mug84 (SPAC22A12.13)


Gene Standard Namemug84 Characterisation Statusbiological_role_inferred
Systematic IDSPAC22A12.13 Feature Typeprotein coding
Synonyms Name DescriptionMeiotically Upregulated Gene
Productpig-P subunit (predicted) Product Size195aa, 22.26 kDa
Genomic Location Chromosome I, 1180184-1181157 (974nt); CDS:1180254-1180841 (588nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0017176phosphatidylinositol N-acetylglucosaminyltransferase activity5
contributes_toISSUniProtKB:P57054GO_REF:0000001
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0006506GPI anchor biosynthetic processISSUniProtKB:P57054GO_REF:000000128
GO:0007126meiotic nuclear divisionIEAUniProtKB-KW:KW-0469GO_REF:0000037330
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005783endoplasmic reticulumIDAPMID:16823372594
ISOSGD:S000002845GO_REF:0000024
GO:0030176integral component of endoplasmic reticulum membraneICGO:0016020, GO:0005783GO_REF:000000167
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002061inviable vegetative cell populationMicroscopymug84ΔNullPECO:0000005, PECO:0000137PMID:236978061337
Microscopymug84ΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001042inviable after spore germination, single or double cell division96
penetrance FYPO_EXT:0000003Microscopymug84ΔNullPECO:0000005, PECO:0000137PMID:23697806
FYPO:0000313inviable after spore germination, without cell division, with abnormal germ tube morphology146
penetrance FYPO_EXT:0000001Microscopymug84ΔNullPECO:0000005, PECO:0000137PMID:23697806
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
111801841181157
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF08510 Pfam IPR013717 PIG-P 80 178 1
TMhelix TMHMM 84 106 959
TMhelix TMHMM 121 143 959
PTHR21726 HMMPANTHER 27 194 2
PTHR21726:SF12 HMMPANTHER 27 194 1

View domain organization at Pfam

Sequence Ontology

Term IDTerm NameReferenceCount
SO:0000418signal_peptide278
SO:0001812transmembrane_helix465

Protein Properties

Ave. residue weight 114.17 Da
Charge -11.00
Isoelectric point 4.36
Molecular weight 22.26 kDa
Number of residues 195
Sequence
Gene Expression

Qualitative Gene Expression

DescriptionLevelEvidenceReference
RNA levelincreased during GO:0051321experimental evidencePMID:16303567

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
NDduring GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
NDduring cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1.3during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
0.31during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Warning
DescriptionQualifierReferenceCount
gene structure updated PMID:21511999432
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4599
conserved in eukaryotes4514
conserved in metazoa3428
conserved in vertebrates3402
conserved in eukaryotes only2498
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


External References
Database Identifier Description
NBRP SPAC22A12.13 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC22A12.13 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC22A12.13 BioGRID Interaction Datasets
Expression Viewer SPAC22A12.13 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC22A12.13 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC22A12.13 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC22A12.13 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC22A12.13 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC22A12.13 Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC22A12.13 Cell Cycle Data
GEO SPAC22A12.13 GEO profiles
PInt SPAC22A12.13 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC22A12.13 Peptides identified in tandem mass spectrometry proteomics experiments
SPD / RIKEN42/42B07Orfeome Localization Data
UniProtKB/SwissProtO13904Meiotically up-regulated gene 84 protein
ModBaseO13904Database of comparative protein structure models
STRINGO13904Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_593243pig-P subunit (predicted)
RefSeq mRNANM_001018640972h- pig-P subunit (predicted) (mug84), mRNA
European Nucleotide ArchiveCAB16583.3ENA Protein Mapping
UniParcUPI000228F47AUniProt Archive
UniPathwayUPA00196Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis

Literature for mug84

Search: Europe PMC or PubMed

Release Version: PomBase:23_46 - 30 Aug 2014