meu13 (SPAC222.15)

Gene Standard Namemeu13 Characterisation Statuspublished
Systematic IDSPAC222.15 Feature Typeprotein coding
SynonymsSPAC821.01 Name DescriptionMeiotic Expression Upregulated
ProductTat binding protein 1(TBP-1)-interacting protein (TBPIP) homolog (predicted) Product Size216aa, 24.67 kDa
Genomic Location Chromosome I, 977709-978637 (929nt); CDS:977709-978637 (929nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
protein binding831
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
reciprocal meiotic recombination43
Annotation ExtensionEvidenceWith/FromReference
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
Annotation ExtensionEvidenceWith/FromReference
mitotic spindle257
Annotation ExtensionEvidenceWith/FromReference
mitotic spindle pole body216
Annotation ExtensionEvidenceWith/FromReference
nuclear chromatin283
Annotation ExtensionEvidenceWith/FromReference
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001357normal vegetative cell population growthCell growth assaymeu13ΔNullPMID:16615890641
FYPO:0002060viable vegetative cell populationMicroscopymeu13ΔNullPECO:0000005, PECO:0000137PMID:236978063759

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphology3089
penetrance FYPO_EXT:0000001Microscopymeu13ΔNullPECO:0000005, PECO:0000137PMID:23697806
Target Of
FYPO affected by mutation in red5 human ZC3H3 homolog PMID:23658229
Ensembl transcript structure with UTRs, exons and introns


Exon Start End
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF07106 Pfam IPR010776 Tat binding protein 1-interacting 16 184 1
PTHR15938 HMMPANTHER IPR010776 Tat binding protein 1-interacting 1 216 1 Gene3D IPR011991 Winged helix-turn-helix DNA-binding domain 8 104 46
Coil ncoils Rabaptin coiled-coil domain 133 154 968
Coil ncoils Rabaptin coiled-coil domain 82 110 968

View domain organization at Pfam

Sequence Ontology

Term IDTerm NameReferenceCount

Protein Properties

Ave. residue weight 114.22 Da
Charge 1.00
Isoelectric point 7.41
Molecular weight 24.67 kDa
Number of residues 216
Gene Expression

Qualitative Gene Expression

RNA levelincreased during GO:0051321experimental evidencePMID:16303567

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
NDduring cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
0.16during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
0.026during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633
meiosis-specific splicing PMID:1589373214
Species Distribution
predominantly single copy (one to one)3092
conserved in fungi4600
conserved in eukaryotes4514
conserved in metazoa3425
conserved in vertebrates3400
conserved in eukaryotes only2497

Manually curated orthologous groups


Orthologs in Compara

Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
mcp7meiosis specific coiled-coil protein Mcp7 Affinity Capture-WesternPMID:15210864
Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
rad4BRCT domain protein Rad4 Phenotypic SuppressionPMID:14718568
Phenotypic Enhancement
mek1Cds1/Rad53/Chk2 family protein kinase Mek1 Phenotypic SuppressionPMID:12482912
Phenotypic EnhancementPMID:12032093
rec12endonuclease Rec12 Phenotypic SuppressionPMID:12482912
cdm1DNA polymerase delta subunit Cdm1 Negative GeneticPMID:18818364
atg1801WD repeat protein involved in autophagy Atg18a Positive GeneticPMID:18818364
rad3ATR checkpoint kinase Rad3 Phenotypic EnhancementPMID:12032093
SPAC1093.03inositol polyphosphate phosphatase (predicted) Positive GeneticPMID:18818364
mcp7meiosis specific coiled-coil protein Mcp7 Phenotypic EnhancementPMID:15210864
mug154conserved fungal protein Negative GeneticPMID:18818364
stp1protein tyrosine phosphatase Stp1 Positive GeneticPMID:18818364
SPCC126.01cconserved fungal protein Positive GeneticPMID:18818364
pus1tRNA pseudouridine synthase Lsp1 Positive GeneticPMID:18818364
rad17RFC related checkpoint protein Rad17 Phenotypic EnhancementPMID:12032093
rsc4RSC complex subunit Rsc4 Negative GeneticPMID:18818364
sgf29SAGA complex subunit Sgf29 Negative GeneticPMID:18818364
rpl160160S ribosomal protein L13/L16 (predicted) Negative GeneticPMID:18818364
cds1replication checkpoint kinase Cds1 Phenotypic EnhancementPMID:12032093
amk2AMP-activated protein kinase beta subunit Amk2 Positive GeneticPMID:18818364
tma23ribosome biogenesis protein Tma23 (predicted) Negative GeneticPMID:18818364
pnn1pinin ortholog, involved in splicing Pnn1 (predicted) Negative GeneticPMID:18818364
tip1CLIP170 family protein Tip1 Negative GeneticPMID:18818364
sdh4TIM22 inner membrane protein import complex anchor subunit Tim18 Negative GeneticPMID:18818364
External References
Database Identifier Description
NBRP SPAC222.15 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC222.15 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC222.15 BioGRID Interaction Datasets
Expression Viewer SPAC222.15 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC222.15 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC222.15 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC222.15 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC222.15 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC222.15 Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC222.15 Cell Cycle Data
GEO SPAC222.15 GEO profiles
PInt SPAC222.15 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC222.15 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC222.15 Fission yeast phenotypic data & analysis
SPD / RIKEN13/13A01Orfeome Localization Data
UniProtKB/SwissProtQ9HGK2Homologous-pairing protein 2
ModBaseQ9HGK2Database of comparative protein structure models
STRINGQ9HGK2Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_001018191homologous-pairing protein 2
RefSeq mRNANM_001018551972h- homologous-pairing protein 2 (meu13), mRNA
European Nucleotide ArchiveBAB17055.1ENA Protein Mapping
European Nucleotide ArchiveCAD33796.1ENA Protein Mapping
UniParcUPI000012EE93UniProt Archive

Literature for meu13

Search: Europe PMC or PubMed

Release Version: PomBase:23_47 - 27 Oct 2014