fip1 (SPAC1F7.07c)


Gene Standard Namefip1 Characterisation Statuspublished
Systematic IDSPAC1F7.07c Feature Typeprotein coding
Synonyms Name Description
Productiron permease Fip1 Product Size397aa, 44.31 kDa
Genomic Location Chromosome I, 4234760-4232998 (1763nt); CDS:4234496-4233303 (1194nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
iron ion transmembrane transporter activity10
Annotation ExtensionEvidenceWith/FromReference
protein binding856
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
high-affinity iron ion transmembrane transport1
Annotation ExtensionEvidenceWith/FromReference
iron assimilation by reduction and transport3
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
endoplasmic reticulum596
Annotation ExtensionEvidenceWith/FromReference
Golgi apparatus357
Annotation ExtensionEvidenceWith/FromReference
high-affinity iron permease complex1
Annotation ExtensionEvidenceWith/FromReference
integral component of membrane1018
Annotation ExtensionEvidenceWith/FromReference
plasma membrane249
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
viable vegetative cell populationfip1ΔNull3795

Cell Phenotype

Term NameAlleleExpressionCount
viable vegetative cell with normal cell morphologyfip1ΔNull3093
Target Of
OntologyRelationshipGeneProductReference
FYPO affected by mutation in cuf1 nutritional copper sensing transcription factor Cuf1 PMID:10593913
GO regulated by fep1 iron-sensing transcription factor Fep1 PMID:12888492
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons4234760..4232998
mRNA4234760..4232998
5' UTR4234760..4234497SPC01951
CDS4234496..4233303
3' UTR4233302..4232998PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF03239 Pfam IPR004923 Iron permease FTR1/Fip1/EfeU 8 318 1
TMhelix TMHMM 291 313 959
TMhelix TMHMM 202 224 959
TMhelix TMHMM 96 118 959
TMhelix TMHMM 59 81 959
TMhelix TMHMM 148 170 959
TMhelix TMHMM 10 32 959
TMhelix TMHMM 175 197 959
PTHR31632 HMMPANTHER IPR004923 Iron permease FTR1/Fip1/EfeU 1 388 1
PTHR31632:SF2 HMMPANTHER 1 388 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 111.62 Da
Charge 0.00
Isoelectric point 6.52
Molecular weight 44.31 kDa
Number of residues 397
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serine 1672
present during mitotic M phaseS375
present during mitotic M phaseS396
present during mitotic M phaseS346
present during mitotic M phaseS345
present during cellular response to thiabendazole, mitotic M phaseS355
present during mitotic M phaseS374
S337, S338, S344, S345, S347, S376, S396
present during mitotic M phaseS344
present during mitotic M phaseS337
present during mitotic M phaseS338
present during mitotic M phaseS376
present during mitotic M phaseS347
Annotation ExtensionEvidenceResidueReference
experimental evidence S337 PMID:24763107
present during mitotic M phase experimental evidence S337 PMID:21712547
experimental evidence S338 PMID:24763107
present during mitotic M phase experimental evidence S338 PMID:21712547
experimental evidence S344 PMID:24763107
present during mitotic M phase experimental evidence S344 PMID:21712547
experimental evidence S345 PMID:24763107
present during mitotic M phase experimental evidence S345 PMID:21712547
present during mitotic M phase experimental evidence S346 PMID:21712547
experimental evidence S347 PMID:24763107
present during mitotic M phase experimental evidence S347 PMID:21712547
present during cellular response to thiabendazole IDA S355 PMID:18257517
present during mitotic M phase experimental evidence S355 PMID:21712547
present during mitotic M phase experimental evidence S374 PMID:21712547
present during mitotic M phase experimental evidence S375 PMID:21712547
experimental evidence S376 PMID:24763107
present during mitotic M phase experimental evidence S376 PMID:21712547
experimental evidence S396 PMID:24763107
present during mitotic M phase experimental evidence S396 PMID:21712547
O-phospho-L-threonine 698
present during mitotic M phaseT357
level fluctuates during mitotic cell cycleT386
T340
present during cellular response to thiabendazole, mitotic M phaseT340
present during mitotic M phaseT386
present during mitotic M phaseT369
Annotation ExtensionEvidenceResidueReference
experimental evidence T340 PMID:24763107
present during mitotic M phase experimental evidence T340 PMID:21712547
present during cellular response to thiabendazole IDA T340 PMID:18257517
present during mitotic M phase experimental evidence T357 PMID:21712547
present during mitotic M phase experimental evidence T369 PMID:21712547
level fluctuates during mitotic cell cycle experimental evidence T386 PMID:24763107
present during mitotic M phase experimental evidence T386 PMID:21712547
phosphorylated residue 1926
Annotation ExtensionEvidenceResidueReference
IDA PMID:19547744
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
79910during GO:0000080PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
106729during GO:0000084PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
76293during GO:0000085PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
97434during GO:0000087PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
4872.54during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
100055during GO:0072690PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
5.3during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
0.95during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
conserved in fungi4604
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
synthetic growth defect withabc3ABC transmembrane transporter Abc3, unknown specificity Synthetic Growth DefectPMID:19915076
External References
Database Identifier Description
NBRP SPAC1F7.07c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC1F7.07c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC1F7.07c BioGRID Interaction Datasets
Expression Viewer SPAC1F7.07c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC1F7.07c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC1F7.07c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC1F7.07c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC1F7.07c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC1F7.07c Transcriptome Viewer (Bähler Lab)
GEO SPAC1F7.07c GEO profiles
PInt SPAC1F7.07c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC1F7.07c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC1F7.07c Fission yeast phenotypic data & analysis
Cyclebase SPAC1F7.07c.1 Cell Cycle Data
SPD / RIKEN19/19A08Orfeome Localization Data
UniProtKB/SwissProtQ09919Plasma membrane iron permease
ModBaseQ09919Database of comparative protein structure models
STRINGQ09919Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_594493iron permease Fip1
RefSeq mRNANM_001019922972h- iron permease Fip1 (fip1), mRNA
European Nucleotide ArchiveCAA91954.1ENA Protein Mapping
UniParcUPI000013A103UniProt Archive

Literature for fip1

Search: Europe PMC or PubMed

Release Version: PomBase:26_51 - 07 Apr 2015