pyp2 (SPAC19D5.01)

Gene Standard Namepyp2 ChromosomeI
Systematic IDSPAC19D5.01 Gene Start5202366
Synonyms Gene End5205202
Producttyrosine phosphatase Pyp2 Gene Length2837
Feature Typeprotein coding CDS Start5202823
Name Description CDS End5204958
Characterisation Statuspublished CDS Length2136

Ensembl Gene Location
  1. Tf2-8
  2. SPNCRNA.1058
  3. SPNCRNA.1059
  4. pyp2
  5. SPAC19D5.02c
  6. cid1
  7. ptr1
Fission Yeast Phenotype Ontology

Ontology Graph

Contact Curators
Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0000017elongated cellMicroscopypyp2+ (wild type)wild_typeOverexpressionPMID:1448087
FYPO:0000411normal cell cycle progressionCell growth assaypyp2delta (deletion)deletionPMID:1448087
FYPO:0000672normal cell morphologyMicroscopypyp2delta (deletion)deletionPMID:1448087
FYPO:0001122elongated vegetative cellnot recorded (overexpression)unknownPMID:1448087
FYPO:0001234slow cell population growthCell growth assaypyp2+ (wild type)wild_typeOverexpressionPMID:1464319
FYPO:0001315normal cell morphology during vegetative growthMicroscopypyp2delta (deletion)deletionNot specifiedPMID:1464319
FYPO:0001420normal vegetative cell population growth rateCell growth assaypyp2delta (deletion)deletionNot specifiedPMID:1464319
FYPO:0001491viable vegetative cellMicroscopypyp2delta (deletion)deletionPMID:20473289
FYPO:0001492elongated viable vegetative cellMicroscopypyp2+ (wild type)wild_typeOverexpressionPMID:1464319
GO Molecular Function

Ontology Graph

Contact Curators
Term IDTerm NameEvidenceWith/FromReference
GO:0004725protein tyrosine phosphatase activity
has_direct_input sty1TASPMID:7657164
inhibited_by CHEBI:35607IDAPMID:1464319
inhibited_by CHEBI:49976IDAPMID:1464319
GO:0005515protein bindingIPIsty1PMID:8649397
GO Biological Process

Ontology Graph

Contact Curators
Term IDTerm NameEvidenceWith/FromReference
GO:0006470protein dephosphorylationIGIsty1PMID:7657164
GO:0010972negative regulation of G2/M transition of mitotic cell cycleIGIwee1PMID:1448087
IMPPMID:1464319
GO:0045835negative regulation of meiosisIMPPMID:1668885
GO:0051403stress-activated MAPK cascadeIGIsty1PMID:8649397
GO Cellular Component

Ontology Graph

Contact Curators
Term IDTerm NameEvidenceWith/FromReference
GO:0005634nucleusIDAPMID:16823372
GO:0005737cytoplasmIDAPMID:10233152
GO:0005739mitochondrionIDAPMID:16823372
GO:0005829cytosolIDAPMID:16823372
Transcript
Contact Curators
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
152023665205202
Protein Features
Contact Curators

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF00581 IPR001763 Pfam Rhodanese-like domain 23 123 7
PF00102 IPR000242 Pfam Protein-tyrosine phosphatase, receptor/non-receptor type 460 695 3
SM00194 IPR000242 SMART Protein-tyrosine phosphatase, receptor/non-receptor type 421 700 3
SM00450 IPR001763 SMART Rhodanese-like domain 11 127 6
PS50206 IPR001763 Prosite Profiles Rhodanese-like domain 21 130 7
PS50055 IPR000242 Prosite Profiles Protein-tyrosine phosphatase, receptor/non-receptor type 461 698 3
PS50056 IPR000387 Prosite Profiles Protein-tyrosine/Dual specificity phosphatase 608 689 6
PS00383 IPR016130 Prosite Patterns Protein-tyrosine phosphatase, active site 628 638 7
G3DSA:3.40.250.10 IPR001763 Gene3D 4 130 8
G3DSA:3.90.190.10 Gene3D 456 700 8
SSF52799 SuperFamily 454 697 9
SSF52821 IPR001763 SuperFamily 26 127 7
PR00700 IPR000242 PRINTS Protein-tyrosine phosphatase, receptor/non-receptor type 589 606 3
PR00700 IPR000242 PRINTS Protein-tyrosine phosphatase, receptor/non-receptor type 665 680 3
PR00700 IPR000242 PRINTS Protein-tyrosine phosphatase, receptor/non-receptor type 681 691 3
PR00700 IPR000242 PRINTS Protein-tyrosine phosphatase, receptor/non-receptor type 499 519 3
PR00700 IPR000242 PRINTS Protein-tyrosine phosphatase, receptor/non-receptor type 485 492 3
PR00700 IPR000242 PRINTS Protein-tyrosine phosphatase, receptor/non-receptor type 625 643 3
PTHR19134 hmmpanther 74 698 3
PTHR19134:SF138 hmmpanther 74 698 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 111.61 Da
Charge 24.00
Isoelectric point 8.89
Molecular weight 79.36 kDa
Number of residues 711
Sequence
Contact Curators
Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127		population_widePMID:23101633
experimental evidencevegetative growth of a single-celled organismPECO:0000005,
PECO:0000014		population_widePMID:23101633
RNA levelNorthern assay evidencevegetative growth of a single-celled organismpresentPMID:1464319
experimental evidencevegetative growth of a single-celled organismPECO:0000014,
PECO:0000005		population_wide0.95PMID:23101633
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide0.14PMID:23101633
Species Distribution
DescriptionQualifierReference
conserved in fungi
conserved in eukaryotes
conserved in metazoa
conserved in vertebrates
conserved in eukaryotes only
Manually curated orthologous groups
SpeciesGeneDescription

Contact Curators
Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
prz1calcineurin responsive transcription factor Prz1 Negative GeneticPMID:22681890
uds1septation protein Uds1 Negative GeneticPMID:22681890
SPBC2F12.05csterol binding ankyrin repeat protein (predicted) Negative GeneticPMID:22681890
mug51variant protein kinase 19 family protein Negative GeneticPMID:22681890
apm4AP-2 adaptor complex subunit Apm4 (predicted) Negative GeneticPMID:22681890
ucp12ATP-dependent RNA helicase Ucp12 (predicted) Negative GeneticPMID:22681890
mto1MT organizer Mto1 Positive GeneticPMID:22681890
SPBC8D2.17alpha-1,2-galactosyltransferase (predicted) Negative GeneticPMID:22681890
SPAC18G6.12chypothetical protein Negative GeneticPMID:22681890
trm13tRNA 2'-O-methyltransferase Trm13 (predicted) Negative GeneticPMID:22681890
hmt2sulfide-quinone oxidoreductase Negative GeneticPMID:22681890
swc2Swr1 complex complex subunit Swc2 Negative GeneticPMID:22681890
sty1MAP kinase Sty1 Phenotypic SuppressionPMID:7501024
wtf21wtf element Wtf21 Negative GeneticPMID:22681890
SPAC1F5.05cconserved eukaryotic protein Negative GeneticPMID:22681890
acp1F-actin capping protein alpha subunit Negative GeneticPMID:22681890
spa1ornithine decarboxylase antizyme with +1 programmed ribosomal frameshift Spa1 Positive GeneticPMID:22681890
dbr1RNA lariat debranching enzyme Dbr1 Negative GeneticPMID:22681890
scs7sphingosine hydroxylase Scs7 Positive GeneticPMID:22681890
wee1M phase inhibitor protein kinase Wee1 Phenotypic SuppressionPMID:1448087
mug147sequence orphan Negative GeneticPMID:22681890
pac10prefoldin subunit 3 Pac10 (predicted) Negative GeneticPMID:22681890
atg14autophagy specific phophatidylinositol 3-kinase complex subunit Atg14 (predicted) Negative GeneticPMID:22681890
moc3transcription factor Moc3 Positive GeneticPMID:22681890
SPCC794.01cglucose-6-phosphate 1-dehydrogenase (predicted) Positive GeneticPMID:22681890
dsc2Golgi Dsc E3 ligase complex subunit Dsc2 Negative GeneticPMID:21504829
SPAC1805.14sequence orphan Negative GeneticPMID:22681890
pvg2galactose residue biosynthesis protein Pvg2 Negative GeneticPMID:22681890
vps17retromer complex subunit Vps17 Synthetic Growth DefectPMID:18931302
cdc25M phase inducer phosphatase Cdc25 Synthetic RescuePMID:1464319
Phenotypic Enhancement
Dosage LethalityPMID:7937842
ckb2CK2 family regulatory subunit (predicted) Negative GeneticPMID:22681890
ryh1GTPase Ryh1 Dosage RescuePMID:23271606
Synthetic Growth DefectPMID:18931302
slm9hira protein Slm9 Synthetic Growth DefectPMID:18931302
SPCP1E11.10ankyrin repeat protein, unknown biological role Negative GeneticPMID:22681890
pmc1mediator complex subunit Pmc1 Dosage RescuePMID:23271606
SPBC32F12.12cGolgi membrane protein involved in vesicle-mediated transport (predicted) Negative GeneticPMID:22681890
pyp1tyrosine phosphatase Pyp1 Synthetic LethalityPMID:1448087
Synthetic LethalityPMID:1464319
cdc2cyclin-dependent protein kinase Cdk1/Cdc2 Phenotypic SuppressionPMID:1448087
SPAC18B11.02ctRNA pseudouridine synthase (predicted) Negative GeneticPMID:22681890
SPCC1281.04pyridoxal reductase (predicted) Negative GeneticPMID:22681890
dsc3Golgi Dsc E3 ligase complex subunit Dsc3 Negative GeneticPMID:21504829
SPAC6B12.07cubiquitin-protein ligase E3 (predicted) Positive GeneticPMID:22681890
SPBC3F6.01cserine/threonine protein phosphatase (predicted) Negative GeneticPMID:22681890
bgs11,3-beta-glucan synthase catalytic subunit Bgs1 Dosage RescuePMID:23271606
rps340S ribosomal protein S3 (predicted) Negative GeneticPMID:22681890
SPCC594.01DUF1769 family protein Negative GeneticPMID:22681890
git5heterotrimeric G protein beta subunit Git5 Negative GeneticPMID:22681890
rfp2SUMO-targeted ubiquitin-protein ligase subunit Rfp2 Positive GeneticPMID:22681890
csn3COP9/signalosome complex subunit Csn3 (predicted) Positive GeneticPMID:22681890
dli1meiotic dynein intermediate light chain Dli1/Dil1 Negative GeneticPMID:22681890
cyr1adenylate cyclase Phenotypic SuppressionPMID:8832414
gld1mitochondrial glycerol dehydrogenase Gld1 Negative GeneticPMID:22681890
ubp3ubiquitin C-terminal hydrolase Ubp3 Phenotypic SuppressionPMID:19547744
rps40340S ribosomal protein S4 (predicted) Negative GeneticPMID:22681890
SPAC31A2.12arrestin/PY protein 1 (predicted) Negative GeneticPMID:22681890
SPAC17H9.08mitochondrial coenzyme A transporter (predicted) Negative GeneticPMID:22681890
pka1cAMP-dependent protein kinase catalytic subunit Pka1 Phenotypic SuppressionPMID:8832414
uge1UDP-glucose 4-epimerase Uge1 Negative GeneticPMID:22681890
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
wee1M phase inhibitor protein kinase Wee1 Biochemical ActivityPMID:8256510
sty1MAP kinase Sty1 Biochemical ActivityPMID:7657164
Affinity Capture-RNAPMID:22144913
Affinity Capture-WesternPMID:8649397
Biochemical Activity
Contact Curators
External References
Database Identifier Description
NBRP SPAC19D5.01 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC19D5.01 Retrieval of eukaryotic orthologs
BioGrid SPAC19D5.01 BioGRID Interaction Datasets
Bähler Lab SPAC19D5.01 Cell Cycle Expression Profile
Bähler Lab SPAC19D5.01 Meiosis/Sporulation Expression Profies
Bähler Lab SPAC19D5.01 Pheromone response/mating expression profiles
Bähler Lab SPAC19D5.01 Environmental stress expression profiles
Bähler Lab SPAC19D5.01 Bähler Lab Transcriptome Viewer
Cyclebase SPAC19D5.01 Cell Cycle Data
PInt SPAC19D5.01 Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPAC19D5.01 Entrez Gene
WikiGene2542200tyrosine phosphatase Pyp2
Uniprot_genenamePYP2
EntrezGene2542200tyrosine phosphatase Pyp2
IntEnz3.1.3.48
SPD / RIKEN37/37E03Orfeome Localization Data
UniProtKB/SwissProtP32586Tyrosine-protein phosphatase 2
ModBaseP32586Database of comparative protein structure models
Pfam Protein DomainsP32586Pfam Domain Arrangement
RefSeq PeptideNP_594899tyrosine phosphatase Pyp2
RefSeq mRNANM_001020328972h- tyrosine phosphatase Pyp2 (pyp2), mRNA
European Nucleotide ArchiveAAB24544ENA Protein Mapping
European Nucleotide ArchiveBAA87093ENA Protein Mapping
European Nucleotide ArchiveCAA42167ENA Protein Mapping
European Nucleotide ArchiveCAB16711ENA Protein Mapping
SPD / RIKEN37/37E03Orfeome Localization Data

Literature for pyp2
Contact Curators

Search: UK PMC or PubMed

Release Version: PomBase:18.34 - 04 Apr 2013