bip1 (SPAC22A12.15c)

Gene Standard Namebip1 ChromosomeI
Systematic IDSPAC22A12.15c Gene Start1185497
Synonymsbip Gene End1182693
ProductER heat shock protein BiP Gene Length2805
Feature Typeprotein coding CDS Start1185303
Name Description CDS End1183312
Characterisation Statuspublished CDS Length1992

Ensembl Gene Location
  1. SPAC22A12.10
  2. SPNCRNA.718
  3. dak1
  4. rrp40
  5. mug84
  6. SPAC22A12.14c
  7. SPNCRNA.719
  8. bip1
  9. SPAC22A12.17c
  10. SPAC22A12.16
  11. SPNCRNA.168
  12. SPNCRNA.720
  13. SPNCRNA.721
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0002061inviable vegetative cell populationMicroscopybip1delta (deletion)deletionPMID:20473289
GO Molecular Function

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Term IDTerm NameEvidenceWith/FromReference
GO:0005515protein bindingIPIcnx1PMID:9860839
GO:0005524ATP bindingICGO:0016887GO_REF:0000001
GO:0016887ATPase activityISOSGD:S000003571GO_REF:0000024
GO:0051082unfolded protein bindingISOSGD:S000003571GO_REF:0000024
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0030433ER-associated protein catabolic processISOSGD:S000003571GO_REF:0000024
GO:0034620cellular response to unfolded proteinISOSGD:S000003571GO_REF:0000024
GO:0051084'de novo' posttranslational protein foldingIDAPMID:9860839
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0005783endoplasmic reticulumIDAPMID:16823372
GO:0005788endoplasmic reticulum lumenIDAPMID:1373379
GO:0005794Golgi apparatusIDAPMID:16823372
GO:0031965nuclear membraneIDAPMID:1373379
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
111854971182693

References

Region Start End Reference
three_prime_UTR11833111182693PMID:21511999
five_prime_UTR11854971185304PMID:21511999
three_prime_UTR11833111182693PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF00012 IPR013126 Pfam Heat shock protein 70 family 37 641 8
TMhelix TMHMM 7 24 955
PS01036 IPR018181 Prosite Patterns Heat shock protein 70 family 364 378 7
PS00297 IPR018181 Prosite Patterns Heat shock protein 70 family 40 47 5
PS00329 IPR018181 Prosite Patterns Heat shock protein 70 family 227 240 6
G3DSA:3.30.30.30 Gene3D 86 146 6
G3DSA:3.30.420.40 Gene3D 232 260 24
G3DSA:3.30.420.40 Gene3D 37 85 24
G3DSA:3.30.420.40 Gene3D 154 231 24
G3DSA:3.30.420.40 Gene3D 346 387 24
G3DSA:3.90.640.10 Gene3D 261 341 16
G3DSA:1.20.1270.10 Gene3D 546 648 6
G3DSA:2.60.34.10 Gene3D 419 545 7
SSF100934 SuperFamily 565 646 7
SSF53067 SuperFamily 221 411 25
SSF53067 SuperFamily 35 218 25
SSF100920 SuperFamily 414 571 7
PTHR19375 hmmpanther 10 660 8
SignalP-noTM signalp 1 24 212
Coil ncoils Rabaptin coiled-coil domain 290 311 974
Coil ncoils Rabaptin coiled-coil domain 543 564 974
PR00301 IPR013126 PRINTS Heat shock protein 70 family 36 49 8
PR00301 IPR013126 PRINTS Heat shock protein 70 family 392 412 8
PR00301 IPR013126 PRINTS Heat shock protein 70 family 173 193 8
PR00301 IPR013126 PRINTS Heat shock protein 70 family 64 76 8
PR00301 IPR013126 PRINTS Heat shock protein 70 family 86 94 8
PR00301 IPR013126 PRINTS Heat shock protein 70 family 233 243 8
PR00301 IPR013126 PRINTS Heat shock protein 70 family 361 377 8
PR00301 IPR013126 PRINTS Heat shock protein 70 family 417 436 8
PR00301 IPR013126 PRINTS Heat shock protein 70 family 498 514 8

View domain organization at Pfam

Protein Modifications (PSI-MOD)

Term IDTerm NameEvidenceResidueReference
MOD:00693glycosylated residueevidenceInferred from Direct AssayPMID:1373379
PMID:8227200

Sequence Ontology

Term IDTerm NameReference
SO:0000418signal_peptide
SO:0001806ER_retention_signalPMID:1373379

Protein Properties

Ave. residue weight 110.45 Da
Charge -28.00
Isoelectric point 4.57
Molecular weight 73.23 kDa
Number of residues 663
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide35320.11PMID:23101633
experimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide123452.29PMID:23101633
RNA levelNorthern assay evidencecellular response to heatincreasedPMID:1373379
experimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide41PMID:23101633
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide4.3PMID:23101633
Species Distribution
DescriptionQualifierReference
predominantly single copy (one to one)
conserved in fungi
conserved in eukaryotes
conserved in metazoa
conserved in vertebrates
conserved in eukaryotes only
Manually curated orthologous groups
SpeciesGeneDescription

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Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
lrp1leucine-rich repeat protein Lrp1 Affinity Capture-MSPMID:23462181
cnx1calnexin Cnx1 Affinity Capture-WesternPMID:9860839
Affinity Capture-WesternPMID:17230581
tea1cell end marker Tea1 Affinity Capture-MSPMID:21652630
nak1PAK-related kinase Nak1 Affinity Capture-MSPMID:23462181
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External References
Database Identifier Description
NBRP SPAC22A12.15c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC22A12.15c Retrieval of eukaryotic orthologs
BioGrid SPAC22A12.15c BioGRID Interaction Datasets
Bähler Lab SPAC22A12.15c Cell Cycle Expression Profile
Bähler Lab SPAC22A12.15c Meiosis/Sporulation Expression Profies
Bähler Lab SPAC22A12.15c Pheromone response/mating expression profiles
Bähler Lab SPAC22A12.15c Environmental stress expression profiles
Bähler Lab SPAC22A12.15c Bähler Lab Transcriptome Viewer
Cyclebase SPAC22A12.15c Cell Cycle Data
PInt SPAC22A12.15c Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPAC22A12.15c Entrez Gene
SPD / RIKEN27/27C11Orfeome Localization Data
WikiGene2541815BiP
Uniprot_genenameBIP1
EntrezGene2541815BiP
UniProtKB/SwissProtP3660478 kDa glucose-regulated protein homolog
ModBaseP36604Database of comparative protein structure models
Pfam Protein DomainsP36604Pfam Domain Arrangement
RefSeq PeptideNP_593245BiP
RefSeq mRNANM_001018642972h- BiP (bip1), mRNA
European Nucleotide ArchiveCAA45762ENA Protein Mapping
European Nucleotide ArchiveCAB16585ENA Protein Mapping
UniParcUPI000012BA5CUniProt Archive

Literature for bip1
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Search: UK PMC or PubMed

Release Version: PomBase:18_35 - 11 May 2013