SPAC222.08c


Gene Standard NameUnassigned Characterisation Statusbiological_role_inferred
Systematic IDSPAC222.08c Feature Typeprotein coding
Synonyms Name Description
Productglutamine aminotransferase subunit (predicted) Product Size234aa, 25.90 kDa
Genomic Location Chromosome I, 958774-957367 (1408nt); CDS:958350-957646 (705nt)

Ensembl Gene Location
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0006541glutamine metabolic processIEAUniProtKB-KW:KW-0315GO_REF:000003719
GO:0008615pyridoxine biosynthetic processISOSGD:S000004701GO_REF:00000243
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005737cytoplasmIDAPMID:168233724201
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000088sensitive to hydroxyurea511
expressivity FYPO_EXT:0000002Cell growth assaySPAC222.08cΔNullPECO:0000137, PECO:0000005PMID:19264558
expressivity FYPO_EXT:0000002Cell Growth AssaySPAC222.08cΔNullPECO:0000137, PECO:0000102PMID:23697806
FYPO:0002060viable vegetative cell populationMicroscopySPAC222.08cΔNullPMID:204732893730
MicroscopySPAC222.08cΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphology3088
penetrance FYPO_EXT:0000001MicroscopySPAC222.08cΔNullPECO:0000005, PECO:0000137PMID:23697806
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
1958774957367

UTRs

Region Coordinates Reference
five_prime_UTR958774..958351PMID:21511999
three_prime_UTR957645..957367PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF01174 Pfam IPR002161 Glutamine amidotransferase subunit PdxT 26 225 1
PS01236 Prosite Patterns IPR021196 PdxT/SNO family, conserved site 62 72 1
PS51130 Prosite Profiles IPR002161 Glutamine amidotransferase subunit PdxT 23 226 1
PTHR31559 HMMPANTHER 12 234 1
3.40.50.880 Gene3D IPR029062 Class I glutamine amidotransferase-like 22 224 20
SSF52317 SuperFamily IPR029062 Class I glutamine amidotransferase-like 23 224 21
PIRSF005639 PIRSF IPR002161 Glutamine amidotransferase subunit PdxT 21 230 1
TIGR03800 tigrfam IPR002161 Glutamine amidotransferase subunit PdxT 23 223 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 110.69 Da
Charge -5.00
Isoelectric point 5.13
Molecular weight 25.90 kDa
Number of residues 234
Sequence
Gene Expression

Qualitative Gene Expression

DescriptionLevelEvidenceReference
RNA levelincreased during GO:0034599expression microarray evidencePMID:12529438

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
40726during GO:0000084PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
31286during GO:0000087PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
37822during GO:0072690PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
15768.51during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
4402.01during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
3.1during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
0.55during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
conserved in fungi4569
conserved in eukaryotes4482
conserved in bacteria1001
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
ams2cell cycle regulated GATA-type transcription factor Ams2 Positive GeneticPMID:22681890
cut3condensin complex subunit Cut3 Positive GeneticPMID:22681890
duo1DASH complex subunit Duo1 Negative GeneticPMID:22681890
snu66U4/U6 x U5 tri-snRNP complex subunit Snu66 Negative GeneticPMID:22681890
hip1hira protein, histone chaperone Hip1 Negative GeneticPMID:22681890
rhb1Rheb GTPase Rhb1 Positive GeneticPMID:22681890
set1histone lysine methyltransferase Set1 Positive GeneticPMID:22681890
SPCC550.15cribosome biogenesis protein (predicted) Negative GeneticPMID:22681890
set6histone lysine methyltransferase Set6 (predicted) Negative GeneticPMID:22681890
pyp1tyrosine phosphatase Pyp1 Negative GeneticPMID:22681890
SPAC644.09alanine racemase (predicted) Negative GeneticPMID:22681890
ufd2ubiquitin-protein ligase E4 (predicted) Positive GeneticPMID:22681890
swd1Set1C complex subunit Swd1 Positive GeneticPMID:22681890
lub1WD repeat protein Lub1 Positive GeneticPMID:22681890
elp3elongator complex subunit Elp3 (predicted) Positive GeneticPMID:22681890
SPCC11E10.07ctranslation initiation factor eIF2B alpha subunit (predicted) Negative GeneticPMID:22681890
res1MBF transcription factor complex subunit Res1 Negative GeneticPMID:22681890
ckb2CK2 family regulatory subunit (predicted) Negative GeneticPMID:22681890
nup60nucleoporin Nup60 Negative GeneticPMID:22681890
dad3DASH complex subunit Dad3 Negative GeneticPMID:22681890
mbx1MADS-box transcription factor Mbx1 Negative GeneticPMID:22681890
hus1checkpoint clamp complex protein Hus1 Positive GeneticPMID:22681890
ask1DASH complex subunit Ask1 Negative GeneticPMID:22681890
dad4DASH complex subunit Dad4 Negative GeneticPMID:22681890
pst2Clr6 histone deacetylase complex subunit Pst2 Negative GeneticPMID:22681890
alp13MRG family Clr6 histone deacetylase complex subunit Alp13 Negative GeneticPMID:22681890
SPBC29A3.09cAAA family ATPase Gcn20 (predicted) Negative GeneticPMID:22681890
epe1Jmjc domain chromatin associated protein Epe1 Negative GeneticPMID:22681890
dad2DASH complex subunit Dad2 Negative GeneticPMID:22681890
tma23ribosome biogenesis protein Tma23 (predicted) Positive GeneticPMID:22681890
mmb1mitochondria microtubule binder Mmb1 Negative GeneticPMID:22681890
SPBC17A3.06phosphoprotein phosphatase (predicted) Positive GeneticPMID:22681890
tom70mitochondrial TOM complex subunit Tom70 (predicted) Positive GeneticPMID:22681890
pob3FACT complex subunit Pob3 Negative GeneticPMID:22681890
arp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:22681890
ypa1protein phosphatase type 2A regulator, PTPA family Ypa1 Negative GeneticPMID:22681890
sdc1Dpy-30 domain protein Sdc1 Negative GeneticPMID:22681890
srb10cyclin-dependent protein Srb mediator subunit kinase Srb10 Positive GeneticPMID:22681890
psl1cyclin pho85 family Psl1 (predicted) Positive GeneticPMID:22681890
rga2Rho-type GTPase activating protein Rga2 Negative GeneticPMID:22681890
hip4histone promoter control protein Hip4 Negative GeneticPMID:22681890
usp102U1 snRNP-associated protein Usp102 Negative GeneticPMID:22681890
met14adenylyl-sulfate kinase (predicted) Positive GeneticPMID:22681890
gma12alpha-1,2-galactosyltransferase Gma12 Negative GeneticPMID:22681890
sif1Sad1 interacting factor 1 Positive GeneticPMID:22681890
bob1prefoldin subunit 5 (predicted) Positive GeneticPMID:22681890
php3CCAAT-binding factor complex subunit Php3 Positive GeneticPMID:22681890
SPCC18.10pyridoxine-pyridoxal-pyridoxamine kinase (predicted) Negative GeneticPMID:22681890
med7mediator complex subunit Med7 Negative GeneticPMID:22681890
reb1RNA polymerase I transcription termination factor Reb1 Negative GeneticPMID:22681890
sac12inositol polyphosphate phosphatase (predicted) Negative GeneticPMID:22681890
ssp2serine/threonine protein kinase Ssp2 Positive GeneticPMID:22681890
SPAC17H9.13cglutamate 5-kinase (predicted) Negative GeneticPMID:22681890
exo1exonuclease I Exo1 Positive GeneticPMID:22681890
SPCC162.11curidine kinase/uracil phosphoribosyltransferase (predicted) Positive GeneticPMID:22681890
prw1Clr6 histone deacetylase complex subunit Prw1 Negative GeneticPMID:22681890
ppm1leucine carboxyl methyltransferase Ppm1 (predicted) Positive GeneticPMID:22681890
SPAC13G7.12ccholine kinase (predicted) Positive GeneticPMID:22681890
dap1cytochrome P450 regulator Dap1 Negative GeneticPMID:22681890
elp2elongator complex subunit Elp2 (predicted) Positive GeneticPMID:22681890
mlh1MutL family protein Mlh1 (predicted) Positive GeneticPMID:22681890
gcn2eIF2 alpha kinase Gcn2 Negative GeneticPMID:22681890
fft3SMARCAD1 family ATP-dependent DNA helicase Fft3 Negative GeneticPMID:22681890
rnc1RNA-binding protein that suppresses calcineurin deletion Rnc1 Negative GeneticPMID:22681890
dam1DASH complex subunit Dam1 Negative GeneticPMID:22681890
spc19DASH complex subunit Spc19 Negative GeneticPMID:22681890
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
hhp1serine/threonine protein kinase Hhp1 Affinity Capture-MSPMID:24055157
hhp2serine/threonine protein kinase Hhp2 Affinity Capture-MSPMID:24055157
SPAC222.08cglutamine aminotransferase subunit (predicted) Two-hybridPMID:23695164
snz1pyridoxine biosynthesis protein Two-hybridPMID:23695164
External References
Database Identifier Description
NBRP SPAC222.08c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC222.08c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC222.08c BioGRID Interaction Datasets
Expression Viewer SPAC222.08c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC222.08c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC222.08c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC222.08c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC222.08c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC222.08c Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC222.08c Cell Cycle Data
GEO SPAC222.08c GEO profiles
PInt SPAC222.08c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC222.08c Peptides identified in tandem mass spectrometry proteomics experiments
WikiGene2541464imidazoleglycerol-phosphate synthase (predicted)
EntrezGene2541464imidazoleglycerol-phosphate synthase (predicted)
SPD / RIKEN08/08C08Orfeome Localization Data
UniProtKB/SwissProtQ9UTE4Uncharacterized glutamine amidotransferase C222.08c
ModBaseQ9UTE4Database of comparative protein structure models
STRINGQ9UTE4Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_593147imidazoleglycerol-phosphate synthase (predicted)
RefSeq mRNANM_001018544972h- imidazoleglycerol-phosphate synthase (predicted) (SPAC222.08c), mRNA
European Nucleotide ArchiveCAB60700ENA Protein Mapping
European Nucleotide ArchiveCAB60700.1ENA Protein Mapping
UniParcUPI000006B729UniProt Archive

Literature for SPAC222.08c

Search: Europe PMC or PubMed

Release Version: PomBase:22_45 - 08 Aug 2014