nan1 (SPAC1B3.13)


Gene Standard Namenan1 Characterisation Statusbiological_role_inferred
Systematic IDSPAC1B3.13 Feature Typeprotein coding
Synonyms Name Description
ProductU3 snoRNP-associated protein Nan1 (predicted) Product Size806aa, 88.94 kDa
Genomic Location Chromosome I, 4951337-4954199 (2863nt); CDS:4951432-4954023 (2592nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
snoRNA binding31
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process

GO Slim Terms

ribosome biogenesis


Term NameCount
maturation of SSU-rRNA39
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
nucleolus359
Annotation ExtensionEvidenceWith/FromReference
small-subunit processome36
Annotation ExtensionEvidenceWith/FromReference
t-UTP complex6
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Inviable

Population Phenotype

Term NameAlleleExpressionCount
inviable vegetative cell populationnan1ΔNull1428

Cell Phenotype

Term NameAlleleExpressionCount
abnormal mitotic cell cyclenan1ΔNull808
inviable after spore germination, single or double cell division, elongated cellnan1ΔNull9
inviable after spore germination, without cell division, with elongated germ tubenan1ΔNull62
inviable after spore germination, without cell division, with normal germ tube morphologynan1ΔNull303
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
149513374951565
249517374954199

UTRs

Region Coordinates Reference
five_prime_UTR4951337..4951431PMID:21511999
mRNA4951337..4954199
exon4951432..4951565,4951737..4954023
three_prime_UTR4954024..4954199AU009650
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00400 Pfam IPR001680 WD40 repeat 262 295 104
SM00320 SMART IPR001680 WD40 repeat 487 529 112
SM00320 SMART IPR001680 WD40 repeat 257 296 112
PS50082 Prosite Profiles IPR001680 WD40 repeat 264 305 100
PS50294 Prosite Profiles IPR017986 WD40-repeat-containing domain 264 305 104
PTHR12816 HMMPANTHER 240 341 3
PTHR12816:SF20 HMMPANTHER 240 341 1
2.130.10.10 Gene3D IPR015943 WD40/YVTN repeat-like-containing domain 449 660 145
2.130.10.10 Gene3D IPR015943 WD40/YVTN repeat-like-containing domain 192 448 145
2.130.10.10 Gene3D IPR015943 WD40/YVTN repeat-like-containing domain 43 136 145
SSF50998 SuperFamily IPR011047 Quinonprotein alcohol dehydrogenase-like superfamily 225 309 7
SSF50998 SuperFamily IPR011047 Quinonprotein alcohol dehydrogenase-like superfamily 38 135 7
SSF50998 SuperFamily IPR011047 Quinonprotein alcohol dehydrogenase-like superfamily 380 533 7
SSF50978 SuperFamily IPR017986 WD40-repeat-containing domain 439 674 135

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0000190WD repeat proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000190

Protein Properties

Ave. residue weight 110.35 Da
Charge 5.00
Isoelectric point 6.84
Molecular weight 88.94 kDa
Number of residues 806
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
21475during GO:0000080PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
22513during GO:0000084PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
22286during GO:0000085PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
20950during GO:0000087PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
10852.94during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
22299during GO:0072690PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
975.95during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
3.8during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
0.71during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633
Warning
DescriptionQualifierReferenceCount
gene structure updated PMID:21511999432
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4604
conserved in eukaryotes4516
conserved in metazoa3432
conserved in vertebrates3407
conserved in eukaryotes only2503
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
affinity captured bymtl1TRAMP complex ATP-dependent RNA helicase (predicted) Affinity Capture-MSPMID:24713849
affinity captured bypir2zf-C2H2 type zinc finger protein, implicated in RNAi (predicted) Affinity Capture-MSPMID:24713849
affinity captured bytea1cell end marker Tea1 Affinity Capture-MSPMID:21652630
External References
Database Identifier Description
NBRP SPAC1B3.13 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC1B3.13 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC1B3.13 BioGRID Interaction Datasets
Expression Viewer SPAC1B3.13 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC1B3.13 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC1B3.13 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC1B3.13 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC1B3.13 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC1B3.13 Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC1B3.13 Cell Cycle Data
GEO SPAC1B3.13 GEO profiles
PInt SPAC1B3.13 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC1B3.13 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC1B3.13 Fission yeast phenotypic data & analysis
SPD / RIKEN29/29D06Orfeome Localization Data
UniProtKB/SwissProtO13878U3 small nucleolar RNA-associated protein 17
ModBaseO13878Database of comparative protein structure models
STRINGO13878Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_594798U3 snoRNP-associated protein Nan1 (predicted)
RefSeq mRNANM_001020226972h- U3 snoRNP-associated protein Nan1 (predicted) (SPAC1B3.13), mRNA
European Nucleotide ArchiveCAB11248.2ENA Protein Mapping
UniParcUPI000228F393UniProt Archive

Literature for nan1

Search: Europe PMC or PubMed

Release Version: PomBase:25_49 - 02 Feb 2015