fip1 (SPAC1F7.07c)

Gene Standard Namefip1 Characterisation Statuspublished
Systematic IDSPAC1F7.07c Feature Typeprotein coding
Synonyms Name Description
Productiron permease Fip1 Product Size397aa, 44.31 kDa
Genomic Location Chromosome I, 4234760-4232998 (1763nt); CDS:4234496-4233303 (1194nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005381iron ion transmembrane transporter activityISOSGD:S000000947GO_REF:000002410
GO:0005515protein bindingIPIfio1PMID:10593913887
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0006827high-affinity iron ion transportISOSGD:S000000947GO_REF:00000241
GO:0033215iron assimilation by reduction and transportTASPMID:169636263
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005794Golgi apparatusIDAPMID:16823372355
GO:0005783endoplasmic reticulumIDAPMID:16823372594
GO:0016021integral component of membraneIEAUniProtKB-KW:KW-0812GO_REF:00000371016
GO:0005886plasma membraneISOSGD:S000000947GO_REF:0000024243
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopyfip1ΔNullPECO:0000005, PECO:0000137PMID:236978063755

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphologyMicroscopyfip1ΔNullPECO:0000005, PECO:0000137PMID:236978063078
penetrance FYPO_EXT:0000001
Target Of
regulated by fep1 iron-sensing transcription factor Fep1 PMID:11956219
Ensembl transcript structure with UTRs, exons and introns


Exon Start End


Region Start End Reference
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF03239 Pfam IPR004923 Iron permease FTR1 8 318 1
TMhelix TMHMM 175 197 959
TMhelix TMHMM 96 118 959
TMhelix TMHMM 148 170 959
TMhelix TMHMM 202 224 959
TMhelix TMHMM 59 81 959
TMhelix TMHMM 291 313 959
TMhelix TMHMM 10 32 959
PTHR31632:SF0 HMMPANTHER 1 390 1
PTHR31632 HMMPANTHER 1 390 1
Low complexity (SEG) seg 155 172
Low complexity (SEG) seg 241 252
Low complexity (SEG) seg 64 81

View domain organization at Pfam

Protein Properties

Ave. residue weight 111.62 Da
Charge 0.00
Isoelectric point 6.52
Molecular weight 44.31 kDa
Number of residues 397

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
MOD:00696phosphorylated residuePMID:182575171192
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
NDduring cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633
4872.54during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
5.3during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
0.95during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633
Species Distribution
conserved in fungi4564

Manually curated orthologous groups


Orthologs in Compara

Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
abc3ABC transporter Abc3, unknown specificity Synthetic Growth DefectPMID:19915076
External References
Database Identifier Description
NBRP SPAC1F7.07c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC1F7.07c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC1F7.07c BioGRID Interaction Datasets
Expression Viewer SPAC1F7.07c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC1F7.07c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC1F7.07c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC1F7.07c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC1F7.07c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC1F7.07c Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC1F7.07c Cell Cycle Data
GEO SPAC1F7.07c GEO profiles
PInt SPAC1F7.07c Protein-Protein Interaction Predictor (Bähler Lab)
WikiGene2541557iron permease Fip1
EntrezGene2541557iron permease Fip1
SPD / RIKEN19/19A08Orfeome Localization Data
UniProtKB/SwissProtQ09919Plasma membrane iron permease
ModBaseQ09919Database of comparative protein structure models
StringQ09919Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_594493iron permease Fip1
RefSeq mRNANM_001019922972h- iron permease Fip1 (fip1), mRNA
European Nucleotide ArchiveCAA91954ENA Protein Mapping
UniParcUPI000013A103UniProt Archive

Literature for fip1

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014