uep1 (SPAC1805.12c)


Gene Standard Nameuep1 Characterisation Statuspublished
Systematic IDSPAC1805.12c Feature Typeprotein coding
Synonymsubi2 Name Description
Productribosomal-ubiquitin fusion protein Ubi2 Product Size128aa, 14.60 kDa
Genomic Location Chromosome I, 2794801-2794057 (745nt); CDS:2794724-2794338 (387nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0003735structural constituent of ribosomeISOSGD:S000001410GO_REF:0000024255
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0006281DNA repairIEAUniProtKB-KW:KW-0234GO_REF:0000037203
GO:0002181cytoplasmic translationNASGO_REF:0000051445
GO:0042254ribosome biogenesisISOSGD:S000001410GO_REF:0000024327
GO:0006412translationISOSGD:S000001410GO_REF:0000024597
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005829cytosolIDAPMID:168233722317
GO:0022625cytosolic large ribosomal subunitISOSGD:S000001410GO_REF:000002482
GO:0005730nucleolusIDAPMID:16823372345
GO:0005634nucleusIDAPMID:168233722730
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopyuep1ΔNullPMID:204732893755
Microscopyuep1ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphologyMicroscopyuep1ΔNullPECO:0000005, PECO:0000137PMID:236978063078
penetrance FYPO_EXT:0000001
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
127948012794057

UTRs

Region Start End Reference
five_prime_UTR27948012794725PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF01020 Pfam IPR001975 Ribosomal protein L40e 78 128 2
PF00240 Pfam IPR000626 Ubiquitin domain 6 74 15
SM00213 SMART IPR000626 Ubiquitin domain 1 72 16
PS50053 Prosite Profiles IPR000626 Ubiquitin domain 1 76 18
PS00299 Prosite Patterns IPR019954 Ubiquitin domain 27 52 7
PTHR10666 HMMPANTHER 1 128 6
G3DSA:3.10.20.90 Gene3D 1 96 26
SSF54236 SuperFamily 1 95 29
PR00348 PRINTS IPR019956 Ubiquitin 53 74 6
PR00348 PRINTS IPR019956 Ubiquitin 32 52 6
PR00348 PRINTS IPR019956 Ubiquitin 11 31 6

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0001447ubiquitin family proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0001447
PBO:0001733ribosomal-ubiquitin fusion proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0001733

Protein Properties

Ave. residue weight 114.02 Da
Charge 15.00
Isoelectric point 10.48
Molecular weight 14.60 kDa
Number of residues 128
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
NDduring cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
NDduring GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
42during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
5.2during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3080
conserved in fungi4564
conserved in eukaryotes4482
conserved in metazoa3419
conserved in vertebrates3394
conserved in eukaryotes only2485
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
SPBC31F10.10czf-MYND type zinc finger protein Positive GeneticPMID:22681890
res1MBF transcription factor complex subunit Res1 Negative GeneticPMID:22681890
ppk14serine/threonine protein kinase Ppk14 (predicted) Negative GeneticPMID:22681890
efc25Ras1 guanyl-nucleotide exchange factor Efc25 Negative GeneticPMID:22681890
arp42SWI/SNF and RSC complex subunit Arp42 Positive GeneticPMID:22681890
prp1U4/U6 x U5 tri-snRNP complex subunit Prp1 Negative GeneticPMID:22681890
vph2endoplasmic reticulum membrane protein involved in assembly of the V-ATPase (predicted) Positive GeneticPMID:22681890
pst2Clr6 histone deacetylase complex subunit Pst2 Negative GeneticPMID:22681890
sum2G2/M transition checkpoint protein Sum2 Negative GeneticPMID:22681890
dsc3Golgi Dsc E3 ligase complex subunit Dsc3 Negative GeneticPMID:21504829
SPAC227.14uridine kinase (predicted) Positive GeneticPMID:22681890
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
rpn1019S proteasome regulatory subunit Rpn10 Co-crystal StructurePMID:20739285
bdf2BET family double bromodomain protein Bdf2 Affinity Capture-MSPMID:24013502
rhp23Rad23 homolog Rhp23 Two-hybridPMID:11788722
External References
Database Identifier Description
NBRP SPAC1805.12c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC1805.12c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC1805.12c BioGRID Interaction Datasets
Expression Viewer SPAC1805.12c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC1805.12c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC1805.12c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC1805.12c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC1805.12c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC1805.12c Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC1805.12c Cell Cycle Data
GEO SPAC1805.12c GEO profiles
PInt SPAC1805.12c Protein-Protein Interaction Predictor (Bähler Lab)
SPD / RIKEN51/51A12Orfeome Localization Data
WikiGene2542428ribosomal-ubiquitin fusion protein Ubi2
WikiGene2541768ribosomal-ubiquitin fusion protein Ubi1
EntrezGene2542428ribosomal-ubiquitin fusion protein Ubi2
EntrezGene2541768ribosomal-ubiquitin fusion protein Ubi1
UniProtKB/SwissProtP0CH06Ubiquitin-60S ribosomal protein L40 Ubiquitin 60S ribosomal protein L40
ModBaseP0CH06Database of comparative protein structure models
StringP0CH06Network display of known and predicted interactions and functional associations
UniProtKB/SwissProtP0CH07Ubiquitin-60S ribosomal protein L40 Ubiquitin 60S ribosomal protein L40
ModBaseP0CH07Database of comparative protein structure models
StringP0CH07Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_593923ribosomal-ubiquitin fusion protein Ubi2
RefSeq mRNANM_001019352972h- ribosomal-ubiquitin fusion protein Ubi2 (uep1), mRNA
European Nucleotide ArchiveCAB16209ENA Protein Mapping
European Nucleotide ArchiveCAB55853ENA Protein Mapping
UniParcUPI0000069E71UniProt Archive

Literature for uep1

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014