byr1 (SPAC1D4.13)


Gene Standard Namebyr1 Characterisation Statuspublished
Systematic IDSPAC1D4.13 Feature Typeprotein coding
Synonymsste1, ste3 Name DescriptionSTErile,
BYpass of Ras
ProductMAP kinase kinase Byr1 Product Size340aa, 38.19 kDa
Genomic Location Chromosome I, 667815-669742 (1928nt); CDS:668153-669175 (1023nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005524ATP bindingIEAUniProtKB-KW:KW-0067GO_REF:0000037559
GO:0004708MAP kinase kinase activityTASPMID:116835003
GO:0005515protein bindingIPIbob1PMID:11683500887
GO:0004674protein serine/threonine kinase activityIEAUniProtKB-KW:KW-0723GO_REF:0000037112
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0000187activation of MAPK activityTASPMID:116835003
GO:0030437ascospore formationIMPPMID:304238699
GO:0000751cell cycle arrest in response to pheromoneTASPMID:84434065
GO:0006995cellular response to nitrogen starvationIGIras1PMID:230005493
GO:0000747conjugation with cellular fusionIMPPMID:304238665
GO:0000750pheromone-dependent signal transduction involved in conjugation with cellular fusionIMPPMID:797589412
GO:0032005signal transduction involved in conjugation with cellular fusionIGIbyr2PMID:844340619
IMPPMID:8196631
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005829cytosolIDAPMID:168233722317
GO:0005634nucleusIDAPMID:168233722730
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000637increased cell population growth rate on glucose carbon sourceCell growth assaybyr1ΔNullPECO:0000102, PECO:0000092PMID:91351475
Cell growth assaybyr1ΔNullPECO:0000102PMID:9135147
Cell growth assaybyr1ΔNullPECO:0000137PMID:3042386
FYPO:0002060viable vegetative cell populationbyr1ΔNullPMID:158211393755
Microscopybyr1ΔNullPMID:20473289
Microscopybyr1ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000302abnormal response to pheromoneMicroscopyste3-JM66Not specifiedPMID:193412120
Microscopyste1-K22Not specifiedPMID:1934121
Microscopyste1-OG15Not specifiedPMID:1934121
FYPO:0000583abolished sporulationCell growth assayhomozygous diploid (byr1::LEU2/byr1::LEU2)Not specifiedPMID:304238625
FYPO:0000822decreased concentration of P-factor in growth mediumMicroscopyste1-OG15Not specifiedPMID:19341219
Microscopyste1-K22Not specifiedPMID:1934121
Microscopyste3-JM66Not specifiedPMID:1934121
FYPO:0000708decreased mating efficiencyhigh throughput nucleotide sequencing assay evidencebyr1ΔNullPECO:0000015PMID:23950735222
FYPO:0001283decreased protein level during cellular response to nitrogen starvationReporter gene assaysterilebyr1Not specifiedPMID:797589412
affecting matPi
FYPO:0001147normal mating efficiencyMicroscopybyr1+ (wild type)OverexpressionPMID:304238612
FYPO:0001315normal vegetative cell morphologyMicroscopybyr1ΔNullPECO:0000137PMID:304238642
FYPO:0000280sterileOtherste3-JM66Not specifiedPMID:318551439
Otherste1-OG15Not specifiedPMID:3185514
Cell growth assaybyr1ΔNullPMID:23370392
Cell growth assaybyr1ΔNullPMID:3042386
FYPO:0001491viable vegetative cellCell growth assaybyr1ΔNullPMID:30423863271
FYPO:0002177viable vegetative cell with normal cell morphologyMicroscopybyr1ΔNullPECO:0000005, PECO:0000137PMID:236978063078
penetrance FYPO_EXT:0000001
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
1667815669742

UTRs

Region Start End Reference
three_prime_UTR669176669742PMID:21511999
five_prime_UTR667815668152PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00069 Pfam IPR000719 Protein kinase domain 67 320 109
SM00220 SMART IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain 66 320 73
PS50011 Prosite Profiles IPR000719 Protein kinase domain 66 320 110
PS00107 Prosite Patterns IPR017441 Protein kinase, ATP binding site 72 93 73
PS00108 Prosite Patterns IPR008271 Serine/threonine-protein kinase, active site 182 194 97
PTHR24360:SF16 HMMPANTHER 57 334 2
PTHR24360 HMMPANTHER 57 334 3
G3DSA:3.30.200.20 Gene3D 63 127 109
G3DSA:1.10.510.10 Gene3D 128 323 112
SSF56112 SuperFamily IPR011009 66 326 127
Coil ncoils Rabaptin coiled-coil domain 27 48 975

View domain organization at Pfam

Protein Properties

Ave. residue weight 112.32 Da
Charge 5.00
Isoelectric point 7.52
Molecular weight 38.19 kDa
Number of residues 340
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
3354.33during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
NDduring cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
0.84during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
2.7during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
orthologs cannot be distinguished132
conserved in fungi4564
conserved in eukaryotes4482
conserved in metazoa3419
conserved in vertebrates3394
conserved in eukaryotes only2485
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
zfs1CCCH tandem zinc finger protein, human Tristetraprolin homolog Zfs1, involved in mRNA catabolism Phenotypic SuppressionPMID:8534915
wis1MAP kinase kinase Wis1 Synthetic Growth DefectPMID:8557102
fan1Fanconi-associated nuclease Fan1 Synthetic LethalityPMID:24192486
ste4adaptor protein Ste4 Phenotypic SuppressionPMID:8816472
ras1GTPase Ras1 Phenotypic SuppressionPMID:1515675
Dosage RescuePMID:3042386
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
cbh2CENP-B homolog Cbh2 Two-hybridPMID:23695164
byr2MAP kinase kinase kinase Byr2 Two-hybridPMID:9315645
Two-hybridPMID:23695164
SPBC56F2.07cribosome biogenesis factor recycling AAA family ATPase (predicted) Two-hybridPMID:23695164
bob1prefoldin subunit 5 (predicted) Two-hybridPMID:11683500
Affinity Capture-Western
spk1MAP kinase Spk1 Two-hybridPMID:9660817
Two-hybridPMID:23695164
External References
Database Identifier Description
NBRP SPAC1D4.13 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC1D4.13 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC1D4.13 BioGRID Interaction Datasets
Expression Viewer SPAC1D4.13 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC1D4.13 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC1D4.13 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC1D4.13 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC1D4.13 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC1D4.13 Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC1D4.13 Cell Cycle Data
GEO SPAC1D4.13 GEO profiles
PInt SPAC1D4.13 Protein-Protein Interaction Predictor (Bähler Lab)
IntEnz2.7.1.-Integrated relational Enzyme database
Rhea2.7.1.-Annotated reactions database
WikiGene2542137MAP kinase kinase Byr1
EntrezGene2542137MAP kinase kinase Byr1
SPD / RIKEN15/15C10Orfeome Localization Data
UniProtKB/SwissProtP10506Protein kinase byr1
ModBaseP10506Database of comparative protein structure models
StringP10506Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_593026MAP kinase kinase Byr1
RefSeq mRNANM_001018425972h- MAP kinase kinase Byr1 (byr1), mRNA
European Nucleotide ArchiveCAA30326ENA Protein Mapping
European Nucleotide ArchiveCAA93222ENA Protein Mapping
UniParcUPI0000126B8FUniProt Archive

Literature for byr1

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014