fip1 (SPAC1F7.07c)


Gene Standard Namefip1 Characterisation Statuspublished
Systematic IDSPAC1F7.07c Feature Typeprotein coding
Synonyms Name Description
Productiron permease Fip1 Product Size397aa, 44.31 kDa
Genomic Location Chromosome I, 4234760-4232998 (1763nt); CDS:4234496-4233303 (1194nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005381iron ion transmembrane transporter activityISOSGD:S000000947GO_REF:000002410
GO:0005515protein bindingIPIfio1PMID:10593913831
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0006827high-affinity iron ion transmembrane transportISOSGD:S000000947GO_REF:00000241
GO:0033215iron assimilation by reduction and transportTASPMID:169636263
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005794Golgi apparatusIDAPMID:16823372355
GO:0005783endoplasmic reticulumIDAPMID:16823372594
GO:0033573high-affinity iron permease complexIEAIPR004923GO_REF:00000021
GO:0016021integral component of membraneIEAUniProtKB-KW:KW-0812GO_REF:00000371018
GO:0005886plasma membraneISOSGD:S000000947GO_REF:0000024247
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopyfip1ΔNullPMID:204732893759
Microscopyfip1ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphology3089
penetrance FYPO_EXT:0000001Microscopyfip1ΔNullPECO:0000005, PECO:0000137PMID:23697806
Target Of
OntologyRelationshipGeneProductReference
GO regulated by fep1 iron-sensing transcription factor Fep1 PMID:12888492
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
142347604232998

UTRs

Region Coordinates Reference
three_prime_UTR4233302..4232998PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF03239 Pfam IPR004923 Iron permease FTR1 8 318 1
TMhelix TMHMM 291 313 959
TMhelix TMHMM 10 32 959
TMhelix TMHMM 59 81 959
TMhelix TMHMM 175 197 959
TMhelix TMHMM 96 118 959
TMhelix TMHMM 202 224 959
TMhelix TMHMM 148 170 959
PTHR31632:SF0 HMMPANTHER 1 390 1
PTHR31632 HMMPANTHER Iron permease FTR1/Fip1/EfeU 1 390 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 111.62 Da
Charge 0.00
Isoelectric point 6.52
Molecular weight 44.31 kDa
Number of residues 397
Modifications

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
MOD:00046O-phospho-L-serineexperimental evidenceS376PMID:247631071670
present during mitotic M phaseexperimental evidenceS344PMID:21712547
present during mitotic M phaseexperimental evidenceS376PMID:21712547
experimental evidenceS347PMID:24763107
experimental evidenceS338PMID:24763107
present during mitotic M phaseexperimental evidenceS346PMID:21712547
experimental evidenceS396PMID:24763107
experimental evidenceS337PMID:24763107
experimental evidenceS345PMID:24763107
present during mitotic M phaseexperimental evidenceS347PMID:21712547
present during mitotic M phaseexperimental evidenceS396PMID:21712547
present during mitotic M phaseexperimental evidenceS375PMID:21712547
present during mitotic M phaseexperimental evidenceS355PMID:21712547
present during mitotic M phaseexperimental evidenceS374PMID:21712547
present during mitotic M phaseexperimental evidenceS345PMID:21712547
present during cellular response to thiabendazoleIDAS355PMID:18257517
present during mitotic M phaseexperimental evidenceS337PMID:21712547
experimental evidenceS344PMID:24763107
present during mitotic M phaseexperimental evidenceS338PMID:21712547
MOD:00047O-phospho-L-threonineIDAT340PMID:18257517692
present during cellular response to thiabendazole
experimental evidenceT340PMID:24763107
level fluctuates during mitotic cell cycleexperimental evidenceT386PMID:24763107
present during mitotic M phaseexperimental evidenceT357PMID:21712547
present during mitotic M phaseexperimental evidenceT369PMID:21712547
present during mitotic M phaseexperimental evidenceT340PMID:21712547
present during mitotic M phaseexperimental evidenceT386PMID:21712547
MOD:00696phosphorylated residueNASPMID:195477441922
NASPMID:18257517
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
79910during GO:0000080PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
106729during GO:0000084PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
76293during GO:0000085PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
97434during GO:0000087PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
100055during GO:0072690PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
4872.54during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
NDduring cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
5.3during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
0.95during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
conserved in fungi4600
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
abc3ABC transporter Abc3, unknown specificity Synthetic Growth DefectPMID:19915076
External References
Database Identifier Description
NBRP SPAC1F7.07c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC1F7.07c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC1F7.07c BioGRID Interaction Datasets
Expression Viewer SPAC1F7.07c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC1F7.07c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC1F7.07c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC1F7.07c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC1F7.07c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC1F7.07c Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC1F7.07c Cell Cycle Data
GEO SPAC1F7.07c GEO profiles
PInt SPAC1F7.07c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC1F7.07c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC1F7.07c Fission yeast phenotypic data & analysis
SPD / RIKEN19/19A08Orfeome Localization Data
UniProtKB/SwissProtQ09919Plasma membrane iron permease
ModBaseQ09919Database of comparative protein structure models
STRINGQ09919Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_594493iron permease Fip1
RefSeq mRNANM_001019922972h- iron permease Fip1 (fip1), mRNA
European Nucleotide ArchiveCAA91954.1ENA Protein Mapping
UniParcUPI000013A103UniProt Archive

Literature for fip1

Search: Europe PMC or PubMed

Release Version: PomBase:23_47 - 27 Oct 2014