hht1 (SPAC1834.04)

Gene Standard Namehht1 ChromosomeI
Systematic IDSPAC1834.04 Gene Start4699691
Synonyms Gene End4700560
Producthistone H3 h3.1 Gene Length870
Feature Typeprotein coding CDS Start4699829
Name Description CDS End4700239
Characterisation Statuspublished CDS Length411

Ensembl Gene Location
  1. sup45
  2. SPNCRNA.1017
  3. aro1
  4. hhf1
  5. hht1
  6. alg9
  7. pmo25
  8. klp3
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0000266sensitive to DNA damaging agentsCell growth assayK56R (K56R)amino_acid_mutationPMID:17369611
FYPO:0000267sensitive to ionizing radiationCell growth assayK56R (K56R)amino_acid_mutationPMID:17369611
FYPO:0002060viable vegetative cell populationMicroscopyhht1delta (deletion)deletionPMID:20473289
GO Molecular Function

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Term IDTerm NameEvidenceWith/FromReference
GO:0003677DNA bindingIEAUniProtKB:KW-0238GO_REF:0000037
GO:0005515protein binding
gene_product_form_id PR:000027576IPIbir1PMID:20929775
gene_product_form_id PR:000027578IPIswi6PMID:11242054
GO:0046982protein heterodimerization activityIEAIPR009072GO_REF:0000002
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0006281DNA repairIEAUniProtKB:KW-0234GO_REF:0000037
GO:0006334nucleosome assemblyIEAIPR000164GO_REF:0000002
GO:0006974response to DNA damage stimulusIMPPMID:17369611
same_pathwayIGIrtt109PMID:17369611
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0000788nuclear nucleosomeNASGO_REF:0000001
GO:0005634nucleusIDAPMID:16823372
GO:0031618nuclear centromeric heterochromatinIDAPMID:20929775
GO:0031933telomeric heterochromatinIDAPMID:20929775
GO:0031934mating-type region heterochromatinIDAPMID:20929775
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
146996914700560

References

Region Start End Reference
five_prime_UTR46996914699828PMID:21511999
five_prime_UTR46996914699828PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF00125 IPR007125 Pfam Histone core 58 132 12
SM00428 IPR000164 SMART Histone H3 34 136 4
PS00322 IPR000164 Prosite Patterns Histone H3 15 21 3
PS00959 IPR000164 Prosite Patterns Histone H3 67 75 3
G3DSA:1.10.20.10 IPR009072 Gene3D 2 134 26
SSF47113 IPR009072 SuperFamily 2 133 26
PR00622 IPR000164 PRINTS Histone H3 34 55 4
PR00622 IPR000164 PRINTS Histone H3 3 17 4
PR00622 IPR000164 PRINTS Histone H3 58 75 4
PR00622 IPR000164 PRINTS Histone H3 114 135 4
PR00622 IPR000164 PRINTS Histone H3 17 31 4
PR00622 IPR000164 PRINTS Histone H3 80 98 4
PR00622 IPR000164 PRINTS Histone H3 98 114 4
PTHR11426 IPR000164 hmmpanther Histone H3 1 136 4

View domain organization at Pfam

Protein Modifications (PSI-MOD)

Term IDTerm NameEvidenceResidueReference
MOD:00064N6-acetyl-L-lysineresidueK56PMID:17369611
evidenceInferred from Direct Assay
MOD:00394acetylated residue
MOD:00427methylated residueduringGO:0030702PMID:14561399
residueK14
residueK4
duringGO:0030702PMID:14561399
residueK9
MOD:00696phosphorylated residueresidueS10

Manually Curated Family or Sub-families

Term IDTerm NameReferenceAll Genes
PBO:0000297histone foldTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000297

Protein Properties

Ave. residue weight 112.92 Da
Charge 21.00
Isoelectric point 11.83
Molecular weight 15.36 kDa
Number of residues 136
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127		population_widePMID:23101633
experimental evidencesingle-celled organism vegetative growth phasePECO:0000005,
PECO:0000014		population_widePMID:23101633
RNA levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide2.1PMID:23101633
experimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide28PMID:23101633
Species Distribution
DescriptionQualifierReference
conserved in fungi
conserved in eukaryotes
conserved in metazoa
conserved in vertebrates
conserved in eukaryotes only
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
rhn1RNA polymerase II transcription termination factor homolog Negative GeneticPMID:18818364
SPCC18.13tRNA (guanine-N7-)-methyltransferase subunit Trm82 (predicted) Negative GeneticPMID:22681890
acp2F-actin capping protein beta subunit (predicted) Negative GeneticPMID:22681890
clr4histone H3 lysine methyltransferase Clr4 Dosage LethalityPMID:16540522
hht2histone H3 h3.2 Negative GeneticPMID:18818364
erp2COPII-coated vesicle component Erp2/3/4 (predicted) Negative GeneticPMID:22681890
pht1histone H2A variant H2A.Z, Pht1 Negative GeneticPMID:22681890
med20mediator complex subunit Med20 Positive GeneticPMID:18818364
ddb1damaged DNA binding protein Ddb1 Negative GeneticPMID:18818364
swd1Set1C complex subunit Swd1 Negative GeneticPMID:22681890
par1protein phosphatase regulatory subunit Par1 Negative GeneticPMID:18818364
mcl1DNA polymerase alpha accessory factor Mcl1 Negative GeneticPMID:22681890
rdp1RNA-directed RNA polymerase Rdp1 Negative GeneticPMID:18818364
alg10dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase Alg10 (predicted) Negative GeneticPMID:22681890
ilv1acetolactate synthase catalytic subunit Negative GeneticPMID:22681890
cay1cactin, spliceosome complex subunit (predicted) Negative GeneticPMID:18818364
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
rik1silencing protein Rik1 Affinity Capture-WesternPMID:20705239
hrk1haspin related kinase Hrk1 Affinity Capture-WesternPMID:20929775
cia1histone chaperone Cia1 Affinity Capture-MSPMID:21211723
Affinity Capture-WesternPMID:22291963
snf21ATP-dependent DNA helicase Snf21 Protein-peptidePMID:22184112
rna1Ran GAP Rna1 Reconstituted ComplexPMID:16540522
Biochemical Activity
cbf11CBF1/Su(H)/LAG-1 family transcription factor Cbf11 Affinity Capture-MSPMID:22540037
dcr1dicer Co-localizationPMID:15976807
clr4histone H3 lysine methyltransferase Clr4 Protein-peptidePMID:22727667
Reconstituted ComplexPMID:18345014
Biochemical ActivityPMID:16540522
Reconstituted Complex
Co-localizationPMID:15976807
sim3NASP family CENP-A chaperone Affinity Capture-WesternPMID:18158900
bir1survivin, Bir1 Affinity Capture-WesternPMID:20929775
paa1protein phosphatase regulatory subunit Paa1 Affinity Capture-MSPMID:22119525
swi6HP1 family chromodomain protein Swi6 Reconstituted ComplexPMID:21211724
Protein-peptidePMID:22727667
Co-localizationPMID:12215653
rsc4RSC complex subunit Rsc4 Affinity Capture-WesternPMID:22184112
Protein-peptide
chp1chromodomain protein Chp1 Protein-peptidePMID:22727667
Co-localizationPMID:15976807
spt16FACT complex subunit Spt16 Reconstituted ComplexPMID:18579787
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External References
Database Identifier Description
NBRP SPAC1834.04 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC1834.04 Retrieval of eukaryotic orthologs
BioGrid SPAC1834.04 BioGRID Interaction Datasets
Bähler Lab SPAC1834.04 Cell Cycle Expression Profile
Bähler Lab SPAC1834.04 Meiosis/Sporulation Expression Profies
Bähler Lab SPAC1834.04 Pheromone response/mating expression profiles
Bähler Lab SPAC1834.04 Environmental stress expression profiles
Bähler Lab SPAC1834.04 Bähler Lab Transcriptome Viewer
Cyclebase SPAC1834.04 Cell Cycle Data
PInt SPAC1834.04 Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPAC1834.04 Entrez Gene
WikiGene2542467histone H3 h3.1
WikiGene2541220histone H3 h3.2
WikiGene2539804histone H3 h3.3
Uniprot_genenameHHT3
Uniprot_genenameHHT1
EntrezGene2542467histone H3 h3.1
EntrezGene2541220histone H3 h3.2
EntrezGene2539804histone H3 h3.3
SPD / RIKEN03/03B12Orfeome Localization Data
UniProtKB/SwissProtP09988Histone H3.1/H3.2
ModBaseP09988Database of comparative protein structure models
Pfam Protein DomainsP09988Pfam Domain Arrangement
UniProtKB/SwissProtP10651Histone H3.3
ModBaseP10651Database of comparative protein structure models
Pfam Protein DomainsP10651Pfam Domain Arrangement
RefSeq PeptideNP_594683histone H3 h3.1
RefSeq mRNANM_001020112972h- histone H3 h3.1 (hht1), mRNA
European Nucleotide ArchiveBAA21441ENA Protein Mapping
European Nucleotide ArchiveCAA17819ENA Protein Mapping
European Nucleotide ArchiveCAA28851ENA Protein Mapping
European Nucleotide ArchiveCAA28852ENA Protein Mapping
European Nucleotide ArchiveCAA28854ENA Protein Mapping
European Nucleotide ArchiveCAB50974ENA Protein Mapping
European Nucleotide ArchiveCAB75772ENA Protein Mapping
UniParcUPI0000162096UniProt Archive

Literature for hht1
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Search: UK PMC or PubMed

Release Version: PomBase:18_35 - 11 May 2013