hhf1 (SPAC1834.03c)

Gene Standard Namehhf1 Characterisation Statuspublished
Systematic IDSPAC1834.03c Feature Typeprotein coding
Synonymsh4.1 Name Description
Producthistone H4 h4.1 Product Size103aa, 11.42 kDa
Genomic Location Chromosome I, 4699544-4698773 (772nt); CDS:4699396-4699085 (312nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
DNA binding381
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
nucleosome assembly28
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
nuclear nucleosome10
Annotation ExtensionEvidenceWith/FromReference
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
viable vegetative cell populationhhf1ΔNull3781

Cell Phenotype

Term NameAlleleExpressionCount
viable vegetative cell with normal cell morphology3092
penetrance FYPO_EXT:0000001hhf1ΔNull
Target Of
FYPO affected by mutation in ams2 cell cycle regulated GATA-type transcription factor Ams2 PMID:20230746
FYPO affected by mutation in ams2 cell cycle regulated GATA-type transcription factor Ams2 PMID:17452352
FYPO affected by mutation in hip1 hira protein, histone chaperone Hip1 PMID:17452352
FYPO affected by mutation in hsk1 Dbf4(Dfp1)-dependent protein kinase Hsk1 PMID:20230746
FYPO affected by mutation in pdp1 PWWP domain protein Pdp1 PMID:19250904
FYPO affected by mutation in set9 histone lysine H3-K20 methyltransferase Set9 PMID:19250904
FYPO affected by mutation in slm9 hira protein Slm9 PMID:17452352
GO regulated by ams2 cell cycle regulated GATA-type transcription factor Ams2 PMID:17452352
GO regulated by ams2 cell cycle regulated GATA-type transcription factor Ams2 PMID:20230746
Ensembl transcript structure with UTRs, exons and introns


Exon Start End
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00125 Pfam IPR007125 Histone core 28 94 11
SM00417 SMART IPR001951 Histone H4 16 90 3
PS00047 Prosite Patterns IPR019809 Histone H4, conserved site 15 19 3
PTHR10484 HMMPANTHER 1 103 5 Gene3D IPR009072 Histone-fold 2 103 27
SSF47113 SuperFamily IPR009072 Histone-fold 3 102 26
PR00623 PRINTS IPR001951 Histone H4 40 60 3
PR00623 PRINTS IPR001951 Histone H4 89 100 3
PR00623 PRINTS IPR001951 Histone H4 77 89 3
PR00623 PRINTS IPR001951 Histone H4 5 16 3
PR00623 PRINTS IPR001951 Histone H4 20 39 3
PR00623 PRINTS IPR001951 Histone H4 62 76 3

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0000297histone foldTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000297

Protein Properties

Ave. residue weight 110.91 Da
Charge 19.00
Isoelectric point 11.91
Molecular weight 11.42 kDa
Number of residues 103
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
181226during GO:0000080PECO:0000126,
single cellmass spectrometry evidencePMID:24763107
202963during GO:0000084PECO:0000126,
single cellmass spectrometry evidencePMID:24763107
170140during GO:0000085PECO:0000126,
single cellmass spectrometry evidencePMID:24763107
190516during GO:0000087PECO:0000126,
single cellmass spectrometry evidencePMID:24763107
201432during GO:0072690PECO:0000126,
single cellmass spectrometry evidencePMID:24763107

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
28during GO:0072690PECO:0000005,
population wideexperimental evidencePMID:23101633
3.4during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population wideexperimental evidencePMID:23101633
Species Distribution
conserved in fungi4604
conserved in eukaryotes4516
conserved in metazoa3432
conserved in vertebrates3407
conserved in eukaryotes only2503

Manually curated orthologous groups


Orthologs in Compara

Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
rng2IQGAP Affinity Capture-MSPMID:20603077
rik1silencing protein Rik1 Affinity Capture-MSPMID:17114925
tea1cell end marker Tea1 Affinity Capture-MSPMID:21652630
red5human ZC3H3 homolog Affinity Capture-MSPMID:24713849
hat1histone acetyltransferase Hat1 Biochemical ActivityPMID:22771823
set9histone lysine H3-K20 methyltransferase Set9 Biochemical ActivityPMID:15550243
nts1Schizosaccharomyces specific protein Affinity Capture-MSPMID:25002536
rna1Ran GAP Rna1 Reconstituted ComplexPMID:16540522
pdp1PWWP domain protein Pdp1 Affinity Capture-WesternPMID:19250904
hhp1serine/threonine protein kinase Hhp1 Affinity Capture-MSPMID:24055157
rmn1RNA-binding protein Affinity Capture-MSPMID:24713849
crb2DNA repair protein Rad9 homolog, Rhp9 Reconstituted ComplexPMID:18826944
cyk3cytokinesis protein Cyk3 (predicted) Affinity Capture-MSPMID:20603077
cbf11CBF1/Su(H)/LAG-1 family transcription factor Cbf11 Affinity Capture-MSPMID:22540037
bdf2BET family double bromodomain protein Bdf2 Protein-peptidePMID:24013502
spt16FACT complex subunit Spt16 Reconstituted ComplexPMID:18579787
cia1histone chaperone Cia1 Affinity Capture-MSPMID:21211723
red1RNA elimination defective protein Red1 Affinity Capture-MSPMID:24713849
mtl1TRAMP complex ATP-dependent RNA helicase (predicted) Affinity Capture-MSPMID:24713849
air1zinc knuckle TRAMP complex subunit Air1 Affinity Capture-MSPMID:20403971
hhp2serine/threonine protein kinase Hhp2 Affinity Capture-MSPMID:24055157
sir2Sir2 family histone deacetylase Sir2 Biochemical ActivityPMID:24013502
Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
ams2cell cycle regulated GATA-type transcription factor Ams2 Dosage RescuePMID:12535531
Negative GeneticPMID:22681890
vps35retromer complex subunit Vps35 Positive GeneticPMID:22681890
cbp1CENP-B homolog Positive GeneticPMID:18818364
hip1hira protein, histone chaperone Hip1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
yaf9YEATS family histone acetyltransferase subunit Yaf9 Negative GeneticPMID:18818364
elp5elongator complex subunit Elp5 (predicted) Negative GeneticPMID:18818364
SPAC186.05chuman TMEM165 homolog, congenital disorders of glycosylation Positive GeneticPMID:22681890
nup132nucleoporin Nup132 Negative GeneticPMID:22681890
pfl9cell surface glycoprotein (predicted), DIPSY family Negative GeneticPMID:22681890
acp2F-actin capping protein beta subunit Acp2 Negative GeneticPMID:22681890
apc10anaphase-promoting complex subunit Apc10 Negative GeneticPMID:22681890
rok1ATP-dependent RNA helicase Rok1 (predicted) Negative GeneticPMID:22681890
gar2nucleolar protein required for rRNA processing Negative GeneticPMID:22681890
ask1DASH complex subunit Ask1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
fml2ATP-dependent 3' to 5' DNA helicase (predicted) Positive GeneticPMID:22681890
epe1Jmjc domain chromatin associated protein Epe1 Phenotypic SuppressionPMID:24013502
dad2DASH complex subunit Dad2 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
SPAC977.13cNegative GeneticPMID:22681890
cnp1centromere-specific histone H3 CENP-A Dosage RescuePMID:25298518
Dosage RescuePMID:12535531
mcl1DNA polymerase alpha accessory factor Mcl1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
bdf2BET family double bromodomain protein Bdf2 Phenotypic SuppressionPMID:24013502
rpl160160S ribosomal protein L13/L16 (predicted) Negative GeneticPMID:22681890
srb10cyclin-dependent protein Srb mediator subunit kinase Srb10 Negative GeneticPMID:22681890
cay1cactin, spliceosome complex subunit (predicted) Negative GeneticPMID:18818364
hip4histone promoter control protein Hip4 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
spc34DASH complex subunit Spc34 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
SPBC1348.07S. pombe specific DUF999 protein family 6 Positive GeneticPMID:22681890
srb11cyclin CycC, Srb mediator subunit Srb11 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
pab2poly(A) binding protein Pab2 Negative GeneticPMID:22681890
SPAC25B8.08conserved fungal protein Positive GeneticPMID:22681890
pof3F-box protein Pof3 Negative GeneticPMID:22681890
hhf2histone H4 h4.2 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
SPBC36B7.08cnucleosome assembly protein (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
pom1DYRK family protein kinase Pom1 Positive GeneticPMID:18818364
ryh1GTPase Ryh1 Positive GeneticPMID:22681890
sds23PP2A-type phosphatase inhibitor Sds23/Moc1 Negative GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPAC1834.03c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC1834.03c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC1834.03c BioGRID Interaction Datasets
Expression Viewer SPAC1834.03c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC1834.03c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC1834.03c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC1834.03c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC1834.03c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC1834.03c Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC1834.03c Cell Cycle Data
GEO SPAC1834.03c GEO profiles
PInt SPAC1834.03c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC1834.03c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC1834.03c Fission yeast phenotypic data & analysis
SPD / RIKEN01/01F02Orfeome Localization Data
UniProtKB/SwissProtP09322Histone H4
ModBaseP09322Database of comparative protein structure models
STRINGP09322Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_594682histone H4 h4.1
RefSeq mRNANM_001020111972h- histone H4 h4.1 (hhf1), mRNA
European Nucleotide ArchiveBAA21442.1ENA Protein Mapping
European Nucleotide ArchiveCAA17818.1ENA Protein Mapping
European Nucleotide ArchiveCAA28850.1ENA Protein Mapping
European Nucleotide ArchiveCAA28853.1ENA Protein Mapping
European Nucleotide ArchiveCAA28855.1ENA Protein Mapping
European Nucleotide ArchiveCAB50975.1ENA Protein Mapping
European Nucleotide ArchiveCAB75771.1ENA Protein Mapping
UniParcUPI0000162095UniProt Archive

Literature for hhf1

Search: Europe PMC or PubMed

Release Version: PomBase:25_48 - 10 Jan 2015