yaf9 (SPAC17G8.07)


Gene Standard Nameyaf9 Characterisation Statuspublished
Systematic IDSPAC17G8.07 Feature Typeprotein coding
Synonyms Name Description
ProductYEATS family histone acetyltransferase subunit Yaf9 Product Size217aa, 24.95 kDa
Genomic Location Chromosome I, 2354127-2355211 (1085nt); CDS:2354401-2355054 (654nt)

Ensembl Gene Location
GO Biological Process
Term NameCount
chromatin silencing112
Annotation ExtensionEvidenceWith/FromReference
DNA repair167
Annotation ExtensionEvidenceWith/FromReference
histone acetylation47
Annotation ExtensionEvidenceWith/FromReference
histone exchange23
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
cytosol2314
Annotation ExtensionEvidenceWith/FromReference
NuA4 histone acetyltransferase complex14
Annotation ExtensionEvidenceWith/FromReference
nucleus2696
Annotation ExtensionEvidenceWith/FromReference
Swr1 complex15
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
sensitive to cadmiumyaf9ΔNull246
sensitive to doxorubicinyaf9ΔNull91
sensitive to hydroxyureayaf9ΔNull534
sensitive to salt stressyaf9ΔNull91
viable vegetative cell populationyaf9ΔNull3809

Cell Phenotype

Term NameAlleleExpressionCount
abnormal microtubule cytoskeletonyaf9ΔNull231
abolished activation of bipolar cell growthyaf9ΔNull13
single microtubule bundleyaf9ΔNull10
viable curved vegetative cellyaf9ΔNull67
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons2354127..2355211
mRNA2354127..2355211
5' UTR2354127..2354400PMID:21511999
CDS2354401..2355054
3' UTR2355055..2355211PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF03366 Pfam IPR005033 YEATS 38 119 2
PS51037 Prosite Profiles IPR005033 YEATS 13 121 2
PTHR23195 HMMPANTHER IPR005033 YEATS 4 212 2
Coil ncoils Rabaptin coiled-coil domain 190 211 968

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0000297histone foldTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000297

Sequence Ontology

Term IDTerm NameReferenceCount
SO:0001080coiled_coil106
qualifier region

Protein Properties

Ave. residue weight 114.96 Da
Charge -7.50
Isoelectric point 5.05
Molecular weight 24.95 kDa
Number of residues 217
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
9573during GO:0000080PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
6703during GO:0000084PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
10087during GO:0000085PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
6174during GO:0000087PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
5885during GO:0072690PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
2459.46during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
5429.13during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1.4during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
0.42during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633
Misc
DescriptionQualifierReferenceCount
proteome hyperlink PMID:190407209
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4603
conserved in eukaryotes4514
conserved in metazoa3424
conserved in vertebrates3399
conserved in eukaryotes only2501
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
affinity captured bytra2NuA4 complex phosphatidylinositol pseudokinase complex subunit Tra2 Affinity Capture-MSPMID:21642955
Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
negative genetic interaction withair1zinc knuckle TRAMP complex subunit Air1 Negative GeneticPMID:18818364
enhances phenotype ofalp13MRG family Clr6 histone deacetylase complex subunit Alp13 Phenotypic EnhancementPMID:19547744
negative genetic interaction withalp16gamma tubulin complex subunit Alp16 Negative GeneticPMID:18818364
negative genetic interaction witharp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:18818364
positive genetic interaction witharp6actin-like protein Arp6 Positive GeneticPMID:18818364
negative genetic interaction witharp8actin-like protein, Ino80 complex subunit Arp8 Negative GeneticPMID:18818364
negative genetic interaction withash2Ash2-trithorax family protein Negative GeneticPMID:18818364
negative genetic interaction withask1DASH complex subunit Ask1 Negative GeneticPMID:18818364
negative genetic interaction withatg1801WD repeat protein involved in autophagy Atg18a Negative GeneticPMID:18818364
negative genetic interaction withbdc1bromodomain containing protein 1, Bdc1 Negative GeneticPMID:18818364
negative genetic interaction withbdf1Swr1 complex bromodomain subunit Brf1 Negative GeneticPMID:18818364
negative genetic interaction withbob1prefoldin subunit 5 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withcay1cactin, spliceosome complex subunit Negative GeneticPMID:18818364
negative genetic interaction withccr4CCR4-Not complex subunit Ccr4 (predicted) Negative GeneticPMID:18818364
positive genetic interaction withcid12poly(A) polymerase Cid12 Positive GeneticPMID:18818364
negative genetic interaction withclr3histone deacetylase (class II) Clr3 Negative GeneticPMID:18818364
negative genetic interaction withcph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Negative GeneticPMID:18818364
negative genetic interaction withcsn1COP9/signalosome complex subunit Csn1 Negative GeneticPMID:18818364
negative genetic interaction withdad1DASH complex subunit Dad1 Negative GeneticPMID:18818364
negative genetic interaction withdbr1RNA lariat debranching enzyme Dbr1 Negative GeneticPMID:18818364
negative genetic interaction withdeg1tRNA-pseudouridine synthase Deg1 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withelp3elongator complex subunit Elp3 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withelp5elongator complex subunit Elp5 (predicted) Negative GeneticPMID:18818364
negative genetic interaction witheme1Holliday junction resolvase subunit Eme1 Negative GeneticPMID:18818364
negative genetic interaction withfin1serine/threonine protein kinase, NIMA related Fin1 Negative GeneticPMID:18818364
negative genetic interaction withgcn5SAGA complex histone acetyltransferase catalytic subunit Gcn5 Negative GeneticPMID:18818364
negative genetic interaction withgfh1gamma tubulin complex subunit Gfh1 Negative GeneticPMID:18818364
positive genetic interaction withgmh5alpha-1,2-galactosyltransferase (predicted) Positive GeneticPMID:18818364
synthetic growth defect withhap2HMG box protein (predicted) Synthetic Growth DefectPMID:25701403
negative genetic interaction withhhf1histone H4 h4.1 Negative GeneticPMID:18818364
negative genetic interaction withhhf2histone H4 h4.2 Negative GeneticPMID:18818364
negative genetic interaction withhif2Set3 complex subunit Hif2 Negative GeneticPMID:18818364
negative genetic interaction withhip1hira protein, histone chaperone Hip1 Negative GeneticPMID:18818364
negative genetic interaction withhip4histone promoter control protein Hip4 Negative GeneticPMID:18818364
negative genetic interaction withhos2histone deacetylase (class I) Hos2 Negative GeneticPMID:18818364
negative genetic interaction withklp6kinesin-like protein Klp6 Negative GeneticPMID:18818364
negative genetic interaction withlsk1P-TEFb-associated cyclin-dependent protein kinase Lsk1 Negative GeneticPMID:18818364
negative genetic interaction withmad1mitotic spindle checkpoint protein Mad1 Negative GeneticPMID:18818364
negative genetic interaction withmcl1DNA polymerase alpha accessory factor Mcl1 Negative GeneticPMID:18818364
negative genetic interaction withmed7mediator complex subunit Med7 Negative GeneticPMID:18818364
negative genetic interaction withmga2IPT/TIG ankyrin repeat containing transcription regulator of fatty acid biosynthesis (predicted) Negative GeneticPMID:18818364
negative genetic interaction withmms19Dos2 silencing complex subunit Mms19 Negative GeneticPMID:18818364
negative genetic interaction withmph1dual specificity protein kinase Mph1 Negative GeneticPMID:18818364
negative genetic interaction withmrc1mediator of replication checkpoint 1 Negative GeneticPMID:18818364
negative genetic interaction withmsn5karyopherin (predicted) Negative GeneticPMID:18818364
negative genetic interaction withmug154conserved fungal protein Negative GeneticPMID:18818364
negative genetic interaction withngg1SAGA complex subunit Ngg1 Negative GeneticPMID:18818364
synthetic growth defect withnht1Ino80 complex HMG box subunit Nht1 Synthetic Growth DefectPMID:25701403
negative genetic interaction withnot2CCR4-Not complex subunit Not2 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withnot3CCR4-Not complex subunit Not3/5 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withnto1histone acetyltransferase complex subunit Nto1 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withpar1protein phosphatase regulatory subunit Par1 Negative GeneticPMID:18818364
negative genetic interaction withpef1Pho85/PhoA-like cyclin-dependent kinase Pef1 Negative GeneticPMID:18818364
negative genetic interaction withpho24-nitrophenylphosphatase Negative GeneticPMID:18818364
positive genetic interaction withpht1histone H2A variant H2A.Z, Pht1 Positive GeneticPMID:18818364
negative genetic interaction withpng2ING family homolog Png2 Negative GeneticPMID:18818364
negative genetic interaction withpom1DYRK family protein kinase Pom1 Negative GeneticPMID:18818364
negative genetic interaction withppk16serine/threonine protein kinase Ppk16 (predicted) Negative GeneticPMID:18818364
positive genetic interaction withppk30Ark1/Prk1 family protein kinase Ppk30 Positive GeneticPMID:18818364
negative genetic interaction withpuf3RNA-binding protein Puf3 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withreb1RNA polymerase I transcription termination factor/ RNA polymerase II transcription factor Reb1 Negative GeneticPMID:18818364
enhances phenotype ofres1MBF transcription factor complex subunit Res1 Phenotypic EnhancementPMID:19547744
positive genetic interaction withres2MBF transcription factor complex subunit Res2 Positive GeneticPMID:18818364
negative genetic interaction withrhn1RNA polymerase II transcription termination factor homolog Negative GeneticPMID:18818364
negative genetic interaction withrhp14XP-A family homolog Rhp14 Negative GeneticPMID:18818364
negative genetic interaction withrnc1RNA-binding protein that suppresses calcineurin deletion Rnc1 Negative GeneticPMID:18818364
negative genetic interaction withrok1ATP-dependent RNA helicase Rok1 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withrpa12DNA-directed RNA polymerase complex I subunit Rpa12 Negative GeneticPMID:18818364
negative genetic interaction withrsc4RSC complex subunit Rsc4 Negative GeneticPMID:18818364
negative genetic interaction withsdc1Dpy-30 domain protein Sdc1 Negative GeneticPMID:18818364
negative genetic interaction withsec28coatomer epsilon subunit (predicted) Negative GeneticPMID:18818364
negative genetic interaction withser2phosphoserine phosphatase Ser2 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withset1histone lysine methyltransferase Set1 Negative GeneticPMID:18818364
negative genetic interaction withset11ribosomal protein lysine methyltransferase Set11 Negative GeneticPMID:18818364
negative genetic interaction withset3histone lysine methyltransferase Set3 Negative GeneticPMID:18818364
negative genetic interaction withsgf29SAGA complex subunit Sgf29 Negative GeneticPMID:18818364
negative genetic interaction withski2Ski complex RNA helicase Ski2 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withSPBC16C6.05mitochondrial translation initiation factor (predicted) Negative GeneticPMID:18818364
negative genetic interaction withSPBC1861.07elongin C (predicted) Negative GeneticPMID:18818364
negative genetic interaction withSPBC31F10.10czf-MYND type zinc finger protein Negative GeneticPMID:18818364
negative genetic interaction withSPBC36B7.08cnucleosome assembly protein (predicted) Negative GeneticPMID:18818364
negative genetic interaction withspc34DASH complex subunit Spc34 Negative GeneticPMID:18818364
negative genetic interaction withSPCC18.10pyridoxine-pyridoxal-pyridoxamine kinase (predicted) Negative GeneticPMID:18818364
negative genetic interaction withSPCC1919.13cribosome biogenesis protein (predicted) Negative GeneticPMID:18818364
negative genetic interaction withspf1Set1C PHD Finger protein Spf1 Negative GeneticPMID:18818364
negative genetic interaction withspp27RNA polymerase I upstream activation factor complex subunit Spp27 Negative GeneticPMID:18818364
negative genetic interaction withssu72phosphoric ester hydrolase Ssu72 (predicted) Negative GeneticPMID:18818364
positive genetic interaction withswc2Swr1 complex complex subunit Swc2 Positive GeneticPMID:18818364
positive genetic interaction withswc5Swr1 complex subunit Swc5 Positive GeneticPMID:18818364
negative genetic interaction withswd2Set1C complex subunit Swd2.1 Negative GeneticPMID:18818364
negative genetic interaction withswd22mRNA cleavage and polyadenylation specificity factor complex subunit, WD repeat protein Swd22 Negative GeneticPMID:18818364
negative genetic interaction withswd3WD repeat protein Swd3 Negative GeneticPMID:18818364
positive genetic interaction withswr1SNF2 family ATP-dependent DNA helicase Swr1 Positive GeneticPMID:18818364
negative genetic interaction withtim13TIM22 inner membrane protein import complex subunit Tim13 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withtma20RNA-binding protein Tma20 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withtop1DNA topoisomerase I Negative GeneticPMID:18818364
positive genetic interaction withubc6ubiquitin conjugating enzyme E2 Ubc6 (predicted) Positive GeneticPMID:18818364
positive genetic interaction withvps71Swr1 complex subunit Vps71 Positive GeneticPMID:18818364
negative genetic interaction withwis2cyclophilin family peptidyl-prolyl cis-trans isomerase Wis2 Negative GeneticPMID:18818364
External References
Database Identifier Description
NBRP SPAC17G8.07 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC17G8.07 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC17G8.07 BioGRID Interaction Datasets
Expression Viewer SPAC17G8.07 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC17G8.07 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC17G8.07 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC17G8.07 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC17G8.07 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC17G8.07 Transcriptome Viewer (Bähler Lab)
GEO SPAC17G8.07 GEO profiles
PInt SPAC17G8.07 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC17G8.07 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC17G8.07 Fission yeast phenotypic data & analysis
Cyclebase SPAC17G8.07.1 Cell Cycle Data
SPD / RIKEN07/07E08Orfeome Localization Data
UniProtKB/SwissProtQ10319Protein AF-9 homolog
ModBaseQ10319Database of comparative protein structure models
STRINGQ10319Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_593730YEATS family histone acetyltransferase subunit Yaf9
RefSeq mRNANM_001019161972h- YEATS family histone acetyltransferase subunit Yaf9 (yaf9), mRNA
European Nucleotide ArchiveCAA93690.1ENA Protein Mapping
UniParcUPI000013A88DUniProt Archive

Literature for yaf9

Search: Europe PMC or PubMed

Release Version: PomBase:26_53 - 27 May 2015