nse2 (SPAC16A10.06c)

Synonymspli2 ChromosomeI
ProductSmc5-6 complex non-SMC subunit 2 Gene Start3090898
Feature Typeprotein coding Gene End3089494
Name Description CDS Start3090697
Characterisation Statuspublished CDS End3089583

Ensembl Gene Location
SPAC16A10.03c sub1 ter1 SPNCRNA.884 SPATRNALYS.05 SPNCRNA.215 rho4 dad1 > nse2 < taz1 SPNCRNA.885 mug74 med13
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
130908983090533
230902853090163
330900473089494

Protein Feature Information
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Protein Features

Ensembl protein image with mapped locations of structural domains
Feature ID Database Description Start End Score All Genes
PF11789 Pfam 166 220 68.9 1
57850 Superfamily 177 234 24.5 55


Protein Modifications

Term IDDescriptionSourceAll Genes
MOD:01149sumoylated lysineTemporary processing gif - replaced by AJAX with count of genes annotated with the term MOD:01149

Protein Properties

Ave. residue weight 114.71 Da
Charge -14.00
Isoelectric point 4.43
Molecular weight 28.68 kDa
Number of residues 250
Sequence
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Fission Yeast Phenotype

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Term IDDescriptionSourceAll Genes
FYPO:0000049inviable
Temporary processing gif - replaced by AJAX with count of genes annotated with the term FYPO:0000049

Gene Ontology Annotations

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Biological Process
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GO IDTermEvidenceWith/FromSourceAll Genes
GO:0000724double-strand break repair via homologous recombinationIGI rhp51Temporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - replaced by AJAX with count of genes annotated with the term GO:0000724
GO:0016925protein sumoylationIDATemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - replaced by AJAX with count of genes annotated with the term GO:0016925
GO:0048478replication fork protectionIGI brc1Temporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - replaced by AJAX with count of genes annotated with the term GO:0048478

Cellular Component
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GO IDTermEvidenceWith/FromSourceAll Genes
GO:0005634nucleusIDATemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - replaced by AJAX with count of genes annotated with the term GO:0005634
IDATemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year reference
GO:0005829cytosolIDATemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - replaced by AJAX with count of genes annotated with the term GO:0005829
GO:0030915Smc5-Smc6 complexIDATemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - replaced by AJAX with count of genes annotated with the term GO:0030915

Molecular Function
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GO IDTermEvidenceWith/FromSourceAll Genes
GO:0005515protein bindingIPI smc5Temporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - replaced by AJAX with count of genes annotated with the term GO:0005515
GO:0019789SUMO ligase activityIDATemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - replaced by AJAX with count of genes annotated with the term GO:0019789

Warning

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DescriptionSourceAll Genes
gene structure updated Temporary processing gif - replaced by AJAX with the citation reference [author (year)]Temporary processing gif - replaced by AJAX with the citation reference [author (year)]Temporary processing gif - replaced by AJAX with the citation reference [author (year)] Temporary processing gif - replaced by AJAX with the citation reference [author (year)]Temporary processing gif - replaced by AJAX with the citation reference [author (year)]Temporary processing gif - replaced by AJAX with the citation reference [author (year)]Temporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000070

Protein Family

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DescriptionSourceAll Genes
zf-MIZTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000656
zinc finger proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000137

Species Distribution

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DescriptionSourceAll Genes
conserved in FungiTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000057
conserved in VertebratesTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000095
conserved in EukaryotesTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000058
conserved in Eukaryotes onlyTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000096
predominantly uniformly single copy (one to one)Temporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000104
conserved in MetazoaTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000094

Manually Curated Orthologs

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SpeciesGeneDescription

Interactions

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Genetic Interactions from BioGRID

Gene Feature Evidence Source
top2DNA topoisomerase II Synthetic Lethality
pli1SUMO E3 ligase Pli1 Synthetic Growth Defect
rhp51RecA family recombinase Rhp51 Synthetic Rescue
nse6Smc5-6 complex non-SMC subunit Nse6 Synthetic Lethality
brc1BRCT domain protein Brc1 Synthetic Lethality

Physical Interactions from BioGRID

Gene Feature Evidence Source
rqh1RecQ type DNA helicase Rqh1 Biochemical Activity
nse4Smc5-6 complex non-SMC subunit Nse4 Affinity Capture-MS
smc5Smc5-6 complex SMC subunit Smc5 Reconstituted Complex
Affinity Capture-MS
Affinity Capture-MS
Reconstituted Complex
nse6Smc5-6 complex non-SMC subunit Nse6 Affinity Capture-Western
Affinity Capture-MS
nse5Smc5-6 complex non-SMC subunit Nse5 Affinity Capture-MS
smc6Smc5-6 complex SMC subunit Smc6 Biochemical Activity
Affinity Capture-MS
Biochemical Activity
nse3Smc5-6 complex non-SMC subunit Nse3 Affinity Capture-Western
Biochemical Activity

External References

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Database Identifier Description
NBRP SPAC16A10.06c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC16A10.06c Retrieval of eukaryotic orthologs
BioGrid SPAC16A10.06c BioGRID Interaction Datasets
Bähler Lab SPAC16A10.06c Cell Cycle Expression Profile
Bähler Lab SPAC16A10.06c Meiosis/Sporulation Expression Profies
Bähler Lab SPAC16A10.06c Pheromone response/mating expression profiles
Bähler Lab SPAC16A10.06c Environmental stress expression profiles
Bähler Lab SPAC16A10.06c Bähler Lab Transcriptome Viewer
Cyclebase SPAC16A10.06c Cell Cycle Data
Entrez Gene SPAC16A10.06c Link to Entrez Gene
SPD / RIKEN43/43G10Orfeome Localization Data
UniProtKB/SwissProtQ4PIR3E3 SUMO-protein ligase nse2
ArrayExpressQ4PIR3Link to ArrayExpress
RefSeq_mRNA_predictedXM_001713025972h- Smc5-6 complex non-SMC subunit 2 (nse2), mRNA
RefSeq_peptide_predictedXP_001713077Smc5-6 complex non-SMC subunit 2
European Nucleotide ArchiveCU329670ENA EMBL mapping
European Nucleotide ArchiveCAJ01913ENA Protein Mapping
UniParcUPI000228F378UniProt Archive

Literature for nse2

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Search: UK PMC or PubMed