byr1 (SPAC1D4.13)

Gene Standard Namebyr1 ChromosomeI
Systematic IDSPAC1D4.13 Gene Start667815
Synonymsste1, ste3 Gene End669742
ProductMAP kinase kinase Byr1 Gene Length1928
Feature Typeprotein coding CDS Start668153
Name DescriptionSTErile,
BYpass of Ras		 CDS End669175
Characterisation Statuspublished CDS Length1023

Ensembl Gene Location
  1. SPNCRNA.671
  2. SPNCRNA.672
  3. SPNCRNA.79
  4. rad15
  5. SPNCRNA.673
  6. byr1
  7. SPNCRNA.674
  8. tho2
  9. tsc1
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0000280sterileOtherste3-JM66 (unknown)unknownNot specifiedPMID:3185514
Otherste1-OG15 (unknown)unknownNot specifiedPMID:3185514
Cell growth assaybyr1delta (deletion)deletionNot specifiedPMID:3042386
FYPO:0000302abnormal response to pheromoneMicroscopyste3-JM66 (unknown)unknownNot specifiedPMID:1934121
Microscopyste1-OG15 (unknown)unknownNot specifiedPMID:1934121
Microscopyste1-K22 (unknown)unknownNot specifiedPMID:1934121
FYPO:0000637increased cell population growth rate on glucose carbon sourceCell growth assaybyr1delta (deletion)deletionPECO:0000092, PECO:0000102PMID:9135147
Cell growth assaybyr1delta (deletion)deletionNot specifiedPECO:0000137PMID:3042386
Cell growth assaybyr1delta (deletion)deletionPECO:0000102PMID:9135147
FYPO:0000822decreased concentration of P-factor in growth mediumMicroscopyste3-JM66 (unknown)unknownNot specifiedPMID:1934121
Microscopyste1-OG15 (unknown)unknownNot specifiedPMID:1934121
Microscopyste1-K22 (unknown)unknownNot specifiedPMID:1934121
FYPO:0001147normal mating efficiencyMicroscopybyr1+ (wild type)wild_typeOverexpressionPMID:3042386
FYPO:0001283decreased protein level during cellular response to nitrogen starvationReporter gene assaysterilebyr1 (unknown)unknownNot specifiedPMID:7975894
assayed_using matPi
FYPO:0001315normal cell morphology during vegetative growthMicroscopybyr1delta (deletion)deletionNot specifiedPECO:0000137PMID:3042386
FYPO:0001491viable vegetative cellCell growth assaybyr1delta (deletion)deletionNot specifiedPMID:3042386
FYPO:0002060viable vegetative cell populationbyr1delta (deletion)deletionPMID:15821139
Microscopybyr1delta (deletion)deletionPMID:20473289
GO Molecular Function

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Term IDTerm NameEvidenceWith/FromReference
GO:0004674protein serine/threonine kinase activityIEAUniProtKB:KW-0723GO_REF:0000037
GO:0004708MAP kinase kinase activityTASPMID:11683500
GO:0005515protein bindingIPIbob1PMID:11683500
GO:0005524ATP bindingIEAUniProtKB:KW-0067GO_REF:0000037
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0000165MAPK cascadeNASGO_REF:0000051
GO:0000747conjugation with cellular fusionIMPPMID:3042386
GO:0000750pheromone-dependent signal transduction involved in conjugation with cellular fusionIMPPMID:7975894
GO:0000751cell cycle arrest in response to pheromoneTASPMID:8443406
GO:0006468protein phosphorylationISMPFAM:PF00069GO_REF:0000001
GO:0006995cellular response to nitrogen starvationIGIras1PMID:2300054
GO:0030437ascospore formationIMPPMID:3042386
GO:0032005signal transduction involved in conjugation with cellular fusionIGIbyr2PMID:8443406
IMPPMID:8196631
GO:0071471cellular response to non-ionic osmotic stressIMPPMID:9135147
GO:0071475cellular hyperosmotic salinity responseIMPPMID:9135147
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0005634nucleusIDAPMID:16823372
GO:0005829cytosolIDAPMID:16823372
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
1667815669742

References

Region Start End Reference
three_prime_UTR669176669742PMID:21511999
five_prime_UTR667815668152PMID:21511999
three_prime_UTR669176669742PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF00069 IPR000719 Pfam Protein kinase, catalytic domain 67 320 109
SM00220 IPR002290 SMART Serine/threonine- / dual specificity protein kinase, catalytic domain 66 320 74
PS00107 IPR017441 Prosite Patterns Protein kinase, ATP binding site 72 93 73
PS00108 IPR008271 Prosite Patterns Serine/threonine-protein kinase, active site 182 194 97
PS50011 IPR000719 Prosite Profiles Protein kinase, catalytic domain 66 320 110
G3DSA:1.10.510.10 Gene3D 128 323 111
G3DSA:3.30.200.20 Gene3D 63 127 108
SSF56112 IPR011009 SuperFamily 66 326 127
PTHR24360 hmmpanther 3 333 2
PTHR24360:SF16 hmmpanther 3 333 1
Coil ncoils Rabaptin coiled-coil domain 27 48 974

View domain organization at Pfam

Protein Modifications (PSI-MOD)

Term IDTerm NameEvidenceResidueReference
MOD:00696phosphorylated residue

Protein Properties

Ave. residue weight 112.32 Da
Charge 5.00
Isoelectric point 7.52
Molecular weight 38.19 kDa
Number of residues 340
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide3354.33PMID:23101633
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127		population_widePMID:23101633
RNA levelexperimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide2.7PMID:23101633
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide0.84PMID:23101633
Species Distribution
DescriptionQualifierReference
orthologs cannot be distinguished
conserved in fungi
conserved in eukaryotes
conserved in metazoa
conserved in vertebrates
conserved in eukaryotes only
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
ras1GTPase Ras1 Phenotypic SuppressionPMID:1515675
Dosage RescuePMID:3042386
zfs1CCCH tandem zinc finger protein, human Tristetraprolin homolog Zfs1, involved in mRNA catabolism Phenotypic SuppressionPMID:8534915
ste4adaptor protein Ste4 Phenotypic SuppressionPMID:8816472
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
spk1MAP kinase Spk1 Two-hybridPMID:9660817
bob1prefoldin subunit 5 (predicted) Two-hybridPMID:11683500
Affinity Capture-Western
byr2MAP kinase kinase kinase Byr2 Two-hybridPMID:9315645
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External References
Database Identifier Description
NBRP SPAC1D4.13 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC1D4.13 Retrieval of eukaryotic orthologs
BioGrid SPAC1D4.13 BioGRID Interaction Datasets
Bähler Lab SPAC1D4.13 Cell Cycle Expression Profile
Bähler Lab SPAC1D4.13 Meiosis/Sporulation Expression Profies
Bähler Lab SPAC1D4.13 Pheromone response/mating expression profiles
Bähler Lab SPAC1D4.13 Environmental stress expression profiles
Bähler Lab SPAC1D4.13 Bähler Lab Transcriptome Viewer
Cyclebase SPAC1D4.13 Cell Cycle Data
PInt SPAC1D4.13 Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPAC1D4.13 Entrez Gene
IntEnz2.7.1.-
WikiGene2542137MAP kinase kinase Byr1
Uniprot_genenameBYR1
EntrezGene2542137MAP kinase kinase Byr1
SPD / RIKEN15/15C10Orfeome Localization Data
UniProtKB/SwissProtP10506Protein kinase byr1
ModBaseP10506Database of comparative protein structure models
Pfam Protein DomainsP10506Pfam Domain Arrangement
RefSeq PeptideNP_593026MAP kinase kinase Byr1
RefSeq mRNANM_001018425972h- MAP kinase kinase Byr1 (byr1), mRNA
European Nucleotide ArchiveCAA30326ENA Protein Mapping
European Nucleotide ArchiveCAA93222ENA Protein Mapping
UniParcUPI0000126B8FUniProt Archive

Literature for byr1
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Search: UK PMC or PubMed

Release Version: PomBase:18_35 - 11 May 2013