lcb2 (SPAC21E11.08)

Gene Standard Namelcb2 Characterisation Statusbiological_role_inferred
Systematic IDSPAC21E11.08 Feature Typeprotein coding
SynonymsSPAC2C4.02 Name Description
Productserine palmitoyltransferase Lcb2 (predicted) Product Size603aa, 67.52 kDa
Genomic Location Chromosome I, 4261533-4263964 (2432nt); CDS:4261888-4263699 (1812nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0004758serine C-palmitoyltransferase activityISOSGD:S000002469GO_REF:00000242
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0030148sphingolipid biosynthetic processISOSGD:S000002469GO_REF:000002420
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005783endoplasmic reticulumIDAPMID:16823372594
GO:0016021integral component of membraneIEAUniProtKB-KW:KW-0812GO_REF:00000371016
GO:0017059serine C-palmitoyltransferase complexISOSGD:S000002469GO_REF:00000243
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002061inviable vegetative cell populationMicroscopylcb2ΔNullPMID:204732891309
Microscopylcb2ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001122elongated vegetative cellMicroscopylcb2ΔNullPECO:0000005, PECO:0000137PMID:23697806624
penetrance FYPO_EXT:0000003
FYPO:0002451inviable vegetative cell with abnormal cell shapeMicroscopylcb2ΔNullPECO:0000005, PECO:0000137PMID:23697806441
FYPO:0000647vegetative cell lysisMicroscopylcb2ΔNullPECO:0000005, PECO:0000137PMID:2369780636
penetrance FYPO_EXT:0000003
Ensembl transcript structure with UTRs, exons and introns


Exon Start End


Region Start End Reference
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00155 Pfam IPR004839 Aminotransferase, class I/classII 190 546 11
TMhelix TMHMM 90 109 959
PS00599 Prosite Patterns IPR001917 Aminotransferase, class-II, pyridoxal-phosphate binding site 395 404 3
PTHR13693 HMMPANTHER 28 589 3
PTHR13693:SF3 HMMPANTHER 28 589 1
G3DSA:3.90.1150.10 Gene3D IPR015422 431 552 23
G3DSA:3.40.640.10 Gene3D IPR015421 210 430 31
SSF53383 SuperFamily IPR015424 136 554 31
Coil ncoils Rabaptin coiled-coil domain 34 55 975
Low complexity (SEG) seg 90 103
Low complexity (SEG) seg 39 51

View domain organization at Pfam

Sequence Ontology

Term IDTerm NameReferenceCount

Protein Properties

Ave. residue weight 111.97 Da
Charge 8.50
Isoelectric point 7.45
Molecular weight 67.52 kDa
Number of residues 603
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
4512.4during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633
17468.94during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
8.7during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
1.6during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633
Species Distribution
predominantly single copy (one to one)3080
conserved in fungi4564
conserved in eukaryotes4482
conserved in metazoa3419
conserved in vertebrates3394
conserved in eukaryotes only2485

Manually curated orthologous groups


Orthologs in Compara

Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
far8SIP/FAR complex striatin subunit, Far8/Csc3 Affinity Capture-MSPMID:22119525
hhp2serine/threonine protein kinase Hhp2 Affinity Capture-MSPMID:24055157
hhp1serine/threonine protein kinase Hhp1 Affinity Capture-MSPMID:24055157
tea1cell end marker Tea1 Affinity Capture-MSPMID:21652630
paa1protein phosphatase regulatory subunit Paa1 Affinity Capture-MSPMID:22119525
External References
Database Identifier Description
NBRP SPAC21E11.08 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC21E11.08 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC21E11.08 BioGRID Interaction Datasets
Expression Viewer SPAC21E11.08 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC21E11.08 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC21E11.08 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC21E11.08 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC21E11.08 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC21E11.08 Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC21E11.08 Cell Cycle Data
GEO SPAC21E11.08 GEO profiles
PInt SPAC21E11.08 Protein-Protein Interaction Predictor (Bähler Lab)
WikiGene3361415serine palmitoyltransferase Lcb2 (predicted)
EntrezGene3361415serine palmitoyltransferase Lcb2 (predicted)
IntEnz2.3.1.50Integrated relational Enzyme database
Rhea2.3.1.50Annotated reactions database
SPD / RIKEN33/33D10Orfeome Localization Data
UniProtKB/SwissProtQ09925Serine palmitoyltransferase 2
ModBaseQ09925Database of comparative protein structure models
StringQ09925Network display of known and predicted interactions and functional associations
RefSeq_mRNA_predictedXM_001713051972h- serine palmitoyltransferase Lcb2 (predicted) (lcb2), mRNA
RefSeq_peptide_predictedXP_001713103serine palmitoyltransferase Lcb2 (predicted)
European Nucleotide ArchiveAAC49534ENA Protein Mapping
European Nucleotide ArchiveCAA91967ENA Protein Mapping
UniParcUPI000012E27FUniProt Archive

Literature for lcb2

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014