uga1 (SPAC19D5.07)


Gene Standard Nameuga1 Characterisation Statuspublished
Systematic IDSPAC19D5.07 Feature Typeprotein coding
Synonyms Name Description
Product4-aminobutyrate aminotransferase (GABA transaminase) Product Size474aa, 52.95 kDa
Genomic Location Chromosome I, 5222447-5224795 (2349nt); CDS:5223184-5224608 (1425nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:00038674-aminobutyrate transaminase activityIDAPMID:173552871
GO:0030170pyridoxal phosphate bindingIDAPMID:1735528726
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0009450gamma-aminobutyric acid catabolic processIDAPMID:173552873
GO:0006536glutamate metabolic processIDAPMID:1735528725
GO:0019740nitrogen utilizationISOSGD:S000003251GO_REF:00000242
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005829cytosolIDAPMID:168233722317
GO:0005739mitochondrionISSMGI:2443582GO_REF:0000001756
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopyuga1ΔNullPECO:0000005, PECO:0000137PMID:236978063755
Microscopyuga1ΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphologyMicroscopyuga1ΔNullPECO:0000005, PECO:0000137PMID:236978063078
penetrance FYPO_EXT:0000001
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
152224475224795

UTRs

Region Start End Reference
three_prime_UTR52246095224795PMID:21511999
five_prime_UTR52224475223183PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00202 Pfam IPR005814 Aminotransferase class-III 55 423 7
PS00600 Prosite Patterns IPR005814 Aminotransferase class-III 299 338 5
PTHR11986 HMMPANTHER IPR005814 Aminotransferase class-III 12 474 7
PTHR11986:SF6 HMMPANTHER IPR004631 12 474 1
G3DSA:3.90.1150.10 Gene3D IPR015422 380 474 23
G3DSA:3.90.1150.10 Gene3D IPR015422 46 87 23
G3DSA:3.40.640.10 Gene3D IPR015421 88 377 31
SSF53383 SuperFamily IPR015424 38 473 31
Low complexity (SEG) seg 63 74
PIRSF000521 PIRSF IPR005814 Aminotransferase class-III 1 474 7
TIGR00699 tigrfam IPR004631 4-aminobutyrate aminotransferase, eukaryotic 12 474 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 111.70 Da
Charge 6.00
Isoelectric point 7.07
Molecular weight 52.95 kDa
Number of residues 474
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
3390.7during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
679.79during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
3.4during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
1.6during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3080
conserved in fungi4564
conserved in eukaryotes4482
conserved in bacteria1001
conserved in metazoa3419
conserved in vertebrates3394
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
fft3SMARCAD1 family ATP-dependent DNA helicase Fft3 Positive GeneticPMID:22681890
ccr4CCR4-Not complex subunit Ccr4 (predicted) Positive GeneticPMID:22681890
hrr1Helicase Required for RNAi-mediated heterochromatin assembly Hrr1 Negative GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPAC19D5.07 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC19D5.07 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC19D5.07 BioGRID Interaction Datasets
Expression Viewer SPAC19D5.07 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC19D5.07 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC19D5.07 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC19D5.07 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC19D5.07 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC19D5.07 Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC19D5.07 Cell Cycle Data
GEO SPAC19D5.07 GEO profiles
PInt SPAC19D5.07 Protein-Protein Interaction Predictor (Bähler Lab)
IntEnz2.6.1.19Integrated relational Enzyme database
Rhea2.6.1.19Annotated reactions database
WikiGene25424944-aminobutyrate aminotransferase (GABA transaminase)
EntrezGene25424944-aminobutyrate aminotransferase (GABA transaminase)
SPD / RIKEN21/21H08Orfeome Localization Data
UniProtKB/SwissProtO138374-aminobutyrate aminotransferase
ModBaseO13837Database of comparative protein structure models
StringO13837Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_5949054-aminobutyrate aminotransferase (GABA transaminase)
RefSeq mRNANM_001020336972h- 4-aminobutyrate aminotransferase (GABA transaminase) (uga1), mRNA
European Nucleotide ArchiveCAB16717ENA Protein Mapping
UniParcUPI000012B12BUniProt Archive

Literature for uga1

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014