fip1 (SPAC1F7.07c)

Gene Standard Namefip1 Characterisation Statuspublished
Systematic IDSPAC1F7.07c Feature Typeprotein coding
Synonyms Name Description
Productiron permease Fip1 Product Size397aa, 44.31 kDa
Genomic Location Chromosome I, 4234760-4232998 (1763nt); CDS:4234496-4233303 (1194nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
iron ion transmembrane transporter activity7
Annotation ExtensionEvidenceWith/FromReference
protein binding887
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
high-affinity iron ion transmembrane transport1
Annotation ExtensionEvidenceWith/FromReference
iron assimilation by reduction and transport3
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
endoplasmic reticulum599
Annotation ExtensionEvidenceWith/FromReference
Golgi apparatus357
Annotation ExtensionEvidenceWith/FromReference
high-affinity iron permease complex1
Annotation ExtensionEvidenceWith/FromReference
integral component of membrane966
Annotation ExtensionEvidenceWith/FromReference
plasma membrane253
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

Term NameGenotypesCount
viable vegetative cell populationfip1Δ3850

Cell Phenotype

Term NameGenotypesCount
viable vegetative cell with normal cell morphologyfip1Δ3102
Target Of
FYPO affected by mutation in ark1 aurora-B kinase Ark1
FYPO affected by mutation in cuf1 nutritional copper sensing transcription factor Cuf1
FYPO affected by mutation in fep1 iron-sensing transcription factor Fep1
GO regulated by fep1 iron-sensing transcription factor Fep1
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
5' UTR4234760..4234497SPC01951
3' UTR4233302..4232998PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF03239 Pfam IPR004923 Iron permease FTR1/Fip1/EfeU 8 318 1
TMhelix TMHMM 59 81 950
TMhelix TMHMM 202 224 950
TMhelix TMHMM 175 197 950
TMhelix TMHMM 10 32 950
TMhelix TMHMM 148 170 950
TMhelix TMHMM 96 118 950
TMhelix TMHMM 291 313 950
PTHR31632 HMMPANTHER IPR004923 Iron permease FTR1/Fip1/EfeU 1 377 1
PTHR31632:SF2 HMMPANTHER 1 377 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 111.62 Da
Charge 0.00
Codon Adaptation Index 0.61
Isoelectric point 6.52
Molecular weight 44.31 kDa
Number of residues 397
Gene Expression

Qualitative Gene Expression

RNA levelpresent during GO:0072690Northern assay evidencePMID:12888492
increased during GO:0010106Northern assay evidencePMID:12888492
absent during GO:0071281Northern assay evidencePMID:12888492

Quantitative Gene Expression

View graphical display of gene expression data for fip1 (SPAC1F7.07c)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
79910during GO:0000080PECO:0000005,
single cellmass spectrometry evidencePMID:24763107
106729during GO:0000084PECO:0000005,
single cellmass spectrometry evidencePMID:24763107
76293during GO:0000085PECO:0000005,
single cellmass spectrometry evidencePMID:24763107
97434during GO:0000087PECO:0000005,
single cellmass spectrometry evidencePMID:24763107
100055during GO:0072690PECO:0000005,
single cellmass spectrometry evidencePMID:24763107
4872.54during GO:0072690PECO:0000014,
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
5.3during GO:0072690PECO:0000014,
population wideexperimental evidencePMID:23101633
0.95during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
conserved in fungi4607

Manually curated orthologous groups


Orthologs in Compara

Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPAC1F7.07c into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
synthetic growth defect withabc3ABC transmembrane transporter Abc3, unknown specificity Synthetic Growth DefectPMID:19915076
External References
Database Identifier Description
NBRP SPAC1F7.07c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC1F7.07c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC1F7.07c BioGRID Interaction Datasets
Expression Viewer SPAC1F7.07c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC1F7.07c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC1F7.07c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC1F7.07c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC1F7.07c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC1F7.07c Transcriptome Viewer (Bähler Lab)
GEO SPAC1F7.07c GEO profiles
PInt SPAC1F7.07c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC1F7.07c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC1F7.07c Fission yeast phenotypic data & analysis
Cyclebase SPAC1F7.07c.1 Cell Cycle Data
SPD / RIKEN19/19A08Orfeome Localization Data
UniProtKB/SwissProtQ09919Plasma membrane iron permease
ModBaseQ09919Database of comparative protein structure models
STRINGQ09919Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_594493iron permease Fip1
RefSeq mRNANM_001019922972h- iron permease Fip1 (fip1), mRNA
European Nucleotide ArchiveCAA91954.1ENA Protein Mapping
UniParcUPI000013A103UniProt Archive

Literature for fip1

Search: Europe PMC or PubMed

Release Version: PomBase:30_61 - 12 Sep 2016