uep1 (SPAC1805.12c)


Gene Standard Nameuep1 Characterisation Statuspublished
Systematic IDSPAC1805.12c Feature Typeprotein coding
Synonymsubi2 Name Description
Productribosomal-ubiquitin fusion protein Ubi2 Product Size128aa, 14.60 kDa
Genomic Location Chromosome I, 2794801-2794057 (745nt); CDS:2794724-2794338 (387nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0003735structural constituent of ribosomeISOSGD:S000001410GO_REF:0000024255
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0002181cytoplasmic translationNASGO_REF:0000051445
GO:0042254ribosome biogenesisISOSGD:S000001410GO_REF:0000024325
GO:0006412translationISOSGD:S000001410GO_REF:0000024597
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005829cytosolIDAPMID:168233722316
GO:0022625cytosolic large ribosomal subunitISOSGD:S000001410GO_REF:000002482
GO:0005730nucleolusIDAPMID:16823372355
GO:0005634nucleusIDAPMID:168233722740
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopyuep1ΔNullPMID:204732893730
Microscopyuep1ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphology3088
penetrance FYPO_EXT:0000001Microscopyuep1ΔNullPECO:0000005, PECO:0000137PMID:23697806
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
127948012794057

UTRs

Region Coordinates Reference
five_prime_UTR2794801..2794725PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF01020 Pfam IPR001975 Ribosomal protein L40e 78 128 2
PF00240 Pfam IPR000626 Ubiquitin-like 6 74 14
SM00213 SMART IPR000626 Ubiquitin-like 1 72 13
PS00299 Prosite Patterns IPR019954 Ubiquitin conserved site 27 52 7
PS50053 Prosite Profiles IPR000626 Ubiquitin-like 1 76 18
PTHR10666 HMMPANTHER 1 128 6
3.10.20.90 Gene3D 1 96 28
SSF54236 SuperFamily IPR029071 Ubiquitin-related domain 1 95 29
PR00348 PRINTS IPR019956 Ubiquitin 11 31 6
PR00348 PRINTS IPR019956 Ubiquitin 53 74 6
PR00348 PRINTS IPR019956 Ubiquitin 32 52 6

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0001447ubiquitin family proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0001447
PBO:0001733ribosomal-ubiquitin fusion proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0001733

Protein Properties

Ave. residue weight 114.02 Da
Charge 15.00
Isoelectric point 10.48
Molecular weight 14.60 kDa
Number of residues 128
Modifications

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
MOD:00046O-phospho-L-serineIDAS57PMID:182575171669
present during cellular response to thiabendazole
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
NDduring GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
NDduring cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
42during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
5.2during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3080
conserved in fungi4569
conserved in eukaryotes4482
conserved in metazoa3419
conserved in vertebrates3393
conserved in eukaryotes only2487
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
SPBC31F10.10czf-MYND type zinc finger protein Positive GeneticPMID:22681890
res1MBF transcription factor complex subunit Res1 Negative GeneticPMID:22681890
ppk14serine/threonine protein kinase Ppk14 (predicted) Negative GeneticPMID:22681890
efc25Ras1 guanyl-nucleotide exchange factor Efc25 Negative GeneticPMID:22681890
arp42SWI/SNF and RSC complex subunit Arp42 Positive GeneticPMID:22681890
prp1U4/U6 x U5 tri-snRNP complex subunit Prp1 Negative GeneticPMID:22681890
vph2endoplasmic reticulum membrane protein involved in assembly of the V-ATPase (predicted) Positive GeneticPMID:22681890
pst2Clr6 histone deacetylase complex subunit Pst2 Negative GeneticPMID:22681890
sum2G2/M transition checkpoint protein Sum2 Negative GeneticPMID:22681890
dsc3Golgi Dsc E3 ligase complex subunit Dsc3 Negative GeneticPMID:21504829
SPAC227.14uridine kinase (predicted) Positive GeneticPMID:22681890
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
rpn1019S proteasome regulatory subunit Rpn10 Co-crystal or NMR structurePMID:20739285
bdf2BET family double bromodomain protein Bdf2 Affinity Capture-MSPMID:24013502
rhp23Rad23 homolog Rhp23 Two-hybridPMID:11788722
External References
Database Identifier Description
NBRP SPAC1805.12c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC1805.12c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC1805.12c BioGRID Interaction Datasets
Expression Viewer SPAC1805.12c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC1805.12c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC1805.12c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC1805.12c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC1805.12c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC1805.12c Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC1805.12c Cell Cycle Data
GEO SPAC1805.12c GEO profiles
PInt SPAC1805.12c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC1805.12c Peptides identified in tandem mass spectrometry proteomics experiments
SPD / RIKEN51/51A12Orfeome Localization Data
WikiGene2542428ribosomal-ubiquitin fusion protein Ubi2
WikiGene2541768ribosomal-ubiquitin fusion protein Ubi1
EntrezGene2542428ribosomal-ubiquitin fusion protein Ubi2
EntrezGene2541768ribosomal-ubiquitin fusion protein Ubi1
UniProtKB/SwissProtP0CH06Ubiquitin-60S ribosomal protein L40
ModBaseP0CH06Database of comparative protein structure models
STRINGP0CH06Network display of known and predicted interactions and functional associations
UniProtKB/SwissProtP0CH07Ubiquitin-60S ribosomal protein L40
ModBaseP0CH07Database of comparative protein structure models
STRINGP0CH07Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_593923ribosomal-ubiquitin fusion protein Ubi2
RefSeq mRNANM_001019352972h- ribosomal-ubiquitin fusion protein Ubi2 (uep1), mRNA
ePDB4II2The European PDB
PDB4II2PDB
PDBsum4II2PDBsum
ePDB4II3The European PDB
PDB4II3PDB
PDBsum4II3PDBsum
European Nucleotide ArchiveCAB16209ENA Protein Mapping
European Nucleotide ArchiveCAB16209.1ENA Protein Mapping
European Nucleotide ArchiveCAB55853ENA Protein Mapping
European Nucleotide ArchiveCAB55853.1ENA Protein Mapping
ReactomeREACT_188294
ReactomeREACT_188524
ReactomeREACT_188542
ReactomeREACT_188549
ReactomeREACT_188560
ReactomeREACT_188568
ReactomeREACT_206850
ReactomeREACT_208775
ReactomeREACT_215140
ReactomeREACT_215320
ReactomeREACT_215930
ReactomeREACT_218991
ReactomeREACT_81558
UniParcUPI0000069E71UniProt Archive

Literature for uep1

Search: Europe PMC or PubMed

Release Version: PomBase:22_45 - 08 Aug 2014