plb1 (SPAC1A6.04c)

Gene Standard Nameplb1 ChromosomeI
Systematic IDSPAC1A6.04c Gene Start1077514
Synonyms Gene End1074331
Productphospholipase B homolog Plb1 Gene Length3184
Feature Typeprotein coding CDS Start1076618
Name Description CDS End1074777
Characterisation Statuspublished CDS Length1842

Ensembl Gene Location
  1. SPAC1A6.01c
  2. SPAC1A6.02
  3. SPAC1A6.03c
  4. SPAC1A6.11
  5. plb1
  6. SPAC1A6.05c
  7. SPNCRNA.710
  8. meu31
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0000085sensitive to camptothecincompetitive growth assay evidenceplb1delta (deletion)deletionPMID:20537132
FYPO:0000266sensitive to DNA damaging agentscompetitive growth assay evidenceplb1delta (deletion)deletionPMID:20537132
FYPO:0002060viable vegetative cell populationMicroscopyplb1delta (deletion)deletionPMID:20473289
GO Molecular Function

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Term IDTerm NameEvidenceWith/FromReference
GO:0004622lysophospholipase activityISSUniProtKB:P39105GO_REF:0000001
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0006970response to osmotic stressIMPPMID:12715160
GO:0007165signal transductionIMPPMID:12715160
GO:0031138negative regulation of conjugation with cellular fusionIMPPMID:12715160
GO:0031670cellular response to nutrientIMPPMID:12715160
GO:0046475glycerophospholipid catabolic processICGO:0004622GO_REF:0000001
GO:0071470cellular response to osmotic stressIMPPMID:12715160
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0005576extracellular regionICGO:0009897GO_REF:0000001
GO:0005634nucleusIDAPMID:16823372
GO:0005829cytosolIDAPMID:16823372
GO:0009277fungal-type cell wallISSUniProtKB:P39105GO_REF:0000001
GO:0009897external side of plasma membraneICGO:0009277GO_REF:0000001
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
110775141074331

References

Region Start End Reference
five_prime_UTR10775141076619PMID:21511999
five_prime_UTR10775141076619PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF01735 IPR002642 Pfam Lysophospholipase, catalytic domain 114 592 6
SM00022 IPR002642 SMART Lysophospholipase, catalytic domain 36 587 6
PS51257 Prosite Profiles 1 16 19
PS51210 IPR002642 Prosite Profiles Lysophospholipase, catalytic domain 55 593 6
G3DSA:3.40.1090.10 Gene3D 55 550 8
SSF52151 IPR016035 SuperFamily 68 566 13
PTHR10728:SF2 hmmpanther 9 596 6
PTHR10728 hmmpanther 9 596 6
SignalP-noTM signalp 1 21 212

View domain organization at Pfam

Protein Properties

Ave. residue weight 109.49 Da
Charge -17.00
Isoelectric point 4.51
Molecular weight 67.12 kDa
Number of residues 613
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide38934.84PMID:23101633
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide32632.59PMID:23101633
RNA levelexperimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide86PMID:23101633
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide17PMID:23101633
Genome Organisation
DescriptionQualifierReference
tandem duplication
Species Distribution
DescriptionQualifierReference
conserved in fungi
conserved in eukaryotes
conserved in metazoa
conserved in vertebrates
conserved in eukaryotes only
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
tea2kinesin-like protein Tea2 Negative GeneticPMID:22681890
SPAC2H10.01transcription factor, zf-fungal binuclear cluster type (predicted) Positive GeneticPMID:22681890
SPAC688.12csequence orphan Negative GeneticPMID:22681890
yox1MBF complex negative regulatory component Yox1 Negative GeneticPMID:22681890
sce3translation initiation factor (predicted) Negative GeneticPMID:22681890
ctu1cytosolic thiouridylase subunit Ctu1 Positive GeneticPMID:22681890
SPBP4H10.16cphosphatase activator (predicted) Negative GeneticPMID:22681890
SPAC9G1.07sequence orphan Negative GeneticPMID:22681890
mto1MT organizer Mto1 Negative GeneticPMID:22681890
tpp1trehalose-6-phosphate phosphatase Tpp1 Negative GeneticPMID:22681890
git3G-protein coupled receptor Git3 Negative GeneticPMID:22681890
Dosage RescuePMID:12715160
pfa3palmitoyltransferase Pfa3 (predicted) Negative GeneticPMID:22681890
tal1transaldolase (predicted) Negative GeneticPMID:22681890
mug154conserved fungal protein Negative GeneticPMID:22681890
clr3histone deacetylase (class II) Clr3 Positive GeneticPMID:22681890
SPCC16A11.03cDUF2009 protein Negative GeneticPMID:22681890
SPBC8E4.05cfumarate lyase superfamily Negative GeneticPMID:22681890
SPAC1786.01ctriacylglycerol lipase (predicted) Positive GeneticPMID:22681890
SPACUNK4.16calpha,alpha-trehalose-phosphate synthase (predicted) Positive GeneticPMID:22681890
snr13-hydroxyisobutyryl-CoA hydrolase snr1 Positive GeneticPMID:22681890
SPAC977.15dienelactone hydrolase family Negative GeneticPMID:22681890
dep1Sds3-like family protein Dep1 Negative GeneticPMID:22681890
alm1medial ring protein Alm1 Negative GeneticPMID:22681890
SPBC24C6.04delta-1-pyrroline-5-carboxylate dehydrogenase (predicted) Positive GeneticPMID:22681890
def1RNAPII degradation factor Def1 (predicted) Negative GeneticPMID:22681890
rex3exonuclease Rex3 (predicted) Negative GeneticPMID:22681890
gpa2heterotrimeric G protein alpha-2 subunit Gpa2 Negative GeneticPMID:22681890
Dosage RescuePMID:12715160
SPAC12B10.09S-adenosylmethionine transporter (predicted) Positive GeneticPMID:22681890
SPCC1281.04pyridoxal reductase (predicted) Negative GeneticPMID:22681890
ppr2mitochondrial PPR repeat protein Ppr2 Negative GeneticPMID:22681890
sck2serine/threonine protein kinase Sck2 Positive GeneticPMID:22681890
dsc1Golgi Dsc E3 ligase complex subunit Dsc1 Negative GeneticPMID:21504829
dli1meiotic dynein intermediate light chain Dli1/Dil1 Negative GeneticPMID:22681890
saf4splicing associated factor Saf4 Negative GeneticPMID:22681890
coq10mitochondrial ubiquinone binding protein Coq10 Positive GeneticPMID:22681890
gpd2glycerol-3-phosphate dehydrogenase Gpd2 Positive GeneticPMID:22681890
SPAPB2B4.04cvacuolar calcium transporting P-type ATPase P2 type, Pmc1 Negative GeneticPMID:22681890
gut2glycerol-3-phosphate dehydrogenase Gut2 (predicted) Positive GeneticPMID:22681890
erg28Erg28 protein (predicted) Negative GeneticPMID:22681890
mug66meiotically upregulated gene Mug66 Negative GeneticPMID:22681890
gld1mitochondrial glycerol dehydrogenase Gld1 Negative GeneticPMID:22681890
SPCPB16A4.05curease accessory protein UREG (predicted) Positive GeneticPMID:22681890
asp1inositol hexakisphosphate kinase/inositol pyrophosphate synthase (predicted) Positive GeneticPMID:22681890
cys11cysteine synthase Negative GeneticPMID:22681890
SPBC1348.02S. pombe specific 5Tm protein family Negative GeneticPMID:22681890
rnc1RNA-binding protein that suppresses calcineurin deletion Rnc1 Negative GeneticPMID:22681890
SPAC17H9.08mitochondrial coenzyme A transporter (predicted) Negative GeneticPMID:22681890
ivn1CDC50 domain protein, implicated in signal transduction (predicted) Positive GeneticPMID:22681890
SPBC1348.03S. pombe specific 5Tm protein family Negative GeneticPMID:22681890
mpp6nuclear exosome-associated RNA binding protein Mpp6 Negative GeneticPMID:22681890
sec63ER protein translocation subcomplex subunit Sec63 (predicted) Positive GeneticPMID:22681890
SPCC622.03chypothetical protein Positive GeneticPMID:22681890
nup60nucleoporin Nup60 Negative GeneticPMID:22681890
agn2glucan endo-1,3-alpha-glucosidase Agn2 Positive GeneticPMID:22681890
wtf15wtf element Wtf15 Positive GeneticPMID:22681890
SPAC212.06cDNA helicase in rearranged telomeric region, truncated Negative GeneticPMID:22681890
SPCC63.06human WDR89 family WD repeat protein Negative GeneticPMID:22681890
tom70mitochondrial TOM complex subunit Tom70 (predicted) Negative GeneticPMID:22681890
mug131S. pombe specific UPF0300 family protein 4 Positive GeneticPMID:22681890
mug112sequence orphan Positive GeneticPMID:22681890
adn1adhesion defective protein, predicted transcriptional regulator (predicted) Positive GeneticPMID:22681890
amt1ammonium transporter Amt1 Negative GeneticPMID:22681890
SPBC31F10.17csequence orphan Negative GeneticPMID:22681890
ppr5mitochondrial PPR repeat protein Ppr5 Negative GeneticPMID:22681890
tcg1single-stranded telomeric binding protein Tgc1 Negative GeneticPMID:22681890
SPCC188.10cpseudogene Negative GeneticPMID:22681890
SPAC17H9.04cRNA-binding protein Negative GeneticPMID:22681890
SPBC18A7.01X-Pro dipeptidase (predicted) Positive GeneticPMID:22681890
ppk27serine/threonine protein kinase Ppk27 (predicted) Negative GeneticPMID:22681890
mug166sequence orphan Positive GeneticPMID:22681890
SPCC1672.04cmitochondrial copper chaperone (predicted) Negative GeneticPMID:22681890
SPAC11E3.12conserved eukaryotic protein, thioredoxin family Positive GeneticPMID:22681890
SPBC1683.06curidine ribohydrolase (predicted) Positive GeneticPMID:22681890
SPAC694.03conserved fungal protein Positive GeneticPMID:22681890
SPAC22F8.03csequence orphan Negative GeneticPMID:22681890
SPCC736.02sequence orphan Positive GeneticPMID:22681890
SPBC16H5.13WD repeat protein, human WDR7 ortholog Positive GeneticPMID:22681890
fcf2rRNA processing protein Fcf2 (predicted) Positive GeneticPMID:22681890
ptp4phosphatidate cytidylyltransferase Ptp4 (predicted) Negative GeneticPMID:22681890
gcn5SAGA complex histone acetyltransferase catalytic subunit Gcn5 Negative GeneticPMID:22681890
rpl240260S ribosomal protein L24 (predicted) Negative GeneticPMID:22681890
SPAC1805.14sequence orphan Negative GeneticPMID:22681890
SPCC1739.08cshort chain dehydrogenase (predicted) Positive GeneticPMID:22681890
mug80cyclin Clg1 (predicted) Negative GeneticPMID:22681890
sgf29SAGA complex subunit Sgf29 Negative GeneticPMID:22681890
moe1translation initiation factor eIF3d Moe1 Negative GeneticPMID:22681890
pdr1ABC transporter Pdr1 Positive GeneticPMID:22681890
arp6actin-like protein Arp6 Negative GeneticPMID:22681890
rox3mediator complex subunit Med19/Rox3 Negative GeneticPMID:22681890
SPCC550.03cSki complex RNA helicase Ski2 (predicted) Positive GeneticPMID:22681890
pht1histone H2A variant H2A.Z, Pht1 Negative GeneticPMID:22681890
rps170140S ribosomal protein S17 (predicted) Negative GeneticPMID:22681890
SPBC582.08alanine aminotransferase (predicted) Positive GeneticPMID:22681890
SPAC750.01aldo/keto reductase family protein Negative GeneticPMID:22681890
png2ING family homolog Png2 Negative GeneticPMID:22681890
git5heterotrimeric G protein beta subunit Git5 Negative GeneticPMID:22681890
SPAPJ691.02yippee-like protein Negative GeneticPMID:22681890
vps1dynamin family protein Vps1 Negative GeneticPMID:22681890
zip2vacuolar membrane zinc transporter (predicted) Positive GeneticPMID:22681890
sds23PP2A-type phosphatase inhibitor Sds23/Moc1 Negative GeneticPMID:22681890
SPAC13G6.09SSU-rRNA maturation protein Tsr4 homolog 2 (predicted) Negative GeneticPMID:22681890
SPBPB2B2.09c2-dehydropantoate 2-reductase (predicted) Positive GeneticPMID:22681890
ada1adenosine deaminase Ada1 (predicted) Negative GeneticPMID:22681890
ubp11ubiquitin C-terminal hydrolase Ubp11 Positive GeneticPMID:22681890
snf59SWI/SNF complex subunit Snf59 Negative GeneticPMID:22681890
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External References
Database Identifier Description
NBRP SPAC1A6.04c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC1A6.04c Retrieval of eukaryotic orthologs
BioGrid SPAC1A6.04c BioGRID Interaction Datasets
Bähler Lab SPAC1A6.04c Cell Cycle Expression Profile
Bähler Lab SPAC1A6.04c Meiosis/Sporulation Expression Profies
Bähler Lab SPAC1A6.04c Pheromone response/mating expression profiles
Bähler Lab SPAC1A6.04c Environmental stress expression profiles
Bähler Lab SPAC1A6.04c Bähler Lab Transcriptome Viewer
Cyclebase SPAC1A6.04c Cell Cycle Data
PInt SPAC1A6.04c Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPAC1A6.04c Entrez Gene
WikiGene2542497lysophospholipase 1
Uniprot_genenamePLB1
EntrezGene2542497lysophospholipase 1
IntEnz3.1.1.5
SPD / RIKEN36/36G12Orfeome Localization Data
UniProtKB/SwissProtP78854Lysophospholipase 1
ModBaseP78854Database of comparative protein structure models
Pfam Protein DomainsP78854Pfam Domain Arrangement
RefSeq PeptideNP_593196lysophospholipase 1
RefSeq mRNANM_001018592972h- lysophospholipase 1 (plb1), mRNA
European Nucleotide ArchiveAAO46159ENA Protein Mapping
European Nucleotide ArchiveBAA13865ENA Protein Mapping
European Nucleotide ArchiveBAA21498ENA Protein Mapping
European Nucleotide ArchiveCAB16354ENA Protein Mapping
UniParcUPI000005FA42UniProt Archive

Literature for plb1
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Search: UK PMC or PubMed

Release Version: PomBase:18_35 - 11 May 2013