yaf9 (SPAC17G8.07)

Gene Standard Nameyaf9 Characterisation Statuspublished
Systematic IDSPAC17G8.07 Feature Typeprotein coding
Synonyms Name Description
ProductYEATS family histone acetyltransferase subunit Yaf9 Product Size217aa, 24.95 kDa
Genomic Location Chromosome I, 2354127-2355211 (1085nt); CDS:2354401-2355054 (654nt)

Ensembl Gene Location
GO Biological Process
Term NameCount
chromatin silencing98
Annotation ExtensionEvidenceWith/FromReference
DNA repair165
Annotation ExtensionEvidenceWith/FromReference
histone acetylation47
Annotation ExtensionEvidenceWith/FromReference
histone exchange24
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
Annotation ExtensionEvidenceWith/FromReference
NuA4 histone acetyltransferase complex14
Annotation ExtensionEvidenceWith/FromReference
Annotation ExtensionEvidenceWith/FromReference
Swr1 complex16
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000096sensitive to cadmium246
expressivity FYPO_EXT:0000002Cell growth assayyaf9ΔNullPECO:0000102, PECO:0000005, PECO:0000137PMID:18684775
FYPO:0003559sensitive to doxorubicin91
expressivity FYPO_EXT:0000003Cell growth assayyaf9ΔNullPECO:0000137PMID:23365689
FYPO:0000088sensitive to hydroxyurea514
expressivity FYPO_EXT:0000003Cell Growth Assayyaf9ΔNullPECO:0000137, PECO:0000102PMID:23697806
FYPO:0000271sensitive to salt stress84
expressivity FYPO_EXT:0000003Cell growth assayyaf9ΔNullPECO:0000207, PECO:0000137, PECO:0000102, PECO:0000005PMID:18684775
FYPO:0002060viable vegetative cell populationMicroscopyyaf9ΔNullPMID:204732893759
Microscopyyaf9ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002399abnormal microtubule cytoskeletonMicroscopyyaf9ΔNullPMID:23697806218
FYPO:0001018abolished activation of bipolar cell growthMicroscopyyaf9ΔNullPMID:2369780612
FYPO:0002400single microtubule bundleMicroscopyyaf9ΔNullPMID:2369780610
FYPO:0002112viable curved vegetative cell60
expressivity FYPO_EXT:0000003
penetrance FYPO_EXT:0000001
Microscopyyaf9ΔNullPECO:0000137, PECO:0000005PMID:23697806
Ensembl transcript structure with UTRs, exons and introns


Exon Start End


Region Coordinates Reference
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF03366 Pfam IPR005033 YEATS 38 119 2
PS51037 Prosite Profiles IPR005033 YEATS 13 121 2
PTHR23195 HMMPANTHER IPR005033 YEATS 1 205 2
Coil ncoils Rabaptin coiled-coil domain 190 211 968

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0000297histone foldTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000297

Sequence Ontology

Term IDTerm NameReferenceCount

Protein Properties

Ave. residue weight 114.96 Da
Charge -7.50
Isoelectric point 5.05
Molecular weight 24.95 kDa
Number of residues 217
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
9573during GO:0000080PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
6703during GO:0000084PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
10087during GO:0000085PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
6174during GO:0000087PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
5885during GO:0072690PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
2459.46during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
5429.13during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1.4during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
0.42during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633
proteome hyperlink PMID:190407209
Species Distribution
predominantly single copy (one to one)3092
conserved in fungi4600
conserved in eukaryotes4514
conserved in metazoa3425
conserved in vertebrates3400
conserved in eukaryotes only2497

Manually curated orthologous groups


Orthologs in Compara

Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
tra2NuA4 complex phosphatidylinositol pseudokinase complex subunit Tra2 Affinity Capture-MSPMID:21642955
Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
SPCC550.03cSki complex RNA helicase Ski2 (predicted) Negative GeneticPMID:18818364
hip1hira protein, histone chaperone Hip1 Negative GeneticPMID:18818364
mph1dual specificity protein kinase Mph1 Negative GeneticPMID:18818364
bdc1bromodomain containing protein 1, Bdc1 Negative GeneticPMID:18818364
elp5elongator complex subunit Elp5 (predicted) Negative GeneticPMID:18818364
mga2IPT/TIG ankyrin repeat containing transcription regulator of fatty acid biosynthesis (predicted) Negative GeneticPMID:18818364
pef1Pho85/PhoA-like cyclin-dependent kinase Pef1 Negative GeneticPMID:18818364
eme1Holliday junction resolvase subunit Eme1 Negative GeneticPMID:18818364
not3CCR4-Not complex subunit Not3/5 (predicted) Negative GeneticPMID:18818364
dbr1RNA lariat debranching enzyme Dbr1 Negative GeneticPMID:18818364
atg1801WD repeat protein involved in autophagy Atg18a Negative GeneticPMID:18818364
ash2Ash2-trithorax family protein Negative GeneticPMID:18818364
gcn5SAGA complex histone acetyltransferase catalytic subunit Gcn5 Negative GeneticPMID:18818364
klp6kinesin-like protein Klp6 Negative GeneticPMID:18818364
mcl1DNA polymerase alpha accessory factor Mcl1 Negative GeneticPMID:18818364
swc5Swr1 complex subunit Swc5 Positive GeneticPMID:18818364
ccr4CCR4-Not complex subunit Ccr4 (predicted) Negative GeneticPMID:18818364
reb1RNA polymerase I transcription termination factor/ RNA polymerase II transcription factor Reb1 Negative GeneticPMID:18818364
swc2Swr1 complex complex subunit Swc2 Positive GeneticPMID:18818364
csn1COP9/signalosome complex subunit Csn1 Negative GeneticPMID:18818364
hip4histone promoter control protein Hip4 Negative GeneticPMID:18818364
spc34DASH complex subunit Spc34 Negative GeneticPMID:18818364
hhf1histone H4 h4.1 Negative GeneticPMID:18818364
bob1prefoldin subunit 5 (predicted) Negative GeneticPMID:18818364
ubc6ubiquitin conjugating enzyme Ubc6 (predicted) Positive GeneticPMID:18818364
hhf2histone H4 h4.2 Negative GeneticPMID:18818364
pom1DYRK family protein kinase Pom1 Negative GeneticPMID:18818364
clr3histone deacetylase (class II) Clr3 Negative GeneticPMID:18818364
SPBC16C6.05mitochondrial translation initiation factor (predicted) Negative GeneticPMID:18818364
gmh5alpha-1,2-galactosyltransferase (predicted) Positive GeneticPMID:18818364
tma20RNA-binding protein Tma20 (predicted) Negative GeneticPMID:18818364
cph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Negative GeneticPMID:18818364
SPBC31F10.10czf-MYND type zinc finger protein Negative GeneticPMID:18818364
elp3elongator complex subunit Elp3 (predicted) Negative GeneticPMID:18818364
sgf29SAGA complex subunit Sgf29 Negative GeneticPMID:18818364
pht1histone H2A variant H2A.Z, Pht1 Positive GeneticPMID:18818364
ser2phosphoserine phosphatase Ser2 (predicted) Negative GeneticPMID:18818364
med7mediator complex subunit Med7 Negative GeneticPMID:18818364
air1zinc knuckle TRAMP complex subunit Air1 Negative GeneticPMID:18818364
arp6actin-like protein Arp6 Positive GeneticPMID:18818364
set11ribosomal protein lysine methyltransferase Set11 Negative GeneticPMID:18818364
deg1tRNA-pseudouridine synthase (predicted) Negative GeneticPMID:18818364
rnc1RNA-binding protein that suppresses calcineurin deletion Rnc1 Negative GeneticPMID:18818364
bdf1Swr1 complex bromodomain subunit Brf1 Negative GeneticPMID:18818364
par1protein phosphatase regulatory subunit Par1 Negative GeneticPMID:18818364
tim13TIM22 inner membrane protein import complex subunit Tim13 (predicted) Negative GeneticPMID:18818364
set1histone lysine methyltransferase Set1 Negative GeneticPMID:18818364
cay1cactin, spliceosome complex subunit (predicted) Negative GeneticPMID:18818364
puf3RNA-binding protein Puf3 (predicted) Negative GeneticPMID:18818364
rpa12DNA-directed RNA polymerase complex I subunit Rpa12 Negative GeneticPMID:18818364
png2ING family homolog Png2 Negative GeneticPMID:18818364
rok1ATP-dependent RNA helicase Rok1 (predicted) Negative GeneticPMID:18818364
SPAC824.04WD repeat protein (predicted) Negative GeneticPMID:18818364
ppk30Ark1/Prk1 family protein kinase Ppk30 Positive GeneticPMID:18818364
not2CCR4-Not complex subunit Not2 (predicted) Negative GeneticPMID:18818364
fin1serine/threonine protein kinase, NIMA related Fin1 Negative GeneticPMID:18818364
msn5karyopherin (predicted) Negative GeneticPMID:18818364
nto1histone acetyltransferase complex subunit Nto1 (predicted) Negative GeneticPMID:18818364
rsc4RSC complex subunit Rsc4 Negative GeneticPMID:18818364
arp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:18818364
ngg1SAGA complex subunit Ngg1 Negative GeneticPMID:18818364
sec28coatomer epsilon subunit (predicted) Negative GeneticPMID:18818364
rhn1RNA polymerase II transcription termination factor homolog Negative GeneticPMID:18818364
spf1Set1C PHD Finger protein Spf1 Negative GeneticPMID:18818364
spp27RNA polymerase I upstream activation factor complex subunit Spp27 Negative GeneticPMID:18818364
mrc1mediator of replication checkpoint 1 Negative GeneticPMID:18818364
vps71Swr1 complex subunit Vps71 Positive GeneticPMID:18818364
pho24-nitrophenylphosphatase Negative GeneticPMID:18818364
swd2Set1C complex subunit Swd2.1 Negative GeneticPMID:18818364
ppk16serine/threonine protein kinase Ppk16 (predicted) Negative GeneticPMID:18818364
rhp14XP-A family homolog Rhp14 Negative GeneticPMID:18818364
dad1DASH complex subunit Dad1 Negative GeneticPMID:18818364
hos2histone deacetylase (class I) Hos2 Negative GeneticPMID:18818364
set3histone lysine methyltransferase Set3 Negative GeneticPMID:18818364
swd3WD repeat protein Swd3 Negative GeneticPMID:18818364
mad1mitotic spindle checkpoint protein Mad1 Negative GeneticPMID:18818364
lsk1P-TEFb-associated cyclin-dependent protein kinase Lsk1 Negative GeneticPMID:18818364
cid12poly(A) polymerase Cid12 Positive GeneticPMID:18818364
gfh1gamma tubulin complex subunit Gfh1 Negative GeneticPMID:18818364
mms19Dos2 silencing complex subunit Mms19 Negative GeneticPMID:18818364
ask1DASH complex subunit Ask1 Negative GeneticPMID:18818364
alp16gamma tubulin complex subunit Alp16 Negative GeneticPMID:18818364
alp13MRG family Clr6 histone deacetylase complex subunit Alp13 Phenotypic EnhancementPMID:19547744
swr1SNF2 family helicase Swr1 Positive GeneticPMID:18818364
mug154conserved fungal protein Negative GeneticPMID:18818364
sdc1Dpy-30 domain protein Sdc1 Negative GeneticPMID:18818364
hif2Set3 complex subunit Hif2 Negative GeneticPMID:18818364
SPCC1919.13cribosome biogenesis protein (predicted) Negative GeneticPMID:18818364
arp8actin-like protein, Ino80 complex subunit Arp8 Negative GeneticPMID:18818364
res2MBF transcription factor complex subunit Res2 Positive GeneticPMID:18818364
top1DNA topoisomerase I Negative GeneticPMID:18818364
SPCC18.10pyridoxine-pyridoxal-pyridoxamine kinase (predicted) Negative GeneticPMID:18818364
res1MBF transcription factor complex subunit Res1 Phenotypic EnhancementPMID:19547744
ssu72phosphoric ester hydrolase Ssu72 (predicted) Negative GeneticPMID:18818364
wis2cyclophilin family peptidyl-prolyl cis-trans isomerase Wis2 Negative GeneticPMID:18818364
SPBC36B7.08cnucleosome assembly protein (predicted) Negative GeneticPMID:18818364
SPBC1861.07elongin C (predicted) Negative GeneticPMID:18818364
External References
Database Identifier Description
NBRP SPAC17G8.07 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC17G8.07 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC17G8.07 BioGRID Interaction Datasets
Expression Viewer SPAC17G8.07 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC17G8.07 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC17G8.07 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC17G8.07 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC17G8.07 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC17G8.07 Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC17G8.07 Cell Cycle Data
GEO SPAC17G8.07 GEO profiles
PInt SPAC17G8.07 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC17G8.07 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC17G8.07 Fission yeast phenotypic data & analysis
SPD / RIKEN07/07E08Orfeome Localization Data
UniProtKB/SwissProtQ10319Protein AF-9 homolog
ModBaseQ10319Database of comparative protein structure models
STRINGQ10319Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_593730YEATS family histone acetyltransferase subunit Yaf9
RefSeq mRNANM_001019161972h- YEATS family histone acetyltransferase subunit Yaf9 (yaf9), mRNA
European Nucleotide ArchiveCAA93690.1ENA Protein Mapping
UniParcUPI000013A88DUniProt Archive

Literature for yaf9

Search: Europe PMC or PubMed

Release Version: PomBase:23_47 - 27 Oct 2014