meu13 (SPAC222.15)

Gene Standard Namemeu13 Characterisation Statuspublished
Systematic IDSPAC222.15 Feature Typeprotein coding
SynonymsSPAC821.01 Name DescriptionMeiotic Expression Upregulated
ProductTat binding protein 1(TBP-1)-interacting protein (TBPIP) homolog (predicted) Product Size216aa, 24.67 kDa
Genomic Location Chromosome I, 977709-978637 (929nt); CDS:977709-978637 (929nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005515protein bindingIPImcp7GO_REF:0000001887
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0007131reciprocal meiotic recombinationIMPPMID:1144712845
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0044732mitotic spindle pole bodyIDAPMID:16823372214
GO:0000790nuclear chromatin247
during meiotic cell cycleNASGO_REF:0000001
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopymeu13ΔNullPECO:0000005, PECO:0000137PMID:236978063755

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphologyMicroscopymeu13ΔNullPECO:0000005, PECO:0000137PMID:236978063078
penetrance FYPO_EXT:0000001
Ensembl transcript structure with UTRs, exons and introns


Exon Start End
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF07106 Pfam IPR010776 Tat binding protein 1-interacting 16 184 1
PTHR15938 HMMPANTHER IPR010776 Tat binding protein 1-interacting 1 216 1
G3DSA: Gene3D IPR011991 8 104 44
Coil ncoils Rabaptin coiled-coil domain 82 110 975
Coil ncoils Rabaptin coiled-coil domain 133 154 975

View domain organization at Pfam

Sequence Ontology

Term IDTerm NameReferenceCount

Protein Properties

Ave. residue weight 114.22 Da
Charge 1.00
Isoelectric point 7.41
Molecular weight 24.67 kDa
Number of residues 216
Gene Expression

Qualitative Gene Expression

RNA levelincreasedexperimental evidencePMID:16303567
during GO:0007126

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
NDduring cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633
NDduring GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
0.16during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
0.026during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633
Species Distribution
predominantly single copy (one to one)3080
conserved in fungi4564
conserved in eukaryotes4482
conserved in metazoa3419
conserved in vertebrates3394
conserved in eukaryotes only2485

Manually curated orthologous groups


Orthologs in Compara

Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
mug154conserved fungal protein Negative GeneticPMID:18818364
rad4BRCT domain protein Rad4 Phenotypic SuppressionPMID:14718568
Phenotypic Enhancement
tip1CLIP170 family protein Tip1 Negative GeneticPMID:18818364
cdm1DNA polymerase delta subunit Cdm1 Negative GeneticPMID:18818364
SPCC126.01cconserved fungal protein Positive GeneticPMID:18818364
pus1tRNA pseudouridine synthase Lsp1 Positive GeneticPMID:18818364
rad17RFC related checkpoint protein Rad17 Phenotypic EnhancementPMID:12032093
mek1Cds1/Rad53/Chk2 family protein kinase Mek1 Phenotypic SuppressionPMID:12482912
Phenotypic EnhancementPMID:12032093
rsc4RSC complex subunit Rsc4 Negative GeneticPMID:18818364
sgf29SAGA complex subunit Sgf29 Negative GeneticPMID:18818364
rpl160160S ribosomal protein L13/L16 (predicted) Negative GeneticPMID:18818364
mcp7meiosis specific coiled-coil protein Mcp7 Phenotypic EnhancementPMID:15210864
atg1801WD repeat protein involved in autophagy Atg18a Positive GeneticPMID:18818364
rec12endonuclease Rec12 Phenotypic SuppressionPMID:12482912
cds1replication checkpoint kinase Cds1 Phenotypic EnhancementPMID:12032093
pnn1pinin ortholog, involved in splicing Pnn1 (predicted) Negative GeneticPMID:18818364
stp1protein tyrosine phosphatase Stp1 Positive GeneticPMID:18818364
sdh4TIM22 inner membrane protein import complex anchor subunit Tim18 Negative GeneticPMID:18818364
SPAC1093.03inositol polyphosphate phosphatase (predicted) Positive GeneticPMID:18818364
tma23ribosome biogenesis protein Tma23 (predicted) Negative GeneticPMID:18818364
amk2AMP-activated protein kinase beta subunit Amk2 Positive GeneticPMID:18818364
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
mcp7meiosis specific coiled-coil protein Mcp7 Affinity Capture-WesternPMID:15210864
External References
Database Identifier Description
NBRP SPAC222.15 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC222.15 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC222.15 BioGRID Interaction Datasets
Expression Viewer SPAC222.15 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC222.15 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC222.15 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC222.15 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC222.15 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC222.15 Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC222.15 Cell Cycle Data
GEO SPAC222.15 GEO profiles
PInt SPAC222.15 Protein-Protein Interaction Predictor (Bähler Lab)
SPD / RIKEN13/13A01Orfeome Localization Data
WikiGene3361533homologous-pairing protein 2
EntrezGene3361533homologous-pairing protein 2
UniProtKB/SwissProtQ9HGK2Homologous-pairing protein 2
ModBaseQ9HGK2Database of comparative protein structure models
StringQ9HGK2Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_001018191homologous-pairing protein 2
RefSeq mRNANM_001018551972h- homologous-pairing protein 2 (meu13), mRNA
European Nucleotide ArchiveBAB17055ENA Protein Mapping
European Nucleotide ArchiveCAD33796ENA Protein Mapping
UniParcUPI000012EE93UniProt Archive

Literature for meu13

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014