str3 (SPAC1F8.03c)

Gene Standard Namestr3 Characterisation Statuspublished
Systematic IDSPAC1F8.03c Feature Typeprotein coding
Synonyms Name Description
Productsiderophore-iron transporter Str3 Product Size630aa, 70.56 kDa
Genomic Location Chromosome I, 90300-88201 (2100nt); CDS:90259-88367 (1893nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0015343siderophore transmembrane transporter activityTASPMID:128884923
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0033214iron assimilation by chelation and transportTASPMID:169636265
GO:0034755iron ion transmembrane transportTASPMID:1288849211
GO:0044718siderophore transmembrane transportTASPMID:128884923
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0016021integral component of membraneIEAUniProtKB-KW:KW-0812GO_REF:00000371018
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopystr3ΔNullPECO:0000005, PECO:0000137PMID:236978063751

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphology3088
penetrance FYPO_EXT:0000001Microscopystr3ΔNullPECO:0000005, PECO:0000137PMID:23697806
Target Of
FYPO affected by mutation in fep1 iron-sensing transcription factor Fep1 PMID:23115244
FYPO affected by mutation in fxn1 frataxin PMID:23115244
GO regulated by fep1 iron-sensing transcription factor Fep1 GO_REF:0000001
Ensembl transcript structure with UTRs, exons and introns


Exon Start End
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF05977 Pfam IPR010290 Transmembrane secretion effector 414 523 1
PF07690 Pfam IPR011701 Major facilitator superfamily 92 354 50
TMhelix TMHMM 153 172 959
TMhelix TMHMM 407 429 959
TMhelix TMHMM 574 596 959
TMhelix TMHMM 335 357 959
TMhelix TMHMM 503 525 959
TMhelix TMHMM 243 262 959
TMhelix TMHMM 176 198 959
TMhelix TMHMM 303 325 959
TMhelix TMHMM 466 488 959
TMhelix TMHMM 119 141 959
TMhelix TMHMM 370 392 959
TMhelix TMHMM 82 104 959
TMhelix TMHMM 211 233 959
PTHR24003:SF8 HMMPANTHER 10 627 1
PTHR24003 HMMPANTHER 10 627 17
1.20.1250.20 Gene3D 88 262 72
1.20.1250.20 Gene3D 571 611 72
1.20.1250.20 Gene3D 366 526 72
SSF103473 SuperFamily IPR016196 Major facilitator superfamily domain, general substrate transporter 72 283 76
SSF103473 SuperFamily IPR016196 Major facilitator superfamily domain, general substrate transporter 365 525 76

View domain organization at Pfam

Sequence Ontology

Term IDTerm NameReferenceCount

Protein Properties

Ave. residue weight 112.00 Da
Charge 7.50
Isoelectric point 8.50
Molecular weight 70.56 kDa
Number of residues 630

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
level fluctuates during mitotic cell cycleS8PMID:24763107
present during mitotic M phaseS10PMID:21712547
present during mitotic M phaseS44PMID:21712547
present during mitotic M phaseS25PMID:21712547
present during mitotic M phaseS8PMID:21712547
present during mitotic M phaseS38PMID:21712547
present during mitotic M phaseS53PMID:21712547
present during mitotic M phaseS58PMID:21712547
present during mitotic M phaseS37PMID:21712547
level fluctuates during mitotic cell cycleS10PMID:24763107
level fluctuates during mitotic cell cycleS25PMID:24763107
present during mitotic M phase
present during mitotic M phaseT622PMID:21712547
MOD:00696phosphorylated residueNASPMID:195477441922
Gene Expression

Qualitative Gene Expression

RNA levelincreased during GO:0010106Northern assay evidencePMID:23115244

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
NDduring GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
NDduring cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
0.76during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
0.072during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633
Species Distribution
conserved in fungi4599
conserved in eukaryotes4514
conserved in bacteria1002

Manually curated orthologous groups


Orthologs in Compara

Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
vps35retromer complex subunit Vps35 Negative GeneticPMID:22681890
SPBC725.05cnucleotide pyrophosphatase (predicted) Negative GeneticPMID:22681890
kin1microtubule affinity-regulating kinase Kin1 Negative GeneticPMID:22681890
cdt2WD repeat protein Cdt2 Positive GeneticPMID:22681890
SPAC1A6.03cphospholipase (predicted) Negative GeneticPMID:22681890
prp1U4/U6 x U5 tri-snRNP complex subunit Prp1 Negative GeneticPMID:22681890
SPBC16H5.13WD repeat protein, human WDR7 ortholog Negative GeneticPMID:22681890
SPBC713.07cvacuolar polyphosphatase (predicted) Negative GeneticPMID:22681890
whi5cell cycle transcriptional repressor Whi5 (predicted) Negative GeneticPMID:22681890
dad1DASH complex subunit Dad1 Positive GeneticPMID:22681890
cph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Negative GeneticPMID:22681890
sdh4TIM22 inner membrane protein import complex anchor subunit Tim18 Negative GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPAC1F8.03c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC1F8.03c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC1F8.03c BioGRID Interaction Datasets
Expression Viewer SPAC1F8.03c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC1F8.03c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC1F8.03c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC1F8.03c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC1F8.03c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC1F8.03c Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC1F8.03c Cell Cycle Data
GEO SPAC1F8.03c GEO profiles
PInt SPAC1F8.03c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC1F8.03c Peptides identified in tandem mass spectrometry proteomics experiments
SPD / RIKEN26/26E04Orfeome Localization Data
UniProtKB/SwissProtQ92341Siderophore iron transporter 3
ModBaseQ92341Database of comparative protein structure models
STRINGQ92341Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_592792siderophore-iron transporter Str3
RefSeq mRNANM_001018192972h- siderophore-iron transporter Str3 (str3), mRNA
European Nucleotide ArchiveCAB03597.1ENA Protein Mapping
UniParcUPI000013A9C7UniProt Archive

Literature for str3

Search: Europe PMC or PubMed

Release Version: PomBase:23_46 - 30 Aug 2014