tim10 (SPAC222.03c)


Gene Standard Nametim10 Characterisation Statusbiological_role_inferred
Systematic IDSPAC222.03c Feature Typeprotein coding
Synonyms Name Description
ProductTim9-Tim10 complex subunit Tim10 (predicted) Product Size89aa, 10.19 kDa
Genomic Location Chromosome I, 948800-947876 (925nt); CDS:948581-947964 (618nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0046872metal ion bindingIEAUniProtKB-KW:KW-0479GO_REF:0000037748
GO:0008565protein transporter activity48
contributes_toISSUniProtKB:P87108GO_REF:0000001
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0045039protein import into mitochondrial inner membraneISSUniProtKB:P87108GO_REF:000000112
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005829cytosolIDAPMID:168233722316
GO:0016020membraneIEAUniProtKB-KW:KW-0472GO_REF:00000371444
GO:0005758mitochondrial intermembrane spaceISSUniProtKB:P87108GO_REF:000000129
GO:0042719mitochondrial intermembrane space protein transporter complexISSUniProtKB:P87108GO_REF:00000014
GO:0005634nucleusIDAPMID:168233722740
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002061inviable vegetative cell populationMicroscopytim10ΔNullPECO:0000005, PECO:0000137PMID:236978061331
Microscopytim10ΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002111inviable tapered vegetative cell134
expressivity FYPO_EXT:0000003
penetrance FYPO_EXT:0000001
Microscopytim10ΔNullPECO:0000137, PECO:0000005PMID:23697806
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
1948800948481
2948132947876

UTRs

Region Coordinates Reference
five_prime_UTR948800..948582PMID:21511999
three_prime_UTR947963..947876PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF02953 Pfam IPR004217 Tim10/DDP family zinc finger 16 82 4
PTHR11038 HMMPANTHER IPR027247 Mitochondrial import inner membrane translocase subunit Tim10/Tim12 2 86 1
PTHR11038:SF16 HMMPANTHER IPR027100 Mitochondrial import inner membrane translocase subunit Tim10 2 86 1
1.10.287.810 Gene3D IPR004217 Tim10/DDP family zinc finger 20 82 4
SSF144122 SuperFamily IPR004217 Tim10/DDP family zinc finger 24 85 4

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0000137zinc finger proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000137
PBO:0000679zf-Tim10/DDP typeTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000679

Protein Properties

Ave. residue weight 114.55 Da
Charge 1.00
Isoelectric point 7.29
Molecular weight 10.19 kDa
Number of residues 89
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
109077during GO:0000080PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
125110during GO:0000084PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
118090during GO:0000085PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
106329during GO:0000087PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
104941during GO:0072690PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
11620.39during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
4181.85during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
3.2during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
0.42during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3080
conserved in fungi4569
conserved in eukaryotes4482
conserved in metazoa3419
conserved in vertebrates3393
conserved in eukaryotes only2487
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


External References
Database Identifier Description
NBRP SPAC222.03c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC222.03c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC222.03c BioGRID Interaction Datasets
Expression Viewer SPAC222.03c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC222.03c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC222.03c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC222.03c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC222.03c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC222.03c Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC222.03c Cell Cycle Data
GEO SPAC222.03c GEO profiles
PInt SPAC222.03c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC222.03c Peptides identified in tandem mass spectrometry proteomics experiments
WikiGene2541950Tim9-Tim10 complex subunit Tim10 (predicted)
EntrezGene2541950Tim9-Tim10 complex subunit Tim10 (predicted)
SPD / RIKEN06/06H11Orfeome Localization Data
UniProtKB/SwissProtQ9UTE9Mitochondrial import inner membrane translocase subunit tim10
ModBaseQ9UTE9Database of comparative protein structure models
STRINGQ9UTE9Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_593142Tim9-Tim10 complex subunit Tim10 (predicted)
RefSeq mRNANM_001018539972h- Tim9-Tim10 complex subunit Tim10 (predicted) (tim10), mRNA
European Nucleotide ArchiveCAB60695ENA Protein Mapping
European Nucleotide ArchiveCAB60695.1ENA Protein Mapping
UniParcUPI000006A805UniProt Archive

Literature for tim10

Search: Europe PMC or PubMed

Release Version: PomBase:22_45 - 08 Aug 2014