uga1 (SPAC19D5.07)


Gene Standard Nameuga1 Characterisation Statuspublished
Systematic IDSPAC19D5.07 Feature Typeprotein coding
Synonyms Name Description
Product4-aminobutyrate aminotransferase (GABA transaminase) Product Size474aa, 52.95 kDa
Genomic Location Chromosome I, 5222447-5224795 (2349nt); CDS:5223184-5224608 (1425nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
4-aminobutyrate transaminase activity1
Annotation ExtensionEvidenceWith/FromReference
pyridoxal phosphate binding26
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
gamma-aminobutyric acid catabolic process3
Annotation ExtensionEvidenceWith/FromReference
glutamate metabolic process25
Annotation ExtensionEvidenceWith/FromReference
nitrogen utilization5
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
cytosol2315
Annotation ExtensionEvidenceWith/FromReference
mitochondrion758
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopyuga1ΔNullPECO:0000005, PECO:0000137PMID:236978063759
Microscopyuga1ΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphology3089
penetrance FYPO_EXT:0000001Microscopyuga1ΔNullPECO:0000005, PECO:0000137PMID:23697806
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
152224475224795

UTRs

Region Coordinates Reference
five_prime_UTR5222447..5223183PMID:21511999
three_prime_UTR5224609..5224795PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00202 Pfam IPR005814 Aminotransferase class-III 55 423 7
PS00600 Prosite Patterns IPR005814 Aminotransferase class-III 299 338 5
PTHR11986 HMMPANTHER IPR005814 Aminotransferase class-III 12 474 7
PTHR11986:SF6 HMMPANTHER IPR004631 4-aminobutyrate aminotransferase, eukaryotic 12 474 1
3.40.640.10 Gene3D IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 88 377 31
3.90.1150.10 Gene3D IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 46 87 25
3.90.1150.10 Gene3D IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 380 474 25
SSF53383 SuperFamily IPR015424 Pyridoxal phosphate-dependent transferase 38 473 31
PIRSF000521 PIRSF IPR005814 Aminotransferase class-III 1 474 7
TIGR00699 tigrfam IPR004631 4-aminobutyrate aminotransferase, eukaryotic 12 474 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 111.70 Da
Charge 6.00
Isoelectric point 7.07
Molecular weight 52.95 kDa
Number of residues 474
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
5539during GO:0000080PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
4978during GO:0000085PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
679.79during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
2864during GO:0072690PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
3390.7during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1.6during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
3.4during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4600
conserved in eukaryotes4514
conserved in bacteria1000
conserved in metazoa3425
conserved in vertebrates3400
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
fft3SMARCAD1 family ATP-dependent DNA helicase Fft3 Positive GeneticPMID:22681890
ccr4CCR4-Not complex subunit Ccr4 (predicted) Positive GeneticPMID:22681890
hrr1Helicase Required for RNAi-mediated heterochromatin assembly Hrr1 Negative GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPAC19D5.07 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC19D5.07 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC19D5.07 BioGRID Interaction Datasets
Expression Viewer SPAC19D5.07 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC19D5.07 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC19D5.07 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC19D5.07 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC19D5.07 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC19D5.07 Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC19D5.07 Cell Cycle Data
GEO SPAC19D5.07 GEO profiles
PInt SPAC19D5.07 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC19D5.07 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC19D5.07 Fission yeast phenotypic data & analysis
IntEnz2.6.1.19Integrated relational Enzyme database
Rhea2.6.1.19Annotated reactions database
SPD / RIKEN21/21H08Orfeome Localization Data
UniProtKB/SwissProtO138374-aminobutyrate aminotransferase
ModBaseO13837Database of comparative protein structure models
STRINGO13837Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_5949054-aminobutyrate aminotransferase (GABA transaminase)
RefSeq mRNANM_001020336972h- 4-aminobutyrate aminotransferase (GABA transaminase) (uga1), mRNA
European Nucleotide ArchiveCAB16717.1ENA Protein Mapping
UniParcUPI000012B12BUniProt Archive

Literature for uga1

Search: Europe PMC or PubMed

Release Version: PomBase:23_47 - 27 Oct 2014