Microscopynaa10ΔNullPECO:0000137, PECO:0000005PMID:23697806
Target Of
OntologyRelationshipGeneProductReference
FYPO affected by mutation in dbr1 RNA lariat debranching enzyme Dbr1 PMID:23754748
FYPO affected by mutation in naa15 NatA N-acetyltransferase complex regulatory subunit Naa15 (predicted) PMID:23912279
FYPO affected by mutation in prp2 U2AF large subunit (U2AF-59) PMID:23754748
FYPO affected by mutation in slu7 splicing factor Slu7 PMID:23754748
GO regulated by naa15 NatA N-acetyltransferase complex regulatory subunit Naa15 (predicted) PMID:23912279
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
137297393729897
237299843730178
337304943730596
437306443730700
537309043731015

UTRs

Region Coordinates Reference
five_prime_UTR3729739..3729806PMID:21511999
three_prime_UTR3730992..3731015PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00583 Pfam IPR000182 GNAT domain 49 124 14
PS51186 Prosite Profiles IPR000182 GNAT domain 1 153 17
PTHR23091 HMMPANTHER 1 172 6
PTHR23091:SF4 HMMPANTHER 1 172 1
3.40.630.30 Gene3D IPR016181 Acyl-CoA N-acyltransferase 1 151 24
SSF55729 SuperFamily IPR016181 Acyl-CoA N-acyltransferase 1 154 26

View domain organization at Pfam

Protein Properties

Ave. residue weight 114.72 Da
Charge 5.00
Isoelectric point 8.39
Molecular weight 20.31 kDa
Number of residues 177
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
14718during GO:0000085PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
15309during GO:0000087PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
615.65during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633
16718during GO:0000084PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
14525during GO:0000080PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
13580.5during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
15130during GO:0072690PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
0.41during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633
2.7during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3080
conserved in fungi4569
conserved in eukaryotes4482
conserved in metazoa3419
conserved in vertebrates3393
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
naa15NatA N-acetyltransferase complex regulatory subunit Naa15 (predicted) Co-crystal or NMR structurePMID:23912279
Co-purification
External References
Database Identifier Description
NBRP SPAC15E1.08 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC15E1.08 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC15E1.08 BioGRID Interaction Datasets
Expression Viewer SPAC15E1.08 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC15E1.08 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC15E1.08 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC15E1.08 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC15E1.08 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC15E1.08 Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC15E1.08 Cell Cycle Data
GEO SPAC15E1.08 GEO profiles
PInt SPAC15E1.08 Protein-Protein Interaction Predictor (Bähler Lab)
WikiGene2542765NatA N-acetyltransferase complex subunit Ard1 (predicted)
EntrezGene2542765NatA N-acetyltransferase complex subunit Ard1 (predicted)
SPD / RIKEN18/18G11Orfeome Localization Data
UniProtKB/SwissProtQ9UTI3N-terminal acetyltransferase A complex catalytic subunit ard1
ModBaseQ9UTI3Database of comparative protein structure models
STRINGQ9UTI3Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_594309NatA N-acetyltransferase complex subunit Ard1 (predicted)
RefSeq mRNANM_001019732972h- NatA N-acetyltransferase complex subunit Ard1 (predicted) (SPAC15E1.08), mRNA
ePDB4KVMThe European PDB
PDB4KVMPDB
PDBsum4KVMPDBsum
ePDB4KVOThe European PDB
PDB4KVOPDB
PDBsum4KVOPDBsum
ePDB4KVXThe European PDB
PDB4KVXPDB
PDBsum4KVXPDBsum
European Nucleotide ArchiveCAB52427ENA Protein Mapping
European Nucleotide ArchiveCAB52427.1ENA Protein Mapping
UniParcUPI000006C102UniProt Archive

Literature for naa10

Search: Europe PMC or PubMed

Release Version: PomBase:22_44 - 08 Jul 2014