ogm1 (SPAC22A12.07c)


Gene Standard Nameogm1 Characterisation Statuspublished
Systematic IDSPAC22A12.07c Feature Typeprotein coding
Synonymsoma1 Name DescriptionO-glycoside mannosyltransferase
Productprotein O-mannosyltransferase Ogm1 Product Size893aa, 101.34 kDa
Genomic Location Chromosome I, 1169743-1166562 (3182nt); CDS:1169503-1166822 (2682nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0004169dolichyl-phosphate-mannose-protein mannosyltransferase activity3
has substrate wsc1IDAPMID:15948957
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0000032cell wall mannoprotein biosynthetic processIMPPMID:1594895710
GO:0044845chain elongation of O-linked mannose residueIMPPMID:158090692
GO:0035269protein O-linked mannosylationIDAPMID:159489575
IGIwsc1PMID:15948957
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0031502dolichyl-phosphate-mannose-protein mannosyltransferase complexIDAPMID:159489573
GO:0012505endomembrane systemIDAPMID:15809069963
GO:0005789endoplasmic reticulum membraneIDAPMID:15809069205
GO:0016021integral component of membraneIEAUniProtKB-KW:KW-0812GO_REF:00000371018
GO:0005634nucleusIEAUniProtKB-KW:KW-0539GO_REF:00000372737
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000082decreased cell population growth at high temperatureCell growth assayogm1ΔNullPECO:0000137, PECO:0000102PMID:15809069144
FYPO:0001164normal growth on glucose carbon sourceCell growth assayogm1ΔNullPECO:0000005, PECO:0000137, PECO:0000102PMID:15809069165
FYPO:0002637normal growth on hygromycin BCell growth assayogm1ΔNullPECO:0000005, PECO:0000102, PECO:0000137PMID:158090693
FYPO:0002642sensitive to amphotericin B69
expressivity FYPO_EXT:0000003Cell growth assayogm1ΔNullPECO:0000137, PECO:0000005PMID:23738021
FYPO:0002641sensitive to micafungin116
expressivity FYPO_EXT:0000002Cell growth assayogm1ΔNullPECO:0000137, PECO:0000005PMID:23738021
FYPO:0002060viable vegetative cell populationMicroscopyogm1ΔNullPMID:204732893751
Microscopyogm1ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000569abolished shmoo formationCell growth assayogm1ΔNullPMID:158090699
FYPO:0001911decreased protein glycosylationGel electrophoresis evidenceogm1ΔNullPECO:0000061PMID:158090697
FYPO:0000280sterileCell growth assayogm1ΔNullPMID:1580906947
FYPO:0000647vegetative cell lysisCell growth assayogm1ΔNullPECO:0000137, PECO:0000005PMID:2373802179
FYPO:0002380viable spheroid vegetative cellMicroscopyogm1ΔNullPMID:1580906940
FYPO:0001510viable vegetative cell, abnormal cell shape, normal cell size215
penetrance FYPO_EXT:0000001Microscopyogm1ΔNullPECO:0000005, PECO:0000137PMID:23697806
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
111697431166562
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF02815 Pfam IPR016093 MIR motif 329 504 3
PF02366 Pfam IPR003342 Glycosyl transferase, family 39 39 282 3
SM00472 SMART IPR016093 MIR motif 444 499 3
SM00472 SMART IPR016093 MIR motif 310 364 3
SM00472 SMART IPR016093 MIR motif 374 433 3
TMhelix TMHMM 121 143 959
TMhelix TMHMM 170 192 959
TMhelix TMHMM 572 594 959
TMhelix TMHMM 29 47 959
TMhelix TMHMM 636 658 959
TMhelix TMHMM 222 244 959
TMhelix TMHMM 257 279 959
TMhelix TMHMM 199 218 959
TMhelix TMHMM 607 626 959
TMhelix TMHMM 671 688 959
PS50919 Prosite Profiles IPR016093 MIR motif 443 499 3
PS50919 Prosite Profiles IPR016093 MIR motif 374 433 3
PS50919 Prosite Profiles IPR016093 MIR motif 310 364 3
PTHR10050:SF12 HMMPANTHER IPR027004 Dolichyl-phosphate-mannose-protein mannosyltransferase 1 1 719 1
PTHR10050 HMMPANTHER IPR027005 Glycosyltransferase 39 like 1 719 3
2.80.10.50 Gene3D 309 506 6
SSF82109 SuperFamily IPR016093 MIR motif 309 497 3
Coil ncoils Rabaptin coiled-coil domain 780 805 968

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0000808PMT familyTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000808
PBO:0000809PMT1 subfamilyTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000809

Sequence Ontology

Term IDTerm NameReferenceCount
SO:0001812transmembrane_helix465

Protein Properties

Ave. residue weight 113.48 Da
Charge -3.00
Isoelectric point 6.34
Molecular weight 101.34 kDa
Number of residues 893
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
58126during GO:0000080PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
59166during GO:0000084PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
62224during GO:0000085PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
65428during GO:0000087PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
9831.27during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
60149during GO:0072690PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
5959.2during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
7.1during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
1.6during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Subunit Composition
DescriptionQualifierReferenceCount
heteromeric(2) PMID:1594895742
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4599
conserved in eukaryotes4514
conserved in metazoa3428
conserved in vertebrates3402
conserved in eukaryotes only2498
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
ogm4protein O-mannosyltransferase Ogm4 Synthetic LethalityPMID:15948957
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
ogm2protein O-mannosyltransferase Ogm2 Affinity Capture-WesternPMID:15948957
hhp2serine/threonine protein kinase Hhp2 Affinity Capture-MSPMID:24055157
paa1protein phosphatase regulatory subunit Paa1 Affinity Capture-MSPMID:22119525
External References
Database Identifier Description
NBRP SPAC22A12.07c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC22A12.07c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC22A12.07c BioGRID Interaction Datasets
Expression Viewer SPAC22A12.07c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC22A12.07c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC22A12.07c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC22A12.07c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC22A12.07c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC22A12.07c Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC22A12.07c Cell Cycle Data
GEO SPAC22A12.07c GEO profiles
PInt SPAC22A12.07c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC22A12.07c Peptides identified in tandem mass spectrometry proteomics experiments
IntEnz2.4.1.109Integrated relational Enzyme database
Rhea2.4.1.109Annotated reactions database
SPD / RIKEN47/47B01Orfeome Localization Data
UniProtKB/SwissProtO13898Dolichyl-phosphate-mannose--protein mannosyltransferase 1
ModBaseO13898Database of comparative protein structure models
STRINGO13898Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_593237protein O-mannosyltransferase Ogm1
RefSeq mRNANM_001018634972h- protein O-mannosyltransferase Ogm1 (ogm1), mRNA
European Nucleotide ArchiveCAB16577.1ENA Protein Mapping
UniParcUPI0000131D0CUniProt Archive
UniPathwayUPA00378Protein modification; protein glycosylation

Literature for ogm1

Search: Europe PMC or PubMed

Release Version: PomBase:23_46 - 30 Aug 2014