bip1 (SPAC22A12.15c)


Gene Standard Namebip1 Characterisation Statuspublished
Systematic IDSPAC22A12.15c Feature Typeprotein coding
Synonymsbip Name Description
ProductER heat shock protein BiP Product Size663aa, 73.23 kDa
Genomic Location Chromosome I, 1185497-1182693 (2805nt); CDS:1185303-1183312 (1992nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005524ATP bindingIEAUniProtKB-KW:KW-0067GO_REF:0000037559
GO:0016887ATPase activityISOSGD:S000003571GO_REF:0000024233
GO:0005515protein bindingIPIcnx1PMID:9860839887
GO:0051082unfolded protein bindingISOSGD:S000003571GO_REF:000002442
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0051084'de novo' posttranslational protein foldingIDAPMID:98608392
GO:0030433ER-associated ubiquitin-dependent protein catabolic processISOSGD:S000003571GO_REF:000002426
GO:0034620cellular response to unfolded proteinISOSGD:S000003571GO_REF:000002415
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005794Golgi apparatusIDAPMID:16823372355
GO:0005783endoplasmic reticulumIDAPMID:16823372594
GO:0005788endoplasmic reticulum lumenIDAPMID:137337913
GO:0031965nuclear membraneIDAPMID:137337950
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002061inviable vegetative cell populationMicroscopybip1ΔNullPMID:204732891309
Microscopybip1ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000049inviable cellCell growth assaybip1Δ::ura4+NullPMID:13733791356
FYPO:0002151inviable sporeMicroscopybip1ΔNullPECO:0000005, PECO:0000137PMID:23697806447
penetrance FYPO_EXT:0000001
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
111854971182693

UTRs

Region Start End Reference
three_prime_UTR11833111182693PMID:21511999
five_prime_UTR11854971185304PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00012 Pfam IPR013126 Heat shock protein 70 family 37 641 8
TMhelix TMHMM 7 24 959
PS00329 Prosite Patterns IPR018181 Heat shock protein 70 family 227 240 6
PS00297 Prosite Patterns IPR018181 Heat shock protein 70 family 40 47 5
PS01036 Prosite Patterns IPR018181 Heat shock protein 70 family 364 378 7
PTHR19375 HMMPANTHER 26 662 8
G3DSA:2.60.34.10 Gene3D 419 545 7
G3DSA:1.20.1270.10 Gene3D 546 648 6
G3DSA:3.90.640.10 Gene3D 261 341 16
G3DSA:3.30.420.40 Gene3D 154 231 24
G3DSA:3.30.420.40 Gene3D 346 387 24
G3DSA:3.30.420.40 Gene3D 232 260 24
G3DSA:3.30.420.40 Gene3D 37 85 24
G3DSA:3.30.30.30 Gene3D 86 146 6
SSF53067 SuperFamily 35 218 25
SSF100920 SuperFamily 414 571 7
SSF53067 SuperFamily 221 411 25
SSF100934 SuperFamily 565 646 7
SignalP-noTM signalp 1 24 212
Coil ncoils Rabaptin coiled-coil domain 543 564 975
Coil ncoils Rabaptin coiled-coil domain 290 311 975
Low complexity (SEG) seg 643 662
Low complexity (SEG) seg 397 408
PR00301 PRINTS IPR013126 Heat shock protein 70 family 498 514 8
PR00301 PRINTS IPR013126 Heat shock protein 70 family 417 436 8
PR00301 PRINTS IPR013126 Heat shock protein 70 family 361 377 8
PR00301 PRINTS IPR013126 Heat shock protein 70 family 233 243 8
PR00301 PRINTS IPR013126 Heat shock protein 70 family 86 94 8
PR00301 PRINTS IPR013126 Heat shock protein 70 family 392 412 8
PR00301 PRINTS IPR013126 Heat shock protein 70 family 173 193 8
PR00301 PRINTS IPR013126 Heat shock protein 70 family 64 76 8
PR00301 PRINTS IPR013126 Heat shock protein 70 family 36 49 8

View domain organization at Pfam

Sequence Ontology

Term IDTerm NameReferenceCount
SO:0000418signal_peptide278
SO:0001806ER_retention_signalPMID:13733792

Protein Properties

Ave. residue weight 110.45 Da
Charge -28.00
Isoelectric point 4.57
Molecular weight 73.23 kDa
Number of residues 663
Modifications

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
MOD:00693glycosylated residueIDAPMID:137337926
PMID:8227200
Sequence
Gene Expression

Qualitative Gene Expression

DescriptionLevelEvidenceReference
RNA levelincreasedNorthern assay evidencePMID:1373379
during GO:0034605

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
123452.29during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
35320.11during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
4.3during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
41during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3080
conserved in fungi4564
conserved in eukaryotes4482
conserved in metazoa3419
conserved in vertebrates3394
conserved in eukaryotes only2485
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
bdf2BET family double bromodomain protein Bdf2 Affinity Capture-MSPMID:24013502
sog2leucine-rich repeat protein Lrp1 Affinity Capture-MSPMID:23462181
nak1PAK-related kinase Nak1 Affinity Capture-MSPMID:23462181
hhp1serine/threonine protein kinase Hhp1 Affinity Capture-MSPMID:24055157
tea1cell end marker Tea1 Affinity Capture-MSPMID:21652630
epe1Jmjc domain chromatin associated protein Epe1 Affinity Capture-MSPMID:24013502
hhp2serine/threonine protein kinase Hhp2 Affinity Capture-MSPMID:24055157
cnx1calnexin Cnx1 Affinity Capture-WesternPMID:9860839
Affinity Capture-WesternPMID:17230581
External References
Database Identifier Description
NBRP SPAC22A12.15c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC22A12.15c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC22A12.15c BioGRID Interaction Datasets
Expression Viewer SPAC22A12.15c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC22A12.15c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC22A12.15c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC22A12.15c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC22A12.15c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC22A12.15c Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC22A12.15c Cell Cycle Data
GEO SPAC22A12.15c GEO profiles
PInt SPAC22A12.15c Protein-Protein Interaction Predictor (Bähler Lab)
SPD / RIKEN27/27C11Orfeome Localization Data
WikiGene2541815BiP
EntrezGene2541815BiP
UniProtKB/SwissProtP3660478 kDa glucose-regulated protein homolog
ModBaseP36604Database of comparative protein structure models
StringP36604Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_593245BiP
RefSeq mRNANM_001018642972h- BiP (bip1), mRNA
European Nucleotide ArchiveCAA45762ENA Protein Mapping
European Nucleotide ArchiveCAB16585ENA Protein Mapping
UniParcUPI000012BA5CUniProt Archive

Literature for bip1

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014