SPAC22A12.10


Gene Standard NameUnassigned Characterisation Statusbiological_role_inferred
Systematic IDSPAC22A12.10 Feature Typeprotein coding
Synonyms Name Description
Productdiacylglycerol cholinephosphotransferase/ diacylglycerol ethanolaminesphotransferase (predicted) Product Size386aa, 44.08 kDa
Genomic Location Chromosome I, 1172209-1176801 (4593nt); CDS:1174571-1175781 (1211nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0004142diacylglycerol cholinephosphotransferase activityISSUniProtKB:P22140GO_REF:00000011
GO:0004307ethanolaminephosphotransferase activityISOSGD:S000001165GO_REF:00000241
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0006657CDP-choline pathwayISSUniProtKB:P22140GO_REF:00000013
GO:0006646phosphatidylethanolamine biosynthetic processISOSGD:S000001165GO_REF:00000248
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005783endoplasmic reticulumISOSGD:S000001165GO_REF:0000024594
GO:0005789endoplasmic reticulum membraneICGO:0005783, GO:0016020GO_REF:0000001205
GO:0016021integral component of membraneIEAUniProtKB-KW:KW-0812GO_REF:00000371018
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopySPAC22A12.10ΔNullPMID:204732893751
MicroscopySPAC22A12.10ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphology3088
penetrance FYPO_EXT:0000001MicroscopySPAC22A12.10ΔNullPECO:0000005, PECO:0000137PMID:23697806
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
111722091174707
211747581176801
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF01066 Pfam IPR000462 CDP-alcohol phosphatidyltransferase 44 144 4
TMhelix TMHMM 252 274 959
TMhelix TMHMM 345 367 959
TMhelix TMHMM 46 68 959
TMhelix TMHMM 313 335 959
TMhelix TMHMM 217 239 959
TMhelix TMHMM 284 306 959
TMhelix TMHMM 135 157 959
TMhelix TMHMM 169 191 959
PS00379 Prosite Patterns IPR000462 CDP-alcohol phosphatidyltransferase 99 121 4
PTHR10414 HMMPANTHER IPR014472 Choline/ethanolamine phosphotransferase 3 386 1
PTHR10414:SF4 HMMPANTHER 3 386 1
PIRSF015665 PIRSF IPR014472 Choline/ethanolamine phosphotransferase 1 386 1

View domain organization at Pfam

Sequence Ontology

Term IDTerm NameReferenceCount
SO:0001812transmembrane_helix465

Protein Properties

Ave. residue weight 114.21 Da
Charge 3.50
Isoelectric point 7.26
Molecular weight 44.08 kDa
Number of residues 386
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
79737during GO:0000080PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
81976during GO:0000084PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
79849during GO:0000085PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
83180during GO:0000087PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
80518during GO:0072690PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
10326.09during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
6634.58during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
5.4during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
1.8during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
conserved in fungi4599
conserved in eukaryotes4514
conserved in metazoa3428
conserved in vertebrates3402
conserved in eukaryotes only2498
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


External References
Database Identifier Description
NBRP SPAC22A12.10 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC22A12.10 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC22A12.10 BioGRID Interaction Datasets
Expression Viewer SPAC22A12.10 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC22A12.10 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC22A12.10 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC22A12.10 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC22A12.10 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC22A12.10 Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC22A12.10 Cell Cycle Data
GEO SPAC22A12.10 GEO profiles
PInt SPAC22A12.10 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC22A12.10 Peptides identified in tandem mass spectrometry proteomics experiments
IntEnz2.7.8.1Integrated relational Enzyme database
Rhea2.7.8.1Annotated reactions database
SPD / RIKEN22/22B04Orfeome Localization Data
IntEnz2.7.8.2Integrated relational Enzyme database
Rhea2.7.8.2Annotated reactions database
UniProtKB/SwissProtO13901Uncharacterized CDP-alcohol phosphatidyltransferase class-I family protein C22A12.10
ModBaseO13901Database of comparative protein structure models
STRINGO13901Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_593240CDP-alcohol phosphatidyltransferase class-I family protein
RefSeq mRNANM_001018637972h- CDP-alcohol phosphatidyltransferase class-I family protein (SPAC22A12.10), mRNA
European Nucleotide ArchiveCAB16580.1ENA Protein Mapping
UniParcUPI000006982FUniProt Archive

Literature for SPAC22A12.10

Search: Europe PMC or PubMed

Release Version: PomBase:23_46 - 30 Aug 2014