hhf1 (SPAC1834.03c)

Gene Standard Namehhf1 ChromosomeI
Systematic IDSPAC1834.03c Gene Start4699544
Synonymsh4.1 Gene End4698773
Producthistone H4 h4.1 Gene Length772
Feature Typeprotein coding CDS Start4699396
Name Description CDS End4699085
Characterisation Statuspublished CDS Length312

Ensembl Gene Location
  1. vrg4
  2. sup45
  3. SPNCRNA.1017
  4. aro1
  5. hhf1
  6. hht1
  7. alg9
  8. pmo25
Fission Yeast Phenotype Ontology

Ontology Graph

Contact Curators
Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0002060viable vegetative cell populationMicroscopyhhf1delta (deletion)deletionPMID:20473289
GO Molecular Function

Ontology Graph

Contact Curators
Term IDTerm NameEvidenceWith/FromReference
GO:0003677DNA bindingIEAUniProtKB:KW-0238GO_REF:0000037
GO:0046982protein heterodimerization activityIEAIPR009072GO_REF:0000002
GO Biological Process

Ontology Graph

Contact Curators
Term IDTerm NameEvidenceWith/FromReference
GO:0006334nucleosome assemblyIEAIPR001951, IPR019809GO_REF:0000002
GO Cellular Component

Ontology Graph

Contact Curators
Term IDTerm NameEvidenceWith/FromReference
GO:0000788nuclear nucleosomeNASGO_REF:0000001
GO:0005634nucleusIDAPMID:16823372
Transcript
Contact Curators
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
146995444698773
Protein Features
Contact Curators

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF00125 IPR007125 Pfam Histone core 28 94 12
SM00417 IPR001951 SMART Histone H4 16 90 3
PS00047 IPR019809 Prosite Patterns Histone H4 15 19 3
G3DSA:1.10.20.10 IPR009072 Gene3D 2 103 26
SSF47113 IPR009072 SuperFamily 3 102 26
PR00623 IPR001951 PRINTS Histone H4 89 100 3
PR00623 IPR001951 PRINTS Histone H4 20 39 3
PR00623 IPR001951 PRINTS Histone H4 77 89 3
PR00623 IPR001951 PRINTS Histone H4 5 16 3
PR00623 IPR001951 PRINTS Histone H4 62 76 3
PR00623 IPR001951 PRINTS Histone H4 40 60 3
PTHR10484 IPR001951 hmmpanther Histone H4 1 103 5

View domain organization at Pfam

Protein Modifications (PSI-MOD)

Term IDTerm NameEvidenceResidueReference
MOD:00394acetylated residue
MOD:00427methylated residueresidueK20

Manually Curated Family or Sub-families

Term IDTerm NameReferenceAll Genes
PBO:0000297histone foldTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000297

Protein Properties

Ave. residue weight 110.91 Da
Charge 19.00
Isoelectric point 11.91
Molecular weight 11.42 kDa
Number of residues 103
Sequence
Contact Curators
Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127		population_widePMID:23101633
experimental evidencesingle-celled organism vegetative growth phasePECO:0000005,
PECO:0000014		population_widePMID:23101633
RNA levelexperimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide28PMID:23101633
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide3.4PMID:23101633
Species Distribution
DescriptionQualifierReference
conserved in fungi
conserved in eukaryotes
conserved in metazoa
conserved in vertebrates
conserved in eukaryotes only
Manually curated orthologous groups
SpeciesGeneDescription

Contact Curators
Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
srb11cyclin CycC, Srb mediator subunit Srb11 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
ryh1GTPase Ryh1 Positive GeneticPMID:22681890
acp2F-actin capping protein beta subunit (predicted) Negative GeneticPMID:22681890
rok1ATP-dependent RNA helicase Rok1 (predicted) Negative GeneticPMID:22681890
rpl160160S ribosomal protein L13/L16 (predicted) Negative GeneticPMID:22681890
SPAC977.13chydrolase, pseudogene Negative GeneticPMID:22681890
ams2cell cycle regulated GATA-type transcription factor Ams2 Dosage RescuePMID:12535531
Negative GeneticPMID:22681890
nup132nucleoporin Nup132 Negative GeneticPMID:22681890
hhf2histone H4 h4.2 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
SPAC186.05chuman TMEM165 homolog Positive GeneticPMID:22681890
SPBC36B7.08cnucleosome assembly protein (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
hip1hira protein, histone chaperone Hip1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
cbp1CENP-B homolog Positive GeneticPMID:18818364
mcl1DNA polymerase alpha accessory factor Mcl1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
srb10cyclin-dependent protein Srb mediator subunit kinase Srb10 Negative GeneticPMID:22681890
sds23PP2A-type phosphatase inhibitor Sds23/Moc1 Negative GeneticPMID:22681890
pab2poly(A) binding protein Pab2 Negative GeneticPMID:22681890
spc34DASH complex subunit Spc34 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
apc10anaphase-promoting complex subunit Apc10 Negative GeneticPMID:22681890
cnp1centromere-specific histone H3 CENP-A Dosage RescuePMID:12535531
elp5elongator complex subunit Elp5 (predicted) Negative GeneticPMID:18818364
pof3F-box protein Pof3 Negative GeneticPMID:22681890
ask1DASH complex subunit Ask1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
yaf9YEATS family histone acetyltransferase subunit Yaf9 Negative GeneticPMID:18818364
cay1cactin, spliceosome complex subunit (predicted) Negative GeneticPMID:18818364
gar2nucleolar protein required for rRNA processing Negative GeneticPMID:22681890
fml2ATP-dependent 3' to 5' DNA helicase (predicted) Positive GeneticPMID:22681890
SPAC186.01cell surface glycoprotein (predicted), DIPSY family Negative GeneticPMID:22681890
dad2DASH complex subunit Dad2 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
pom1DYRK family protein kinase Pom1 Positive GeneticPMID:18818364
SPBC1348.07S. pombe specific DUF999 protein family 6 Positive GeneticPMID:22681890
hip4histone promoter control protein Hip4 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
vps35retromer complex subunit Vps35 Positive GeneticPMID:22681890
SPAC25B8.08conserved fungal protein Positive GeneticPMID:22681890
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
air1zinc knuckle TRAMP complex subunit Air1 Affinity Capture-MSPMID:20403971
cia1histone chaperone Cia1 Affinity Capture-MSPMID:21211723
rik1silencing protein Rik1 Affinity Capture-MSPMID:17114925
tea1cell end marker Tea1 Affinity Capture-MSPMID:21652630
rna1Ran GAP Rna1 Reconstituted ComplexPMID:16540522
set9histone lysine methyltransferase Set9 Biochemical ActivityPMID:15550243
cbf11CBF1/Su(H)/LAG-1 family transcription factor Cbf11 Affinity Capture-MSPMID:22540037
rng2IQGAP Affinity Capture-MSPMID:20603077
crb2DNA repair protein Rad9 homolog, Rhp9 Reconstituted ComplexPMID:18826944
Co-localizationPMID:16778077
cyk3cytokinesis protein Cyk3 (predicted) Affinity Capture-MSPMID:20603077
pdp1PWWP domain protein Pdp1 Protein-peptidePMID:22150589
spt16FACT complex subunit Spt16 Reconstituted ComplexPMID:18579787
hat1histone acetyltransferase Hat1 Biochemical ActivityPMID:22771823
Contact Curators
External References
Database Identifier Description
NBRP SPAC1834.03c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC1834.03c Retrieval of eukaryotic orthologs
BioGrid SPAC1834.03c BioGRID Interaction Datasets
Bähler Lab SPAC1834.03c Cell Cycle Expression Profile
Bähler Lab SPAC1834.03c Meiosis/Sporulation Expression Profies
Bähler Lab SPAC1834.03c Pheromone response/mating expression profiles
Bähler Lab SPAC1834.03c Environmental stress expression profiles
Bähler Lab SPAC1834.03c Bähler Lab Transcriptome Viewer
Cyclebase SPAC1834.03c Cell Cycle Data
PInt SPAC1834.03c Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPAC1834.03c Entrez Gene
SPD / RIKEN01/01F02Orfeome Localization Data
WikiGene2542463histone H4 h4.1
WikiGene2541200histone H4 h4.2
WikiGene2539991histone H4 h4.3
Uniprot_genenameHHF1
EntrezGene2542463histone H4 h4.1
EntrezGene2541200histone H4 h4.2
EntrezGene2539991histone H4 h4.3
UniProtKB/SwissProtP09322Histone H4
ModBaseP09322Database of comparative protein structure models
Pfam Protein DomainsP09322Pfam Domain Arrangement
RefSeq PeptideNP_594682histone H4 h4.1
RefSeq mRNANM_001020111972h- histone H4 h4.1 (hhf1), mRNA
European Nucleotide ArchiveBAA21442ENA Protein Mapping
European Nucleotide ArchiveCAA17818ENA Protein Mapping
European Nucleotide ArchiveCAA28850ENA Protein Mapping
European Nucleotide ArchiveCAA28853ENA Protein Mapping
European Nucleotide ArchiveCAA28855ENA Protein Mapping
European Nucleotide ArchiveCAB50975ENA Protein Mapping
European Nucleotide ArchiveCAB75771ENA Protein Mapping
UniParcUPI0000162095UniProt Archive

Literature for hhf1
Contact Curators

Search: UK PMC or PubMed

Release Version: PomBase:18_35 - 11 May 2013