meu13 (SPAC222.15)

Gene Standard Namemeu13 Characterisation Statuspublished
Systematic IDSPAC222.15 Feature Typeprotein coding
Synonyms Name DescriptionMeiotic Expression Upregulated
ProductTat binding protein 1(TBP-1)-interacting protein (TBPIP) homolog (predicted) Product Size216aa, 24.67 kDa
Genomic Location Chromosome I, 977709-978637 (929nt); CDS:977709-978637 (929nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
protein binding862
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
DNA recombination118
Annotation ExtensionEvidenceWith/FromReference
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
Annotation ExtensionEvidenceWith/FromReference
horsetail nucleus12
Annotation ExtensionEvidenceWith/FromReference
nuclear chromatin344
Annotation ExtensionEvidenceWith/FromReference
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

Term NameGenotypesCount
decreased spore germination frequencymeu13Δ60
normal vegetative cell population growthmeu13Δ819
viable vegetative cell populationmeu13Δ3831

Cell Phenotype

Term NameGenotypesCount
abnormal linear element morphologymeu13Δ6
abnormal nuclear separation after meiosismeu13Δ8
abnormal sporulation resulting in formation of ascus with fewer than four sporesmeu13Δ75
decreased gene conversionmeu13Δ16
decreased homologous chromosome pairingmeu13Δ4
decreased intergenic meiotic recombinationmeu13Δ24
decreased intragenic meiotic recombinationmeu13Δ30
decreased protein degradation36
affecting mcp7meu13Δ
delayed onset of meiosis Imeu13Δ2
normal horsetail movementmeu13Δ4
normal meiotic sister chromatid cohesionmeu13Δ5
normal meiotic telomere clusteringmeu13Δ7
unequal homologous chromosome segregationmeu13Δ14
viable vegetative cell with normal cell morphologymeu13Δ3099

FYPO Multi-allele Phenotypes

Cell Phenotype

Term NameGenotypes
normal onset of meiosis Imeu13Δ, mcp7Δ
Target Of
FYPO affected by mutation in mcp7 meiosis specific coiled-coil protein Mcp7
FYPO affected by mutation in red5 human ZC3H3 homolog
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons977709..977757, 977804..977857, 977905..978006, 978049..978189, 978333..978637
Intron977758..977803, 977858..977904, 978007..978048, 978190..978332
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF07106 Pfam IPR010776 Tat binding protein 1-interacting 16 184 1
PTHR15938 HMMPANTHER IPR010776 Tat binding protein 1-interacting 8 209 1 Gene3D IPR011991 Winged helix-turn-helix DNA-binding domain 8 104 46
Coil ncoils Predicted coiled-coil protein (DUF2205) 133 153 1050
Coil ncoils Predicted coiled-coil protein (DUF2205) 82 109 1050

View domain organization at Pfam

Term IDTerm NameReferenceCount

Protein Properties

Ave. residue weight 114.22 Da
Charge 1.00
Codon Adaptation Index 0.42
Isoelectric point 7.41
Molecular weight 24.67 kDa
Number of residues 216
Gene Expression

Qualitative Gene Expression

protein levelincreased during GO:0051328Western blot evidencePMID:15210864
absent during GO:0007127Western blot evidencePMID:15210864
absent during GO:0007135Western blot evidencePMID:15210864
increased during GO:0007128fusion protein localization evidencePMID:11447128
RNA levelabsent during GO:0072690Northern assay evidencePMID:11447128
increased during GO:0051321Northern assay evidencePMID:11447128
increased during GO:0051321experimental evidencePMID:16303567

Quantitative Gene Expression

View graphical display of gene expression data for meu13 (SPAC222.15)

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
0.16during GO:0072690PECO:0000014,
population wideexperimental evidencePMID:23101633
0.026during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
population wideexperimental evidencePMID:23101633
meiosis-specific splicing PMID:1589373214
Taxonomic Conservation
predominantly single copy (one to one)3090
conserved in fungi4604
conserved in eukaryotes4514
conserved in metazoa3422
conserved in vertebrates3397
conserved in eukaryotes only2504

Manually curated orthologous groups


Orthologs in Compara

Physical Interactions

Source: BioGRID

Load gene that interact physically with SPAC222.15 into the Query Builder
View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
affinity captured byskb1type II protein arginine N-methyltransferase Skb1 Affinity Capture-MSPMID:25009287
binds activation domain construct withskb1type II protein arginine N-methyltransferase Skb1 Two-hybridPMID:25009287
affinity capturesskb1type II protein arginine N-methyltransferase Skb1 Affinity Capture-WesternPMID:25009287
binds DNA-binding domain construct withskb1type II protein arginine N-methyltransferase Skb1 Two-hybridPMID:25009287
Genetic Interactions

Source: BioGRID

Load gene that interact genetically with SPAC222.15 into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
rescuesskb1type II protein arginine N-methyltransferase Skb1 Phenotypic SuppressionPMID:25009287
External References
Database Identifier Description
NBRP SPAC222.15 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC222.15 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC222.15 BioGRID Interaction Datasets
Expression Viewer SPAC222.15 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC222.15 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC222.15 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC222.15 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC222.15 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC222.15 Transcriptome Viewer (Bähler Lab)
GEO SPAC222.15 GEO profiles
PInt SPAC222.15 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC222.15 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC222.15 Fission yeast phenotypic data & analysis
Cyclebase SPAC222.15.1 Cell Cycle Data
SPD / RIKEN13/13A01Orfeome Localization Data
UniProtKB/SwissProtQ9HGK2Homologous-pairing protein 2
ModBaseQ9HGK2Database of comparative protein structure models
STRINGQ9HGK2Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_001018191homologous-pairing protein 2
RefSeq mRNANM_001018551972h- homologous-pairing protein 2 (meu13), mRNA
European Nucleotide ArchiveAB017038ENA EMBL mapping
European Nucleotide ArchiveCU329670ENA EMBL mapping
European Nucleotide ArchiveBAB17055ENA Protein Mapping
European Nucleotide ArchiveCAD33796ENA Protein Mapping
UniParcUPI000012EE93UniProt Archive

Literature for meu13

Search: Europe PMC or PubMed

Release Version: PomBase:30_57 - 27 Jan 2016