dsc3 (SPAC20H4.02)


Gene Standard Namedsc3 Characterisation Statuspublished
Systematic IDSPAC20H4.02 Feature Typeprotein coding
Synonyms Name DescriptionDefective in SREBP Cleavage
ProductGolgi Dsc E3 ligase complex subunit Dsc3 Product Size250aa, 28.26 kDa
Genomic Location Chromosome I, 2113811-2114930 (1120nt); CDS:2114011-2114763 (753nt)

Ensembl Gene Location
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0016485protein processing269
has input sre2IMPPMID:23729666
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005794Golgi apparatusIEAUniProtKB-KW:KW-0333GO_REF:0000037355
GO:0005783endoplasmic reticulumIDAPMID:16823372594
GO:0016021integral component of membraneIEAUniProtKB-KW:KW-0812GO_REF:00000371016
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001098sensitive to 4-nitroquinoline N-oxideCell growth assaydsc3ΔNullPECO:0000005, PECO:0000137PMID:19264558159
expressivity FYPO_EXT:0000002
FYPO:0001701sensitive to bortezomibCell growth assaydsc3ΔNullPECO:0000137, PECO:0000005PMID:21760946256
expressivity FYPO_EXT:0000001
FYPO:0000096sensitive to cadmiumcell growth assaydsc3ΔNullPECO:0000137, PECO:0000102, PECO:0000005PMID:18684775244
expressivity FYPO_EXT:0000003
FYPO:0001245sensitive to cobaltCell growth assaydsc3ΔNullPECO:0000005, PECO:0000201PMID:2280634456
expressivity FYPO_EXT:0000001
FYPO:0000088sensitive to hydroxyureaCell Growth Assaydsc3ΔNullPECO:0000102, PECO:0000137PMID:23697806233
expressivity FYPO_EXT:0000003
FYPO:0002060viable vegetative cell populationMicroscopydsc3ΔNullPECO:0000137, PECO:0000005PMID:236978063755
Microscopydsc3ΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002447abnormal protein N-linked glycosylationWestern blot assaydsc3ΔNullPMID:237605073
affecting dsc1
FYPO:0001422decreased protein processingWestern blot assaydsc3ΔNullPMID:2372966611
affecting sre2
FYPO:0001510viable vegetative cell, abnormal cell shape, normal cell sizeMicroscopydsc3ΔNullPECO:0000005, PECO:0000137PMID:23697806215
expressivity FYPO_EXT:0000003
penetrance FYPO_EXT:0000001
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
121138112114930

UTRs

Region Start End Reference
five_prime_UTR21138112114010PMID:21511999
three_prime_UTR21147642114930PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF10302 Pfam IPR019413 Domain of unknown function DUF2407 N-terminal 9 98 1
PF13373 Pfam IPR025390 Domain of unknown function DUF2407 C-terminal 135 246 1
TMhelix TMHMM 197 219 959
TMhelix TMHMM 226 248 959

View domain organization at Pfam

Protein Properties

Ave. residue weight 113.05 Da
Charge -10.00
Isoelectric point 4.56
Molecular weight 28.26 kDa
Number of residues 250
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
NDduring cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population_wideexperimental evidencePMID:23101633
NDduring GO:0072690PECO:0000014,
PECO:0000005
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
3during GO:0072690PECO:0000014,
PECO:0000005
population_wideexperimental evidencePMID:23101633
0.93during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3080
conserved in fungi only603
conserved in fungi4564
conserved in eukaryotes4482
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
SPAC323.07cMatE family transporter (predicted) Negative GeneticPMID:21504829
but1neddylation pathway protein But1 Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
rhn1RNA polymerase II transcription termination factor homolog Positive GeneticPMID:21504829
tae1AdoMet dependent proline dimethyltransferase involved in translation Tae1 (predicted) Positive GeneticPMID:21504829
trm12tRNA methyltransferase Trm12 (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
SPAC2H10.01transcription factor, zf-fungal binuclear cluster type (predicted) Negative GeneticPMID:21504829
fsv1SNARE Fsv1 Negative GeneticPMID:21504829
fio1iron transport multicopper oxidase Fio1 Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
SPBC8D2.17alpha-1,2-galactosyltransferase (predicted) Negative GeneticPMID:21504829
tpp1trehalose-6-phosphate phosphatase Tpp1 Negative GeneticPMID:21504829
SPBC725.10tspO homolog, involved in the cytoplasmic to mitochondrial transport of haem (predicted) Negative GeneticPMID:21504829
psh3ER chaperone SHR3 homologue Psh3 Positive GeneticPMID:21504829
gos1SNARE Gos1 (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
pmc2mediator complex subunit Pmc2/Med1 Negative GeneticPMID:21504829
fep1iron-sensing transcription factor Fep1 Negative GeneticPMID:21504829
nap1nucleosome assembly protein Nap1 Negative GeneticPMID:21504829
vps901guanyl-nucleotide exchange factor Vps901 (predicted) Negative GeneticPMID:21504829
SPBPB2B2.18sequence orphan Negative GeneticPMID:22681890
vps25ESCRT II complex subunit Vps25 Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
SPBC27B12.05WD repeat protein involved in transcriptional regulation (predicted) Positive GeneticPMID:21504829
snf5SWI/SNF complex subunit Snf5 Positive GeneticPMID:21504829
ura3dihydroorotate dehydrogenase Ura3 Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
rps280240S ribosomal protein S28, Rps2802 Negative GeneticPMID:21504829
SPBC30B4.06cmitochondrial GIDA family tRNA uridine 5-carboxymethylaminomethyl modification enzyme (predicted) Positive GeneticPMID:21504829
poz1Pot1 associated protein Poz1 Negative GeneticPMID:21504829
mug143sequence orphan Negative GeneticPMID:21504829
meu10GPI anchored cell surface protein involved in ascospore wall assembly Meu10 Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
SPAC30D11.11Haemolysin-III family protein (predicted) Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
gdh1NADP-specific glutamate dehydrogenase Gdh1 (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
pyp2tyrosine phosphatase Pyp2 Negative GeneticPMID:21504829
spo6Spo4-Spo6 kinase complex regulatory subunit Spo6 Negative GeneticPMID:21504829
dsc1Golgi Dsc E3 ligase complex subunit Dsc1 Negative GeneticPMID:21504829
SPAC8C9.04sequence orphan Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
rpl430260S ribosomal protein L37a (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
SPBC887.16dubious Positive GeneticPMID:21504829
meu34ubiquitin-protein ligase E3 Meu34 (predicted) Negative GeneticPMID:21504829
SPBC354.08cDUF221 family protein Negative GeneticPMID:21504829
SPAC977.17MIP water channel (predicted) Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
rpl170260S ribosomal protein L17 (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
raf2Rik1-associated factor Raf2 Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
ivn1CDC50 domain protein, implicated in signal transduction (predicted) Positive GeneticPMID:21504829
meu22amino acid permease, predicted Meu22 Negative GeneticPMID:21504829
vph2endoplasmic reticulum membrane protein involved in assembly of the V-ATPase (predicted) Positive GeneticPMID:21504829
atp12F1-ATPase chaperone Atp12 (predicted) Negative GeneticPMID:21504829
nup60nucleoporin Nup60 Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
sre1sterol regulatory element binding protein, transcription factor Sre1 Dosage RescuePMID:22086920
ppr5mitochondrial PPR repeat protein Ppr5 Negative GeneticPMID:21504829
rps250240S ribosomal protein S25 (predicted) Negative GeneticPMID:21504829
bag101BAG family molecular chaperone regulator Bag101 (predicted) Negative GeneticPMID:21504829
mde1sequence orphan Negative GeneticPMID:21504829
elp1elongator subunit Elp1 (predicted) Positive GeneticPMID:21504829
tma20RNA-binding protein Tma20 (predicted) Positive GeneticPMID:21504829
SPBC8E4.01cinorganic phosphate transporter (predicted) Negative GeneticPMID:21504829
mug183histone chaperone Rtt106-like (predicted) Negative GeneticPMID:21504829
SPBC9B6.03zf-FYVE type zinc finger protein Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
ath1ataxin-2 homolog Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
trs130TRAPP complex subunit Trs130 (predicted) Negative GeneticPMID:21504829
ado1adenosine kinase (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
SPCC126.12NGG1 interacting factor 3 family, implicated in transcription Positive GeneticPMID:21504829
SPAC922.063-oxoacyl-Positive GeneticPMID:21504829
SPBCPT2R1.01cS. pombe specific DUF999 protein family 9 Negative GeneticPMID:21504829
aps1diadenosine 5',5'''-p1,p6-hexaphosphate hydrolase Aps1 Negative GeneticPMID:21504829
mrt4mRNA turnover and ribosome assembly protein Mrt4 (predicted) Negative GeneticPMID:21504829
SPAC694.02DEAD/DEAH box helicase Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
SPAC5H10.04NADPH dehydrogenase (predicted) Negative GeneticPMID:21504829
rps170140S ribosomal protein S17 (predicted) Negative GeneticPMID:21504829
asl1cell wall protein Asl1, predicted O-glucosyl hydrolase Negative GeneticPMID:21504829
set10ribosomal lysine methyltransferase Set10 Positive GeneticPMID:21504829
dbl8tRNA-splicing endonuclease positive effector Dbl8 Negative GeneticPMID:21504829
SPAC186.04cN-terminal of transmembrane channel, truncated Negative GeneticPMID:21504829
SPAC56E4.07N-acetyltransferase (predicted) Positive GeneticPMID:21504829
sft1SNARE Sft1 (predicted) Negative GeneticPMID:22681890
mak1histidine kinase Mak1 Negative GeneticPMID:21504829
SPCC285.10cSPRY domain protein Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
slc11-acylglycerol-3-phosphate O-acyltransferase Slc1 (predicted) Positive GeneticPMID:21504829
SPBC56F2.08cRNA-binding protein (predicted) Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
SPAC750.08cNAD-dependent malic enzyme (predicted), partial Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
SPACUNK4.10glyoxylate reductase (predicted) Negative GeneticPMID:21504829
mug35sequence orphan Positive GeneticPMID:21504829
SPBC21B10.07glycosyl hydrolase family 16 (predicted) Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
nep2NEDD8 protease Nep2 Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
SPAC3A12.06csodium/calcium exchanger (predicted) Negative GeneticPMID:21504829
fis1mitochondrial fission protein Fis1 (predicted) Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
pho7transcription factor Pho7 Negative GeneticPMID:21504829
spn3septin Spn3 Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
apq12nuclear membrane organization protein Apq12 (predicted) Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
SPAC29A4.17cmitochondrial FUN14 family protein Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
bro1BRO1 domain protein Bro1 (predicted) Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
SPBP35G2.14RNA-binding protein Negative GeneticPMID:21504829
SPAC186.06ER unfolded protein response protein (predicted) Negative GeneticPMID:21504829
lub1WD repeat protein Lub1 Negative GeneticPMID:21504829
SPBC6B1.03cPal1 family protein Negative GeneticPMID:21504829
rpl230160S ribosomal protein L23 Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
did4ESCRT III complex subunit Did4 Negative GeneticPMID:21504829
bdc1bromodomain containing protein 1, Bdc1 Negative GeneticPMID:21504829
skb5Shk1 kinase binding protein 5 Negative GeneticPMID:21504829
SPAC644.08methionine salvage haloacid dehalogenase-like hydrolase (predicted) Negative GeneticPMID:21504829
omh1alpha-1,2-mannosyltransferase Omh1 Negative GeneticPMID:21504829
grx3monothiol glutaredoxin Grx3 Negative GeneticPMID:21504829
upf1ATP-dependent RNA helicase Upf1 Positive GeneticPMID:22681890
Positive GeneticPMID:21504829
csk1cyclin-dependent kinase activating kinase Csk1 Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
mak3histidine kinase Mak3 Negative GeneticPMID:21504829
nup97nucleoporin Nic96 homolog Positive GeneticPMID:21504829
ucp6UBA domain protein Ucp6 Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
SPAC2F3.07csequence orphan Positive GeneticPMID:21504829
zds1zds family protein phosphatase type A regulator Zds1 (predicted) Negative GeneticPMID:21504829
gal10UDP-glucose 4-epimerase/aldose 1-epimerase Gal10 Negative GeneticPMID:21504829
nop16ribosome biogenesis protein Nop16 (predicted) Negative GeneticPMID:21504829
mto2MT organizer Mto2 Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
SPCC663.15cconserved fungal protein Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
wis2cyclophilin family peptidyl-prolyl cis-trans isomerase Wis2 Negative GeneticPMID:21504829
SPCC613.08CDK regulator, involved in ribosome export (predicted) Negative GeneticPMID:21504829
ubp4ubiquitin C-terminal hydrolase Ubp4 Negative GeneticPMID:21504829
rud3Golgi matrix protein Rud3 (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
atg1autophagy and CVT pathway serine/threonine protein kinase Atg1 Positive GeneticPMID:21504829
SPBC2F12.05csterol binding ankyrin repeat protein (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
SPBC16A3.16mitochondrial inner membrane protein involved in cytochrome c oxidase assembly Pet191 (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
mex67mRNA export receptor, Tap, nucleoporin Mex67 Negative GeneticPMID:21504829
adn1adhesion defective protein, predicted transcriptional regulator (predicted) Negative GeneticPMID:21504829
cek1serine/threonine protein kinase Cek1 Negative GeneticPMID:21504829
inv1beta-fructofuranosidase Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
tcg1single-stranded telomeric binding protein Tgc1 Negative GeneticPMID:21504829
pac2cAMP-independent regulatory protein Pac2 Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
SPAC1687.09ENTH/VHS domain protein (predicted) Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
vac7Vac7 ortholog (predicted) Negative GeneticPMID:21504829
SPAP32A8.03cubiquitin-protein ligase E3 (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
skb1type II protein arginine N-methyltransferase Skb1 Negative GeneticPMID:21504829
SPBC1289.14adducin (predicted) Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
ebs1EST1 family nonsense-mediated mRNA decay (NMD) pathway protein Ebs1 (predicted) Positive GeneticPMID:21504829
abc2glutathione S-conjugate-exporting ATPase Abc2 Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
SPCC794.03amino acid permease (predicted) Positive GeneticPMID:21504829
mug20sequence orphan Negative GeneticPMID:21504829
fta5cell surface glycoprotein Positive GeneticPMID:21504829
SPCC1795.10cSed5 Vesicle Protein Svp26 (predicted) Negative GeneticPMID:21504829
eme1Holliday junction resolvase subunit Eme1 Negative GeneticPMID:21504829
SPCC18.17c26S proteasome non-ATPase regulatory subunit (predicted) Positive GeneticPMID:21504829
SPAC328.04AAA family ATPase, unknown biological role Negative GeneticPMID:21504829
SPBC713.07cvacuolar polyphosphatase (predicted) Negative GeneticPMID:21504829
SPCC4B3.02cGolgi transport protein Got1 (predicted) Negative GeneticPMID:21504829
SPCC1393.08transcription factor, zf-GATA type (predicted) Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
SPBC16D10.08cheat shock protein Hsp104 (predicted) Negative GeneticPMID:21504829
SPAC30C2.08conserved fungal protein Negative GeneticPMID:21504829
cuf1nutritional copper sensing transcription factor Cuf1 Positive GeneticPMID:21504829
SPAC6F6.13cDUF726 family protein Negative GeneticPMID:21504829
mfr1fizzy-related protein Mfr1 Negative GeneticPMID:21504829
ada1adenosine deaminase Ada1 Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
SPCC550.11karyopherin (predicted) Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
btf3nascent polypeptide-associated complex beta subunit Negative GeneticPMID:21504829
oga1Stm1 homolog Oga1 Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
tea2kinesin-like protein Tea2 Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
SPAC3H8.02sec14 cytosolic factor family phosphatidylinositol transporter (predicted) Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
pph3serine/threonine protein phosphatase, PP4 complex subunit Pph3 (predicted) Positive GeneticPMID:21504829
prz1calcineurin responsive transcription factor Prz1 Negative GeneticPMID:21504829
hhp2serine/threonine protein kinase Hhp2 Positive GeneticPMID:21504829
SPBC8E4.03agmatinase 2 (predicted) Negative GeneticPMID:21504829
SPBC839.02arrestin Aly1 related, implicated in endocytosis Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
mfm3M-factor precursor Mfm3 Negative GeneticPMID:21504829
SPCC306.11sequence orphan Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
SPAC1952.09cacetyl-CoA hydrolase (predicted) Positive GeneticPMID:21504829
uep1ribosomal-ubiquitin fusion protein Ubi2 Negative GeneticPMID:21504829
SPBC25H2.03vacuolar protein involved in phosphoinositide metabolism (predicted) Negative GeneticPMID:21504829
dlc1dynein light chain Dlc1 Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
SPBC1198.08dipeptidase Dug1 (predicted) Negative GeneticPMID:21504829
apl5AP-3 adaptor complex subunit Apl5 (predicted) Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
msy1MS calcium ion channel protein Msy1 Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
ppk8serine/threonine protein kinase Ppk8 (predicted) Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
fhl1forkhead transcription factor Fhl1 Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
clr3histone deacetylase (class II) Clr3 Positive GeneticPMID:21504829
rpl190260S ribosomal protein L19 Negative GeneticPMID:21504829
rrf1mitochondrial translation termination factor Rrf1 Negative GeneticPMID:21504829
SPAPB1E7.04cchitinase (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
SPAC869.04formamidase-like protein (predicted) Negative GeneticPMID:21504829
SPBPB7E8.01sequence orphan, predicted GPI anchor Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
dad2DASH complex subunit Dad2 Negative GeneticPMID:21504829
rpl120260S ribosomal protein L12.1/L12A Negative GeneticPMID:21504829
reb1RNA polymerase I transcription termination factor Reb1 Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
SPBC17A3.06phosphoprotein phosphatase (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
mfm2M-factor precursor Mfm2 Negative GeneticPMID:21504829
def1RNAPII degradation factor Def1 (predicted) Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
SPAC3F10.091-(5-phosphoribosyl)-5-Negative GeneticPMID:21504829
rad2514-3-3 protein Rad25 Negative GeneticPMID:21504829
SPBC713.09sequence orphan Negative GeneticPMID:21504829
SPAC3A12.13ctranslation initiation factor eIF3j (p35) Negative GeneticPMID:22681890
SPCC1393.13DUF89 family protein Negative GeneticPMID:21504829
pzh1serine/threonine protein phosphatase Pzh1 Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
sck2serine/threonine protein kinase Sck2 Negative GeneticPMID:21504829
erg28Erg28 protein (predicted) Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
pof8F-box protein Pof8 Negative GeneticPMID:21504829
spp27RNA polymerase I upstream activation factor complex subunit Spp27 Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
SPBC365.07cTATA element modulatory factor homolog (predicted) Negative GeneticPMID:21504829
SPBC530.06ctranslation initiation factor eIF3 alpha subunit (p135) (predicted) Negative GeneticPMID:21504829
gyp1GTPase activating protein Gyp1 (predicted) Negative GeneticPMID:21504829
qcr8ubiquinol-cytochrome-c reductase complex subunit 7 Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
tef101translation elongation factor EF-1 alpha Ef1a-a Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
plc1phosphoinositide phospholipase C Plc1 Negative GeneticPMID:21504829
arf6ADP-ribosylation factor, Arf family Arf6 Negative GeneticPMID:21504829
hrp3ATP-dependent DNA helicase Hrp3 Negative GeneticPMID:21504829
SPBP4G3.03PI31 proteasome regulator (predicted) Negative GeneticPMID:21504829
vps29retromer complex subunit Vps29 Negative GeneticPMID:21504829
SPCC63.06human WDR89 family WD repeat protein Negative GeneticPMID:21504829
mug123meiotically upregulated gene Mug123 Negative GeneticPMID:21504829
SPBC577.11DUF3074 family protein Negative GeneticPMID:21504829
SPBC21B10.08csequence orphan Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
ptl1triacylglycerol lipase ptl1 Negative GeneticPMID:21504829
rer1Rer1 family protein (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
SPAC8C9.05D-Tyr-tRNA deacylase (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
sut1alpha-glucoside transporter Sut1 Positive GeneticPMID:22681890
SPBPB2B2.17cS. pombe specific 5Tm protein family Negative GeneticPMID:22681890
pep7prevacuole/endosomal FYVE tethering component Pep7 (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
SPCC1442.02central kinetochore associated family protein (predicted) Negative GeneticPMID:21504829
rad2414-3-3 protein Rad24 Negative GeneticPMID:21504829
SPAC27D7.02cGRIP domain protein (predicted) Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
raf1Rik1-associated factor Raf1 Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
sib1ferrichrome synthetase Sib1 Positive GeneticPMID:21504829
SPCC794.01cglucose-6-phosphate 1-dehydrogenase (predicted) Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
SPCC162.06cvacuolar sorting protein Vps60 (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
SPBC18H10.18csequence orphan Negative GeneticPMID:21504829
trp1322TRP-like ion channel (predicted) Negative GeneticPMID:21504829
rox3mediator complex subunit Med19/Rox3 Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
pdr1ABC transporter Pdr1 Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
ape2aminopeptidase Ape2 (predicted) Negative GeneticPMID:21504829
ppk11PAK-related kinase Ppk11 Negative GeneticPMID:21504829
SPAC17G6.03phosphoprotein phosphatase (predicted) Negative GeneticPMID:21504829
ubp11ubiquitin C-terminal hydrolase Ubp11 Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
SPAP8A3.07cphospho-2-dehydro-3-deoxyheptonate aldolase (predicted) Negative GeneticPMID:21504829
ubr1N-end-recognizing protein Ubr1 Negative GeneticPMID:21504829
mug122PX/PXA domain protein Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
shf1small histone ubiquitination factor Shf1 Negative GeneticPMID:22681890
alp14TOG ortholog Alp14 Negative GeneticPMID:21504829
ppk21serine/threonine protein kinase Ppk21 Negative GeneticPMID:21504829
hfl1Lazarus1 family transmembrane transporter Negative GeneticPMID:21504829
mpc2mitochondrial pyruvate transmembrane transporter subunit Mpc2 Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
SPBC3B9.05helper of TIM (predicted) Positive GeneticPMID:21504829
puf3RNA-binding protein Puf3 (predicted) Positive GeneticPMID:22681890
SPCC965.13pyridoxal family membrane transporter (predicted) Negative GeneticPMID:21504829
SPBC12C2.03cmethionine synthase reductase (predicted) Negative GeneticPMID:21504829
pas4peroxisomal ubiquitin-protein ligase E3 (predicted) Positive GeneticPMID:21504829
akr1palmitoyltransferase Akr1 (predicted) Positive GeneticPMID:21504829
SPAC11G7.01sequence orphan Negative GeneticPMID:21504829
SPAC3H5.08cWD repeat protein, human WDR44 family Negative GeneticPMID:21504829
set1histone lysine methyltransferase Set1 Negative GeneticPMID:22681890
SPAC11D3.155-oxoprolinase (ATP-hydrolizing) (predicted) Negative GeneticPMID:21504829
nup124nucleoporin Nup124 Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
SPBC1289.13calpha-1,2-galactosyltransferase (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
lsg1Lsk1 complex gamma subunit (predicted) Positive GeneticPMID:22681890
Positive GeneticPMID:21504829
SPAC977.05cconserved fungal family Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
nab3poly(A) binding protein Nab3 (predicted) Negative GeneticPMID:21504829
ptr2PTR family peptide transporter Ptr2 Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
omh5alpha-1,2-mannosyltransferase Omh5 (predicted) Positive GeneticPMID:21504829
SPAC5H10.07sequence orphan Negative GeneticPMID:21504829
pkp1mitochondrial pyruvate dehydrogenase (lipoamide) kinase Pkp1 (predicted) Negative GeneticPMID:21504829
gsk3serine/threonine protein kinase Gsk3 Negative GeneticPMID:21504829
SPCC1235.01sequence orphan Negative GeneticPMID:21504829
sst6ESCRT I complex subunit Vps23 Negative GeneticPMID:22681890
ubc16ubiquitin conjugating enzyme Ubc16 (predicted) Negative GeneticPMID:21504829
gal1galactokinase Gal1 Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
sen1ATP-dependent 5' to 3' DNA/RNA helicase Sen1 Negative GeneticPMID:21504829
SPBC1271.09glycerophosphodiester transporter (predicted) Positive GeneticPMID:21504829
alg5dolichyl-phosphate beta-glucosyltransferase Alg5 (predicted) Negative GeneticPMID:21504829
etf2electron transfer flavoprotein beta subunit EtfB (predicted) Negative GeneticPMID:21504829
rpl160360S ribosomal protein L13/L16 (predicted) Negative GeneticPMID:21504829
fus1formin Fus1 Negative GeneticPMID:21504829
clr5Clr5 protein Negative GeneticPMID:21504829
mug100sequence orphan Negative GeneticPMID:21504829
swi3replication fork protection complex subunit Swi3 Negative GeneticPMID:21504829
SPAC24C9.12cglycine hydroxymethyltransferase (predicted) Negative GeneticPMID:21504829
thi9thiamine transporter Thi9 Negative GeneticPMID:22681890
sft2Golgi transport protein Sft2 (predicted) Negative GeneticPMID:21504829
SPAPB21F2.02Dopey family protein (predicted) Negative GeneticPMID:21504829
trm112protein and tRNA methyltransferase regulatory subunit Trm112 (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
zfs1CCCH tandem zinc finger protein, human Tristetraprolin homolog Zfs1, involved in mRNA catabolism Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
SPAC12G12.07cconserved fungal protein Positive GeneticPMID:21504829
SPAC1039.02phosphoprotein phosphatase (predicted) Negative GeneticPMID:21504829
ght6hexose transporter Ght6 Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
atg9autophagy associated protein Atg9 Positive GeneticPMID:21504829
Positive GeneticPMID:22681890
amt1ammonium transporter Amt1 Negative GeneticPMID:21504829
SPAC26H5.07cseven transmembrane receptor protein (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
mug170arrestin Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
meu6meiotic chromosome segregation protein Meu6 Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
mug15sequence orphan Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
scs7sphingosine hydroxylase Scs7 Positive GeneticPMID:21504829
Positive GeneticPMID:22681890
rad50DNA repair protein Rad50 Negative GeneticPMID:21504829
rpl100260S ribosomal protein L10 Negative GeneticPMID:21504829
rga8Rho-type GTPase activating protein Rga8 Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
SPBC3B8.04cmembrane transporter (predicted) Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
SPAC29A4.13urease accessory protein UreF (predicted) Negative GeneticPMID:21504829
SPBC16H5.12cconserved fungal protein Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
rpl110260S ribosomal protein L11 (predicted) Negative GeneticPMID:21504829
SPBC29A10.16ccytochrome b5 (predicted) Positive GeneticPMID:21504829
vms1Cdc48p-Npl4p-Vms1p AAA ATPase complex subunit involved in ubiquitin-dependent protein catabolic process Vms1 (predicted) Positive GeneticPMID:21504829
cam2myosin I light chain Cam2 Negative GeneticPMID:21504829
sum2G2/M transition checkpoint protein Sum2 Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
SPBC337.07ccarboxypeptidase (predicted) Positive GeneticPMID:21504829
vps20ESCRT III complex subunit Vps20 Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
bud23rRNA (guanine) methyltransferase Bud23 (predicted) Negative GeneticPMID:21504829
SPCC285.05purine nucleoside transmembrane transporter (predicted) Negative GeneticPMID:21504829
sgf29SAGA complex subunit Sgf29 Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
mms1E3 ubiquitin ligase complex subunit Mms1 (predicted) Negative GeneticPMID:21504829
SPBC23G7.13curea transporter (predicted) Negative GeneticPMID:21504829
dis323'-5'-exoribonuclease activity Dis3L2 Negative GeneticPMID:21504829
caf5spermine family transmembrane transporter Caf5 Positive GeneticPMID:21504829
rpl200160S ribosomal protein L20a (predicted) Negative GeneticPMID:21504829
SPAC9.07cGTPase Rbg1 (predicted) Positive GeneticPMID:21504829
gti1gluconate transporter inducer Gti1 Negative GeneticPMID:21504829
SPAC8C9.12cmitochondrial iron ion transporter (predicted) Negative GeneticPMID:21504829
SPBC1604.12sequence orphan Positive GeneticPMID:21504829
oca2serine/threonine protein kinase Oca2 Negative GeneticPMID:21504829
ccr1NADPH-cytochrome p450 reductase Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
zip2vacuolar membrane zinc transporter (predicted) Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
tif452translation initiation factor eIF4E 4F complex subunit Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
vps3CORVET complex subunit, GTPase regulator Vps3 (predicted) Negative GeneticPMID:21504829
SPAC1A6.03cphospholipase (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
mug94sequence orphan Negative GeneticPMID:21504829
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
sre2membrane-tethered transcription factor Sre2 Affinity Capture-WesternPMID:23760507
dsc2Golgi Dsc E3 ligase complex subunit Dsc2 Affinity Capture-WesternPMID:22086920
Affinity Capture-WesternPMID:21504829
Co-purification
Affinity Capture-WesternPMID:23760507
dsc4Golgi Dsc E3 ligase complex subunit Dsc3 Affinity Capture-WesternPMID:23760507
dsc1Golgi Dsc E3 ligase complex subunit Dsc1 Affinity Capture-WesternPMID:23760507
Affinity Capture-MSPMID:21504829
dsc5UBX domain containing protein required for Sre1 cleavage Affinity Capture-WesternPMID:23760507
External References
Database Identifier Description
NBRP SPAC20H4.02 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC20H4.02 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC20H4.02 BioGRID Interaction Datasets
Expression Viewer SPAC20H4.02 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC20H4.02 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC20H4.02 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC20H4.02 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC20H4.02 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC20H4.02 Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC20H4.02 Cell Cycle Data
GEO SPAC20H4.02 GEO profiles
PInt SPAC20H4.02 Protein-Protein Interaction Predictor (Bähler Lab)
WikiGene2541990conserved fungal protein
EntrezGene2541990conserved fungal protein
SPD / RIKEN41/41F01Orfeome Localization Data
UniProtKB/SwissProtQ9HE10DSC E3 ubiquitin ligase complex subunit 3
ModBaseQ9HE10Database of comparative protein structure models
StringQ9HE10Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_593622conserved fungal protein
RefSeq mRNANM_001019053972h- conserved fungal protein (SPAC20H4.02), mRNA
European Nucleotide ArchiveCAC19732ENA Protein Mapping
UniParcUPI000006B752UniProt Archive

Literature for dsc3

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014