bro1 (SPAC17G6.05c)

Gene Standard Namebro1 ChromosomeI
Systematic IDSPAC17G6.05c Gene Start3598863
Synonyms Gene End3596387
ProductBRO1 domain protein Bro1 (predicted) Gene Length2477
Feature Typeprotein coding CDS Start3598799
Name Description CDS End3596472
Characterisation Statusbiological_role_inferred CDS Length2328

Ensembl Gene Location
  1. SPNCRNA.600
  2. tco1
  3. SPAC17G6.03
  4. SPATRNALEU.03
  5. SPNCRNA.226
  6. cpp1
  7. bro1
  8. rps2401
  9. SPAC17G6.07c
  10. pep7
  11. sec62
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0002060viable vegetative cell populationMicroscopybro1delta (deletion)deletionPMID:20473289
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0006511ubiquitin-dependent protein catabolic processISOSGD:S000006005GO_REF:0000024
GO:0043328protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathwayISOSGD:S000006005GO_REF:0000024
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0005737cytoplasmISOSGD:S000006005GO_REF:0000024
GO:0005768endosomeISOSGD:S000006005GO_REF:0000024
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
135988633596387

References

Region Start End Reference
five_prime_UTR35988633598800PMID:21511999
three_prime_UTR35964713596387PMID:21511999
three_prime_UTR35964713596387PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF13949 IPR025304 Pfam ALIX V-shaped domain 437 748 2
PF03097 IPR004328 Pfam BRO1 domain 7 403 2
SM01041 IPR004328 SMART BRO1 domain 7 404 2
PS51180 IPR004328 Prosite Profiles BRO1 domain 7 414 2
G3DSA:1.25.40.280 IPR004328 Gene3D 5 377 2
G3DSA:1.20.140.50 Gene3D 689 736 1
G3DSA:1.20.140.50 Gene3D 439 559 1
G3DSA:1.20.120.560 Gene3D 581 676 1
G3DSA:1.20.120.560 Gene3D 381 427 1
Coil ncoils Rabaptin coiled-coil domain 576 597 974
Coil ncoils Rabaptin coiled-coil domain 473 494 974
PTHR23030 hmmpanther 1 775 2
PTHR23030:SF2 hmmpanther 1 775 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 111.77 Da
Charge -3.50
Isoelectric point 6.11
Molecular weight 86.62 kDa
Number of residues 775
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide4328.36PMID:23101633
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide1903.96PMID:23101633
RNA levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide0.87PMID:23101633
experimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide2.1PMID:23101633
Species Distribution
DescriptionQualifierReference
predominantly single copy (one to one)
conserved in fungi
conserved in eukaryotes
conserved in metazoa
conserved in vertebrates
conserved in eukaryotes only
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
gcn5SAGA complex histone acetyltransferase catalytic subunit Gcn5 Positive GeneticPMID:22681890
SPCC1223.01ubiquitin-protein ligase E3 (predicted) Positive GeneticPMID:22681890
vps17retromer complex subunit Vps17 Negative GeneticPMID:22681890
ssm4dynactin microtubule-binding subunit, p150-Glued Ssm4 Negative GeneticPMID:22681890
SPCC162.11curidine kinase/uracil phosphoribosyltransferase (predicted) Negative GeneticPMID:22681890
sep1forkhead transcription factor Sep1 Negative GeneticPMID:22681890
spc19DASH complex subunit Spc19 Negative GeneticPMID:22681890
hus1checkpoint clamp complex protein Hus1 Positive GeneticPMID:22681890
dsc3Golgi Dsc E3 ligase complex subunit Dsc3 Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
SPAC821.05translation initiation factor eIF3h (p40) Negative GeneticPMID:22681890
dsc1Golgi Dsc E3 ligase complex subunit Dsc1 Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
sif1Sad1 interacting factor 1 Positive GeneticPMID:22681890
vps5retromer complex subunit Vps5 Negative GeneticPMID:22681890
aut12autophagy associated protein Aut12 (predicted) Negative GeneticPMID:22681890
ccr4CCR4-Not complex subunit Ccr4 (predicted) Positive GeneticPMID:22681890
dbr1RNA lariat debranching enzyme Dbr1 Negative GeneticPMID:22681890
dsc4Golgi Dsc E3 ligase complex subunit Dsc3 Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
kin1microtubule affinity-regulating kinase Kin1 Negative GeneticPMID:22681890
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External References
Database Identifier Description
NBRP SPAC17G6.05c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC17G6.05c Retrieval of eukaryotic orthologs
BioGrid SPAC17G6.05c BioGRID Interaction Datasets
Bähler Lab SPAC17G6.05c Cell Cycle Expression Profile
Bähler Lab SPAC17G6.05c Meiosis/Sporulation Expression Profies
Bähler Lab SPAC17G6.05c Pheromone response/mating expression profiles
Bähler Lab SPAC17G6.05c Environmental stress expression profiles
Bähler Lab SPAC17G6.05c Bähler Lab Transcriptome Viewer
Cyclebase SPAC17G6.05c Cell Cycle Data
PInt SPAC17G6.05c Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPAC17G6.05c Entrez Gene
WikiGene2542419vacuolar protein-sorting protein
Uniprot_genenameBRO1
EntrezGene2542419vacuolar protein-sorting protein
SPD / RIKEN28/28D03Orfeome Localization Data
UniProtKB/SwissProtO13783Vacuolar protein-sorting protein bro1
ModBaseO13783Database of comparative protein structure models
Pfam Protein DomainsO13783Pfam Domain Arrangement
RefSeq PeptideNP_594252vacuolar protein-sorting protein
RefSeq mRNANM_001019675972h- vacuolar protein-sorting protein (SPAC17G6.05c), mRNA
European Nucleotide ArchiveCAB16216ENA Protein Mapping
UniParcUPI00000695D4UniProt Archive

Literature for bro1
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Search: UK PMC or PubMed

Release Version: PomBase:18_35 - 11 May 2013