sts1 (SPAC20G4.07c)

Gene Standard Namests1 ChromosomeI
Systematic IDSPAC20G4.07c Gene Start4828141
Synonymserg4 Gene End4826601
ProductC-24(28) sterol reductase Sts1 Gene Length1541
Feature Typeprotein coding CDS Start4828044
Name Descriptionstaurosporine supersensitive CDS End4826683
Characterisation Statuspublished CDS Length1362

Ensembl Gene Location
  1. hri1
  2. prl54
  3. hus1
  4. SPNCRNA.1027
  5. SPAC20G4.05c
  6. adf1
  7. SPAC20G4.09
  8. sts1
  9. pdc1
  10. aap1
  11. SPAC4F10.03c
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0000070resistance to amphotericin Bsts1delta (deletion)deletionPMID:18310029
FYPO:0000076resistance to nystatinsts1delta (deletion)deletionPMID:18310029
FYPO:0000080sensitive to coldCell growth assaysts1delta (deletion)deletionPMID:1320960
FYPO:0000097sensitive to caffeineCell growth assaysts1delta (deletion)deletionPMID:1320960
FYPO:0000100sensitive to chloramphenicolCell growth assaysts1delta (deletion)deletionPMID:1320960
FYPO:0000104sensitive to cycloheximidests1delta (deletion)deletionPMID:18310029
FYPO:0000112sensitive to sorbitolCell growth assaysts1delta (deletion)deletionPMID:1320960
FYPO:0000113sensitive to staurosporineCell growth assaysts1delta (deletion)deletionPMID:1320960
Cell growth assaysts1 (unknown)unknownEndogenousPMID:1320960
Cell growth assaysts1-5 (unknown)unknownNot specifiedPECO:0000102, PECO:0000201, PECO:0000005PMID:1899230
FYPO:0000121abnormal sporulationno_name (unrecorded)unrecordedPMID:18310029
FYPO:0000841sensitive to sodium dodecyl sulfateCell growth assaysts1delta (deletion)deletionPMID:1320960
FYPO:0000963normal cell population growth on hydroxyureaCell growth assaysts1delta (deletion)deletionPMID:1320960
FYPO:0000964normal cell population growth on thiabendazoleCell growth assaysts1delta (deletion)deletionPMID:1320960
FYPO:0001491viable vegetative cellCell growth assaysts1delta (deletion)deletionPMID:1320960
FYPO:0002060viable vegetative cell populationMicroscopysts1delta (deletion)deletionPMID:20473289
GO Molecular Function

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Term IDTerm NameEvidenceWith/FromReference
GO:0000246delta24(24-1) sterol reductase activityISSUniProtKB:P25340GO_REF:0000001
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
NOT GO:0006623protein targeting to vacuoleIMPPMID:18310029
GO:0006696ergosterol biosynthetic processIMPPMID:18310029
NOT GO:0006897endocytosisIMPPMID:18310029
GO:0030437ascospore formationIMPPMID:18310029
GO:0042493response to drugIMPPMID:1320960
GO:0071210protein insertion into membrane raft
has_input pma1IMPPMID:18310029
has_input SPBC359.03IMPPMID:18310029
GO:0071470cellular response to osmotic stressIMPPMID:1320960
GO:0071473cellular response to cation stressIMPPMID:1320960
GO:0090002establishment of protein localization to plasma membrane
has_input SPBC359.03IMPPMID:18310029
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0005789endoplasmic reticulum membraneISSUniProtKB:P25340GO_REF:0000001
GO:0016021integral to membraneIEAUniProtKB:KW-0812GO_REF:0000037
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
148281414826601

References

Region Start End Reference
three_prime_UTR48266824826601PMID:21511999
three_prime_UTR48266824826601PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF01222 IPR001171 Pfam Ergosterol biosynthesis ERG4/ERG24 8 453 2
TMhelix TMHMM 396 418 955
TMhelix TMHMM 277 299 955
TMhelix TMHMM 210 229 955
TMhelix TMHMM 118 140 955
TMhelix TMHMM 13 35 955
TMhelix TMHMM 75 97 955
TMhelix TMHMM 304 326 955
TMhelix TMHMM 150 172 955
PS01018 IPR018083 Prosite Patterns Sterol reductase, conserved site 417 440 2
PS01017 IPR018083 Prosite Patterns Sterol reductase, conserved site 185 200 2
PTHR21257 hmmpanther 1 453 2
PTHR21257:SF4 hmmpanther 1 453 1

View domain organization at Pfam

Sequence Ontology

Term IDTerm NameReference
SO:0001812transmembrane_helix

Protein Properties

Ave. residue weight 116.00 Da
Charge 23.00
Isoelectric point 9.05
Molecular weight 52.55 kDa
Number of residues 453
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide5338.44PMID:23101633
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide1870.63PMID:23101633
RNA levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide0.47PMID:23101633
experimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide5.2PMID:23101633
Species Distribution
DescriptionQualifierReference
predominantly single copy (one to one)
conserved in fungi
conserved in eukaryotes
conserved in metazoa
conserved in vertebrates
conserved in eukaryotes only
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
ppb1calcium-dependent serine/threonine protein phosphatase calcineurin A, catalytic subunit Ppb1 Synthetic LethalityPMID:7983142
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External References
Database Identifier Description
NBRP SPAC20G4.07c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC20G4.07c Retrieval of eukaryotic orthologs
BioGrid SPAC20G4.07c BioGRID Interaction Datasets
Bähler Lab SPAC20G4.07c Cell Cycle Expression Profile
Bähler Lab SPAC20G4.07c Meiosis/Sporulation Expression Profies
Bähler Lab SPAC20G4.07c Pheromone response/mating expression profiles
Bähler Lab SPAC20G4.07c Environmental stress expression profiles
Bähler Lab SPAC20G4.07c Bähler Lab Transcriptome Viewer
Cyclebase SPAC20G4.07c Cell Cycle Data
PInt SPAC20G4.07c Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPAC20G4.07c Entrez Gene
WikiGene2541740C-24(28) sterol reductase Sts1
Uniprot_genenameSTS1
EntrezGene2541740C-24(28) sterol reductase Sts1
IntEnz1.3.1.71
SPD / RIKEN44/44C10Orfeome Localization Data
UniProtKB/SwissProtP36209Delta(24(24(1)))-sterol reductase
ModBaseP36209Database of comparative protein structure models
Pfam Protein DomainsP36209Pfam Domain Arrangement
RefSeq PeptideNP_594742C-24(28) sterol reductase Sts1
RefSeq mRNANM_001020170972h- C-24(28) sterol reductase Sts1 (sts1), mRNA
European Nucleotide ArchiveCAA45113ENA Protein Mapping
European Nucleotide ArchiveCAB11256ENA Protein Mapping
UniParcUPI000013614FUniProt Archive

Literature for sts1
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Search: UK PMC or PubMed

Release Version: PomBase:18_35 - 11 May 2013