fip1 (SPAC1F7.07c)

Gene Standard Namefip1 Characterisation Statuspublished
Systematic IDSPAC1F7.07c Feature Typeprotein coding
Synonyms Name Description
Productiron permease Fip1 Product Size397aa, 44.31 kDa
Genomic Location Chromosome I, 4234760-4232998 (1763nt); CDS:4234496-4233303 (1194nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
iron ion transmembrane transporter activity10
Annotation ExtensionEvidenceWith/FromReference
protein binding831
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
high-affinity iron ion transmembrane transport1
Annotation ExtensionEvidenceWith/FromReference
iron assimilation by reduction and transport3
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
endoplasmic reticulum594
Annotation ExtensionEvidenceWith/FromReference
Golgi apparatus355
Annotation ExtensionEvidenceWith/FromReference
high-affinity iron permease complex1
Annotation ExtensionEvidenceWith/FromReference
integral component of membrane1018
Annotation ExtensionEvidenceWith/FromReference
plasma membrane247
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopyfip1ΔNullPMID:204732893759
Microscopyfip1ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphology3089
penetrance FYPO_EXT:0000001Microscopyfip1ΔNullPECO:0000005, PECO:0000137PMID:23697806
Target Of
GO regulated by fep1 iron-sensing transcription factor Fep1 PMID:12888492
Ensembl transcript structure with UTRs, exons and introns


Exon Start End


Region Coordinates Reference
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF03239 Pfam IPR004923 Iron permease FTR1 8 318 1
TMhelix TMHMM 291 313 959
TMhelix TMHMM 10 32 959
TMhelix TMHMM 59 81 959
TMhelix TMHMM 175 197 959
TMhelix TMHMM 96 118 959
TMhelix TMHMM 202 224 959
TMhelix TMHMM 148 170 959
PTHR31632:SF0 HMMPANTHER 1 390 1
PTHR31632 HMMPANTHER Iron permease FTR1/Fip1/EfeU 1 390 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 111.62 Da
Charge 0.00
Isoelectric point 6.52
Molecular weight 44.31 kDa
Number of residues 397

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
MOD:00046O-phospho-L-serineexperimental evidenceS376PMID:247631071670
present during mitotic M phaseexperimental evidenceS344PMID:21712547
present during mitotic M phaseexperimental evidenceS376PMID:21712547
experimental evidenceS347PMID:24763107
experimental evidenceS338PMID:24763107
present during mitotic M phaseexperimental evidenceS346PMID:21712547
experimental evidenceS396PMID:24763107
experimental evidenceS337PMID:24763107
experimental evidenceS345PMID:24763107
present during mitotic M phaseexperimental evidenceS347PMID:21712547
present during mitotic M phaseexperimental evidenceS396PMID:21712547
present during mitotic M phaseexperimental evidenceS375PMID:21712547
present during mitotic M phaseexperimental evidenceS355PMID:21712547
present during mitotic M phaseexperimental evidenceS374PMID:21712547
present during mitotic M phaseexperimental evidenceS345PMID:21712547
present during cellular response to thiabendazoleIDAS355PMID:18257517
present during mitotic M phaseexperimental evidenceS337PMID:21712547
experimental evidenceS344PMID:24763107
present during mitotic M phaseexperimental evidenceS338PMID:21712547
present during cellular response to thiabendazole
experimental evidenceT340PMID:24763107
level fluctuates during mitotic cell cycleexperimental evidenceT386PMID:24763107
present during mitotic M phaseexperimental evidenceT357PMID:21712547
present during mitotic M phaseexperimental evidenceT369PMID:21712547
present during mitotic M phaseexperimental evidenceT340PMID:21712547
present during mitotic M phaseexperimental evidenceT386PMID:21712547
MOD:00696phosphorylated residueNASPMID:195477441922
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
79910during GO:0000080PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
106729during GO:0000084PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
76293during GO:0000085PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
97434during GO:0000087PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
100055during GO:0072690PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
4872.54during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
NDduring cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
5.3during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
0.95during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633
Species Distribution
conserved in fungi4600

Manually curated orthologous groups


Orthologs in Compara

Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
abc3ABC transporter Abc3, unknown specificity Synthetic Growth DefectPMID:19915076
External References
Database Identifier Description
NBRP SPAC1F7.07c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC1F7.07c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC1F7.07c BioGRID Interaction Datasets
Expression Viewer SPAC1F7.07c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC1F7.07c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC1F7.07c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC1F7.07c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC1F7.07c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC1F7.07c Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC1F7.07c Cell Cycle Data
GEO SPAC1F7.07c GEO profiles
PInt SPAC1F7.07c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC1F7.07c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC1F7.07c Fission yeast phenotypic data & analysis
SPD / RIKEN19/19A08Orfeome Localization Data
UniProtKB/SwissProtQ09919Plasma membrane iron permease
ModBaseQ09919Database of comparative protein structure models
STRINGQ09919Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_594493iron permease Fip1
RefSeq mRNANM_001019922972h- iron permease Fip1 (fip1), mRNA
European Nucleotide ArchiveCAA91954.1ENA Protein Mapping
UniParcUPI000013A103UniProt Archive

Literature for fip1

Search: Europe PMC or PubMed

Release Version: PomBase:23_47 - 27 Oct 2014