Gene Standard NameUnassigned Characterisation Statusconserved unknown
Systematic IDSPAC186.05c Feature Typeprotein coding
Synonyms Name Description
Producthuman TMEM165 homolog, implicated in calcium transport Product Size262aa, 29.27 kDa
Genomic Location Chromosome I, 5541502-5540032 (1471nt); CDS:5541138-5540350 (789nt)

Ensembl Gene Location
GO Cellular Component
Term NameCount
endoplasmic reticulum602
Annotation ExtensionEvidenceWith/FromReference
integral component of membrane969
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

Term NameGenotypesCount
sensitive to hydroxyureaSPAC186.05cΔ595
viable vegetative cell populationSPAC186.05cΔ3862

Cell Phenotype

Term NameGenotypesCount
viable vegetative cell with normal cell morphologySPAC186.05cΔ3103
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
5' UTR5541502..5541139PMID:21511999
3' UTR5540349..5540032PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF01169 Pfam IPR001727 Gdt1 family 181 254 2
PF01169 Pfam IPR001727 Gdt1 family 29 102 2
TMhelix TMHMM 57 79 950
TMhelix TMHMM 89 106 950
TMhelix TMHMM 211 233 950
TMhelix TMHMM 237 259 950
PTHR12608:SF1 HMMPANTHER 29 262 2
PTHR12608 HMMPANTHER IPR001727 Gdt1 family 29 262 2
Coil ncoils Predicted coiled-coil protein (DUF2205) 116 136 1049

View domain organization at Pfam

Term IDTerm NameReferenceCount

Protein Properties

Ave. residue weight 111.73 Da
Charge 7.50
Codon Adaptation Index 0.35
Isoelectric point 9.54
Molecular weight 29.27 kDa
Number of residues 262
Gene Expression

Quantitative Gene Expression

View graphical display of gene expression data for SPAC186.05c

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
0.032during GO:0072690PECO:0000126,
population wideexperimental evidencePMID:23101633
0.066during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
population wideexperimental evidencePMID:23101633
Disease Association
congenital disorders of glycosylation30
Taxonomic Conservation
predominantly single copy (one to one)3087
conserved in fungi4608
conserved in eukaryotes4516
conserved in bacteria1005
conserved in metazoa3498
conserved in vertebrates3473

Manually curated orthologous groups


Orthologs in Compara

Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPAC186.05c into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
positive genetic interaction withklp3kinesin-like protein Klp3 Positive GeneticPMID:22681890
positive genetic interaction withace2transcription factor Ace2 Positive GeneticPMID:22681890
positive genetic interaction withdus3tRNA dihydrouridine synthase Dus3 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withfta6Mis6-Sim4 complex Fta6 Positive GeneticPMID:22681890
positive genetic interaction withclp1Cdc14-related protein phosphatase Clp1/Flp1 Positive GeneticPMID:22681890
positive genetic interaction withfft3SMARCAD1 family ATP-dependent DNA helicase Fft3 Positive GeneticPMID:22681890
positive genetic interaction withcbh1kinetochore protein, CENP-B homolog Cbh1 Positive GeneticPMID:22681890
positive genetic interaction withrad9checkpoint clamp complex protein Rad9 Positive GeneticPMID:22681890
positive genetic interaction withhhf1histone H4 h4.1 Positive GeneticPMID:22681890
positive genetic interaction withSPAC144.05ATP-dependent DNA helicase/ ubiquitin-protein ligase E3 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withhip4histone promoter control protein Hip4 Positive GeneticPMID:22681890
positive genetic interaction withreb1RNA polymerase I transcription termination factor/ RNA polymerase II transcription factor Reb1 Positive GeneticPMID:22681890
positive genetic interaction withgid8GID complex subunit Gid8 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withsts5RNB-like protein Negative GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPAC186.05c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC186.05c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC186.05c BioGRID Interaction Datasets
Expression Viewer SPAC186.05c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC186.05c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC186.05c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC186.05c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC186.05c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC186.05c Transcriptome Viewer (Bähler Lab)
GEO SPAC186.05c GEO profiles
PInt SPAC186.05c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC186.05c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC186.05c Fission yeast phenotypic data & analysis
Cyclebase SPAC186.05c.1 Cell Cycle Data
SPD / RIKEN09/09H08Orfeome Localization Data
UniProtKB/SwissProtQ9P7Q0GDT1-like protein C186.05c
ModBaseQ9P7Q0Database of comparative protein structure models
STRINGQ9P7Q0Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_595023GDT1-like protein
RefSeq mRNANM_001020453972h- GDT1-like protein (SPAC186.05c), mRNA
European Nucleotide ArchiveCAB75869.1ENA Protein Mapping
UniParcUPI0000069580UniProt Archive

Literature for SPAC186.05c

Search: Europe PMC or PubMed

Release Version: PomBase:30_62 - 30 Jan 2017