sfp1 (SPAC16.05c)


Gene Standard Namesfp1 Characterisation Statusbiological role inferred
Systematic IDSPAC16.05c Feature Typeprotein coding
Synonyms Name Description
Producttranscription factor Sfp1 (predicted) Product Size442aa, 48.23 kDa
Genomic Location Chromosome I, 4434012-4431869 (2144nt); CDS:4433632-4432304 (1329nt)

Ensembl Gene Location
GO Molecular Function
GO Biological Process
GO Cellular Component
Term NameCount
cytoplasm4209
Annotation ExtensionEvidenceWith/FromReference
cytosol2306
Annotation ExtensionEvidenceWith/FromReference
nucleus2690
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

Term NameGenotypesCount
decreased cell population growth on glucose carbon sourcesfp1+ (wild type)293
viable vegetative cell populationsfp1Δ3831

Cell Phenotype

Term NameGenotypesCount
abnormal septationsfp1+ (wild type)282
viable elongated vegetative cellsfp1+ (wild type)313
viable vegetative cell with normal cell morphologysfp1Δ3099
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons4434012..4431869
5' UTR4434012..4433633SPC00022
3' UTR4432303..4431869SPC06207
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
SM00355 SMART IPR015880 Zinc finger, C2H2-like 84 105 19
SM00355 SMART IPR015880 Zinc finger, C2H2-like 399 422 19
SM00355 SMART IPR015880 Zinc finger, C2H2-like 350 375 19
PS00028 Prosite Patterns IPR007087 Zinc finger, C2H2 352 375 28
PS00028 Prosite Patterns IPR007087 Zinc finger, C2H2 401 422 28
PS50157 Prosite Profiles IPR007087 Zinc finger, C2H2 399 422 20
PS50157 Prosite Profiles IPR007087 Zinc finger, C2H2 350 375 20
PTHR23057 HMMPANTHER 4 439 1
3.30.160.60 Gene3D IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain 396 421 15
3.30.160.60 Gene3D IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain 347 372 15
SSF57667 SuperFamily 348 418 26

View domain organization at Pfam

Term IDTerm NameReferenceCount
PBO:0000137zinc finger proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000137
PBO:0000153zf-C2H2 typeTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000153

Protein Properties

Ave. residue weight 109.11 Da
Charge -1.50
Codon Adaptation Index 0.52
Isoelectric point 6.37
Molecular weight 48.23 kDa
Number of residues 442
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serine 1675
present during mitotic M phaseS377
Annotation ExtensionEvidenceResidueReference
present during mitotic M phase experimental evidence S377 PMID:21712547
O-phospho-L-threonine 700
present during mitotic M phaseT380
Annotation ExtensionEvidenceResidueReference
present during mitotic M phase experimental evidence T380 PMID:21712547
Sequence
Gene Expression

Quantitative Gene Expression

View graphical display of gene expression data for sfp1 (SPAC16.05c)

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
7.9during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
7.2during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
Disease Association
DescriptionQualifierReferenceCount
cancercancer_census148
Taxonomic Conservation
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3090
conserved in fungi4604
conserved in eukaryotes4514
conserved in metazoa3422
conserved in vertebrates3397
conserved in eukaryotes only2504
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Load gene that interact genetically with SPAC16.05c into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
positive genetic interaction withphp5CCAAT-binding factor complex subunit Php5 Positive GeneticPMID:22681890
positive genetic interaction withhip4histone promoter control protein Hip4 Positive GeneticPMID:22681890
positive genetic interaction withiwr1RNA polymerase II nuclear import protein Iwr1 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withxap5xap-5-like protein Positive GeneticPMID:24957674
External References
Database Identifier Description
NBRP SPAC16.05c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC16.05c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC16.05c BioGRID Interaction Datasets
Expression Viewer SPAC16.05c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC16.05c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC16.05c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC16.05c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC16.05c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC16.05c Transcriptome Viewer (Bähler Lab)
GEO SPAC16.05c GEO profiles
PInt SPAC16.05c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC16.05c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC16.05c Fission yeast phenotypic data & analysis
Cyclebase SPAC16.05c.1 Cell Cycle Data
SPD / RIKEN20/20E11Orfeome Localization Data
UniProtKB/SwissProtQ9UTH8Zinc finger protein sfp1
ModBaseQ9UTH8Database of comparative protein structure models
STRINGQ9UTH8Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_594573transcription factor Sfp1 (predicted)
RefSeq mRNANM_001020002972h- transcription factor Sfp1 (predicted) (sfp1), mRNA
European Nucleotide ArchiveCU329670ENA EMBL mapping
European Nucleotide ArchiveCAB57403ENA Protein Mapping
UniParcUPI000006C5B2UniProt Archive

Literature for sfp1

Search: Europe PMC or PubMed

Release Version: PomBase:30_57 - 27 Jan 2016