fmt1 (SPAC1805.09c)


Gene Standard Namefmt1 Characterisation Statusbiological_role_inferred
Systematic IDSPAC1805.09c Feature Typeprotein coding
Synonyms Name Description
Productmethionyl-tRNA formyltransferase Fmt1 (predicted) Product Size340aa, 38.04 kDa
Genomic Location Chromosome I, 2791285-2790112 (1174nt); CDS:2791221-2790199 (1023nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0004479methionyl-tRNA formyltransferase activityISOSGD:S000000109GO_REF:00000241
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0071951conversion of methionyl-tRNA to N-formyl-methionyl-tRNAISOSGD:S000000109GO_REF:00000241
GO:0032543mitochondrial translationNASGO_REF:0000051143
GO:0006413translational initiationISOSGD:S000000109GO_REF:000002448
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005737cytoplasmIDAPMID:168233724198
GO:0005739mitochondrionISOSGD:S000000109GO_REF:0000024756
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopyfmt1ΔNullPECO:0000005, PECO:0000137PMID:236978063755
Microscopyfmt1ΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphologyMicroscopyfmt1ΔNullPECO:0000005, PECO:0000137PMID:236978063078
penetrance FYPO_EXT:0000001
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
127912852790112

UTRs

Region Start End Reference
three_prime_UTR27901982790112PMID:21511999
five_prime_UTR27912852791222PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF02911 Pfam IPR005793 Formyl transferase, C-terminal 228 325 1
PF00551 Pfam IPR002376 Formyl transferase, N-terminal 82 167 2
PTHR11138 HMMPANTHER IPR015518 Methionine tRNA Formyltransferase-like 1 325 1
G3DSA:3.40.50.170 Gene3D IPR002376 6 182 2
G3DSA:3.10.25.10 Gene3D IPR005793 232 309 1
SSF53328 SuperFamily IPR002376 5 182 2
SSF50486 SuperFamily IPR011034 229 327 1
Low complexity (SEG) seg 291 302

View domain organization at Pfam

Protein Properties

Ave. residue weight 111.89 Da
Charge 18.00
Isoelectric point 10.10
Molecular weight 38.04 kDa
Number of residues 340
Sequence
Gene Expression

Qualitative Gene Expression

DescriptionLevelEvidenceReference
RNA levelincreasedexpression microarray evidencePMID:12529438
during GO:0071470

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
NDduring cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
NDduring GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
0.058during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
0.19during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3080
conserved in fungi4564
conserved in eukaryotes4482
conserved in bacteria1001
conserved in metazoa3419
conserved in vertebrates3394
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
res1MBF transcription factor complex subunit Res1 Positive GeneticPMID:22681890
dmc1RecA family ATPase Dmc1 Negative GeneticPMID:22681890
prp4serine/threonine protein kinase Prp4 Negative GeneticPMID:22681890
prw1Clr6 histone deacetylase complex subunit Prw1 Positive GeneticPMID:22681890
cph2Clr6 histone deacetylase associated PHD protein-2 Cph2 Positive GeneticPMID:22681890
elp2elongator complex subunit Elp2 (predicted) Positive GeneticPMID:22681890
hip4histone promoter control protein Hip4 Positive GeneticPMID:22681890
hop1linear element associated protein Hop1 Positive GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPAC1805.09c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC1805.09c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC1805.09c BioGRID Interaction Datasets
Expression Viewer SPAC1805.09c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC1805.09c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC1805.09c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC1805.09c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC1805.09c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC1805.09c Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC1805.09c Cell Cycle Data
GEO SPAC1805.09c GEO profiles
PInt SPAC1805.09c Protein-Protein Interaction Predictor (Bähler Lab)
WikiGene2542294methionyl-tRNA formyltransferase Fmt1 (predicted)
EntrezGene2542294methionyl-tRNA formyltransferase Fmt1 (predicted)
SPD / RIKEN15/15C11Orfeome Localization Data
UniProtKB/SwissProtQ9UTG6Putative methionyl-tRNA formyltransferase
ModBaseQ9UTG6Database of comparative protein structure models
StringQ9UTG6Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_593920methionyl-tRNA formyltransferase Fmt1 (predicted)
RefSeq mRNANM_001019349972h- methionyl-tRNA formyltransferase Fmt1 (predicted) (fmt1), mRNA
European Nucleotide ArchiveCAB55850ENA Protein Mapping
UniParcUPI000012AB09UniProt Archive

Literature for fmt1

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014