str3 (SPAC1F8.03c)


Gene Standard Namestr3 Characterisation Statuspublished
Systematic IDSPAC1F8.03c Feature Typeprotein coding
SynonymsSPNCRNA.106 Name DescriptionSiderophore TRansporter
Productsiderophore-iron transporter Str3 Product Size630aa, 70.56 kDa
Genomic Location Chromosome I, 90300-88201 (2100nt); CDS:90259-88367 (1893nt)

Ensembl Gene Location
GO Biological Process
Term NameCount
cellular iron ion homeostasis19
Annotation ExtensionEvidenceWith/FromReference
iron assimilation by chelation and transport4
Annotation ExtensionEvidenceWith/FromReference
transmembrane transport362
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
cytoplasm4211
Annotation ExtensionEvidenceWith/FromReference
integral component of membrane968
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Single-allele Phenotypes

Population Phenotype

Term NameGenotypesCount
viable vegetative cell populationstr3Δ3819

Cell Phenotype

Term NameGenotypesCount
viable vegetative cell with normal cell morphologystr3Δ3097
Target Of
OntologyRelationshipGeneProduct
FYPO affected by mutation in fep1 iron-sensing transcription factor Fep1
FYPO affected by mutation in fxn1 frataxin Fxn1
GO regulated by fep1 iron-sensing transcription factor Fep1
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons90300..88201
mRNA90300..88201
5' UTR90300..90260PMID:21511999
CDS90259..88367
3' UTR88366..88201PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF07690 Pfam IPR011701 Major facilitator superfamily 92 354 50
TMhelix TMHMM 243 262 959
TMhelix TMHMM 466 488 959
TMhelix TMHMM 370 392 959
TMhelix TMHMM 119 141 959
TMhelix TMHMM 211 233 959
TMhelix TMHMM 176 198 959
TMhelix TMHMM 503 525 959
TMhelix TMHMM 335 357 959
TMhelix TMHMM 303 325 959
TMhelix TMHMM 153 172 959
TMhelix TMHMM 574 596 959
TMhelix TMHMM 407 429 959
TMhelix TMHMM 82 104 959
PTHR23501:SF58 HMMPANTHER 300 627 1
PTHR23501:SF58 HMMPANTHER 50 270 1
PTHR23501:SF58 HMMPANTHER 10 30 1
PTHR23501 HMMPANTHER 300 627 10
PTHR23501 HMMPANTHER 50 270 10
PTHR23501 HMMPANTHER 10 30 10
1.20.1250.20 Gene3D Sugar phosphate transporter 571 611 72
1.20.1250.20 Gene3D Sugar phosphate transporter 366 526 72
1.20.1250.20 Gene3D Sugar phosphate transporter 88 262 72
SSF103473 SuperFamily IPR020846 Major facilitator superfamily domain 72 283 76
SSF103473 SuperFamily IPR020846 Major facilitator superfamily domain 365 525 76

View domain organization at Pfam

Term IDTerm NameReferenceCount
SO:0001812transmembrane_helix465

Protein Properties

Ave. residue weight 112.00 Da
Charge 7.50
Isoelectric point 8.50
Molecular weight 70.56 kDa
Number of residues 630
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serine 1674
level fluctuates during mitotic cell cycleS8
present during mitotic M phaseS58
present during mitotic M phaseS8
present during mitotic M phaseS37
present during mitotic M phaseS44
S44, S58, S73
present during mitotic M phaseS38
present during mitotic M phaseS10
level fluctuates during mitotic cell cycleS25
level fluctuates during mitotic cell cycleS10
present during mitotic M phaseS25
present during mitotic M phaseS53
Annotation ExtensionEvidenceResidueReference
level fluctuates during mitotic cell cycle experimental evidence S8 PMID:24763107
present during mitotic M phase experimental evidence S8 PMID:21712547
level fluctuates during mitotic cell cycle experimental evidence S10 PMID:24763107
present during mitotic M phase experimental evidence S10 PMID:21712547
present during mitotic M phase experimental evidence S25 PMID:21712547
level fluctuates during mitotic cell cycle experimental evidence S25 PMID:24763107
present during mitotic M phase experimental evidence S37 PMID:21712547
present during mitotic M phase experimental evidence S38 PMID:21712547
experimental evidence S44 PMID:24763107
present during mitotic M phase experimental evidence S44 PMID:21712547
present during mitotic M phase experimental evidence S53 PMID:21712547
experimental evidence S58 PMID:24763107
present during mitotic M phase experimental evidence S58 PMID:21712547
experimental evidence S73 PMID:24763107
O-phospho-L-threonine 699
present during mitotic M phaseT622
present during mitotic M phaseT6
Annotation ExtensionEvidenceResidueReference
present during mitotic M phase experimental evidence T6 PMID:21712547
present during mitotic M phase experimental evidence T622 PMID:21712547
phosphorylated residue 1930
Annotation ExtensionEvidenceResidueReference
IDA PMID:19547744
Sequence
Gene Expression

Qualitative Gene Expression

DescriptionLevelEvidenceReference
RNA leveldecreased during GO:0071281Northern assay evidencePMID:12888492
increased during GO:0010106Northern assay evidencePMID:23115244
increased during GO:0010106Northern assay evidencePMID:12888492
present during GO:0072690Northern assay evidencePMID:12888492

Quantitative Gene Expression

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
0.76during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
0.072during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
DescriptionQualifierReferenceCount
conserved in fungi4604
conserved in eukaryotes4514
conserved in bacteria1000
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Load gene that interact geneitically with SPAC1F8.03c into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
negative genetic interaction withcph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Negative GeneticPMID:22681890
negative genetic interaction withvps35retromer complex subunit Vps35 Negative GeneticPMID:22681890
negative genetic interaction withprp1U4/U6 x U5 tri-snRNP complex subunit Prp1 Negative GeneticPMID:22681890
negative genetic interaction withnpp1nucleotide pyrophosphatase Npp1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPAC1A6.03cphospholipase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPBC16H5.13WD repeat protein, human WDR7 ortholog Negative GeneticPMID:22681890
negative genetic interaction withwhi5cell cycle transcriptional repressor Whi5 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withkin1microtubule affinity-regulating kinase Kin1 Negative GeneticPMID:22681890
negative genetic interaction withsdh4TIM22 inner membrane protein import complex anchor subunit Tim18 Negative GeneticPMID:22681890
negative genetic interaction withSPBC713.07cvacuolar polyphosphatase (predicted) Negative GeneticPMID:22681890
positive genetic interaction withdad1DASH complex subunit Dad1 Positive GeneticPMID:22681890
positive genetic interaction withcdt2WD repeat protein Cdt2 Positive GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPAC1F8.03c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC1F8.03c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC1F8.03c BioGRID Interaction Datasets
Expression Viewer SPAC1F8.03c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC1F8.03c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC1F8.03c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC1F8.03c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC1F8.03c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC1F8.03c Transcriptome Viewer (Bähler Lab)
GEO SPAC1F8.03c GEO profiles
PInt SPAC1F8.03c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC1F8.03c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC1F8.03c Fission yeast phenotypic data & analysis
Cyclebase SPAC1F8.03c.1 Cell Cycle Data
SPD / RIKEN26/26E04Orfeome Localization Data
UniProtKB/SwissProtQ92341Siderophore iron transporter 3
ModBaseQ92341Database of comparative protein structure models
STRINGQ92341Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_592792siderophore-iron transporter Str3
RefSeq mRNANM_001018192972h- siderophore-iron transporter Str3 (str3), mRNA
European Nucleotide ArchiveCU329670ENA EMBL mapping
European Nucleotide ArchiveCAB03597ENA Protein Mapping
European Nucleotide ArchiveCAB03597.1ENA Protein Mapping
UniParcUPI000013A9C7UniProt Archive

Literature for str3

Search: Europe PMC or PubMed

Release Version: PomBase:29_56 - 12 Nov 2015