mal3 (SPAC18G6.15)


Gene Standard Namemal3 Characterisation Statuspublished
Systematic IDSPAC18G6.15 Feature Typeprotein coding
Synonyms Name Description
ProductEB1 family Mal3 Product Size308aa, 35.09 kDa
Genomic Location Chromosome I, 2243558-2245220 (1663nt); CDS:2243636-2244622 (987nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
ATPase activator activity3
Annotation ExtensionEvidenceWith/FromReference
microtubule binding20
Annotation ExtensionEvidenceWith/FromReference
microtubule plus-end binding5
Annotation ExtensionEvidenceWith/FromReference
protein binding856
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
attachment of mitotic spindle microtubules to kinetochore26
Annotation ExtensionEvidenceWith/FromReference
cellular protein localization551
Annotation ExtensionEvidenceWith/FromReference
dynein-driven meiotic oscillatory nuclear movement11
Annotation ExtensionEvidenceWith/FromReference
gamma-tubulin complex localization6
Annotation ExtensionEvidenceWith/FromReference
karyogamy involved in conjugation with cellular fusion10
Annotation ExtensionEvidenceWith/FromReference
microtubule polymerization14
Annotation ExtensionEvidenceWith/FromReference
microtubule-based movement23
Annotation ExtensionEvidenceWith/FromReference
mitotic spindle assembly14
Annotation ExtensionEvidenceWith/FromReference
mitotic spindle stabilization2
Annotation ExtensionEvidenceWith/FromReference
nuclear migration involved in conjugation with cellular fusion3
Annotation ExtensionEvidenceWith/FromReference
positive regulation of ATPase activity3
Annotation ExtensionEvidenceWith/FromReference
protein localization to microtubule2
Annotation ExtensionEvidenceWith/FromReference
regulation of filamentous growth12
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
astral microtubule8
Annotation ExtensionEvidenceWith/FromReference
cell cortex of cell tip44
Annotation ExtensionEvidenceWith/FromReference
cortical microtubule3
Annotation ExtensionEvidenceWith/FromReference
cytoplasmic microtubule11
Annotation ExtensionEvidenceWith/FromReference
cytosol2314
Annotation ExtensionEvidenceWith/FromReference
microtubule cytoskeleton293
mitotic spindle259
Annotation ExtensionEvidenceWith/FromReference
mitotic spindle midzone8
Annotation ExtensionEvidenceWith/FromReference
mitotic spindle pole body216
Annotation ExtensionEvidenceWith/FromReference
nucleus2695
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
abnormal filament morphologymal3ΔNull5
inviable vegetative cell populationmal3+ (wild type)Overexpression1435
normal mating efficiencymal3ΔNull24
sensitive to 4-nitroquinoline N-oxidemal3ΔNull159
sensitive to thiabendazolema3-1Not specified211
mal3ΔNull
slow vegetative cell population growthmal3+ (wild type)Overexpression326
viable vegetative cell populationmal3ΔNull3795
unnamed (unrecorded)

Cell Phenotype

Term NameAlleleExpressionCount
abnormal cell cycle arrest in mitotic M phasemal3ΔNull25
abnormal horsetail movementmal3ΔNull11
abnormal microtubule cytoskeleton morphology during matingmal3ΔNull1
abnormal microtubule cytoskeleton morphology during mitotic interphasemal3ΔNull186
abnormal mitotic cell cycle phasemal3ΔNull133
abnormal mitotic spindle midzone assemblymal3+ (wild type)Overexpression4
abnormal nuclear migration during matingmal3ΔNull1
abnormal sporulation resulting in formation of ascus with more or fewer than four sporesmal3ΔNull71
abnormal sporulation resulting in formation of ascus with more than four sporesmal3ΔNull8
abolished mitotic spindle assemblymal3+ (wild type)Overexpression3
abolished protein localization to cell tipmal3ΔNull29
abolished protein localization to microtubule during mitosis1
affecting klp2mal3ΔNull
decreased nuclear fusion during matingmal3ΔNull4
decreased spore germinationmal3ΔNull28
decreased sporulationmal3ΔNull71
increased duration of mitotic anaphase Amal3ΔNull5
increased duration of mitotic M phasemal3ΔNull18
increased minichromosome loss upon segregation during vegetative growthmal3-1Endogenous14
mal3ΔNull
increased protein localization to kinetochore during vegetative growth4
affecting bub1mal3ΔNull
inviable elongated vegetative cellmal3+ (wild type)Overexpression408
inviable sporemal3ΔNull470
mislocalized post-anaphase arraymal3ΔNull1
mislocalized septum during vegetative growthmal3ΔNull34
misoriented septum during vegetative growthmal3ΔNull22
normal actin cable morphologymal3ΔNull4
normal actin cytoskeleton morphology during vegetative growthmal3ΔNull13
normal protein localization to kinetochore25
affecting mad2mal3ΔNull
nucleus mislocalized to cell tip during interphasemal3+ (wild type)Overexpression2
mal3ΔNull
overlapping meiosis I spindlesmal3ΔNull2
S-shaped cellmal3ΔNull27
separate mitotic half spindles presentmal3+ (wild type)Overexpression4
short cytoplasmic microtubulesmal3ΔNull14
telophase nuclear clusteringmal3ΔNull5
twin haploid meiosismal3ΔNull1
unequal homologous chromosome segregationmal3ΔNull8
viable branched vegetative cellmal3ΔNull18
viable curved elongated vegetative cellmal3ΔNull15
viable curved vegetative cellmal3ΔNull65
Target Of
OntologyRelationshipGeneProductReference
FYPO affected by mutation in klp2 minus end-directed kinesin-14, Klp2 PMID:23087209
GO localized by tea2 kinesin-like protein Tea2 PMID:15665379
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons2243558..2243677, 2243738..2245220
mRNA2243558..2245220
5' UTR2243558..2243635PMID:21511999
CDS2243636..2243677, 2243738..2244622
3' UTR2244623..2245220PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00307 Pfam IPR001715 Calponin homology domain 5 98 6
PF03271 Pfam IPR004953 EB1, C-terminal 197 240 1
PS51230 Prosite Profiles IPR004953 EB1, C-terminal 173 247 1
PTHR10623 HMMPANTHER IPR027328 Microtubule-associated protein RP/EB 3 298 1
PTHR10623:SF6 HMMPANTHER 3 298 1
1.10.418.10 Gene3D IPR001715 Calponin homology domain 3 118 6
SSF47576 SuperFamily IPR001715 Calponin homology domain 3 117 6
0049734 SuperFamily IPR004953 EB1, C-terminal 180 246 1
Coil ncoils Rabaptin coiled-coil domain 167 195 968

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0001435calponin homology (CH) domainTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0001435

Protein Properties

Ave. residue weight 113.94 Da
Charge -10.50
Isoelectric point 4.60
Molecular weight 35.09 kDa
Number of residues 308
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serineS297 1672
present during mitotic M phaseS297
Annotation ExtensionEvidenceResidueReference
experimental evidence S297 PMID:24763107
present during mitotic M phase experimental evidence S297 PMID:21712547
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
15511during GO:0000080PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
15834during GO:0000085PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
14909during GO:0072690PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
5234.28during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
2171.13during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
7during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
0.95during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633
Complementation
DescriptionQualifierReference
functionally complemented by human MAPRE1
Miscellaneous Functional Group
DescriptionQualifierReferenceCount
plus end tracking protein3
Species Distribution
DescriptionQualifierReferenceCount
conserved in fungi4604
conserved in eukaryotes4516
conserved in metazoa3430
conserved in vertebrates3405
conserved in eukaryotes only2502
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
forms complex withatb2tubulin alpha 2 Reconstituted ComplexPMID:17190604
affinity capturescds1replication checkpoint kinase Cds1 Affinity Capture-WesternPMID:21336311
forms complex withklp2minus end-directed kinesin-14, Klp2 Reconstituted ComplexPMID:23087209
binds activation domain construct withmal3EB1 family Mal3 Two-hybridPMID:16951255
co-fractionates withmal3EB1 family Mal3 Co-fractionationPMID:15665379
binds activation domain construct withmoe1translation initiation factor eIF3d Moe1 Two-hybridPMID:11102508
forms complex withmoe1translation initiation factor eIF3d Moe1 Reconstituted ComplexPMID:11102508
nda2tubulin alpha 1 Co-crystal or NMR structurePMID:22500803
forms complex withnda2tubulin alpha 1 Reconstituted ComplexPMID:18794845
nda3tubulin beta Nda3 Co-crystal or NMR structurePMID:22500803
affinity captured bypeg1CLASP family microtubule-associated protein Affinity Capture-WesternPMID:16951255
binds DNA-binding domain construct withpeg1CLASP family microtubule-associated protein Two-hybridPMID:16951255
binds activation domain construct withpeg1CLASP family microtubule-associated protein Two-hybridPMID:16951255
affinity capturespeg1CLASP family microtubule-associated protein Affinity Capture-WesternPMID:16951255
affinity capturesspc7NMS complex subunit, Spc105/KNL-1 family member, blinkin, Spc7 Affinity Capture-WesternPMID:15371542
affinity captured byspc7NMS complex subunit, Spc105/KNL-1 family member, blinkin, Spc7 Affinity Capture-WesternPMID:15371542
affinity captured bytea1cell end marker Tea1 Affinity Capture-MSPMID:21652630
co-fractionates withtea2kinesin-like protein Tea2 Co-fractionationPMID:15665379
affinity captured bytea2kinesin-like protein Tea2 Affinity Capture-WesternPMID:15177031
binds activation domain construct withtip1CLIP170 family protein Tip1 Two-hybridPMID:16951255
binds DNA-binding domain construct withtip1CLIP170 family protein Tip1 Two-hybridPMID:16951255
forms complex withtip1CLIP170 family protein Tip1 Reconstituted ComplexPMID:15177031
affinity captured bytip1CLIP170 family protein Tip1 Affinity Capture-WesternPMID:15177031
forms complex withtip1CLIP170 family protein Tip1 Reconstituted ComplexPMID:15177031
forms complex withtip1CLIP170 family protein Tip1 Reconstituted ComplexPMID:15062095
affinity captured bytip1CLIP170 family protein Tip1 Affinity Capture-WesternPMID:15062095
forms complex withtip1CLIP170 family protein Tip1 Reconstituted ComplexPMID:15062095
Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
negative genetic interaction withago1argonaute Negative GeneticPMID:18818364
negative genetic interaction withago1argonaute Negative GeneticPMID:22681890
negative genetic interaction withalp13MRG family Clr6 histone deacetylase complex subunit Alp13 Negative GeneticPMID:22681890
enhances phenotype ofalp13MRG family Clr6 histone deacetylase complex subunit Alp13 Phenotypic EnhancementPMID:19547744
negative genetic interaction withalp14TOG/XMAP14 family protein Alp14 Negative GeneticPMID:18818364
synthetic lethal withalp14TOG/XMAP14 family protein Alp14 Synthetic LethalityPMID:15371542
negative genetic interaction withamo1nuclear rim protein Amo1 Negative GeneticPMID:18818364
negative genetic interaction withams2cell cycle regulated GATA-type transcription factor Ams2 Negative GeneticPMID:22681890
negative genetic interaction withapq12nuclear membrane organization protein Apq12 (predicted) Negative GeneticPMID:22681890
synthetically rescued byaps1diadenosine 5',5'''-p1,p6-hexaphosphate hydrolase Aps1 Synthetic RescuePMID:25254656
negative genetic interaction witharp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:18818364
negative genetic interaction witharp8actin-like protein, Ino80 complex subunit Arp8 Negative GeneticPMID:18818364
synthetic growth defect withase1antiparallel microtubule cross-linking factor Ase1 Synthetic Growth DefectPMID:18931302
negative genetic interaction withash2Ash2-trithorax family protein Negative GeneticPMID:18818364
negative genetic interaction withask1DASH complex subunit Ask1 Negative GeneticPMID:18818364
negative genetic interaction withask1DASH complex subunit Ask1 Negative GeneticPMID:22681890
enhances phenotype ofasp1inositol hexakisphosphate kinase/inositol pyrophosphate synthase (predicted) Phenotypic EnhancementPMID:20624911
synthetic growth defect withasp1inositol hexakisphosphate kinase/inositol pyrophosphate synthase (predicted) Synthetic Growth DefectPMID:25254656
synthetically rescued byasp1inositol hexakisphosphate kinase/inositol pyrophosphate synthase (predicted) Synthetic RescuePMID:25254656
rescued by overexpression ofasp1inositol hexakisphosphate kinase/inositol pyrophosphate synthase (predicted) Dosage RescuePMID:25254656
overexpression rescuesatb2tubulin alpha 2 Dosage RescuePMID:16394105
synthetic growth defect withatb2tubulin alpha 2 Synthetic Growth DefectPMID:16394105
positive genetic interaction withatb2tubulin alpha 2 Positive GeneticPMID:22681890
synthetic growth defect withbub1mitotic spindle checkpoint kinase Bub1 Synthetic Growth DefectPMID:16179942
synthetic growth defect withbub3mitotic spindle checkpoint protein Bub3 Synthetic Growth DefectPMID:16179942
negative genetic interaction withcaf1CCR4-Not complex CAF1 family ribonuclease subunit Caf1 Negative GeneticPMID:18818364
negative genetic interaction withcay1cactin, spliceosome complex subunit (predicted) Negative GeneticPMID:18818364
negative genetic interaction withcbp1CENP-B homolog Negative GeneticPMID:18818364
rescued bycdc16two-component GAP Cdc16 Phenotypic SuppressionPMID:20498706
negative genetic interaction withcid12poly(A) polymerase Cid12 Negative GeneticPMID:18818364
synthetic growth defect withclp1Cdc14-related protein phosphatase Clp1/Flp1 Synthetic Growth DefectPMID:18931302
negative genetic interaction withclr4histone H3 lysine methyltransferase Clr4 Negative GeneticPMID:18818364
negative genetic interaction withclr4histone H3 lysine methyltransferase Clr4 Negative GeneticPMID:22681890
negative genetic interaction withcph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Negative GeneticPMID:18818364
negative genetic interaction withcph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Negative GeneticPMID:22681890
negative genetic interaction withdad2DASH complex subunit Dad2 Negative GeneticPMID:18818364
negative genetic interaction withdad2DASH complex subunit Dad2 Negative GeneticPMID:22681890
negative genetic interaction withdad3DASH complex subunit Dad3 Negative GeneticPMID:22681890
negative genetic interaction withdad4DASH complex subunit Dad4 Negative GeneticPMID:22681890
rescued by overexpression ofdam1DASH complex subunit Dam1 Dosage RescuePMID:16079915
synthetic growth defect withdcr1dicer Synthetic Growth DefectPMID:18931302
negative genetic interaction withdcr1dicer Negative GeneticPMID:18818364
negative genetic interaction withdcr1dicer Negative GeneticPMID:22681890
phenotype enhanced bydhc1dynein heavy chain Dhc1 Phenotypic EnhancementPMID:23755176
negative genetic interaction withduo1DASH complex subunit Duo1 Negative GeneticPMID:22681890
synthetic growth defect withefc25Ras1 guanyl-nucleotide exchange factor Efc25 Synthetic Growth DefectPMID:18931302
negative genetic interaction withefc25Ras1 guanyl-nucleotide exchange factor Efc25 Negative GeneticPMID:22681890
negative genetic interaction withelp3elongator complex subunit Elp3 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withelp4elongator complex subunit Elp4 (predicted) Negative GeneticPMID:18818364
negative genetic interaction witheme1Holliday junction resolvase subunit Eme1 Negative GeneticPMID:18818364
negative genetic interaction withers1RNA-silencing factor Ers1 Negative GeneticPMID:18818364
negative genetic interaction withers1RNA-silencing factor Ers1 Negative GeneticPMID:22681890
synthetic growth defect withfin1serine/threonine protein kinase, NIMA related Fin1 Synthetic Growth DefectPMID:18931302
negative genetic interaction withfin1serine/threonine protein kinase, NIMA related Fin1 Negative GeneticPMID:18818364
negative genetic interaction withfin1serine/threonine protein kinase, NIMA related Fin1 Negative GeneticPMID:22681890
synthetic growth defect withfor3formin For3 Synthetic Growth DefectPMID:18931302
negative genetic interaction withgcn5SAGA complex histone acetyltransferase catalytic subunit Gcn5 Negative GeneticPMID:18818364
negative genetic interaction withhip1hira protein, histone chaperone Hip1 Negative GeneticPMID:18818364
negative genetic interaction withhip1hira protein, histone chaperone Hip1 Negative GeneticPMID:22681890
negative genetic interaction withhip4histone promoter control protein Hip4 Negative GeneticPMID:18818364
negative genetic interaction withhip4histone promoter control protein Hip4 Negative GeneticPMID:22681890
negative genetic interaction withhrp3ATP-dependent DNA helicase Hrp3 Negative GeneticPMID:22681890
negative genetic interaction withhrr1Helicase Required for RNAi-mediated heterochromatin assembly Hrr1 Negative GeneticPMID:18818364
negative genetic interaction withhrr1Helicase Required for RNAi-mediated heterochromatin assembly Hrr1 Negative GeneticPMID:22681890
positive genetic interaction withhus1checkpoint clamp complex protein Hus1 Positive GeneticPMID:22681890
negative genetic interaction withint6eIF3e subunit Int6 Negative GeneticPMID:22681890
negative genetic interaction withkin1microtubule affinity-regulating kinase Kin1 Negative GeneticPMID:22681890
negative genetic interaction withlsk1P-TEFb-associated cyclin-dependent protein kinase Lsk1 Negative GeneticPMID:18818364
synthetic growth defect withmad1mitotic spindle checkpoint protein Mad1 Synthetic Growth DefectPMID:18931302
negative genetic interaction withmad1mitotic spindle checkpoint protein Mad1 Negative GeneticPMID:18818364
rescued bymad2mitotic spindle checkpoint protein Mad2 Phenotypic SuppressionPMID:20498706
synthetic growth defect withmad3mitotic spindle checkpoint protein Mad3 Synthetic Growth DefectPMID:16179942
negative genetic interaction withmag1DNA-3-methyladenine glycosylase Mag1 Negative GeneticPMID:22681890
negative genetic interaction withmei4meiotic forkhead transcription factor Mei4 Negative GeneticPMID:18818364
negative genetic interaction withmid1medial ring protein Mid1 Negative GeneticPMID:22681890
negative genetic interaction withmis4adherin, cohesin loading factor Mis4 Negative GeneticPMID:23050226
synthetic growth defect withmoe1translation initiation factor eIF3d Moe1 Synthetic Growth DefectPMID:11102508
synthetic growth defect withmph1dual specificity protein kinase Mph1 Synthetic Growth DefectPMID:18931302
negative genetic interaction withmph1dual specificity protein kinase Mph1 Negative GeneticPMID:18818364
synthetic growth defect withmph1dual specificity protein kinase Mph1 Synthetic Growth DefectPMID:16179942
negative genetic interaction withmph1dual specificity protein kinase Mph1 Negative GeneticPMID:22681890
negative genetic interaction withmre11Mre11 nuclease Negative GeneticPMID:18818364
negative genetic interaction withmto1MT organizer Mto1 Negative GeneticPMID:22681890
rescued bymtr1microtubule regulator Mtr1 Phenotypic SuppressionPMID:24928430
enhances phenotype ofmyo51myosin type V Phenotypic EnhancementPMID:23051734
enhances phenotype ofmyo52myosin type V Phenotypic EnhancementPMID:23051734
rescued bynda2tubulin alpha 1 Phenotypic SuppressionPMID:9348288
rescued bynda3tubulin beta Nda3 Phenotypic SuppressionPMID:9348288
negative genetic interaction withngg1SAGA complex subunit Ngg1 Negative GeneticPMID:18818364
negative genetic interaction withngg1SAGA complex subunit Ngg1 Negative GeneticPMID:22681890
negative genetic interaction withnrm1MBF complex corepressor Nrm1 Negative GeneticPMID:22681890
positive genetic interaction withpab2poly(A) binding protein Pab2 Positive GeneticPMID:22681890
negative genetic interaction withpac2cAMP-independent regulatory protein Pac2 Negative GeneticPMID:22681890
negative genetic interaction withpar1protein phosphatase regulatory subunit Par1 Negative GeneticPMID:18818364
phenotype enhanced bypat1serine/threonine protein kinase Ran1/Pat1 Phenotypic EnhancementPMID:23755176
synthetically rescuespeg1CLASP family microtubule-associated protein Synthetic RescuePMID:16951255
positive genetic interaction withpho24-nitrophenylphosphatase Positive GeneticPMID:22681890
negative genetic interaction withpom1DYRK family protein kinase Pom1 Negative GeneticPMID:18818364
negative genetic interaction withpom1DYRK family protein kinase Pom1 Negative GeneticPMID:22681890
positive genetic interaction withppk30Ark1/Prk1 family protein kinase Ppk30 Positive GeneticPMID:18818364
negative genetic interaction withprp4serine/threonine protein kinase Prp4 Negative GeneticPMID:22681890
negative genetic interaction withprw1Clr6 histone deacetylase complex subunit Prw1 Negative GeneticPMID:22681890
negative genetic interaction withpub1HECT-type ubiquitin-protein ligase E3 Pub1 Negative GeneticPMID:18818364
negative genetic interaction withraf1CLRC ubiquitin E3 ligase complex specificiy factor Raf1/Dos1 Negative GeneticPMID:18818364
negative genetic interaction withraf1CLRC ubiquitin E3 ligase complex specificiy factor Raf1/Dos1 Negative GeneticPMID:22681890
negative genetic interaction withraf2Rik1-associated factor Raf2 Negative GeneticPMID:18818364
negative genetic interaction withraf2Rik1-associated factor Raf2 Negative GeneticPMID:22681890
negative genetic interaction withrdp1RNA-directed RNA polymerase Rdp1 Negative GeneticPMID:18818364
negative genetic interaction withres1MBF transcription factor complex subunit Res1 Negative GeneticPMID:22681890
negative genetic interaction withres2MBF transcription factor complex subunit Res2 Negative GeneticPMID:18818364
synthetic growth defect withrik1silencing protein Rik1 Synthetic Growth DefectPMID:18931302
negative genetic interaction withrik1silencing protein Rik1 Negative GeneticPMID:18818364
negative genetic interaction withrik1silencing protein Rik1 Negative GeneticPMID:22681890
synthetic growth defect withrim20BRO1 domain protein Rim20 (predicted) Synthetic Growth DefectPMID:18931302
negative genetic interaction withrpa12DNA-directed RNA polymerase complex I subunit Rpa12 Negative GeneticPMID:18818364
negative genetic interaction withrpa12DNA-directed RNA polymerase complex I subunit Rpa12 Negative GeneticPMID:22681890
rescued byrps180140S ribosomal protein S18 (predicted) Phenotypic SuppressionPMID:24928430
positive genetic interaction withrrp1ATP-dependent DNA helicase/ ubiquitin-protein ligase E3 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withrsc1RSC complex subunit Rsc1 Negative GeneticPMID:18818364
negative genetic interaction withrsc4RSC complex subunit Rsc4 Negative GeneticPMID:22681890
enhances phenotype ofrxt2histone deacetylase complex subunit Rxt2 Phenotypic EnhancementPMID:19547744
negative genetic interaction withryh1GTPase Ryh1 Negative GeneticPMID:18818364
negative genetic interaction withsdc1Dpy-30 domain protein Sdc1 Negative GeneticPMID:18818364
negative genetic interaction withset1histone lysine methyltransferase Set1 Negative GeneticPMID:18818364
negative genetic interaction withsgf29SAGA complex subunit Sgf29 Negative GeneticPMID:18818364
negative genetic interaction withsgf73SAGA complex subunit Sgf73 Negative GeneticPMID:25076038
enhances phenotype ofsid2NDR kinase Sid2 Phenotypic EnhancementPMID:23087209
positive genetic interaction withSPAC15E1.10PI31 proteasome inhibitor (predicted) Positive GeneticPMID:22681890
negative genetic interaction withSPAC1805.14Schizosaccharomyces specific protein Negative GeneticPMID:22681890
negative genetic interaction withSPAC1805.16cpurine nucleoside phosphorylase (predicted) Negative GeneticPMID:22681890
positive genetic interaction withSPAC23A1.07ubiquitin-protein ligase E3 (predicted) Positive GeneticPMID:18818364
negative genetic interaction withSPBC13E7.03cRNA hairpin binding protein (predicted) Negative GeneticPMID:22681890
positive genetic interaction withSPBC15C4.06cubiquitin-protein ligase E3 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withSPBC31F10.10czf-MYND type zinc finger protein Negative GeneticPMID:18818364
negative genetic interaction withSPBC31F10.10czf-MYND type zinc finger protein Negative GeneticPMID:22681890
positive genetic interaction withSPBC582.10cATP-dependent DNA helicase Rhp16b (predicted) Positive GeneticPMID:22681890
negative genetic interaction withspc19DASH complex subunit Spc19 Negative GeneticPMID:22681890
negative genetic interaction withspc34DASH complex subunit Spc34 Negative GeneticPMID:18818364
rescued by overexpression ofspc7NMS complex subunit, Spc105/KNL-1 family member, blinkin, Spc7 Dosage RescuePMID:15371542
negative genetic interaction withspf1Set1C PHD Finger protein Spf1 Negative GeneticPMID:18818364
enhances phenotype ofspi1Ran GTPase Spi1 Phenotypic EnhancementPMID:11086011
synthetic growth defect withspi1Ran GTPase Spi1 Synthetic Growth DefectPMID:11086011
negative genetic interaction withspn1mitotic septin Spn1 Negative GeneticPMID:18818364
phenotype enhanced byssm4dynactin microtubule-binding subunit, p150-Glued Ssm4 Phenotypic EnhancementPMID:23755176
negative genetic interaction withsts5RNB-like protein Negative GeneticPMID:22681890
negative genetic interaction withsum2G2/M transition checkpoint protein Sum2 Negative GeneticPMID:18818364
negative genetic interaction withswd2Set1C complex subunit Swd2.1 Negative GeneticPMID:18818364
negative genetic interaction withswd3WD repeat protein Swd3 Negative GeneticPMID:18818364
negative genetic interaction withswd3WD repeat protein Swd3 Negative GeneticPMID:22681890
negative genetic interaction withswi6HP1 family chromodomain protein Swi6 Negative GeneticPMID:18818364
negative genetic interaction withswi6HP1 family chromodomain protein Swi6 Negative GeneticPMID:22681890
negative genetic interaction withtas3RITS complex subunit 3 Negative GeneticPMID:18818364
negative genetic interaction withtas3RITS complex subunit 3 Negative GeneticPMID:22681890
positive genetic interaction withtea2kinesin-like protein Tea2 Positive GeneticPMID:22681890
negative genetic interaction withtif38translation initiation factor eIF3h (p40) Negative GeneticPMID:22681890
rescuestip1CLIP170 family protein Tip1 Phenotypic SuppressionPMID:23613905
negative genetic interaction withtma23ribosome biogenesis protein Tma23 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withtos4FHA domain protein Tos4 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withubp2ubiquitin C-terminal hydrolase Ubp2 Negative GeneticPMID:22681890
negative genetic interaction withusp102U1 snRNP-associated protein Usp102 Negative GeneticPMID:22681890
negative genetic interaction withypa2protein phosphatase type 2A regulator, PTPA family Ypa2 Negative GeneticPMID:18818364
negative genetic interaction withypa2protein phosphatase type 2A regulator, PTPA family Ypa2 Negative GeneticPMID:22681890
negative genetic interaction withzds1zds family protein phosphatase type A regulator Zds1 (predicted) Negative GeneticPMID:18818364
External References
Database Identifier Description
NBRP SPAC18G6.15 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC18G6.15 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC18G6.15 BioGRID Interaction Datasets
Expression Viewer SPAC18G6.15 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC18G6.15 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC18G6.15 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC18G6.15 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC18G6.15 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC18G6.15 Transcriptome Viewer (Bähler Lab)
GEO SPAC18G6.15 GEO profiles
PInt SPAC18G6.15 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC18G6.15 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC18G6.15 Fission yeast phenotypic data & analysis
Cyclebase SPAC18G6.15.1 Cell Cycle Data
SPD / RIKEN14/14C11Orfeome Localization Data
UniProtKB/SwissProtQ10113Microtubule integrity protein mal3
ModBaseQ10113Database of comparative protein structure models
STRINGQ10113Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_593678EB1 family Mal3
RefSeq mRNANM_001019110972h- EB1 family Mal3 (mal3), mRNA
ePDB4ABOThe European PDB
PDB4ABOPDB
PDBsum4ABOPDBsum
European Nucleotide ArchiveCAA70707.1ENA Protein Mapping
European Nucleotide ArchiveCAA92392.1ENA Protein Mapping
UniParcUPI000012EB3EUniProt Archive

Literature for mal3

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Release Version: PomBase:26_51 - 07 Apr 2015