scs7 (SPAC19G12.08)


Gene Standard Namescs7 Characterisation Statuspublished
Systematic IDSPAC19G12.08 Feature Typeprotein coding
Synonyms Name Description
Productsphingosine hydroxylase Scs7 Product Size347aa, 40.23 kDa
Genomic Location Chromosome I, 4056794-4058815 (2022nt); CDS:4056958-4058289 (1332nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
fatty acid alpha-hydroxylase activity1
Annotation ExtensionEvidenceWith/FromReference
iron ion binding19
Annotation ExtensionEvidenceWith/FromReference
sphingosine hydroxylase activity2
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
fatty acid biosynthetic process30
Annotation ExtensionEvidenceWith/FromReference
mannosyl-inositol phosphorylceramide metabolic process5
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
endoplasmic reticulum595
Annotation ExtensionEvidenceWith/FromReference
endoplasmic reticulum membrane201
Annotation ExtensionEvidenceWith/FromReference
integral component of membrane962
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

Term NameGenotypesCount
normal growth on trichostatin Ascs7Δ114
sensitive to 4-nitroquinoline N-oxidescs7Δ159
sensitive to 5-fluorouracilscs7Δ273
sensitive to cadmiumscs7Δ249
sensitive to camptothecinscs7Δ227
sensitive to hydroxyureascs7Δ547
sensitive to salt stressscs7Δ98
sensitive to sodium butyratescs7Δ93
sensitive to valproic acidscs7Δ155
viable vegetative cell populationscs7Δ3831

Cell Phenotype

Term NameGenotypesCount
viable vegetative cell with normal cell morphologyscs7Δ3099
Target Of
OntologyRelationshipGeneProduct
GO regulated by sre1 sterol regulatory element binding protein, transcription factor Sre1
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons4056794..4057015, 4057304..4058815
Intron4057016..4057303
5' UTR4056794..4056957SPC10699
3' UTR4058290..4058815PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF04116 Pfam IPR006694 Fatty acid hydroxylase 189 331 5
TMhelix TMHMM 156 175 960
TMhelix TMHMM 180 202 960
TMhelix TMHMM 217 234 960
TMhelix TMHMM 241 263 960
TMhelix TMHMM 267 289 960
PTHR12863 HMMPANTHER 2 339 1
PIRSF005149 PIRSF IPR014430 Sterol desaturase Scs7 2 345 1

View domain organization at Pfam

Term IDTerm NameReferenceCount
SO:0001812transmembrane_helix465

Protein Properties

Ave. residue weight 115.94 Da
Charge 10.00
Codon Adaptation Index 0.78
Isoelectric point 7.81
Molecular weight 40.23 kDa
Number of residues 347
Sequence
Gene Expression

Quantitative Gene Expression

View graphical display of gene expression data for scs7 (SPAC19G12.08)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
31679during GO:0000080PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
34999during GO:0000084PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
33472during GO:0000085PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
31008during GO:0000087PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
19929.07during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
30476during GO:0072690PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
2496.23during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
15during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
4during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3090
conserved in fungi4604
conserved in eukaryotes4514
conserved in metazoa3422
conserved in vertebrates3397
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Load gene that interact genetically with SPAC19G12.08 into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
rescuessme2meiRNA sme2 Phenotypic SuppressionPMID:23980030
External References
Database Identifier Description
NBRP SPAC19G12.08 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC19G12.08 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC19G12.08 BioGRID Interaction Datasets
Expression Viewer SPAC19G12.08 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC19G12.08 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC19G12.08 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC19G12.08 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC19G12.08 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC19G12.08 Transcriptome Viewer (Bähler Lab)
GEO SPAC19G12.08 GEO profiles
PInt SPAC19G12.08 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC19G12.08 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC19G12.08 Fission yeast phenotypic data & analysis
Cyclebase SPAC19G12.08.1 Cell Cycle Data
SPD / RIKEN20/20F03Orfeome Localization Data
UniProtKB/SwissProtO13846Ceramide very long chain fatty acid hydroxylase-like protein C19G12.08
ModBaseO13846Database of comparative protein structure models
STRINGO13846Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_594423sphingosine hydroxylase Scs7
RefSeq mRNANM_001019852972h- sphingosine hydroxylase Scs7 (scs7), mRNA
European Nucleotide ArchiveCU329670ENA EMBL mapping
European Nucleotide ArchiveCAB10119ENA Protein Mapping
UniParcUPI000006B93AUniProt Archive

Literature for scs7

Search: Europe PMC or PubMed

Release Version: PomBase:30_57 - 27 Jan 2016