yak3 (SPAC1F7.12)

Gene Standard Nameyak3 Characterisation Statuspublished
Systematic IDSPAC1F7.12 Feature Typeprotein coding
SynonymsSPAC21E11.01, yakC Name Description
Productaldose reductase ARK13 family YakC Product Size340aa, 37.71 kDa
Genomic Location Chromosome I, 4248777-4250231 (1455nt); CDS:4249066-4250088 (1023nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0016614oxidoreductase activity, acting on CH-OH group of donorsIDAPMID:1235908066
NOT GO:0050235pyridoxal 4-dehydrogenase activityIDAPMID:12359080
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopyyak3ΔNullPMID:204732893759
Microscopyyak3ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphology3089
penetrance FYPO_EXT:0000001Microscopyyak3ΔNullPECO:0000005, PECO:0000137PMID:23697806
Ensembl transcript structure with UTRs, exons and introns


Exon Start End


Region Coordinates Reference
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00248 Pfam IPR023210 NADP-dependent oxidoreductase domain 16 312 15
PTHR11732:SF12 HMMPANTHER 3 340 4
PTHR11732 HMMPANTHER IPR001395 Aldo/keto reductase 3 340 14 Gene3D IPR023210 NADP-dependent oxidoreductase domain 3 324 15
SSF51430 SuperFamily IPR023210 NADP-dependent oxidoreductase domain 4 317 15

View domain organization at Pfam

Protein Properties

Ave. residue weight 110.91 Da
Charge 0.50
Isoelectric point 6.74
Molecular weight 37.71 kDa
Number of residues 340
Gene Expression

Qualitative Gene Expression

RNA levelincreased during GO:0034599expression microarray evidencePMID:12529438

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
69987during GO:0000080PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
67713during GO:0000084PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
60284during GO:0000085PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
64942during GO:0000087PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
12989.08during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
63030during GO:0072690PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
27365.62during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
4.8during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
2.5during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633
Species Distribution
no apparent S. cerevisiae ortholog602
conserved in fungi4600
conserved in eukaryotes4514

Orthologs in Compara

External References
Database Identifier Description
NBRP SPAC1F7.12 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC1F7.12 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC1F7.12 BioGRID Interaction Datasets
Expression Viewer SPAC1F7.12 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC1F7.12 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC1F7.12 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC1F7.12 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC1F7.12 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC1F7.12 Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC1F7.12 Cell Cycle Data
GEO SPAC1F7.12 GEO profiles
PInt SPAC1F7.12 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC1F7.12 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC1F7.12 Fission yeast phenotypic data & analysis
SPD / RIKEN15/15C12Orfeome Localization Data
UniProtKB/SwissProtQ09923Aldo-keto reductase yakc [NADP(+)]
ModBaseQ09923Database of comparative protein structure models
STRINGQ09923Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_594498aldose reductase ARK13 family YakC
RefSeq mRNANM_001019927972h- aldose reductase ARK13 family YakC (yak3), mRNA
European Nucleotide ArchiveCAA91959.1ENA Protein Mapping
UniParcUPI000013A107UniProt Archive

Literature for yak3

Search: Europe PMC or PubMed

Release Version: PomBase:23_47 - 27 Oct 2014