str3 (SPAC1F8.03c)


Gene Standard Namestr3 Characterisation Statuspublished
Systematic IDSPAC1F8.03c Feature Typeprotein coding
Synonyms Name Description
Productsiderophore-iron transporter Str3 Product Size630aa, 70.56 kDa
Genomic Location Chromosome I, 90300-88201 (2100nt); CDS:90259-88367 (1893nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
siderophore transmembrane transporter activity3
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
iron assimilation by chelation and transport5
Annotation ExtensionEvidenceWith/FromReference
iron ion transmembrane transport12
Annotation ExtensionEvidenceWith/FromReference
siderophore transmembrane transport3
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
cytoplasm4206
Annotation ExtensionEvidenceWith/FromReference
integral component of membrane1018
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
viable vegetative cell populationstr3ΔNull3781

Cell Phenotype

Term NameAlleleExpressionCount
viable vegetative cell with normal cell morphology3092
penetrance FYPO_EXT:0000001str3ΔNull
Target Of
OntologyRelationshipGeneProductReference
FYPO affected by mutation in fep1 iron-sensing transcription factor Fep1 PMID:23115244
FYPO affected by mutation in fxn1 frataxin Fxn1 PMID:23115244
GO regulated by fep1 iron-sensing transcription factor Fep1 PMID:12888492
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
19030088201

UTRs

Region Coordinates Reference
five_prime_UTR90300..90260PMID:21511999
three_prime_UTR88366..88201PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF05977 Pfam IPR010290 Transmembrane secretion effector 414 523 1
PF07690 Pfam IPR011701 Major facilitator superfamily 92 354 50
TMhelix TMHMM 407 429 959
TMhelix TMHMM 303 325 959
TMhelix TMHMM 153 172 959
TMhelix TMHMM 466 488 959
TMhelix TMHMM 370 392 959
TMhelix TMHMM 82 104 959
TMhelix TMHMM 574 596 959
TMhelix TMHMM 176 198 959
TMhelix TMHMM 503 525 959
TMhelix TMHMM 335 357 959
TMhelix TMHMM 211 233 959
TMhelix TMHMM 243 262 959
TMhelix TMHMM 119 141 959
PTHR24003 HMMPANTHER 1 630 17
PTHR24003:SF507 HMMPANTHER 1 630 1
1.20.1250.20 Gene3D 88 262 72
1.20.1250.20 Gene3D 571 611 72
1.20.1250.20 Gene3D 366 526 72
SSF103473 SuperFamily IPR020846 Major facilitator superfamily domain 72 283 76
SSF103473 SuperFamily IPR020846 Major facilitator superfamily domain 365 525 76

View domain organization at Pfam

Sequence Ontology

Term IDTerm NameReferenceCount
SO:0001812transmembrane_helix465

Protein Properties

Ave. residue weight 112.00 Da
Charge 7.50
Isoelectric point 8.50
Molecular weight 70.56 kDa
Number of residues 630
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serine 1670
level fluctuates during mitotic cell cycleS10
S44, S58, S73
present during mitotic M phaseS53
present during mitotic M phaseS37
present during mitotic M phaseS58
present during mitotic M phaseS38
level fluctuates during mitotic cell cycleS8
level fluctuates during mitotic cell cycleS25
present during mitotic M phaseS10
present during mitotic M phaseS25
present during mitotic M phaseS8
present during mitotic M phaseS44
Annotation ExtensionEvidenceResidueReference
present during mitotic M phase experimental evidence S8 PMID:21712547
level fluctuates during mitotic cell cycle experimental evidence S8 PMID:24763107
present during mitotic M phase experimental evidence S10 PMID:21712547
level fluctuates during mitotic cell cycle experimental evidence S10 PMID:24763107
level fluctuates during mitotic cell cycle experimental evidence S25 PMID:24763107
present during mitotic M phase experimental evidence S25 PMID:21712547
present during mitotic M phase experimental evidence S37 PMID:21712547
present during mitotic M phase experimental evidence S38 PMID:21712547
experimental evidence S44 PMID:24763107
present during mitotic M phase experimental evidence S44 PMID:21712547
present during mitotic M phase experimental evidence S53 PMID:21712547
experimental evidence S58 PMID:24763107
present during mitotic M phase experimental evidence S58 PMID:21712547
experimental evidence S73 PMID:24763107
O-phospho-L-threonine 693
present during mitotic M phaseT6
present during mitotic M phaseT622
Annotation ExtensionEvidenceResidueReference
present during mitotic M phase experimental evidence T6 PMID:21712547
present during mitotic M phase experimental evidence T622 PMID:21712547
phosphorylated residue 1922
Annotation ExtensionEvidenceResidueReference
IDA PMID:19547744
Sequence
Gene Expression

Qualitative Gene Expression

DescriptionLevelEvidenceReference
RNA levelincreased during GO:0010106Northern assay evidencePMID:23115244

Quantitative Gene Expression

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
0.76during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
0.072during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
conserved in fungi4604
conserved in eukaryotes4516
conserved in bacteria1000
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
vps35retromer complex subunit Vps35 Negative GeneticPMID:22681890
SPBC725.05cnucleotide pyrophosphatase (predicted) Negative GeneticPMID:22681890
kin1microtubule affinity-regulating kinase Kin1 Negative GeneticPMID:22681890
cdt2WD repeat protein Cdt2 Positive GeneticPMID:22681890
SPAC1A6.03cphospholipase (predicted) Negative GeneticPMID:22681890
prp1U4/U6 x U5 tri-snRNP complex subunit Prp1 Negative GeneticPMID:22681890
SPBC16H5.13WD repeat protein, human WDR7 ortholog Negative GeneticPMID:22681890
SPBC713.07cvacuolar polyphosphatase (predicted) Negative GeneticPMID:22681890
whi5cell cycle transcriptional repressor Whi5 (predicted) Negative GeneticPMID:22681890
dad1DASH complex subunit Dad1 Positive GeneticPMID:22681890
cph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Negative GeneticPMID:22681890
sdh4TIM22 inner membrane protein import complex anchor subunit Tim18 Negative GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPAC1F8.03c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC1F8.03c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC1F8.03c BioGRID Interaction Datasets
Expression Viewer SPAC1F8.03c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC1F8.03c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC1F8.03c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC1F8.03c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC1F8.03c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC1F8.03c Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC1F8.03c Cell Cycle Data
GEO SPAC1F8.03c GEO profiles
PInt SPAC1F8.03c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC1F8.03c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC1F8.03c Fission yeast phenotypic data & analysis
SPD / RIKEN26/26E04Orfeome Localization Data
UniProtKB/SwissProtQ92341Siderophore iron transporter 3
ModBaseQ92341Database of comparative protein structure models
STRINGQ92341Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_592792siderophore-iron transporter Str3
RefSeq mRNANM_001018192972h- siderophore-iron transporter Str3 (str3), mRNA
European Nucleotide ArchiveCAB03597.1ENA Protein Mapping
UniParcUPI000013A9C7UniProt Archive

Literature for str3

Search: Europe PMC or PubMed

Release Version: PomBase:25_48 - 10 Jan 2015