hrp1 (SPAC1783.05)

Gene Standard Namehrp1 ChromosomeI
Systematic IDSPAC1783.05 Gene Start2194820
Synonymschd1 Gene End2199471
ProductATP-dependent DNA helicase Hrp1 Gene Length4652
Feature Typeprotein coding CDS Start2195017
Name DescriptionHelicase-Related protein from S. Pombe CDS End2199138
Characterisation Statuspublished CDS Length4122

Ensembl Gene Location
  1. SPAC1783.01
  2. vps66
  3. fta2
  4. hst4
  5. hrp1
  6. SPNCRNA.803
  7. atg12
  8. SPNCRNA.804
  9. pap1
  10. rpl1502
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0000143transcription regulation phenotypeChromatin immunoprecipitation experimenthrp1delta (deletion)deletionPMID:20622008
FYPO:0002060viable vegetative cell populationMicroscopyhrp1delta (deletion)deletionPMID:20473289
GO Molecular Function

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Term IDTerm NameEvidenceWith/FromReference
GO:0003677DNA bindingIEAUniProtKB:KW-0238GO_REF:0000037
GO:0004003ATP-dependent DNA helicase activityISMIPR002464GO_REF:0000001
GO:0005515protein bindingIPInap1PMID:17510629
GO:0005524ATP bindingIEAUniProtKB:KW-0067GO_REF:0000037
GO:0008094DNA-dependent ATPase activityIDAPMID:10756203
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0000122negative regulation of transcription from RNA polymerase II promoterIMPPMID:20622008
GO:0006338chromatin remodelingIMPPMID:10756203
GO:0006369termination of RNA polymerase II transcriptionIMPPMID:12504018
GO:0007076mitotic chromosome condensationIMPPMID:10756203
GO:0030466chromatin silencing at silent mating-type cassetteIMPPMID:15908586
GO:0030702chromatin silencing at centromereIMPPMID:15908586
GO:0035067negative regulation of histone acetylationIMPPMID:15908586
GO:0045944positive regulation of transcription from RNA polymerase II promoterIMPPMID:20622008
GO:0048096chromatin-mediated maintenance of transcriptionTASPMID:9520266
GO:0060303regulation of nucleosome densityIMPPMID:17510629
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0000779condensed chromosome, centromeric regionIDAPMID:15908586
GO:0000790nuclear chromatinICGO:0004003GO_REF:0000001
GO:0005634nucleusIDAPMID:10756203
GO:0016592mediator complexIPIPMID:20622008
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
121948202199471

References

Region Start End Reference
three_prime_UTR21991392199471PMID:21511999
five_prime_UTR21948202195016PMID:21511999
three_prime_UTR21991392199471PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF00176 IPR000330 Pfam SNF2-related 393 677 20
PF00385 IPR023780 Pfam Chromo domain/shadow 208 264 7
PF00385 IPR023780 Pfam Chromo domain/shadow 305 356 7
PF00271 IPR001650 Pfam Helicase, C-terminal 739 818 69
SM00487 IPR014001 SMART Helicase, superfamily 1/2, ATP-binding domain 386 580 69
SM00490 IPR001650 SMART Helicase, C-terminal 734 818 67
SM00298 IPR000953 SMART Chromo domain/shadow 206 269 9
SM00298 IPR000953 SMART Chromo domain/shadow 302 358 9
PS50013 IPR000953 Prosite Profiles Chromo domain/shadow 304 365 7
PS50013 IPR000953 Prosite Profiles Chromo domain/shadow 203 276 7
PS51194 IPR001650 Prosite Profiles Helicase, C-terminal 708 869 69
PS51192 IPR014001 Prosite Profiles Helicase, superfamily 1/2, ATP-binding domain 402 573 69
G3DSA:3.40.50.300 Gene3D 701 846 279
G3DSA:3.40.50.300 Gene3D 387 570 279
G3DSA:2.40.50.40 Gene3D 198 268 7
G3DSA:2.40.50.40 Gene3D 301 359 7
SSF54160 IPR016197 SuperFamily 282 356 9
SSF54160 IPR016197 SuperFamily 203 269 9
SSF52540 SuperFamily 610 891 294
SSF52540 SuperFamily 336 608 294
Coil ncoils Rabaptin coiled-coil domain 951 986 974
Coil ncoils Rabaptin coiled-coil domain 1314 1347 974
PTHR10799 hmmpanther 23 1235 21
PTHR10799:SF70 hmmpanther 23 1235 2

View domain organization at Pfam

Protein Modifications (PSI-MOD)

Term IDTerm NameEvidenceResidueReference
MOD:00696phosphorylated residuePMID:18257517

Manually Curated Family or Sub-families

Term IDTerm NameReferenceAll Genes
PBO:0000174DEAD/DEAH box helicaseTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000174
PBO:0000175helicase C-terminal domainTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000175
PBO:0001050chromodomain proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0001050

Protein Properties

Ave. residue weight 115.48 Da
Charge -18.00
Isoelectric point 5.59
Molecular weight 158.55 kDa
Number of residues 1373
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencePECO:0000014,
PECO:0000005		population_wide2183.98PMID:23101633
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide378.2PMID:23101633
RNA levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide1.2PMID:23101633
experimental evidencePECO:0000014,
PECO:0000005		population_wide5.4PMID:23101633
Misc
DescriptionQualifierReference
targets correlated with Clr3 and Sir2 targets PMID:17510629
overlapping genome wide occupancy in coding regions Nap1/Hrp1/Hrp3 PMID:17510629
overlapping genome wide occupancy in promoters Nap1/Hrp1/Hrp3 PMID:17510629
Species Distribution
DescriptionQualifierReference
conserved in fungi
conserved in eukaryotes
conserved in metazoa
conserved in vertebrates
conserved in eukaryotes only
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
clp1Cdc14-related protein phosphatase Clp1/Flp1 Negative GeneticPMID:22681890
ptc2protein phosphatase 2C Ptc2 Negative GeneticPMID:18818364
csn1COP9/signalosome complex subunit Csn1 Negative GeneticPMID:18818364
alp14TOG ortholog Alp14 Negative GeneticPMID:18818364
clr4histone H3 lysine methyltransferase Clr4 Positive GeneticPMID:22681890
mug33conserved fungal protein Positive GeneticPMID:22681890
med13mediator complex subunit Srb9 Negative GeneticPMID:18818364
ash2Ash2-trithorax family protein Negative GeneticPMID:18818364
omh6alpha-1,2-mannosyltransferase Omh6 (predicted) Negative GeneticPMID:22681890
hip1hira protein, histone chaperone Hip1 Negative GeneticPMID:18818364
mcl1DNA polymerase alpha accessory factor Mcl1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
mga2IPT/TIG ankyrin repeat containing transcription regulator of fatty acid biosynthesis (predicted) Negative GeneticPMID:18818364
mug154conserved fungal protein Negative GeneticPMID:18818364
ago1argonaute Negative GeneticPMID:18818364
apq12nuclear membrane organization protein Apq12 (predicted) Negative GeneticPMID:22681890
fep1iron-sensing transcription factor Fep1 Positive GeneticPMID:22681890
vps901guanyl-nucleotide exchange factor Vps901 (predicted) Negative GeneticPMID:22681890
ask1DASH complex subunit Ask1 Negative GeneticPMID:18818364
SPCC16C4.20cHMG box protein (predicted) Negative GeneticPMID:22681890
bdf1Swr1 complex bromodomain subunit Brf1 Negative GeneticPMID:18818364
dep1Sds3-like family protein Dep1 Negative GeneticPMID:22681890
dad2DASH complex subunit Dad2 Negative GeneticPMID:18818364
mgr2mitochondrial membrane protein Mgr2 (predicted) Negative GeneticPMID:22681890
spf1Set1C PHD Finger protein Spf1 Negative GeneticPMID:18818364
set11ribosomal protein lysine methyltransferase Set11 Negative GeneticPMID:18818364
ngg1SAGA complex subunit Ngg1 Positive GeneticPMID:18818364
SPBC29A3.09cAAA family ATPase Gcn20 (predicted) Negative GeneticPMID:18818364
mis6inner centromere protein, CENP-I ortholog Mis6 Synthetic Growth DefectPMID:15908586
get3GET complex ATPase subunit Get3 (predicted) Positive GeneticPMID:22681890
sdh4TIM22 inner membrane protein import complex anchor subunit Tim18 Negative GeneticPMID:18818364
ppr2mitochondrial PPR repeat protein Ppr2 Negative GeneticPMID:22681890
SPCC1840.09NAD dependent epimerase/dehydratase family protein Negative GeneticPMID:22681890
srb10cyclin-dependent protein Srb mediator subunit kinase Srb10 Negative GeneticPMID:22681890
mug30ubiquitin-protein ligase E3 (predicted) Positive GeneticPMID:22681890
ubp3ubiquitin C-terminal hydrolase Ubp3 Positive GeneticPMID:18818364
SPCC757.12alpha-amylase homolog (predicted) Negative GeneticPMID:18818364
SPAC9E9.09caldehyde dehydrogenase (predicted) Negative GeneticPMID:22681890
rpl170260S ribosomal protein L17 (predicted) Negative GeneticPMID:22681890
vph2endoplasmic reticulum membrane protein involved in assembly of the V-ATPase (predicted) Positive GeneticPMID:18818364
vps71Swr1 complex subunit Vps71 Negative GeneticPMID:18818364
hrp3ATP-dependent DNA helicase Hrp3 Phenotypic EnhancementPMID:23032292
Synthetic LethalityPMID:23103765
Phenotypic Enhancement
Synthetic LethalityPMID:15908586
med15mediator complex subunit Med15 Synthetic LethalityPMID:20622008
rpl160160S ribosomal protein L13/L16 (predicted) Negative GeneticPMID:18818364
elp2elongator complex subunit Elp2 (predicted) Negative GeneticPMID:18818364
nop52nucleolar protein Nop52 family (predicted) Negative GeneticPMID:22681890
tma23ribosome biogenesis protein Tma23 (predicted) Negative GeneticPMID:18818364
fkbp39FKBP-type peptidyl-prolyl cis-trans isomerase (predicted) Negative GeneticPMID:18818364
ser2phosphoserine phosphatase Ser2 (predicted) Negative GeneticPMID:18818364
cph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
cmk1calcium/calmodulin-dependent protein kinase Cmk1 Negative GeneticPMID:22681890
SPAC1093.03inositol polyphosphate phosphatase (predicted) Positive GeneticPMID:18818364
amo1nuclear rim protein Amo1 Negative GeneticPMID:18818364
set2histone lysine methyltransferase Set2 Positive GeneticPMID:22681890
ccr4CCR4-Not complex subunit Ccr4 (predicted) Positive GeneticPMID:18818364
scs7sphingosine hydroxylase Scs7 Positive GeneticPMID:18818364
SPCC584.15carrestin/PY protein 2 Positive GeneticPMID:22681890
raf1Rik1-associated factor Raf1 Positive GeneticPMID:22681890
gcn5SAGA complex histone acetyltransferase catalytic subunit Gcn5 Positive GeneticPMID:18818364
srb11cyclin CycC, Srb mediator subunit Srb11 Negative GeneticPMID:18818364
ckb2CK2 family regulatory subunit (predicted) Negative GeneticPMID:18818364
cdm1DNA polymerase delta subunit Cdm1 Negative GeneticPMID:18818364
mit1SHREC complex subunit Mit1 Synthetic LethalityPMID:23103765
SPCC550.03cSki complex RNA helicase Ski2 (predicted) Negative GeneticPMID:18818364
cho1phosphatidyl-N-methylethanolamine N-methyltransferase (predicted) Negative GeneticPMID:18818364
arp8actin-like protein, Ino80 complex subunit Arp8 Negative GeneticPMID:22681890
SPAC6F6.04cmembrane transporter (predicted) Negative GeneticPMID:22681890
eri1double-strand siRNA ribonuclease Eri1 Negative GeneticPMID:22681890
SPBC31F10.10czf-MYND type zinc finger protein Negative GeneticPMID:18818364
SPBC56F2.08cRNA-binding protein (predicted) Negative GeneticPMID:18818364
hip4histone promoter control protein Hip4 Negative GeneticPMID:18818364
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
med15mediator complex subunit Med15 Affinity Capture-WesternPMID:20622008
far8SIP/FAR complex striatin subunit, Far8/Csc3 Affinity Capture-MSPMID:22119525
med13mediator complex subunit Srb9 Affinity Capture-WesternPMID:20622008
cbf11CBF1/Su(H)/LAG-1 family transcription factor Cbf11 Affinity Capture-MSPMID:22540037
lsd2histone demethylase SWIRM2 (predicted) Affinity Capture-MSPMID:16990277
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External References
Database Identifier Description
NBRP SPAC1783.05 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC1783.05 Retrieval of eukaryotic orthologs
BioGrid SPAC1783.05 BioGRID Interaction Datasets
Bähler Lab SPAC1783.05 Cell Cycle Expression Profile
Bähler Lab SPAC1783.05 Meiosis/Sporulation Expression Profies
Bähler Lab SPAC1783.05 Pheromone response/mating expression profiles
Bähler Lab SPAC1783.05 Environmental stress expression profiles
Bähler Lab SPAC1783.05 Bähler Lab Transcriptome Viewer
Cyclebase SPAC1783.05 Cell Cycle Data
PInt SPAC1783.05 Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPAC1783.05 Entrez Gene
WikiGene2542363ATP-dependent DNA helicase Hrp1
Uniprot_genenameHRP1
EntrezGene2542363ATP-dependent DNA helicase Hrp1
UniProtKB/SwissProtQ9US25Chromodomain helicase hrp1
ModBaseQ9US25Database of comparative protein structure models
Pfam Protein DomainsQ9US25Pfam Domain Arrangement
RefSeq PeptideNP_593660ATP-dependent DNA helicase Hrp1
RefSeq mRNANM_001019092972h- ATP-dependent DNA helicase Hrp1 (hrp1), mRNA
European Nucleotide ArchiveBAA87156ENA Protein Mapping
European Nucleotide ArchiveCAA67494ENA Protein Mapping
European Nucleotide ArchiveCAB66168ENA Protein Mapping
SPD / RIKEN48/48G01Orfeome Localization Data
UniParcUPI000012CBC9UniProt Archive

Literature for hrp1
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Search: UK PMC or PubMed

Release Version: PomBase:18_35 - 11 May 2013