naa10 (SPAC15E1.08)


Gene Standard Namenaa10 Characterisation Statusbiological_role_inferred
Systematic IDSPAC15E1.08 Feature Typeprotein coding
Synonymsard1 Name DescriptionN-Alpha-Acetyltransferase
ProductNatA N-acetyltransferase complex catalytic subunit Naa10 (predicted) Product Size177aa, 20.31 kDa
Genomic Location Chromosome I, 3729739-3731015 (1277nt); CDS:3729807-3730991 (1185nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
peptide alpha-N-acetyltransferase activity5
Annotation ExtensionEvidenceWith/FromReference
peptide-glutamate-N-acetyltransferase activity1
Annotation ExtensionEvidenceWith/FromReference
peptide-serine-N-acetyltransferase activity1
Annotation ExtensionEvidenceWith/FromReference
protein binding831
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
N-terminal peptidyl-glutamic acid acetylation1
Annotation ExtensionEvidenceWith/FromReference
N-terminal peptidyl-methionine acetylation10
Annotation ExtensionEvidenceWith/FromReference
N-terminal peptidyl-serine acetylation2
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
cytoplasm4205
Annotation ExtensionEvidenceWith/FromReference
cytosol2315
Annotation ExtensionEvidenceWith/FromReference
NatA complex4
Annotation ExtensionEvidenceWith/FromReference
nucleus2740
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Inviable

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002061inviable vegetative cell populationMicroscopynaa10ΔNullPECO:0000005, PECO:0000137PMID:236978061338
Microscopynaa10ΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002666abolished peptide-serine-N-acetyltransferase activity1
affecting GO:0031415Enzyme assay dataY139A (Y139A)Not specifiedPECO:0000061PMID:23912279
affecting GO:0031415Enzyme assay dataE24A (E24A)Not specifiedPECO:0000061PMID:23912279
FYPO:0002667decreased peptide-serine-N-acetyltransferase activity2
affecting GO:0031415Enzyme assay dataE61A (E61A)Not specifiedPECO:0000061PMID:23912279
affecting GO:0031415Enzyme assay dataP23A (P23A)Not specifiedPECO:0000061PMID:23912279
affecting GO:0031415Enzyme assay dataR80A (R80A)Not specifiedPECO:0000061PMID:23912279
affecting GO:0031415Enzyme assay dataK29A (K29A)Not specifiedPECO:0000061PMID:23912279
affecting GO:0031415Enzyme assay dataH72A (H72A)Not specifiedPECO:0000061PMID:23912279
affecting GO:0031415Enzyme assay dataH111A (H111A)Not specifiedPECO:0000061PMID:23912279
affecting GO:0031415Enzyme assay dataY33A (Y33A)Not specifiedPECO:0000061PMID:23912279
affecting GO:0031415Enzyme assay dataH20A (H20A)Not specifiedPECO:0000061PMID:23912279
affecting GO:0031415Enzyme assay dataL22A (L22A)Not specifiedPECO:0000061PMID:23912279
affecting GO:0031415Enzyme assay dataE24Q (E24Q)Not specifiedPECO:0000061PMID:23912279
affecting GO:0031415Enzyme assay dataK59A (K59A)Not specifiedPECO:0000061PMID:23912279
affecting GO:0031415Enzyme assay dataR113A (R113A)Not specifiedPECO:0000061PMID:23912279
affecting GO:0031415Enzyme assay dataE24D (E24D)Not specifiedPECO:0000061PMID:23912279
affecting GO:0031415Enzyme assay dataK29A,Y33A (K29A, Y33A)Not specifiedPECO:0000061PMID:23912279
affecting GO:0031415Enzyme assay dataK59A,E62A (K59A, E62A)Not specifiedPECO:0000061PMID:23912279
affecting GO:0031415Enzyme assay dataY26A (Y26A)Not specifiedPECO:0000061PMID:23912279
affecting GO:0031415Enzyme assay dataE62A (E62A)Not specifiedPECO:0000061PMID:23912279
affecting GO:0031415Enzyme assay dataK59A,E61A (K59A, E61A)Not specifiedPECO:0000061PMID:23912279
FYPO:0002670increased peptide-glutamate-N-acetyltransferase activity1
affecting GO:0031415Enzyme assay dataE24A (E24A)Not specifiedPECO:0000061PMID:23912279
FYPO:0001511inviable vegetative cell, abnormal cell shape, normal cell size199
expressivity FYPO_EXT:0000003
penetrance FYPO_EXT:0000001
Microscopynaa10ΔNullPECO:0000137, PECO:0000005PMID:23697806
Target Of
OntologyRelationshipGeneProductReference
FYPO affected by mutation in dbr1 RNA lariat debranching enzyme Dbr1 PMID:23754748
FYPO affected by mutation in naa15 NatA N-acetyltransferase complex regulatory subunit Naa15 (predicted) PMID:23912279
FYPO affected by mutation in prp2 U2AF large subunit (U2AF-59) PMID:23754748
FYPO affected by mutation in slu7 splicing factor Slu7 PMID:23754748
GO regulated by naa15 NatA N-acetyltransferase complex regulatory subunit Naa15 (predicted) PMID:23912279
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
137297393729897
237299843730178
337304943730596
437306443730700
537309043731015

UTRs

Region Coordinates Reference
five_prime_UTR3729739..3729806PMID:21511999
three_prime_UTR3730992..3731015PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00583 Pfam IPR000182 GNAT domain 49 124 13
PS51186 Prosite Profiles IPR000182 GNAT domain 1 153 17
PTHR23091 HMMPANTHER 1 153 5
PTHR23091:SF4 HMMPANTHER 1 153 1
3.40.630.30 Gene3D IPR016181 Acyl-CoA N-acyltransferase 1 151 24
SSF55729 SuperFamily IPR016181 Acyl-CoA N-acyltransferase 1 154 26

View domain organization at Pfam

Protein Properties

Ave. residue weight 114.72 Da
Charge 5.00
Isoelectric point 8.39
Molecular weight 20.31 kDa
Number of residues 177
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
14525during GO:0000080PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
16718during GO:0000084PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
14718during GO:0000085PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
15309during GO:0000087PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
13580.5during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
15130during GO:0072690PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
615.65during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
2.7during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
0.41during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4600
conserved in eukaryotes4514
conserved in metazoa3425
conserved in vertebrates3400
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
pir2zf-C2H2 type zinc finger protein, implicated in RNAi (predicted) Affinity Capture-MSPMID:24713849
naa15NatA N-acetyltransferase complex regulatory subunit Naa15 (predicted) Co-purificationPMID:23912279
Co-crystal or NMR structure
External References
Database Identifier Description
NBRP SPAC15E1.08 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC15E1.08 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC15E1.08 BioGRID Interaction Datasets
Expression Viewer SPAC15E1.08 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC15E1.08 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC15E1.08 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC15E1.08 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC15E1.08 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC15E1.08 Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC15E1.08 Cell Cycle Data
GEO SPAC15E1.08 GEO profiles
PInt SPAC15E1.08 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC15E1.08 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC15E1.08 Fission yeast phenotypic data & analysis
SPD / RIKEN18/18G11Orfeome Localization Data
UniProtKB/SwissProtQ9UTI3N-terminal acetyltransferase A complex catalytic subunit ard1
ModBaseQ9UTI3Database of comparative protein structure models
STRINGQ9UTI3Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_594309NatA N-acetyltransferase complex catalytic subunit Naa10 (predicted)
RefSeq mRNANM_001019732972h- NatA N-acetyltransferase complex catalytic subunit Naa10 (predicted) (naa10), mRNA
ePDB4KVMThe European PDB
PDB4KVMPDB
PDBsum4KVMPDBsum
ePDB4KVOThe European PDB
PDB4KVOPDB
PDBsum4KVOPDBsum
ePDB4KVXThe European PDB
PDB4KVXPDB
PDBsum4KVXPDBsum
European Nucleotide ArchiveCAB52427.1ENA Protein Mapping
UniParcUPI000006C102UniProt Archive

Literature for naa10

Search: Europe PMC or PubMed

Release Version: PomBase:23_47 - 27 Oct 2014