sno1 (SPAC222.08c)


Gene Standard Namesno1 Characterisation Statusbiological_role_inferred
Systematic IDSPAC222.08c Feature Typeprotein coding
Synonyms Name Description
Productglutamine aminotransferase subunit Sno1 (predicted) Product Size234aa, 25.90 kDa
Genomic Location Chromosome I, 958774-957367 (1408nt); CDS:958350-957646 (705nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
glutaminase activity1
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
pyridoxal phosphate biosynthetic process6
Annotation ExtensionEvidenceWith/FromReference
pyridoxine biosynthetic process3
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
cytoplasm4209
Annotation ExtensionEvidenceWith/FromReference
glutaminase complex1
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
sensitive to hydroxyureasno1ΔNull534
viable vegetative cell populationsno1ΔNull3809

Cell Phenotype

Term NameAlleleExpressionCount
viable vegetative cell with normal cell morphologysno1ΔNull3094
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons958774..957367
mRNA958774..957367
5' UTR958774..958351PMID:21511999
CDS958350..957646
3' UTR957645..957367PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF01174 Pfam IPR002161 Pyridoxal 5'-phosphate synthase subunit PdxT/SNO 26 225 1
PS01236 Prosite Patterns IPR021196 PdxT/SNO family, conserved site 62 72 1
PS51130 Prosite Profiles IPR002161 Pyridoxal 5'-phosphate synthase subunit PdxT/SNO 23 226 1
PTHR31559 HMMPANTHER 12 234 1
3.40.50.880 Gene3D IPR029062 Class I glutamine amidotransferase-like 22 224 20
SSF52317 SuperFamily IPR029062 Class I glutamine amidotransferase-like 23 224 21
PIRSF005639 PIRSF IPR002161 Pyridoxal 5'-phosphate synthase subunit PdxT/SNO 18 228 1
TIGR03800 tigrfam IPR002161 Pyridoxal 5'-phosphate synthase subunit PdxT/SNO 23 223 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 110.69 Da
Charge -5.00
Isoelectric point 5.13
Molecular weight 25.90 kDa
Number of residues 234
Sequence
Gene Expression

Qualitative Gene Expression

DescriptionLevelEvidenceReference
RNA levelincreased during GO:0034599expression microarray evidencePMID:12529438

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
40726during GO:0000084PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
31286during GO:0000087PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
15768.51during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
37822during GO:0072690PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
4402.01during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
3.1during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
0.55during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
conserved in fungi4603
conserved in eukaryotes4514
conserved in bacteria1001
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
binds activation domain construct withsno1glutamine aminotransferase subunit Sno1 (predicted) Two-hybridPMID:23695164
binds activation domain construct withsnz1pyridoxine biosynthesis protein Two-hybridPMID:23695164
Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
negative genetic interaction withalp13MRG family Clr6 histone deacetylase complex subunit Alp13 Negative GeneticPMID:22681890
positive genetic interaction withams2cell cycle regulated GATA-type transcription factor Ams2 Positive GeneticPMID:22681890
negative genetic interaction witharp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:22681890
negative genetic interaction withask1DASH complex subunit Ask1 Negative GeneticPMID:22681890
positive genetic interaction withbob1prefoldin subunit 5 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withckb2CK2 family regulatory subunit Ckb2 (predicted) Negative GeneticPMID:22681890
positive genetic interaction withcut3condensin complex subunit Cut3 Positive GeneticPMID:22681890
negative genetic interaction withdad2DASH complex subunit Dad2 Negative GeneticPMID:22681890
negative genetic interaction withdad3DASH complex subunit Dad3 Negative GeneticPMID:22681890
negative genetic interaction withdad4DASH complex subunit Dad4 Negative GeneticPMID:22681890
negative genetic interaction withdam1DASH complex subunit Dam1 Negative GeneticPMID:22681890
negative genetic interaction withdap1cytochrome P450 regulator Dap1 Negative GeneticPMID:22681890
negative genetic interaction withduo1DASH complex subunit Duo1 Negative GeneticPMID:22681890
positive genetic interaction witheki1choline/ethanolamine kinase Eki1 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withelp2elongator complex subunit Elp2 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withelp3elongator complex subunit Elp3 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withepe1Jmjc domain chromatin associated protein Epe1 Negative GeneticPMID:22681890
positive genetic interaction withexo1exonuclease I Exo1 Positive GeneticPMID:22681890
negative genetic interaction withfft3SMARCAD1 family ATP-dependent DNA helicase Fft3 Negative GeneticPMID:22681890
negative genetic interaction withgcn2eIF2 alpha kinase Gcn2 Negative GeneticPMID:22681890
negative genetic interaction withgcn20AAA family ATPase Gcn20 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withgma12alpha-1,2-galactosyltransferase Gma12 Negative GeneticPMID:22681890
negative genetic interaction withhip1hira protein, histone chaperone Hip1 Negative GeneticPMID:22681890
negative genetic interaction withhip4histone promoter control protein Hip4 Negative GeneticPMID:22681890
positive genetic interaction withhus1checkpoint clamp complex protein Hus1 Positive GeneticPMID:22681890
positive genetic interaction withlub1WD repeat protein Lub1 Positive GeneticPMID:22681890
negative genetic interaction withmbx1MADS-box transcription factor Mbx1 Negative GeneticPMID:22681890
negative genetic interaction withmed7mediator complex subunit Med7 Negative GeneticPMID:22681890
positive genetic interaction withmet14adenylyl-sulfate kinase (predicted) Positive GeneticPMID:22681890
positive genetic interaction withmlh1MutL family protein Mlh1 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withmmb1mitochondrial microtubule binder Mmb1 Negative GeneticPMID:22681890
negative genetic interaction withnup60nucleoporin Nup60 Negative GeneticPMID:22681890
positive genetic interaction withphp3CCAAT-binding factor complex subunit Php3 Positive GeneticPMID:22681890
negative genetic interaction withpob3FACT complex subunit Pob3 Negative GeneticPMID:22681890
positive genetic interaction withppm1leucine carboxyl methyltransferase, involved in regulation of autophagy Ppm1 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withprw1Clr6 histone deacetylase complex subunit Prw1 Negative GeneticPMID:22681890
positive genetic interaction withpsl1cyclin pho85 family Psl1 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withpst2Clr6 histone deacetylase complex subunit Pst2 Negative GeneticPMID:22681890
negative genetic interaction withpyp1tyrosine phosphatase Pyp1 Negative GeneticPMID:22681890
negative genetic interaction withreb1RNA polymerase I transcription termination factor/ RNA polymerase II transcription factor Reb1 Negative GeneticPMID:22681890
negative genetic interaction withres1MBF transcription factor complex subunit Res1 Negative GeneticPMID:22681890
negative genetic interaction withrga2Rho-type GTPase activating protein Rga2 Negative GeneticPMID:22681890
positive genetic interaction withrhb1Rheb GTPase Rhb1 Positive GeneticPMID:22681890
negative genetic interaction withrnc1RNA-binding protein that suppresses calcineurin deletion Rnc1 Negative GeneticPMID:22681890
negative genetic interaction withsac12inositol polyphosphate phosphatase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withsdc1Dpy-30 domain protein Sdc1 Negative GeneticPMID:22681890
positive genetic interaction withset1histone lysine methyltransferase Set1 Positive GeneticPMID:22681890
negative genetic interaction withset6histone lysine methyltransferase Set6 (predicted) Negative GeneticPMID:22681890
positive genetic interaction withsif1Sad1 interacting factor 1 Positive GeneticPMID:22681890
negative genetic interaction withsnu66U4/U6 x U5 tri-snRNP complex subunit Snu66 Negative GeneticPMID:22681890
negative genetic interaction withSPAC17H9.13cglutamate 5-kinase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPAC644.09alanine racemase (predicted) Negative GeneticPMID:22681890
positive genetic interaction withSPBC17A3.06phosphoprotein phosphatase (predicted) Positive GeneticPMID:22681890
negative genetic interaction withspc19DASH complex subunit Spc19 Negative GeneticPMID:22681890
negative genetic interaction withSPCC11E10.07ctranslation initiation factor eIF2B alpha subunit (predicted) Negative GeneticPMID:22681890
positive genetic interaction withSPCC162.11curidine kinase/uracil phosphoribosyltransferase (predicted) Positive GeneticPMID:22681890
negative genetic interaction withSPCC18.10pyridoxine-pyridoxal-pyridoxamine kinase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPCC550.15cribosome biogenesis protein (predicted) Negative GeneticPMID:22681890
positive genetic interaction withsrb10cyclin-dependent protein Srb mediator subunit kinase Srb10 Positive GeneticPMID:22681890
positive genetic interaction withssp2AMP-activated protein serine/threonine kinase alpha subunit Ssp2 Positive GeneticPMID:22681890
positive genetic interaction withswd1Set1C complex subunit Swd1 Positive GeneticPMID:22681890
positive genetic interaction withtma23ribosome biogenesis protein Tma23 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withtom70mitochondrial TOM complex subunit Tom70 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withufd2ubiquitin-protein ligase E4 Ufd2 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withusp102U1 snRNP-associated protein Usp102 Negative GeneticPMID:22681890
positive genetic interaction withxap5xap-5-like protein Positive GeneticPMID:24957674
negative genetic interaction withypa1protein phosphatase type 2A regulator, PTPA family Ypa1 Negative GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPAC222.08c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC222.08c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC222.08c BioGRID Interaction Datasets
Expression Viewer SPAC222.08c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC222.08c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC222.08c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC222.08c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC222.08c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC222.08c Transcriptome Viewer (Bähler Lab)
GEO SPAC222.08c GEO profiles
PInt SPAC222.08c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC222.08c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC222.08c Fission yeast phenotypic data & analysis
Cyclebase SPAC222.08c.1 Cell Cycle Data
SPD / RIKEN08/08C08Orfeome Localization Data
UniProtKB/SwissProtQ9UTE4Uncharacterized glutamine amidotransferase C222.08c
ModBaseQ9UTE4Database of comparative protein structure models
STRINGQ9UTE4Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_593147glutamine aminotransferase subunit
RefSeq mRNANM_001018544972h- glutamine aminotransferase subunit (SPAC222.08c), mRNA
European Nucleotide ArchiveCAB60700.1ENA Protein Mapping
MetaCycPWY-6466Pyridoxal 5'-phosphate biosynthesis II
KEGG_Enzyme00250+3.5.1.2Alanine, aspartate and glutamate metabolism
KEGG_Enzyme00330+3.5.1.2Arginine and proline metabolism
KEGG_Enzyme00471+3.5.1.2D-Glutamine and D-glutamate metabolism
KEGG_Enzyme00750+4.3.3.6Vitamin B6 metabolism
UniParcUPI000006B729UniProt Archive
UniPathwayUPA00245Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis

Literature for sno1

Search: Europe PMC or PubMed

Release Version: PomBase:26_53 - 27 May 2015