mal3 (SPAC18G6.15)


Gene Standard Namemal3 Characterisation Statuspublished
Systematic IDSPAC18G6.15 Feature Typeprotein coding
Synonyms Name Description
ProductEB1 family Mal3 Product Size308aa, 35.09 kDa
Genomic Location Chromosome I, 2243558-2245220 (1663nt); CDS:2243636-2244622 (987nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
ATPase activator activity4
Annotation ExtensionEvidenceWith/FromReference
cytoskeletal adaptor activity1
Annotation ExtensionEvidenceWith/FromReference
microtubule binding20
Annotation ExtensionEvidenceWith/FromReference
microtubule plus-end binding5
Annotation ExtensionEvidenceWith/FromReference
protein binding887
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
attachment of mitotic spindle microtubules to kinetochore39
Annotation ExtensionEvidenceWith/FromReference
cellular protein localization495
Annotation ExtensionEvidenceWith/FromReference
dynein-driven meiotic oscillatory nuclear movement11
Annotation ExtensionEvidenceWith/FromReference
establishment of bipolar cell polarity11
Annotation ExtensionEvidenceWith/FromReference
gamma-tubulin complex localization to mitotic spindle pole body2
Annotation ExtensionEvidenceWith/FromReference
karyogamy involved in conjugation with cellular fusion9
Annotation ExtensionEvidenceWith/FromReference
mitotic spindle assembly18
Annotation ExtensionEvidenceWith/FromReference
mitotic spindle organization24
Annotation ExtensionEvidenceWith/FromReference
nuclear migration involved in conjugation with cellular fusion3
Annotation ExtensionEvidenceWith/FromReference
protein localization to microtubule2
Annotation ExtensionEvidenceWith/FromReference
protein localization to microtubule minus-end1
Annotation ExtensionEvidenceWith/FromReference
protein localization to microtubule plus-end1
Annotation ExtensionEvidenceWith/FromReference
regulation of filamentous growth10
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
astral microtubule9
Annotation ExtensionEvidenceWith/FromReference
cell cortex of cell tip48
Annotation ExtensionEvidenceWith/FromReference
cortical microtubule7
Annotation ExtensionEvidenceWith/FromReference
cytoplasmic microtubule15
Annotation ExtensionEvidenceWith/FromReference
cytosol2302
Annotation ExtensionEvidenceWith/FromReference
microtubule cytoskeleton301
Annotation ExtensionEvidenceWith/FromReference
mitotic spindle271
Annotation ExtensionEvidenceWith/FromReference
mitotic spindle astral microtubule3
Annotation ExtensionEvidenceWith/FromReference
mitotic spindle midzone24
Annotation ExtensionEvidenceWith/FromReference
mitotic spindle pole body220
Annotation ExtensionEvidenceWith/FromReference
nucleus2700
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

Term NameGenotypesCount
abnormal filament morphologymal3Δ5
decreased spore germination frequencymal3Δ69
decreased sporulation frequencymal3Δ103
inviable vegetative cell populationmal3+1455
normal mating efficiencymal3Δ30
sensitive to 4-nitroquinoline N-oxidemal3Δ159
sensitive to thiabendazolemal3Δ329
ma3-1
slow vegetative cell population growthmal3+367
viable vegetative cell population3850
mal3Δ

Cell Phenotype

Term NameGenotypesCount
abnormal cell cycle arrest in mitotic M phasemal3Δ32
abnormal horsetail movementmal3Δ16
abnormal microtubule cytoskeleton morphology during matingmal3Δ1
abnormal microtubule cytoskeleton morphology during mitotic interphasemal3Δ186
abnormal mitotic cell cycle phasemal3Δ161
abnormal mitotic spindle midzone assemblymal3+15
abnormal nuclear migration during matingmal3Δ1
abnormal sporulation resulting in formation of ascus with more or fewer than four sporesmal3Δ99
abnormal sporulation resulting in formation of ascus with more than four sporesmal3Δ8
abolished mitotic spindle assemblymal3+3
abolished protein binding147
affecting moa1 and mal3mal3ΔC (149-308)
abolished protein localization to cell tipmal3Δ29
abolished protein localization to cortical microtubule cytoskeleton during mitotic interphase1
affects localization of tea2mal3Δ
abolished protein localization to microtubule during mitosis2
affects localization of klp2mal3Δ
decreased nuclear fusion during matingmal3Δ5
increased duration of mitotic anaphase Amal3Δ5
increased duration of mitotic M phasemal3Δ23
increased minichromosome loss upon segregation during vegetative growthmal3Δ21
mal3-1
increased protein localization to kinetochore during vegetative growth4
affects localization of bub1mal3Δ
inviable elongated vegetative cellmal3+420
inviable sporemal3Δ476
long cytoplasmic interphase microtubulesmal3Δ1
mislocalized post-anaphase arraymal3Δ1
mislocalized septum during vegetative growthmal3Δ45
misoriented septum during vegetative growthmal3Δ29
normal actin cable morphologymal3Δ4
normal actin cytoskeleton morphology during vegetative growthmal3Δ17
normal protein localization to kinetochore during vegetative growth30
affecting mad2mal3Δ
nucleus mislocalized towards cell tip during mitotic interphasemal3Δ5
mal3+
overlapping meiosis I spindlesmal3Δ2
S-shaped cellmal3Δ27
separate mitotic half spindles presentmal3+5
short cytoplasmic microtubulesmal3Δ20
T-shaped vegetative cellmal3Δ18
telophase nuclear clusteringmal3Δ5
twin haploid meiosismal3Δ3
unequal homologous chromosome segregationmal3Δ14
viable branched, elongated vegetative cellmal3Δ20
viable curved elongated vegetative cellmal3Δ20
viable curved vegetative cellmal3Δ70

FYPO Multi-allele Phenotypes

Population Phenotype

Term NameGenotypes
decreased vegetative cell population growthmoa1Δ, mal3Δ
sensitive to thiabendazolemoa1Δ, mal3Δ

Cell Phenotype

Term NameGenotypes
abnormal mitotic sister chromatid segregationmoa1Δ, mal3Δ
asymmetric gamma-tubulin complex localization to single mitotic spindle pole bodymoa1Δ, mal3Δ
bent mitotic spindlemoa1Δ, mal3Δ
cutmoa1Δ, mal3Δ
decreased protein transport along microtubule
affects localization of tea2Switch II (E366A), mal3Δ
affects localization of tea2P-loop (G223E), mal3Δ
mitotic metaphase/anaphase transition delaymoa1Δ, mal3Δ
monopolar actin cortical patch localizationmoa1Δ, mal3Δ
monoseptate vegetative cell with binucleate and anucleate compartmentsmoa1Δ, mal3Δ
normal mitotic spindle pole body duplicationmoa1Δ, mal3Δ
normal protein localization to microtubule cytoskeleton during mitotic interphase
affecting tea2Switch II (E366A), mal3Δ
affecting tea2P-loop (G223E), mal3Δ
short cytoplasmic microtubules present in decreased numbersmoa1Δ, mal3Δ
T-shaped vegetative cellask1Δ, mal3Δ
Target Of
OntologyRelationshipGeneProduct
FYPO affected by mutation in klp2 minus-end directed microtubule motor kinesin-14, Klp2
FYPO affected by mutation in mal3 EB1 family Mal3
FYPO affected by mutation in moa1 meiotic cohesin complex associated protein (Meikin) Moa1
GO localized by tea2 kinesin family plus-end microtubule motor Tea2
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons2243558..2243677, 2243738..2245220
Intron2243678..2243737
mRNA2243558..2245220
5' UTR2243558..2243635PMID:21511999
CDS2243636..2243677, 2243738..2244622
3' UTR2244623..2245220PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF03271 Pfam IPR004953 EB1, C-terminal 198 240 1
PS51230 Prosite Profiles IPR004953 EB1, C-terminal 173 247 1
PTHR10623:SF6 HMMPANTHER 4 281 1
PTHR10623 HMMPANTHER IPR027328 Microtubule-associated protein RP/EB 4 281 1
1.10.418.10 Gene3D IPR001715 Calponin homology domain 3 118 6
SSF47576 SuperFamily IPR001715 Calponin homology domain 3 117 6
0049734 SuperFamily IPR004953 EB1, C-terminal 180 246 1
Coil ncoils Predicted coiled-coil protein (DUF2205) 167 194 1055

View domain organization at Pfam

Term IDTerm NameReferenceCount
PBO:0001435calponin homology (CH) domainTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0001435

Protein Properties

Ave. residue weight 113.94 Da
Charge -10.50
Codon Adaptation Index 0.43
Isoelectric point 4.60
Molecular weight 35.09 kDa
Number of residues 308
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serine 2289
present during mitotic M phaseS297
S144, S286, S297
Annotation ExtensionEvidenceResidueReference
present during mitotic M phase experimental evidence S297 PMID:21712547
experimental evidence S297 PMID:24763107
IDA S297 PMID:25720772
IDA S286 PMID:25720772
IDA S144 PMID:25720772
O-phosphorylated residueS144,S147,S151 2457
Annotation ExtensionEvidenceResidueReference
IDA S144,S147,S151 PMID:25720772
Sequence
Gene Expression

Quantitative Gene Expression

View graphical display of gene expression data for mal3 (SPAC18G6.15)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
15511during GO:0000080PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
15834during GO:0000085PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
5234.28during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
14909during GO:0072690PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
2171.13during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
7during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
0.95during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
Complementation
DescriptionQualifierReference
functionally complemented by human MAPRE1
Miscellaneous Functional Group
DescriptionQualifierReferenceCount
plus end tracking protein3
Taxonomic Conservation
DescriptionQualifierReferenceCount
conserved in fungi4607
conserved in eukaryotes4517
conserved in metazoa3427
conserved in vertebrates3402
conserved in eukaryotes only2502
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Load genes that interact physically with SPAC18G6.15 into the Query Builder
View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
binds activation domain construct withtip1CLIP170 family protein Tip1 Two-hybridPMID:16951255
binds activation domain construct withmal3EB1 family Mal3 Two-hybridPMID:26771498
binds activation domain construct withtea2kinesin family plus-end microtubule motor Tea2 Two-hybridPMID:26771498
binds activation domain construct withpeg1CLASP family microtubule-associated protein Two-hybridPMID:26771498
binds activation domain construct withmoe1translation initiation factor eIF3d Moe1 Two-hybridPMID:11102508
forms complex withklp2minus-end directed microtubule motor kinesin-14, Klp2 Reconstituted ComplexPMID:23087209
forms complex withtip1CLIP170 family protein Tip1 Reconstituted ComplexPMID:15062095
forms complex withnda2tubulin alpha 1 Reconstituted ComplexPMID:18794845
forms complex withmoe1translation initiation factor eIF3d Moe1 Reconstituted ComplexPMID:11102508
forms complex withatb2tubulin alpha 2 Reconstituted ComplexPMID:17190604
affinity captured bypeg1CLASP family microtubule-associated protein Affinity Capture-WesternPMID:16951255
affinity captured bytea2kinesin family plus-end microtubule motor Tea2 Affinity Capture-WesternPMID:15177031
affinity captured bytea1cell end marker Tea1 Affinity Capture-MSPMID:21652630
affinity captured bytip1CLIP170 family protein Tip1 Affinity Capture-WesternPMID:15177031
affinity captured byspc7NMS complex subunit, Spc105/KNL-1 family member, blinkin, Spc7 Affinity Capture-WesternPMID:15371542
co-locates (via crystalisation or NMR) withnda3tubulin beta Nda3 Co-crystal or NMR structurePMID:22500803
co-locates (via crystalisation or NMR) withnda2tubulin alpha 1 Co-crystal or NMR structurePMID:22500803
affinity capturespeg1CLASP family microtubule-associated protein Affinity Capture-WesternPMID:16951255
affinity capturescds1replication checkpoint kinase Cds1 Affinity Capture-WesternPMID:21336311
affinity capturesspc7NMS complex subunit, Spc105/KNL-1 family member, blinkin, Spc7 Affinity Capture-WesternPMID:15371542
binds DNA-binding domain construct withpeg1CLASP family microtubule-associated protein Two-hybridPMID:16951255
binds DNA-binding domain construct withtip1CLIP170 family protein Tip1 Two-hybridPMID:16951255
co-fractionates withmal3EB1 family Mal3 Co-fractionationPMID:15665379
co-fractionates withtea2kinesin family plus-end microtubule motor Tea2 Co-fractionationPMID:15665379
Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPAC18G6.15 into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
synthetically rescued bynda2tubulin alpha 1 Synthetic RescuePMID:9348288
synthetically rescued bynda3tubulin beta Nda3 Synthetic RescuePMID:9348288
synthetically rescued byaps1diadenosine 5',5'''-p1,p6-hexaphosphate hydrolase Aps1 Synthetic RescuePMID:25254656
synthetically rescued byasp1inositol hexakisphosphate kinase/inositol pyrophosphate synthase (predicted) Synthetic RescuePMID:25254656
phenotype enhanced bypat1serine/threonine protein kinase Ran1/Pat1 Phenotypic EnhancementPMID:23755176
phenotype enhanced byssm4dynactin microtubule-binding subunit, p150-Glued Ssm4 Phenotypic EnhancementPMID:23755176
phenotype enhanced bydhc1minus-end directed microtubule motor, dynein heavy chain Dhc1 Phenotypic EnhancementPMID:23755176
rescued by overexpression ofdam1DASH complex subunit Dam1 Dosage RescuePMID:16079915
rescued by overexpression ofspc7NMS complex subunit, Spc105/KNL-1 family member, blinkin, Spc7 Dosage RescuePMID:15371542
rescued by overexpression ofasp1inositol hexakisphosphate kinase/inositol pyrophosphate synthase (predicted) Dosage RescuePMID:25254656
negative genetic interaction withkin1microtubule affinity-regulating kinase Kin1 Negative GeneticPMID:22681890
negative genetic interaction withhip4histone promoter control protein Hip4 Negative GeneticPMID:22681890
negative genetic interaction withelp4elongator complex subunit Elp4 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withcay1cactin, spliceosome complex subunit Negative GeneticPMID:18818364
negative genetic interaction withdad3DASH complex subunit Dad3 Negative GeneticPMID:22681890
negative genetic interaction withpom1DYRK family protein kinase Pom1 Negative GeneticPMID:18818364
negative genetic interaction withtas3RITS complex subunit 3 Negative GeneticPMID:22681890
negative genetic interaction withhip1hira protein, histone chaperone Hip1 Negative GeneticPMID:18818364
negative genetic interaction withcph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Negative GeneticPMID:18818364
negative genetic interaction withraf2Rik1-associated factor Raf2 Negative GeneticPMID:18818364
negative genetic interaction withmph1dual specificity protein kinase Mph1 Negative GeneticPMID:22681890
negative genetic interaction withpar1protein phosphatase PP2A regulatory subunit B-56 Par1 Negative GeneticPMID:18818364
negative genetic interaction withhrp3ATP-dependent DNA helicase Hrp3 Negative GeneticPMID:22681890
negative genetic interaction withsts5RNB-like protein Negative GeneticPMID:22681890
negative genetic interaction withhrr1Helicase Required for RNAi-mediated heterochromatin assembly Hrr1 Negative GeneticPMID:22681890
negative genetic interaction withsdc1Dpy-30 domain protein Sdc1 Negative GeneticPMID:18818364
negative genetic interaction withalp13MRG family Clr6 histone deacetylase complex subunit Alp13 Negative GeneticPMID:22681890
negative genetic interaction withspc19DASH complex subunit Spc19 Negative GeneticPMID:22681890
negative genetic interaction withduo1DASH complex subunit Duo1 Negative GeneticPMID:22681890
negative genetic interaction withSPAC1805.16cpurine nucleoside phosphorylase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withago1argonaute Negative GeneticPMID:22681890
negative genetic interaction withcbp1CENP-B homolog Negative GeneticPMID:18818364
negative genetic interaction withrsc4RSC complex subunit Rsc4 Negative GeneticPMID:22681890
negative genetic interaction withdcr1dicer Negative GeneticPMID:22681890
negative genetic interaction withmto1MT organizer Mto1 Negative GeneticPMID:22681890
negative genetic interaction withSPAC1805.14Schizosaccharomyces specific protein Negative GeneticPMID:22681890
negative genetic interaction withrdp1RNA-directed RNA polymerase Rdp1 Negative GeneticPMID:18818364
negative genetic interaction withprp4serine/threonine protein kinase Prp4 Negative GeneticPMID:22681890
negative genetic interaction withint6eIF3e subunit Int6 Negative GeneticPMID:22681890
negative genetic interaction withams2cell cycle regulated GATA-type transcription factor Ams2 Negative GeneticPMID:22681890
negative genetic interaction withapq12nuclear membrane organization protein Apq12 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withmis4cohesin loading factor (adherin) Mis4 Negative GeneticPMID:23050226
negative genetic interaction withelp3elongator complex subunit Elp3 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withmei4meiotic forkhead transcription factor Mei4 Negative GeneticPMID:18818364
negative genetic interaction withubp2ubiquitin C-terminal hydrolase Ubp2 Negative GeneticPMID:22681890
negative genetic interaction withswi6HP1 family chromodomain protein Swi6 Negative GeneticPMID:22681890
negative genetic interaction withspc34DASH complex subunit Spc34 Negative GeneticPMID:18818364
negative genetic interaction withtif38translation initiation factor eIF3h (p40) Negative GeneticPMID:22681890
negative genetic interaction withcid12poly(A) polymerase Cid12 Negative GeneticPMID:18818364
negative genetic interaction withrpa12DNA-directed RNA polymerase complex I subunit Rpa12 Negative GeneticPMID:22681890
negative genetic interaction withzds1zds family protein phosphatase type A regulator Zds1 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withtos4FHA domain protein Tos4 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withsgf73SAGA complex subunit Sgf73 Negative GeneticPMID:25076038
negative genetic interaction withryh1GTPase Ryh1 Negative GeneticPMID:18818364
negative genetic interaction witheme1Holliday junction resolvase subunit Eme1 Negative GeneticPMID:18818364
negative genetic interaction withres2MBF transcription factor complex subunit Res2 Negative GeneticPMID:18818364
negative genetic interaction withfin1serine/threonine protein kinase, NIMA related Fin1 Negative GeneticPMID:18818364
negative genetic interaction withswd3WD repeat protein Swd3 Negative GeneticPMID:22681890
negative genetic interaction withusp102U1 snRNP-associated protein Usp102 Negative GeneticPMID:22681890
negative genetic interaction withngg1SAGA complex subunit Ngg1/Ada3 Negative GeneticPMID:18818364
negative genetic interaction withamo1nuclear rim protein Amo1 Negative GeneticPMID:18818364
negative genetic interaction withash2Ash2-trithorax family protein Negative GeneticPMID:18818364
negative genetic interaction withypa2protein phosphatase type 2A regulator, PTPA family Ypa2 Negative GeneticPMID:22681890
negative genetic interaction withmid1medial ring protein Mid1 Negative GeneticPMID:22681890
negative genetic interaction withSPBC31F10.10czf-MYND type zinc finger protein Negative GeneticPMID:22681890
negative genetic interaction withspf1Set1C PHD Finger protein Spf1 Negative GeneticPMID:18818364
negative genetic interaction withmag1DNA-3-methyladenine glycosylase Mag1 Negative GeneticPMID:22681890
negative genetic interaction witharp8actin-like protein, Ino80 complex subunit Arp8 Negative GeneticPMID:18818364
negative genetic interaction withalp14TOG/XMAP14 family protein Alp14 Negative GeneticPMID:18818364
negative genetic interaction withrik1silencing protein Rik1 Negative GeneticPMID:18818364
negative genetic interaction withmre11Mre11 nuclease Negative GeneticPMID:18818364
negative genetic interaction withefc25Ras1 guanyl-nucleotide exchange factor Efc25 Negative GeneticPMID:22681890
negative genetic interaction withraf1CLRC ubiquitin E3 ligase complex specificiy factor Raf1/Dos1 Negative GeneticPMID:22681890
negative genetic interaction withlsk1P-TEFb-associated cyclin-dependent protein kinase Lsk1 Negative GeneticPMID:18818364
negative genetic interaction withrsc1RSC complex subunit Rsc1 Negative GeneticPMID:18818364
negative genetic interaction withcaf1CCR4-Not complex CAF1 family ribonuclease subunit Caf1 Negative GeneticPMID:18818364
negative genetic interaction witharp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:18818364
negative genetic interaction withgcn5SAGA complex histone acetyltransferase catalytic subunit Gcn5 Negative GeneticPMID:18818364
negative genetic interaction withask1DASH complex subunit Ask1 Negative GeneticPMID:18818364
negative genetic interaction withSPBC13E7.03cRNA hairpin binding protein (predicted) Negative GeneticPMID:22681890
negative genetic interaction withers1RNA-silencing factor Ers1 Negative GeneticPMID:22681890
negative genetic interaction withsum2translation initiation inhibitor (predicted) Negative GeneticPMID:18818364
negative genetic interaction withclr4histone H3 lysine methyltransferase Clr4 Negative GeneticPMID:22681890
negative genetic interaction withtma23ribosome biogenesis protein Tma23 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withdad4DASH complex subunit Dad4 Negative GeneticPMID:22681890
negative genetic interaction withpac2cAMP-independent regulatory protein Pac2 Negative GeneticPMID:22681890
negative genetic interaction withspn1mitotic septin Spn1 Negative GeneticPMID:18818364
negative genetic interaction withnrm1MBF complex corepressor Nrm1 Negative GeneticPMID:22681890
negative genetic interaction withdad2DASH complex subunit Dad2 Negative GeneticPMID:22681890
negative genetic interaction withswd2Set1C complex subunit Swd2.1 Negative GeneticPMID:18818364
negative genetic interaction withmad1mitotic spindle checkpoint protein Mad1 Negative GeneticPMID:18818364
negative genetic interaction withsgf29SAGA complex subunit Sgf29 Negative GeneticPMID:18818364
negative genetic interaction withres1MBF transcription factor complex subunit Res1 Negative GeneticPMID:22681890
negative genetic interaction withpub1HECT-type ubiquitin-protein ligase E3 Pub1 Negative GeneticPMID:18818364
negative genetic interaction withprw1Clr6 histone deacetylase complex subunit Prw1 Negative GeneticPMID:22681890
negative genetic interaction withset1histone lysine methyltransferase Set1 Negative GeneticPMID:18818364
synthetic growth defect withmad3mitotic spindle checkpoint protein Mad3 Synthetic Growth DefectPMID:16179942
synthetic growth defect withase1antiparallel microtubule cross-linking factor Ase1 Synthetic Growth DefectPMID:18931302
synthetic growth defect withrik1silencing protein Rik1 Synthetic Growth DefectPMID:18931302
synthetic growth defect withmad1mitotic spindle checkpoint protein Mad1 Synthetic Growth DefectPMID:18931302
synthetic growth defect withatb2tubulin alpha 2 Synthetic Growth DefectPMID:16394105
synthetic growth defect withfin1serine/threonine protein kinase, NIMA related Fin1 Synthetic Growth DefectPMID:18931302
synthetic growth defect withmph1dual specificity protein kinase Mph1 Synthetic Growth DefectPMID:18931302
synthetic growth defect withfor3formin For3 Synthetic Growth DefectPMID:18931302
synthetic growth defect withefc25Ras1 guanyl-nucleotide exchange factor Efc25 Synthetic Growth DefectPMID:18931302
synthetic growth defect withbub3mitotic spindle checkpoint protein Bub3 Synthetic Growth DefectPMID:16179942
synthetic growth defect withbub1mitotic spindle checkpoint kinase Bub1 Synthetic Growth DefectPMID:16179942
synthetic growth defect withrim20BRO1 domain protein Rim20 (predicted) Synthetic Growth DefectPMID:18931302
synthetic growth defect withasp1inositol hexakisphosphate kinase/inositol pyrophosphate synthase (predicted) Synthetic Growth DefectPMID:25254656
synthetic growth defect withmoe1translation initiation factor eIF3d Moe1 Synthetic Growth DefectPMID:11102508
synthetic growth defect withdcr1dicer Synthetic Growth DefectPMID:18931302
synthetic growth defect withspi1Ran GTPase Spi1 Synthetic Growth DefectPMID:11086011
synthetic growth defect withclp1Cdc14-related protein phosphatase Clp1/Flp1 Synthetic Growth DefectPMID:18931302
rescuestip1CLIP170 family protein Tip1 Phenotypic SuppressionPMID:23613905
rescuessid2NDR kinase Sid2 Phenotypic SuppressionPMID:23087209
overexpression rescuesatb2tubulin alpha 2 Dosage RescuePMID:16394105
rescued bytea1cell end marker Tea1 Phenotypic SuppressionPMID:25422470
rescued bycdc16two-component GAP Cdc16 Phenotypic SuppressionPMID:20498706
rescued bymad2mitotic spindle checkpoint protein Mad2 Phenotypic SuppressionPMID:20498706
rescued byrps180140S ribosomal protein S18 (predicted) Phenotypic SuppressionPMID:24928430
rescued bymtr1microtubule regulator Mtr1 Phenotypic SuppressionPMID:24928430
enhances phenotype ofmyo52myosin type V Phenotypic EnhancementPMID:23051734
enhances phenotype ofrxt2histone deacetylase complex subunit Rxt2 Phenotypic EnhancementPMID:19547744
enhances phenotype ofmyo51myosin type V Phenotypic EnhancementPMID:23051734
enhances phenotype ofalp13MRG family Clr6 histone deacetylase complex subunit Alp13 Phenotypic EnhancementPMID:19547744
enhances phenotype ofspi1Ran GTPase Spi1 Phenotypic EnhancementPMID:11086011
enhances phenotype ofknk1AAA family ATPase kink, Knk1 Phenotypic EnhancementPMID:25422470
enhances phenotype ofasp1inositol hexakisphosphate kinase/inositol pyrophosphate synthase (predicted) Phenotypic EnhancementPMID:20624911
positive genetic interaction withrrp1ATP-dependent DNA helicase/ ubiquitin-protein ligase E3 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withpho24-nitrophenylphosphatase Positive GeneticPMID:22681890
positive genetic interaction withSPBC15C4.06cubiquitin-protein ligase E3 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withtea2kinesin family plus-end microtubule motor Tea2 Positive GeneticPMID:22681890
positive genetic interaction withSPBC582.10cATP-dependent DNA helicase Rhp16b (predicted) Positive GeneticPMID:22681890
positive genetic interaction withppk30Ark1/Prk1 family protein kinase Ppk30 Positive GeneticPMID:18818364
positive genetic interaction withpab2poly(A) binding protein Pab2 Positive GeneticPMID:22681890
positive genetic interaction withhus1checkpoint clamp complex protein Hus1 Positive GeneticPMID:22681890
positive genetic interaction withfub1PI31 proteasome inhibitor Fub1 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withatb2tubulin alpha 2 Positive GeneticPMID:22681890
positive genetic interaction withSPAC23A1.07ubiquitin-protein ligase E3 (predicted) Positive GeneticPMID:18818364
synthetically rescuespeg1CLASP family microtubule-associated protein Synthetic RescuePMID:16951255
synthetic lethal withalp14TOG/XMAP14 family protein Alp14 Synthetic LethalityPMID:15371542
External References
Database Identifier Description
NBRP SPAC18G6.15 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC18G6.15 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC18G6.15 BioGRID Interaction Datasets
Expression Viewer SPAC18G6.15 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC18G6.15 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC18G6.15 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC18G6.15 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC18G6.15 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC18G6.15 Transcriptome Viewer (Bähler Lab)
GEO SPAC18G6.15 GEO profiles
PInt SPAC18G6.15 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC18G6.15 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC18G6.15 Fission yeast phenotypic data & analysis
Cyclebase SPAC18G6.15.1 Cell Cycle Data
SPD / RIKEN14/14C11Orfeome Localization Data
UniProtKB/SwissProtQ10113Microtubule integrity protein mal3
ModBaseQ10113Database of comparative protein structure models
STRINGQ10113Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_593678EB1 family Mal3
RefSeq mRNANM_001019110972h- EB1 family Mal3 (mal3), mRNA
ePDB4ABOThe European PDB
PDB4ABOPDB
PDBsum4ABOPDBsum
European Nucleotide ArchiveCAA70707.1ENA Protein Mapping
European Nucleotide ArchiveCAA92392.1ENA Protein Mapping
UniParcUPI000012EB3EUniProt Archive

Literature for mal3

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Release Version: PomBase:30_61 - 12 Sep 2016