tco1 (SPAC17G6.02c)

Gene Standard Nametco1 Characterisation Statuspublished
Systematic IDSPAC17G6.02c Feature Typeprotein coding
Synonyms Name Description
ProductRTA1-like protein Product Size324aa, 35.93 kDa
Genomic Location Chromosome I, 3590624-3588615 (2010nt); CDS:3589949-3588975 (975nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
phospholipid-translocating ATPase activity6
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
cellular response to oxidative stress52
Annotation ExtensionEvidenceWith/FromReference
phospholipid translocation5
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
cell division site305
Annotation ExtensionEvidenceWith/FromReference
cell tip194
Annotation ExtensionEvidenceWith/FromReference
Annotation ExtensionEvidenceWith/FromReference
Golgi apparatus357
Annotation ExtensionEvidenceWith/FromReference
integral component of membrane1018
Annotation ExtensionEvidenceWith/FromReference
plasma membrane249
Annotation ExtensionEvidenceWith/FromReference
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
viable vegetative cell populationtco1ΔNull3792

Cell Phenotype

Term NameAlleleExpressionCount
viable vegetative cell with normal cell morphologytco1ΔNull3092
Target Of
FYPO affected by mutation in end4 Huntingtin-interacting protein homolog PMID:21832151
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
5' UTR3590624..3589950PMID:21511999
3' UTR3588974..3588615PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF04479 Pfam IPR007568 RTA-like protein 43 272 1
TMhelix TMHMM 238 260 959
TMhelix TMHMM 113 135 959
TMhelix TMHMM 155 177 959
TMhelix TMHMM 39 56 959
TMhelix TMHMM 206 223 959
TMhelix TMHMM 71 93 959
TMhelix TMHMM 10 32 959
PTHR31461 HMMPANTHER 3 324 1
PTHR31461:SF1 HMMPANTHER 3 324 1

View domain organization at Pfam

Sequence Ontology

Term IDTerm NameReferenceCount

Protein Properties

Ave. residue weight 110.90 Da
Charge -2.00
Isoelectric point 6.08
Molecular weight 35.93 kDa
Number of residues 324

Protein Modifications

Term NameResidueCount
O-phospho-L-serine 1672
present during mitotic M phaseS320
present during mitotic M phaseS318
present during mitotic M phaseS321
Annotation ExtensionEvidenceResidueReference
present during mitotic M phase experimental evidence S318 PMID:21712547
present during mitotic M phase experimental evidence S320 PMID:21712547
present during mitotic M phase experimental evidence S321 PMID:21712547
Gene Expression

Qualitative Gene Expression

RNA levelincreased in presence of purvalanol A expression microarray evidencePMID:22840777

Quantitative Gene Expression

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
3.7during GO:0072690PECO:0000005,
population wideexperimental evidencePMID:23101633
2.2during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population wideexperimental evidencePMID:23101633
Genome Organisation
alternative transcripts PMID:1827664513
in the current viewer tco1 gene is hidden behind SPNCRNA.6002
Species Distribution
conserved in fungi4604

Manually curated orthologous groups


Orthologs in Compara

Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
positive genetic interaction withatp15F0-ATPase epsilon subunit (predicted) Positive GeneticPMID:22681890
negative genetic interaction withbst1GPI inositol deacylase Bst1 (predicted) Negative GeneticPMID:22681890
positive genetic interaction withddb1damaged DNA binding protein Ddb1 Positive GeneticPMID:22681890
negative genetic interaction withdsc1Golgi Dsc E3 ligase complex subunit Dsc1 Negative GeneticPMID:21504829
positive genetic interaction withmrpl1mitochondrial ribosomal protein subunit L1 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withrpl200160S ribosomal protein L20a (predicted) Positive GeneticPMID:22681890
positive genetic interaction withshf1small histone ubiquitination factor Shf1 Positive GeneticPMID:22681890
positive genetic interaction withSPBC13E7.03cRNA hairpin binding protein (predicted) Positive GeneticPMID:22681890
positive genetic interaction withSPBC1861.05pseudouridine-metabolizing bifunctional protein (predicted) Positive GeneticPMID:22681890
negative genetic interaction withsre2membrane-tethered transcription factor Sre2 Negative GeneticPMID:21504829
External References
Database Identifier Description
NBRP SPAC17G6.02c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC17G6.02c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC17G6.02c BioGRID Interaction Datasets
Expression Viewer SPAC17G6.02c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC17G6.02c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC17G6.02c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC17G6.02c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC17G6.02c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC17G6.02c Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC17G6.02c Cell Cycle Data
GEO SPAC17G6.02c GEO profiles
PInt SPAC17G6.02c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC17G6.02c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC17G6.02c Fission yeast phenotypic data & analysis
SPD / RIKEN13/13H11Orfeome Localization Data
UniProtKB/SwissProtO13780Uncharacterized protein C17G6.02c
ModBaseO13780Database of comparative protein structure models
STRINGO13780Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_594249RTA1-like protein
RefSeq mRNANM_001019672972h- RTA1-like protein (tco1), mRNA
European Nucleotide ArchiveBAA87202.1ENA Protein Mapping
European Nucleotide ArchiveCAB16213.1ENA Protein Mapping
UniParcUPI000006AB49UniProt Archive

Literature for tco1

Search: Europe PMC or PubMed

Release Version: PomBase:25_50 - 10 Mar 2015