dbr1 (SPAC17A5.02c)

Synonyms ChromosomeI
ProductRNA lariat debranching enzyme Dbr1 Gene Start1755715
Feature Typeprotein coding Gene End1753774
Name Description CDS Start1755638
Characterisation Statuspublished CDS End1754033

Ensembl Gene Location
SPAC105.03c pex6 rec25 > dbr1 < SPNCRNA.759 rpl301 mde10 SPNCRNA.556 SPAC17A5.05c SPAC17A5.19 ptr8
Transcript
Contact Curators | Back to Top
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
117557151755331
217552851755164
317551181754350
417543101754186
517541451753774

Protein Feature Information
Contact Curators | Back to Top

Protein Features

Ensembl protein image with mapped locations of structural domains
Feature ID Database Description Start End Score All Genes
PF00149 Pfam Metallophosphoesterase domain 16 238 57.6 20
PF05011 Pfam Lariat debranching enzyme, C-terminal 326 462 143.4 1
56300 Superfamily 16 276 94.9 22

Protein Properties

Ave. residue weight 114.15 Da
Charge 5.00
Isoelectric point 7.19
Molecular weight 54.57 kDa
Number of residues 478
Sequence
Contact Curators | Back to Top

Fission Yeast Phenotype

 Contact Curators | Back to Top
Term IDDescriptionSourceAll Genes
FYPO:0000124viable
Temporary processing gif - replaced by AJAX with count of genes annotated with the term FYPO:0000124
FYPO:0000017elongated cellsTemporary processing gif - replaced by AJAX with count of genes annotated with the term FYPO:0000017

Gene Ontology Annotations

 Contact Curators | Back to Top
Biological Process
Contact Curators | Back to Top
GO IDTermEvidenceWith/FromSourceAll Genes
GO:0043144snoRNA processingISS UniProtKB:P24309GO_REF:0000001Temporary processing gif - replaced by AJAX with count of genes annotated with the term GO:0043144
GO:0045292nuclear mRNA cis splicing, via spliceosomeIMPTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - replaced by AJAX with count of genes annotated with the term GO:0045292

Cellular Component
Contact Curators | Back to Top
GO IDTermEvidenceWith/FromSourceAll Genes
GO:0005634nucleusIC GO:0008419GO_REF:0000001Temporary processing gif - replaced by AJAX with count of genes annotated with the term GO:0005634
IDATemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year reference

Molecular Function
Contact Curators | Back to Top
GO IDTermEvidenceWith/FromSourceAll Genes
GO:0008419RNA lariat debranching enzyme activityIGI UniProtKB:P24309Temporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - replaced by AJAX with count of genes annotated with the term GO:0008419

Complementation

 Contact Curators | Back to Top
DescriptionSourceAll Genes
functionally complemented by human DRB1 Temporary processing gif - replaced by AJAX with the citation reference [author (year)]Temporary processing gif - replaced by AJAX with the citation reference [author (year)]Temporary processing gif - replaced by AJAX with the citation reference [author (year)]Temporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0001162

Warning

 Contact Curators | Back to Top
DescriptionSourceAll Genes
gene structure conflictTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0001163
gene structure updated Temporary processing gif - replaced by AJAX with the citation reference [author (year)]Temporary processing gif - replaced by AJAX with the citation reference [author (year)]Temporary processing gif - replaced by AJAX with the citation reference [author (year)]Temporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000070

Species Distribution

 Contact Curators | Back to Top
DescriptionSourceAll Genes
conserved in FungiTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000057
conserved in VertebratesTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000095
conserved in EukaryotesTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000058
conserved in Eukaryotes onlyTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000096
predominantly uniformly single copy (one to one)Temporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000104
conserved in MetazoaTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000094

Manually Curated Orthologs

 Contact Curators | Back to Top
SpeciesGeneDescription

Interactions

Contact Curators | Back to Top

Genetic Interactions from BioGRID

Gene Feature Evidence Source
sdc1Dpy-30 domain protein Sdc1 Negative Genetic
clr4histone H3 methyltransferase Clr4 Negative Genetic
SPBC30B4.02cR3H and G-patch domain, implicated in splicing (predicted) Negative Genetic
SPCC162.11curidine kinase/uracil phosphoribosyltransferase (predicted) Positive Genetic
SPAC13A11.06pyruvate decarboxylase (predicted) Negative Genetic
set1histone lysine methyltransferase Set1 Negative Genetic
hip1hira protein, histone chaperone Hip1 Negative Genetic
mug154conserved fungal protein Negative Genetic
ago1argonaute Negative Genetic
spc34DASH complex subunit Spc34 Negative Genetic
cyp7cyclophilin family peptidyl-prolyl cis-trans isomerase Cyp7 (predicted) Negative Genetic
SPBC1861.07elongin C (predicted) Negative Genetic
ask1DASH complex subunit Ask1 Negative Genetic
wee1M phase inhibitor protein kinase Wee1 Synthetic Growth Defect
ubc13ubiquitin conjugating enzyme Ubc13 Positive Genetic
ski3Ski complex TPR repeat subunit Ski3 (predicted) Negative Genetic
SPBC15C4.06cubiquitin-protein ligase E3 (predicted) Negative Genetic
dad2DASH complex subunit Dad2 Negative Genetic
spf1Set1C PHD Finger protein Spf1 Negative Genetic
arp42SWI/SNF and RSC complex subunit Arp42 Negative Genetic
SPCC18.10pyridoxine-pyridoxal-pyridoxamine kinase (predicted) Negative Genetic
SPBC29A3.09cAAA family ATPase Gcn20 (predicted) Negative Genetic
SPAPB21F2.03ribosome biogenesis protein (predicted) Negative Genetic
sdh4TIM22 inner membrane protein import complex anchor subunit Tim18 Negative Genetic
ers1RNA-silencing factor Ers1 Negative Genetic
SPCC550.15cribosome biogenesis protein (predicted) Negative Genetic
set3histone lysine methyltransferase Set3 Negative Genetic
par1protein phosphatase regulatory subunit Par1 Negative Genetic
pob3FACT complex component Pob3 Negative Genetic
pef1Pho85/PhoA-like cyclin-dependent kinase Pef1 Negative Genetic
SPBC13E7.08cRNA polymerase II associated Paf1 complex (predicted) Positive Genetic
cka1serine/threonine protein kinase Cka1 Synthetic Growth Defect
rpa12DNA-directed RNA polymerase complex I subunit Rpa12 Negative Genetic
SPAC4H3.07cprotein phosphatase Fmp31 (predicted) Positive Genetic
ies2Ino80 complex subunit Ies2 Negative Genetic
tas3RITS complex subunit 3 Negative Genetic
raf2Rik1-associated factor Raf2 Negative Genetic
epe1Jmjc domain chromatin associated protein Epe1 Negative Genetic
ubp8SAGA complex ubiquitin C-terminal hydrolase Ubp8 Positive Genetic
vph2endoplasmic reticulum membrane protein involved in assembly of the V-ATPase (predicted) Negative Genetic
hif2Set3 complex subunit Hif2 Negative Genetic
vps71Swr1 complex subunit Vps71 Negative Genetic
rpl160160S ribosomal protein L13/L16 (predicted) Negative Genetic
elp2elongator complex subunit Elp2 (predicted) Positive Genetic
SPAC1952.02ribosome biogenesis protein (predicted) Negative Genetic
hrr1Helicase Required for RNAi-mediated heterochromatin assembly Hrr1 Negative Genetic
swd1Set1C complex subunit Swd1 Negative Genetic
SPAC1093.03inositol polyphosphate phosphatase (predicted) Negative Genetic
ccr4CCR4-Not complex subunit Ccr4 (predicted) Negative Genetic
scs7sphingosine hydroxylase Scs7 Positive Genetic
SPBC16H5.13WD repeat protein, human WDR7 ortholog Negative Genetic
rad2414-3-3 protein Rad24 Synthetic Growth Defect
hos2histone deacetylase (class I) Hos2 Negative Genetic
raf1Rik1-associated factor Raf1 Negative Genetic
not3CCR4-Not complex subunit Not3/5 (predicted) Negative Genetic
lsk1P-TEFb-associated cyclin-dependent protein kinase Lsk1 Negative Genetic
dsk1SR protein-specific kinase Dsk1 Negative Genetic
pht1histone H2A variant H2A.Z, Pht1 Negative Genetic
png2ING family homolog Png2 Negative Genetic
rik1silencing protein Rik1 Negative Genetic
dcr1dicer Negative Genetic
pab2poly(A) binding protein Pab2 Negative Genetic
SPBC31F10.10czf-MYND type zinc finger protein Negative Genetic
iki1elongator complex subunit Iki1 (predicted) Negative Genetic
yaf9YEATS family histone acetyltransferase subunit Yaf9 Negative Genetic
ssu72phosphoric ester hydrolase Ssu72 (predicted) Negative Genetic
hip4histone promoter control protein Hip4 Negative Genetic


External References

 Contact Curators | Back to Top
Database Identifier Description
NBRP SPAC17A5.02c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC17A5.02c Retrieval of eukaryotic orthologs
BioGrid SPAC17A5.02c BioGRID Interaction Datasets
Bähler Lab SPAC17A5.02c Cell Cycle Expression Profile
Bähler Lab SPAC17A5.02c Meiosis/Sporulation Expression Profies
Bähler Lab SPAC17A5.02c Pheromone response/mating expression profiles
Bähler Lab SPAC17A5.02c Environmental stress expression profiles
Bähler Lab SPAC17A5.02c Bähler Lab Transcriptome Viewer
Cyclebase SPAC17A5.02c Cell Cycle Data
Entrez Gene SPAC17A5.02c Link to Entrez Gene
SPD / RIKEN40/40F04Orfeome Localization Data
UniProtKB/SwissProtO13765Lariat debranching enzyme
ArrayExpressO13765Link to ArrayExpress
RefSeq PeptideNP_593470RNA lariat debranching enzyme Dbr1
RefSeq mRNANM_001018903972h- RNA lariat debranching enzyme Dbr1 (dbr1), mRNA
European Nucleotide ArchiveCU329670ENA EMBL mapping
European Nucleotide ArchiveU63635ENA EMBL mapping
European Nucleotide ArchiveAAC49619ENA Protein Mapping
European Nucleotide ArchiveCAB11502ENA Protein Mapping
UniParcUPI00001691C4UniProt Archive

Literature for dbr1

 Contact Curators | Back to Top
Search: UK PMC or PubMed