pep7 (SPAC17G6.08)

Gene Standard Namepep7 ChromosomeI
Systematic IDSPAC17G6.08 Gene Start3601674
Synonymsvac1 Gene End3603904
Productprevacuole/endosomal FYVE tethering component Pep7 (predicted) Gene Length2231
Feature Typeprotein coding CDS Start3601879
Name Description CDS End3603489
Characterisation Statusbiological_role_inferred CDS Length1611

Ensembl Gene Location
  1. cpp1
  2. bro1
  3. rps2401
  4. SPAC17G6.07c
  5. pep7
  6. sec62
  7. ssr1
  8. SPAC17G6.11c
  9. SPNCRNA.921
  10. SPNCRNA.227
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0002060viable vegetative cell populationMicroscopypep7delta (deletion)deletionPMID:20473289
GO Molecular Function

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Term IDTerm NameEvidenceWith/FromReference
GO:0008270zinc ion bindingIEAIPR007087GO_REF:0000002
GO:0032266phosphatidylinositol-3-phosphate bindingISOSGD:S000002731GO_REF:0000024
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0006896Golgi to vacuole transportISOSGD:S000002731GO_REF:0000024
GO:0006904vesicle docking involved in exocytosisISOSGD:S000002731GO_REF:0000024
GO:0006906vesicle fusionISOSGD:S000002731GO_REF:0000024
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0005737cytoplasmIDAPMID:16823372
GO:0005794Golgi apparatusIDAPMID:16823372
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
136016743603904

References

Region Start End Reference
three_prime_UTR36034903603904PMID:21511999
five_prime_UTR36016743601878PMID:21511999
three_prime_UTR36034903603904PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF01363 IPR000306 Pfam Zinc finger, FYVE-type 271 331 5
PF01363 IPR000306 Pfam Zinc finger, FYVE-type 130 198 5
SM00064 IPR000306 SMART Zinc finger, FYVE-type 126 202 6
SM00064 IPR000306 SMART Zinc finger, FYVE-type 267 333 6
SM00355 IPR015880 SMART Zinc finger, C2H2-like 156 179 28
SM00355 IPR015880 SMART Zinc finger, C2H2-like 39 62 28
PS00028 IPR007087 Prosite Patterns Zinc finger, C2H2 41 62 28
PS50178 IPR017455 Prosite Profiles Zinc finger, FYVE-related 275 332 5
PS50178 IPR017455 Prosite Profiles Zinc finger, FYVE-related 145 201 5
G3DSA:3.30.40.10 IPR013083 Gene3D 128 198 84
G3DSA:3.30.40.10 IPR013083 Gene3D 267 331 84
SSF57903 IPR011011 SuperFamily 129 218 25
SSF57903 IPR011011 SuperFamily 253 331 25
SSF140125 SuperFamily 477 522 1
PTHR13510 hmmpanther 14 536 1
PTHR13510:SF9 hmmpanther 14 536 1
Coil ncoils Rabaptin coiled-coil domain 456 488 974

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceAll Genes
PBO:0000137zinc finger proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000137
PBO:0000153zf-C2H2 typeTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000153
PBO:0001569zf-FYVE typeTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0001569

Protein Properties

Ave. residue weight 116.48 Da
Charge 14.00
Isoelectric point 7.97
Molecular weight 62.43 kDa
Number of residues 536
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide857.6PMID:23101633
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127		population_widePMID:23101633
RNA levelexperimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide0.84PMID:23101633
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide0.31PMID:23101633
Species Distribution
DescriptionQualifierReference
predominantly single copy (one to one)
conserved in fungi
conserved in eukaryotes
conserved in metazoa
conserved in vertebrates
conserved in eukaryotes only
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
dsc4Golgi Dsc E3 ligase complex subunit Dsc3 Negative GeneticPMID:21504829
dsc1Golgi Dsc E3 ligase complex subunit Dsc1 Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
dsc3Golgi Dsc E3 ligase complex subunit Dsc3 Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
res1MBF transcription factor complex subunit Res1 Negative GeneticPMID:22681890
aut12autophagy associated protein Aut12 (predicted) Negative GeneticPMID:22681890
cdc18MCM loader Positive GeneticPMID:22681890
shg1Set1C complex subunit Shg1 Negative GeneticPMID:22681890
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External References
Database Identifier Description
NBRP SPAC17G6.08 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC17G6.08 Retrieval of eukaryotic orthologs
BioGrid SPAC17G6.08 BioGRID Interaction Datasets
Bähler Lab SPAC17G6.08 Cell Cycle Expression Profile
Bähler Lab SPAC17G6.08 Meiosis/Sporulation Expression Profies
Bähler Lab SPAC17G6.08 Pheromone response/mating expression profiles
Bähler Lab SPAC17G6.08 Environmental stress expression profiles
Bähler Lab SPAC17G6.08 Bähler Lab Transcriptome Viewer
Cyclebase SPAC17G6.08 Cell Cycle Data
PInt SPAC17G6.08 Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPAC17G6.08 Entrez Gene
WikiGene2542423prevacuole/endosomal FYVE tethering component Pep7 (predicted)
Uniprot_genenamePEP7
EntrezGene2542423prevacuole/endosomal FYVE tethering component Pep7 (predicted)
SPD / RIKEN25/25H01Orfeome Localization Data
UniProtKB/SwissProtO13786Vacuolar segregation protein pep7
ModBaseO13786Database of comparative protein structure models
Pfam Protein DomainsO13786Pfam Domain Arrangement
RefSeq PeptideNP_594255prevacuole/endosomal FYVE tethering component Pep7 (predicted)
RefSeq mRNANM_001019678972h- prevacuole/endosomal FYVE tethering component Pep7 (predicted) (pep7), mRNA
European Nucleotide ArchiveCAB16219ENA Protein Mapping
UniParcUPI000006AA47UniProt Archive

Literature for pep7
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Search: UK PMC or PubMed

Release Version: PomBase:18_35 - 11 May 2013