fmt1 (SPAC1805.09c)

Gene Standard Namefmt1 Characterisation Statusbiological role inferred
Systematic IDSPAC1805.09c Feature Typeprotein coding
Synonyms Name Description
Productmitochondrial methionyl-tRNA formyltransferase Fmt1 (predicted) Product Size340aa, 38.04 kDa
Genomic Location Chromosome I, 2791285-2790112 (1174nt); CDS:2791221-2790199 (1023nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
methionyl-tRNA formyltransferase activity1
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
GO Cellular Component
Term NameCount
Annotation ExtensionEvidenceWith/FromReference
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Single-allele Phenotypes

Population Phenotype

Term NameGenotypesCount
viable vegetative cell populationfmt1Δ3815

Cell Phenotype

Term NameGenotypesCount
viable vegetative cell with normal cell morphologyfmt1Δ3095
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
5' UTR2791285..2791222PMID:21511999
3' UTR2790198..2790112PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF02911 Pfam IPR005793 Formyl transferase, C-terminal 228 327 1
PF00551 Pfam IPR002376 Formyl transferase, N-terminal 82 167 2
PTHR11138:SF2 HMMPANTHER 1 331 1
PTHR11138 HMMPANTHER IPR015518 Methionine tRNA Formyltransferase-like 1 331 1 Gene3D IPR005793 Formyl transferase, C-terminal 232 309 1 Gene3D IPR002376 Formyl transferase, N-terminal 6 182 2
SSF50486 SuperFamily IPR011034 Formyl transferase, C-terminal-like 229 327 1
SSF53328 SuperFamily IPR002376 Formyl transferase, N-terminal 5 182 2

View domain organization at Pfam

Protein Properties

Ave. residue weight 111.89 Da
Charge 18.00
Codon Adpatation Index 0.31
Isoelectric point 10.10
Molecular weight 38.04 kDa
Number of residues 340
Gene Expression

Qualitative Gene Expression

RNA levelincreased during GO:0071470expression microarray evidencePMID:12529438

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
2992during GO:0000080PECO:0000005,
single cellmass spectrometry evidencePMID:24763107
3488during GO:0000084PECO:0000005,
single cellmass spectrometry evidencePMID:24763107
3111during GO:0000085PECO:0000005,
single cellmass spectrometry evidencePMID:24763107
3295during GO:0000087PECO:0000005,
single cellmass spectrometry evidencePMID:24763107
3480during GO:0072690PECO:0000005,
single cellmass spectrometry evidencePMID:24763107

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
0.19during GO:0072690PECO:0000014,
population wideexperimental evidencePMID:23101633
0.058during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
predominantly single copy (one to one)3090
conserved in fungi4604
conserved in eukaryotes4514
conserved in bacteria1000
conserved in metazoa3421
conserved in vertebrates3396

Manually curated orthologous groups


Orthologs in Compara

Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
positive genetic interaction withcph2Clr6 histone deacetylase associated PHD protein-2 Cph2 Positive GeneticPMID:22681890
negative genetic interaction withdmc1RecA family ATPase Dmc1 Negative GeneticPMID:22681890
positive genetic interaction withelp2elongator complex subunit Elp2 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withhip4histone promoter control protein Hip4 Positive GeneticPMID:22681890
positive genetic interaction withhop1linear element associated protein Hop1 Positive GeneticPMID:22681890
negative genetic interaction withprp4serine/threonine protein kinase Prp4 Negative GeneticPMID:22681890
positive genetic interaction withprw1Clr6 histone deacetylase complex subunit Prw1 Positive GeneticPMID:22681890
positive genetic interaction withres1MBF transcription factor complex subunit Res1 Positive GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPAC1805.09c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC1805.09c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC1805.09c BioGRID Interaction Datasets
Expression Viewer SPAC1805.09c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC1805.09c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC1805.09c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC1805.09c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC1805.09c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC1805.09c Transcriptome Viewer (Bähler Lab)
GEO SPAC1805.09c GEO profiles
PInt SPAC1805.09c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC1805.09c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC1805.09c Fission yeast phenotypic data & analysis
Cyclebase SPAC1805.09c.1 Cell Cycle Data
SPD / RIKEN15/15C11Orfeome Localization Data
UniProtKB/SwissProtQ9UTG6Putative methionyl-tRNA formyltransferase
ModBaseQ9UTG6Database of comparative protein structure models
STRINGQ9UTG6Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_593920methionyl-tRNA formyltransferase Fmt1 (predicted)
RefSeq mRNANM_001019349972h- methionyl-tRNA formyltransferase Fmt1 (predicted) (fmt1), mRNA
European Nucleotide ArchiveCU329670ENA EMBL mapping
European Nucleotide ArchiveCAB55850ENA Protein Mapping
European Nucleotide ArchiveCAB55850.1ENA Protein Mapping
KEGG00670+ carbon pool by folate
KEGG00970+ biosynthesis
UniParcUPI000012AB09UniProt Archive

Literature for fmt1

Search: Europe PMC or PubMed

Release Version: PomBase:28_55 - 09 Sep 2015