ogm1 (SPAC22A12.07c)


Gene Standard Nameogm1 Characterisation Statuspublished
Systematic IDSPAC22A12.07c Feature Typeprotein coding
Synonymsoma1 Name DescriptionO-glycoside mannosyltransferase
Productprotein O-mannosyltransferase Ogm1 Product Size893aa, 101.34 kDa
Genomic Location Chromosome I, 1169743-1166562 (3182nt); CDS:1169503-1166822 (2682nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
dolichyl-phosphate-mannose-protein mannosyltransferase activity3
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
cell wall mannoprotein biosynthetic process10
Annotation ExtensionEvidenceWith/FromReference
chain elongation of O-linked mannose residue2
Annotation ExtensionEvidenceWith/FromReference
protein O-linked mannosylation5
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
endomembrane system961
Annotation ExtensionEvidenceWith/FromReference
endoplasmic reticulum membrane201
Annotation ExtensionEvidenceWith/FromReference
integral component of membrane968
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Single-allele Phenotypes

Population Phenotype

Term NameGenotypesCount
decreased cell population growth at high temperatureogm1Δ155
normal growth on glucose carbon sourceogm1Δ240
normal growth on hygromycin Bogm1Δ3
sensitive to 5-fluorouracilogm1Δ272
sensitive to amphotericin Bogm1Δ69
sensitive to caffeine during vegetative growthogm1Δ110
sensitive to cell wall-degrading enzymesogm1Δ44
sensitive to micafunginogm1Δ116
viable vegetative cell populationogm1Δ3819

Cell Phenotype

Term NameGenotypesCount
abolished shmoo formationogm1Δ11
branched septumogm1Δ4
decreased protein glycosylationogm1Δ8
increased cell wall thickness during vegetative growthogm1Δ11
sterileogm1Δ57
vegetative cell lysisogm1Δ86
viable pear-shaped vegetative cellogm1Δ12
viable spheroid vegetative cellogm1Δ50
viable vegetative cellogm1Δ3641
viable vegetative cell, abnormal cell shape, normal cell sizeogm1Δ215
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons1169743..1166562
mRNA1169743..1166562
5' UTR1169743..1169504PMID:21511999
CDS1169503..1166822
3' UTR1166821..1166562PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF16192 Pfam IPR032421 Protein O-mannosyl-transferase, C-terminal four TM domain 518 710 3
PF02366 Pfam IPR003342 Glycosyl transferase family 39/83 39 283 3
PF02815 Pfam IPR016093 MIR motif 330 495 3
SM00472 SMART IPR016093 MIR motif 444 499 3
SM00472 SMART IPR016093 MIR motif 374 433 3
SM00472 SMART IPR016093 MIR motif 310 364 3
TMhelix TMHMM 199 218 959
TMhelix TMHMM 121 143 959
TMhelix TMHMM 636 658 959
TMhelix TMHMM 607 626 959
TMhelix TMHMM 29 47 959
TMhelix TMHMM 170 192 959
TMhelix TMHMM 222 244 959
TMhelix TMHMM 257 279 959
TMhelix TMHMM 671 688 959
TMhelix TMHMM 572 594 959
PS50919 Prosite Profiles IPR016093 MIR motif 443 499 3
PS50919 Prosite Profiles IPR016093 MIR motif 310 364 3
PS50919 Prosite Profiles IPR016093 MIR motif 374 433 3
PTHR10050:SF28 HMMPANTHER IPR027004 Dolichyl-phosphate-mannose-protein mannosyltransferase 1/5 2 720 1
PTHR10050 HMMPANTHER IPR027005 Glycosyltransferase 39-like 2 720 3
2.80.10.50 Gene3D Interleukin-1 receptor antagonist protein 309 506 6
SSF82109 SuperFamily IPR016093 MIR motif 309 497 3
Coil ncoils Predicted coiled-coil protein (DUF2205) 780 804 1048

View domain organization at Pfam

Term IDTerm NameReferenceCount
PBO:0000808PMT familyTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000808
PBO:0000809PMT1 subfamilyTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000809

Term IDTerm NameReferenceCount
SO:0001812transmembrane_helix465

Protein Properties

Ave. residue weight 113.48 Da
Charge -3.00
Isoelectric point 6.34
Molecular weight 101.34 kDa
Number of residues 893
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
58126during GO:0000080PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
59166during GO:0000084PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
62224during GO:0000085PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
65428during GO:0000087PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
9831.27during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
60149during GO:0072690PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
5959.2during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
7.1during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
1.6during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
Disease Association
DescriptionQualifierReferenceCount
neurological disorders PMID:1688702699
Walker-Warburg syndrome PMID:168870263
Subunit Composition
DescriptionQualifierReferenceCount
heteromeric(2) PMID:1594895741
Taxonomic Conservation
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3090
conserved in fungi4604
conserved in eukaryotes4514
conserved in metazoa3421
conserved in vertebrates3396
conserved in eukaryotes only2503
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Load gene that interact physically with SPAC22A12.07c into the Query Builder
View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
affinity captured bypaa1protein phosphatase regulatory subunit Paa1 Affinity Capture-MSPMID:22119525
affinity capturesogm2protein O-mannosyltransferase Ogm2 Affinity Capture-WesternPMID:15948957
Genetic Interactions

Source: BioGRID

Load gene that interact geneitically with SPAC22A12.07c into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
synthetic lethal withogm4protein O-mannosyltransferase Ogm4 Synthetic LethalityPMID:15948957
External References
Database Identifier Description
NBRP SPAC22A12.07c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC22A12.07c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC22A12.07c BioGRID Interaction Datasets
Expression Viewer SPAC22A12.07c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC22A12.07c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC22A12.07c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC22A12.07c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC22A12.07c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC22A12.07c Transcriptome Viewer (Bähler Lab)
GEO SPAC22A12.07c GEO profiles
PInt SPAC22A12.07c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC22A12.07c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC22A12.07c Fission yeast phenotypic data & analysis
Cyclebase SPAC22A12.07c.1 Cell Cycle Data
IntEnz2.4.1.109Integrated relational Enzyme database
Rhea2.4.1.109Annotated reactions database
SPD / RIKEN47/47B01Orfeome Localization Data
UniProtKB/SwissProtO13898Dolichyl-phosphate-mannose--protein mannosyltransferase 1
ModBaseO13898Database of comparative protein structure models
STRINGO13898Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_593237protein O-mannosyltransferase Ogm1
RefSeq mRNANM_001018634972h- protein O-mannosyltransferase Ogm1 (ogm1), mRNA
European Nucleotide ArchiveCU329670ENA EMBL mapping
European Nucleotide ArchiveCAB16577ENA Protein Mapping
European Nucleotide ArchiveCAB16577.1ENA Protein Mapping
KEGG00514+2.4.1.109Other types of O-glycan biosynthesis
UniParcUPI0000131D0CUniProt Archive
UniPathwayUPA00378with

Literature for ogm1

Search: Europe PMC or PubMed

Release Version: PomBase:29_56 - 12 Nov 2015